Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes by Yong Li, Steven A Rosenberg, Paul F Robbins, Zhiya Yu, Maria Parkhurst, Billel Gasmi, Nikolaos Zacharakis, Todd D Prickett, Jared J Gartner, Sri Krishna, Stephanie L Goff, Satyajit Ray, Frank J Lowery, Sivasish Sindiri, Alakesh Bera, Noam Levin, Sanghyun P Kim, Charles A Marquardt, Nolan R Vale, Lior Levy, Tiffany Benzine, Robert V Masi, Rafiqul Islam

“…This allowed the effective isolation of novel neoantigen-reactive TCRs. Out of the 25 consecutive TIL samples, neoantigenic stimulation enabled the identification of 16 unique reactivities and 42 TCRs, while conventional TIL expansion identified 9 reactivities and 14 TCRs. …”
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A self-activated and protective module enhances the preclinical performance of allogeneic anti-CD70 CAR-T cells by Zhao Zhang, Lianfeng Zhao, Tinghui Huang, Zhengliang Chen, Zhengliang Chen, Yaoyao Zhao, Yaoyao Zhao, Junqing Liang, Xudong Ao, Xiaoqiong Jia, Lei Kang, Linghui Kong, Qi Jing, Jianhua Hu, Lili Gu, Feiyan Pan, Zhigang Hu, Lingfeng He, Muya Zhou, Jiannan Chen, Zhigang Guo

“…Anti-CD70 UCAR-T cells were then generated by knocking out TRAC, B2M, and HLA-DRA. To address the limitations of UCAR-T therapy, we developed an 'all-in-one' self-activated and protective (SAP) module, integrated into the CAR scaffold. …”
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Comparative evaluation of sensititre YeastOne and VITEK2 antifungal susceptibility tests with CLSI broth microdilution method of clinical Cryptococcus isolates in Taiwan by Tzu-Ping Weng, Shin-Wei Wang, Shih-Ting Lo, Shu-Li Su, Ming-I Hsieh, Pei-Jane Tsai, Pei-Fang Tsai, Chi-Jung Wu, Nan-Yao Lee, Wen-Chien Ko, Po-Lin Chen

“…The results of FLC MIC by SYO should be interpreted cautiously and correlated with therapeutic response, and further verification with the CLSI BMD method or VITEK2 is required.IMPORTANCEThe study pointed out the major errors of fluconazole susceptibility results in clinical Cryptococcus neoformans isolates between the commercial Sensititre YeastOne Susceptibility Plate version YO10C and the standard CLSI broth microdilution method. …”
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ADMINISTRATIVE PREREQUISITES FOR FINANCIAL MANAGEMENT AND MARKETING OF SMALL BUSINESSES AT THE REGIONAL LEVEL by Natalia Koval, Oksana Kubai, Natalia Germaniuk

“…Small business (small entrepreneurship) is a business activity carried out by subjects of the market economy in accordance with the criteria established by laws, state bodies or other representative organisations. …”
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Editorial by Jörg Tremmel, Marisa dos Reis, Joseph Burke, Raphaelle Schwarzberg (†)

“…Maja Göpel and Malte Arhelger’s article sets out to reflect on this growing trend and how it can inform the creation of a European level institution for the protection of the rights of future generations. …”
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The Impact of Sanctions’ Reduction and the Financial Strength of Companies on the Development of Garment Exports, Considering the Mediation Role of Direct and Indirect Exports. by Farshad Alidaei, Mostafa Hashemi Tilehnouei, hossein vazifedoost

“…They can be agents or companies that carry out the export. Agents act as brokers or establish a relationship between the exporter and foreign buyers (Grozdanovska et al., 2017).Export development programs include all commercial, informational, and educational actions. …”
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Investigating the relationship between customer experience components on commitment and customer engagement behaviors in the retail industry by Alireza Naalchi Kashi

