Spatiotemporal and genomic analysis of carbapenem resistance elements in Enterobacterales from hospital inpatients and natural water ecosystems of an Irish city by Mark Maguire, Carlos Serna, Natalia Montero Serra, Aneta Kovarova, Louise O’Connor, Niamh Cahill, Brigid Hooban, Niall DeLappe, Wendy Brennan, Genevieve Devane, Martin Cormican, Dearbháile Morris, Simone C. Coughlan, Georgios Miliotis, Bruno Gonzalez-Zorn, Liam P. Burke

“…However, the dynamics of carbapenemase-bearing MGE dissemination between Enterobacterales in humans and environmental waters are poorly understood. We carried out whole-genome sequencing, combining short- and long-sequencing reads to enable complete characterization of CPE isolated from patients, wastewaters, and natural waters between 2018 and 2020 in Galway, Ireland. …”
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Assessment of Bowel Preparation Using Low-Volume Sulphate-Based Preparations in Comparison with Macrogols: A Multicenter, Randomized, Comparative Clinical Study of the 3rd Phase by E. D. Fedorov, V. V. Veselov, S. V. Kashin, E. V. Tikhomirova, A. V. Veselov, D. V. Zavyalov, A. Kornowski, T. E. Gorskaya, M. Volteau, T. Ponchon

“…The authors also express their appreciation to Olga Kapitonova, an employee of the Almedis company (Moscow, Russia) for her assistance in compiling medical texts, which activity was carried out under the financial support of the Ipsen company (Moscow, Russia) in accordance with the Good Publication Practice (GPP).…”
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Análisis de habilidades y percepciones sobre mHealth en el manejo de pacientes crónicos por profesionales de atención primaria by Daniel Monasor Ortola, José Joaquín Mira Solves, Antonio Esteve Ríos

“…Results: A total of 181 professionals participated, showing high proficiency in managing mobile applications (median score of 8 out of 10; IQR = 2), with higher proficiency observed among younger professionals (P < .001). 56.35% had prescribed official or scientifically endorsed digital information. …”
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Pratiques de l’automédication à l’ère de la pandémie COVID-19 dans trois villes de l’Ouest algérien [Practices of self-medication in the COVID-19 pandemic era in three cities of We... by Derouicha Matmou, Asma Memou, Yassine Merad, Ayoub Bouzid, Sohaïb Abd-El-Koudous Bouzid, Aissa Brik, Mounia Sakouhi

“…Materials and methods- The study was carried out during the pandemic from January 01st, 2022 to March 31st, 2022 using a questionnaire distributed to community pharmacists prac­ticing in Tiaret, Sidi Bel-Abbes and El-Bayadh. …”
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Effects of post-traumatic stress disorder and social support on post-traumatic growth in parents of children with craniocerebral tumors (颅脑肿瘤患儿父母创伤后应激障碍、社会支持与创伤后成长的相关性分析)... by LUO Jingwen (罗静文), ZHANG Hongyang (张宏扬), ZHU Ruifang (朱瑞芳)

“…Results Totally 110 questionnaires were sent out, 100 were effectively received with effective recovery of 90. 91%. …”
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Oral delivery of bovine tuberculosis vaccine to free-ranging white-tailed deer by Kurt VerCauteren, Abigail Feuka, Michael Lavelle, Michael Glow, Keely Kohen, Patrick Ryan, Tony Aderman, Anthony Duffiney, Mitchell Palmer, Paola M. Boggiatto, Carly Kanipe, Hayden Hamby, Emily Ruell, Melinda Cosgrove, Michael Vanderklok, Nathan Snow, Kim M. Pepin, Henry Campa