“…Extended Abstract Introduction Creating an excellent customer experience is a major and challenging issue in marketing (Saeedi et al, 2023; Raeisi Ziarani et al, 2023) and for companies in today's competitive world, it has created a competitive environment where four out of five companies compete with each other for customer experience; and success belongs to those companies that create a better experience for customers (Saeedi et al, 2022); because creating a positive experience is the basis for business growth and development (Raeisi Ziarani et al, 2023). …”
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Improving the experience of health services for trans and gender-diverse young people and their families: an exploratory qualitative study by Melissa Stepney, Samantha Martin, Magdalena Mikulak, Sara Ryan, Jay Stewart, Richard Ma, Adam Barnett

“…This research was carried out against a backdrop of increasing evidence of repeated failings in health care for trans people. …”
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Repairbads: An automatic and adaptive method to repair bad channels and segments for OPM-MEG by Fulong Wang, Yujie Ma, Tianyu Gao, Yue Tao, Ruonan Wang, Ruochen Zhao, Fuzhi Cao, Yang Gao, Xiaolin Ning

“…Repairbads employs Riemannian Potato combined with joint decorrelation to project out artifact components, achieving automatic bad segment repair. …”
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Galactin-8 DNA methylation mediates macrophage autophagy through the MAPK/mTOR pathway to alleviate atherosclerosis by Bing Xia, Yan-lin Lu, Jin Peng, Jing-wei Liang, Fang-qin Li, Jiu-yang Ding, Chang-wu Wan, Cui-yun Le, Jia-lin Dai, Jie-Wang, Bing Guo, Jiang Huang

“…However, the mechanism of GAL8 DNA methylation and gene expression in AS has not been elucidated, prompting us to carry out further research on it. ApoE-/- mice were used to establish an atherosclerosis model, and DNA methylation inhibitor DO05 and MAPK/mTOR inhibitor UO126 were used for intervention. …”
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Improving quality and outcomes of extracorporeal cardiopulmonary resuscitation in refractory cardiac arrest: the Phoenix ECPR project by Michael Taylor, Vasileios Panoulas, Jill Smith, Alex Rosenberg, Mark Mason, Ian McGovern, Majid Akhtar, Sachin Mehta, Waqas Akhtar, Anthony McKay, Sumesh Thiruthalil, Orinta Kviatkovske, Donna Hall, Eftychia Galiatsou, Sofia Pinto, Maria Comanici, Emanuele Gerlando, Timothy Pitt, Joe Hughes, Olaf Maunz, Elia Keating, Julia Gangata, Eleanor Ross, Sophie Avetoom, Jane Durrant, Ciara Collins, Anand Jothidasan, Maria Monteagudo-Vela, Jerry Mitchell, Hatem Soliman Aboumarie, Caroline Bullen, Sundeep Kaul, Clara Hernandez Caballero, Ana Hurtado, Nick Lees

“…A new structured system including a systematic screening process, strict exclusion criteria, assessment of resuscitation adequacy through physiological stop criteria, drilled and standardised cannulation process, post-resuscitation care and neuroprognostication was rolled out on 1 April 2023. A comparison of ECPR performed pre and post was undertaken.Results With the institution of the new system, 13 patients were treated with ECPR over 1 year; of which nine (69.2%) survived with good neurological outcomes at 6 months. …”
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Determination of Zinc Requirement in Suckling Calves using Some Non-Linear Models by Mohammad Javad Elyasi, Khalil zaboli

“…The present study was carried out to determine the optimal requirement of Zn in Holstein suckling calves using some models. …”
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Макроморфологічні та мікроморфологічні дослідження ґрунтів Консулівського городища (І ст. до н. е. – ІІ ст. н. е.)... by Жанна Матвіїшина, Анатолій Кушнір, Надія Гаврилюк, Матера Марчин