“…Consumption, still images, and video data were analyzed to assess uptake of vaccine DUs by deer.Results and discussionVaccine DUs were deployed in 2024 at 11 agricultural sites on private land which had previously demonstrated moderate to high deer activity and at all but two sites &gt;50% of distributed vaccine DU’s were consumed, with 100% consumed at two sites. Deer learned to seek out and consume vaccine DU’s in just 1 to 3 days, with individuals often eating more than the 1 or 2 needed to vaccinate themselves. …”
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Longitudinal associations of flare and damage accrual in patients with systemic lupus erythematosus by Rangi Kandane-Rathnayake, Sang-Cheol Bae, Zhanguo Li, Shereen Oon, Vera Golder, Mandana Nikpour, Masayoshi Harigai, Zhuoli Zhang, Eric Morand, Chak Sing Lau, Worawit Louthrenoo, Alberta Hoi, Sandra Navarra, Sean O’Neill, Shue-Fen Luo, Yanjie Hao, Yasuhiro Katsumata, Dominique Milea, Aisha Lateef, Laniyati Hamijoyo, Sargunan Sockalingam, Madelynn Chan, Jiacai Cho, Leonid Zamora, Fiona Goldblatt, Yeong-Jian Jan Wu, Xiaomeng Xu, Aldo A Navarro Rojas

“…Multivariable, multifailure survival analyses were carried out to quantify the association between flares and damage accrual.Results 1556 patients with SLE with a median (IQR) of 5.7 (3.9, 7.0) years of follow-up were studied. 39.5% (n=614) of patients had damage at enrolment, and 31.9% (n=496) accrued damage during the study observation period. …”
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Mitigating overconfidence bias: A cross-sectional pilot study of male maintenance workers in the engineering sector by Luca DI GIAMPAOLO, Federica MARINO, Claudia GIURGOLA, Piergiorgio ASTOLFI, Luca COPPETA, Simone DE SIO, Paola BORRELLI, Teresa GALANTI, Laura FORCELLA, Maria Elisa MAIOLO, Kavita BATRA, Murat YILDIRIM, Hicham KHABBACHE, Amelia RIZZO, Mahmood BAHRAMIZADEH, Hiroo WADA, Qiao NIU, Hector NIETO, Francesco CHIRICO

“…The validated questionnaire of Cavazza & Serpe was administered, on a voluntary basis, used for data collection, and subsequently descriptive analysis was carried out for data interpretation. Results: The study surveyed 184 male maintenance workers (response rate: 81.1%). …”
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Gene Therapy for Inflammatory Cascade in Intrauterine Injury with Engineered Extracellular Vesicles Hybrid Snail Mucus‐enhanced Adhesive Hydrogels by Xiaotong Peng, Tao Wang, Bo Dai, Yiping Zhu, Mei Ji, Pusheng Yang, Jiaxin Zhang, Wenwen Liu, Yaxin Miao, Yonghang Liu, Shuo Wang, Jing Sun

“…However, clinically used hyaluronic acid (HA) hydrogels are prone to slip out of injury sites due to poor bio‐adhesion properties. …”
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Lentivirus‐mediated gene therapy for Fabry disease: 5‐year End‐of‐Study results from the Canadian FACTs trial by Aneal Khan, Dwayne L. Barber, William M. McKillop, C. Anthony Rupar, Christiane Auray‐Blais, Graeme Fraser, Daniel H. Fowler, Alexandra Berger, Ronan Foley, Armand Keating, Michael L. West, Jeffrey A. Medin

“…Body weight, blood pressure, urinary protein levels, eGFR, troponin levels, and LVMI were tracked. Results Four out of 5 patients went home the same day as their infusions; one was kept overnight for observation. …”
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Prevalence and factors associated with severe fatigue 2 years into the COVID-19 pandemic: a cross-sectional population-based study in Geneva, Switzerland by Silvia Stringhini, Idris Guessous, C Martinez, A Flahault, S Hurst, N Vuilleumier, L Kaiser, K M Posfay-Barbe, O Zimmermann, S Stringhini, A Uppal, P Schaller, J Berthelot, D Pittet, H Baysson, Hélène Baysson, S Yerly, E Lorthe, Mayssam Nehme, Nick Pullen, María-Eugenia Zaballa, A Bal, Clément Romain Hugo Graindorge, Stephanie Schrempft, I Arm-Vernez, A S Azman, D Bachmann, J-F Balavoine, R P Barbe, A R Bouhet, G Bryand-Rumley, F Chappuis, P Collombet, S Coudurier-Boeuf, D S Courvoisier, C de Mestral, P D’ippolito, R Dubos, R Dumont, N El Merjani, N Francioli, C Graindorge, I Guessous, S Harnal, G Kathari, O Kherad, J Lamour, P Lescuyer, A G L’Huillier, A J Loizeau, S Mechoullam, L Metral-Boffod, M Nehme, N Noël, F Pennacchio, J Perez-Saez, G Poulain, C Pugin, N Pullen, V Richard, D Rochat, S Rouzinov, K Samir, H S Ramirez, E Satin, S Schrempft, C Semaani, S Testini, D Urrutia-Rivas, C Verolet, P Vetter, J Villers, G Violot, A Wisniak, M-E Zaballa