“…The purpose of this article is to present new results of the study of soil samples from the Konsulivske settlement (1st century BC – 2st century AD), carried out by means of macromorphological and micromorphological analyses, and to show their significance for the archaeological characterisation of this settlement. …”
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A phase 2, double-blind, placebo-controlled trial of a valproate/lithium combination in ALS patients by M.-C. Boll, M. Alcaraz-Zubeldia, C. Rios, D. González-Esquivel, S. Montes

“…Secondary outcome variables included BMI, respiratory monitoring, quality of life, and a global impression of the treatment. Results: Out of 42 patients enrolled, 20 individuals receiving VPA-Li and 18 on placebo treatment were included in the final analysis. …”
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A combined use of Panax ginseng extract and the probiotic, Lactobacillus plantarum in the diet of Asian seabass, Lates calcarifer: Effects on growth, immunity and survival after ba... by Xiaojie Hou, Jianfeng Zhang, Neda Behmagham, Hamed Ghafarifarsani

“…All experiments were carried out in three replicates and fish (Mean weight: 25.3 ± 4.2 g) of all treatments fed for 60 days. …”
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A Predictive Model for Pulmonary Aspergillosis in ICU Patients: A Multicenter Retrospective Cohort Study by Li Y, Ren X, Wang Q, Shen S, Li Y, Qian X, Tang Y, Jia J, Zhang H, Ding J, Song Y, Zhang S, Wang S, Xu Y, Jiang Y, He X, Dai M, Zhong L, Xiong Y, Pan Y, Wang M, Shao H, Cai H, Huang L, Wang H

“…The performance of this model was then assessed and validated in the validation cohort.Results: Out of 1737 patients initially included in the study, 898 were ultimately analyzed, of which 100 (11%) were diagnosed with IPA. …”
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Editorial by Lindsay B. Flynn

“…The approach considers the specific needs of young people shut out of housing markets, young people who may be experiencing severe housing insecurity or homelessness, and the spatial dimension of such challenges. …”
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Curative effect of auricular copper scraping combined with auricular acupoint pressing on insomnia after Methylprednisolone pulse therapy for thyroid-associated ophthalmopathy (耳部铜... by MA Yan (马艳), ZHAO Yue (赵悦), LIN Yuxiao (林育潇), LIU Xiao (刘笑), SONG Yumin (宋玉敏)

“…Results Two patients dropped out of the study. The effective rate of sleep improvement in observation group was 87. 18%(34/39), which was significantly higher than 41. 46%(17/41) in control group (P < 0. 05). …”
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Three-dimensional aortic arch geometry and blood flow in neonates after surgical repair for aortic coarctation by Katrin Fricke, Katrin Fricke, Lea Christierson, Lea Christierson, Lea Christierson, Einar Heiberg, Einar Heiberg, Pia Sjöberg, Pia Sjöberg, Erik Hedström, Erik Hedström, Erik Hedström, Erik Hedström, Kristoffer Steiner, Constance G. Weismann, Constance G. Weismann, Constance G. Weismann, Johannes Töger, Johannes Töger, Petru Liuba, Petru Liuba

“…Continuous data are presented as median and interquartile range.ResultsThe median age at CoA surgery was 9 days. Four out of the included 28 patients (14%) developed re-CoA within the first 12 months after surgery. …”
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New Parameters for Impedance–pH Monitoring in Diagnosing Gastroesophageal Reflux Disease and Predicting its Severity by O. A. Storonova, A. S. Trukhmanov, A. A. Makushina, A. V. Paraskevova, V. T. Ivashkin

“…The present articleidentifies possible correlations between new parameters for impedance–pH monitoring, such as mean nocturnal baseline impedance (MNBI); post-reflux swallow-induced peristaltic wave index (PSPW); and the main parameter, acid exposure time (AET), as well as esophageal motor function. The authors set out to assess the values of MNBI and the PSPW index as additional criteria improving the diagnostic efficacy of impedance-pH monitoring, the completeness of clinical phenotyping of gastroesophageal reflux disease (GERD), as well as determining the probability of a more severe disease course. …”
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