“…Objectives This study aims (1) to assess the prevalence of severe fatigue among the general population of Geneva, 2 years into the COVID-19 pandemic and (2) to identify pandemic and non-pandemic factors associated with severe fatigue.Design Cross-sectional population-based survey conducted in Spring 2022.Setting General adult population of Geneva, Switzerland.Participants 6870 adult participants, randomly selected from the general population, included in the Specchio-COVID-19 cohort study, were invited to answer an online health survey.Outcome and cofactor measure Prevalence of severe fatigue was measured by the Chalder Fatigue Questionnaire with a cut-off score≥4 out of 11. We assessed prevalence ratios of severe fatigue considering sociodemographic factors, health and behavioural characteristics (body mass index, depression, recent diagnosis of chronic disease or allergy, acute health event, smoking status, physical activity and sleep quality) and recent self-reported COVID-19 infections.Results A total of 4040 individuals participated (participation rate 59%, 58% were women, mean age 53.2 (SD=14.1 years)). …”
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Electroacupuncture Relieves Suppression of Autophagy in Interstitial Cells of Cajal of Diabetic Gastroparesis Rats by Xing Wei, Yaping Lin, Dongfeng Zhao, Xiaojuan Xiao, Qiao Chen, Siyi Chen, Yan Peng

“…In this study, we aimed to figure out the relationship between DGP and autophagy of ICCs. …”
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Deep Learning-Based Identification of Echocardiographic Abnormalities From Electrocardiograms by Goro Fujiki, MD, Satoshi Kodera, MD, PhD, Naoto Setoguchi, MD, Kengo Tanabe, MD, PhD, Kotaro Miyaji, MD, PhD, Shunichi Kushida, MD, PhD, Mike Saji, MD, PhD, Mamoru Nanasato, MD, PhD, Hisataka Maki, MD, PhD, Hideo Fujita, MD, PhD, Nahoko Kato, MD, PhD, Hiroyuki Watanabe, MD, PhD, Minami Suzuki, MD, Masao Takahashi, MD, PhD, Naoko Sawada, MD, PhD, Jiro Ando, MD, Masataka Sato, MD, Shinnosuke Sawano, MD, PhD, Susumu Katsushika, MD, PhD, Hiroki Shinohara, MD, PhD, Norifumi Takeda, MD, PhD, Katsuhito Fujiu, MD, PhD, Hiroshi Akazawa, MD, PhD, Hiroyuki Morita, MD, PhD, Issei Komuro, MD, PhD

“…Results: For the composite findings label, the area under the receiver-operating characteristic curve was 0.80 (95% CI: 0.80-0.81) on hold-out validation and 0.78 (95% CI: 0.78-0.79) on external validation. …”
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Human hair biochar to remove malachite green dye and bisphenol-A contamination by M. Kamaraj, P. Kamali, R. Kaviya, K. Abishek, B. Navinkumar, T.G. Nithya, L.S. Wong, J. Aravind

“…The topography, structure, surface area, and functional group analysis of human hair biochar were carried out using analytical techniques that reveal the biochar has the potential for adsorbent characteristics. …”
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Performance Analysis of Costs and Implementation Time Using Earned Value Method on the Distribution Pipe Network Expansion in Samarinda City by Dedy Sugi Hartawan, Wateno Oetomo, Risma Marleno

“…This research was carried out with the aim of determining the cost and time for completing the project. …”
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Polimorfisme Gen Apolipoprotein E Pada Penderita Sindrom Down Trisomi 21 by Malinda Meinapuri

“…DNA extraction was done by using the commonly used salting out method in CEBIOR Semarang Indonesia. Subsequently polimorphism of APOE gene analysis has been done by using PCR and RFLP.Result : Thirty three samples were Down Syndrom patients, consist of 18 male and 15 female. …”
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Development and validation of a food-related quality of life questionnaire (CANUT-QVA) for cancer patients by Kenza Drareni, Catherine Mercier, Reisya Rizki Riantiningtyas, Anestis Dougkas, Benjamin Riche, Pascale Roux, Chantal Fingal, Hélène Labrosse, Fadila Farsi, David Dayde, Mélanie Roche, Julie Anne Nazare, Arnaud Fournel, Delphine Maucort-Boulch, Moustafa Bensafi, Véronique Mourier, Amandine Bruyas, Agnès Giboreau

“…Analysis of test-retest reliability was also performed to evaluate reproducibility. Results: Out of the 46 items, 39 items showed significant differences between patients and healthy controls. …”
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Physical and molecular identification of fish and shrimp diseases in some farms of West Java, Banten and Jakarta, Indonesia by Adam Saba Anggara, Ida Ayu Mirah Meliana Dewi, Kismono Kudoasmoro, Putu Eka Sudaryatma, Putu Angga Wiradana

“…Monitoring was carried out in two stages, namely the period March–April 2021 and September 2021 by taking samples from several ponds in Bogor, Tangerang, Depok and Jakarta. …”
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PPARα-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma by Valentin Van den bossche, Julie Vignau, Engy Vigneron, Isabella Rizzi, Hannah Zaryouh, An Wouters, Jérôme Ambroise, Steven Van Laere, Simon Beyaert, Raphaël Helaers, Cédric van Marcke, Lionel Mignion, Elise Y. Lepicard, Bénédicte F. Jordan, Céline Guilbaud, Olivier Lowyck, Hajar Dahou, Antonella Mendola, Manon Desgres, Léo Aubert, Isabelle Gerin, Guido T. Bommer, Romain Boidot, Perrine Vermonden, Aurélien Warnant, Yvan Larondelle, Jean-Pascal Machiels, Olivier Feron, Sandra Schmitz, Cyril Corbet

“…Importantly, the PPARα-related gene signature, in human clinical datasets, correlates with lower response to anti-EGFR therapy and poor survival in HNSCC patients, thereby validating its clinical relevance. This study points out lipid metabolism rewiring as a non-genetic resistance-causing mechanism in HNSCC that may be therapeutically targeted to overcome acquired resistance to anti-EGFR therapy.…”
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Abnormal Liver Tests during Hospitalization Predict Mortality in Patients with COVID-19: A Multicenter Study from South America by Domingo Balderramo, Angelo Z. Mattos, Victoria Mulqui, Talita Chiesa, Zuly Plácido-Damián, Jaysoom Abarca, Andrea Bolomo, Yanina Carlino, Isadora Z. Bombassaro, Denusa Wiltgen, Laura Tenorio Castillo, Karina Díaz, Johana Acuña, Estela Manero, Jhon Prieto, Enrique Carrera, Javier Díaz-Ferrer, Jose D. Debes

“…ALEx2 on admission was present in 87 (29.2%) patients and was found to be independently associated with 1-week mortality (odds ratio (OR) = 3.55; 95% confidence interval (95%CI) 1.05–12.05). Moreover, 84 (39.8%) out of 211 patients without ALEx2 at admission developed de novo-ALEx2, which was independently associated with mortality during second week of hospitalization (OR = 6.09; 95%CI 1.28–29) and overall mortality (OR = 2.93, 95%CI 1.05–8.19). …”
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