Delayed Titanium Hypersensitivity and Retained Foreign Body Causing Late Abdominal Complications by Molly S. Jain, Sivasthikka Lingarajah, Enkhmaa Luvsannyam, Manoj Reddy Somagutta, Ravi Pankajbhai Jagani, Jay Sanni, Enomfon Ebose, Frederick M. Tiesenga, Juaquito M. Jorge

“…The case also unfolds rare differential diagnoses to keep in mind when encountering a patient with abdominal pain and associated nonspecific symptoms.…”
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A Case of Gastric Metastatic Melanoma 15 Years after the Initial Diagnosis of Cutaneous Melanoma by Sohail Farshad, Scott Keeney, Alexandra Halalau, Gehad Ghaith

“…This case illustrates the rare occurrence of metastatic melanoma to the stomach which occurred 15 years after the initial skin diagnosis of melanoma was made, its endoscopic appearance, and how the nonspecific symptoms frequently lead to a delayed diagnosis or one that is not made at all until after autopsy. …”
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A Tongue Lesion as a Sign of a Systemic Disease by Chrysoula I. Liakou, Joan Koh, Antonios Tsimpidakis, Katrina Rios, Charalabos Paskalis, Athanasios Pipilis, Dimitrios Kantianis, Thomas Georgiadis, Evangelia Razis

“…It is a disease difficult to identify due to its nonspecific symptoms and manifestations. Amyloidosis of the tongue, either isolated or part of the systemic disease, is rare and its features resemble those of a tumor. …”
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A Case of Idiopathic Hypereosinophilic Syndrome Causing Mitral Valve Papillary Muscle Rupture by Tiffany Tamse, Avind Rampersad, Alejandro Jordan-Villegas, Jill Ireland

“…Our patient is a 17-year-old adolescent female who presented with nonspecific symptoms of abdominal pain and malaise. She was incidentally found to have hypereosinophilia of 16,000 on complete blood count and nonspecific colitis and pulmonary edema on computed tomography. …”
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Splenic Lymphangioma Mimicking Lymphomatous Involvement: A Case Report with Review of the Literature by Neda Soleimani, Fatemeh Pouraminaee, Mohammad Hossein Anbardar, Ali Bahador, Benyamin Rahimi, Sahand Mohammadzadeh, Fatemeh Aghakhaninejad, Mohammad Farahmand, Mahsa Hasani

“…Most patients are asymptomatic, but in large and multifocal lesions, the patient may have some nonspecific symptoms such as abdominal pain, abdominal distention, nausea, vomiting, and loss of appetite. …”
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Pertussis Vaccination for Adults: An Updated Guide for Clinicians by Kay Choong See

“…Diagnosing pertussis in adults can be challenging due to its nonspecific symptoms, underreporting, and the limited sensitivity of available diagnostic tests. …”
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Severe Malaria in an Adult Patient from Low-Endemic Area in Flores Island, East Nusa Tenggara by Maria Teressa, Asep Purnama, Joshua Henrina, Agustinus Wiraatmadja, Angela M. B. Boro, Candida I. L. Sam, Tersila A. D. Dedang, Alius Cahyadi

“…This case emphasizes despite living in a low-endemic malaria area, physicians should remain meticulous and consider malaria as differential diagnosis even after initially presenting with nonspecific symptoms. Consequently, malarial screening should be performed to modify the risk of mortality. …”
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Primary Ovarian Choriocarcinoma: Rare Entity by Mequanent Tariku Adow, Shimelis Fantu Gebresilasie, Natnael Alemayehu Abebe

“…In patients with adnexal mass presenting with nonspecific symptoms especially with high Doppler blood flow of the mass on ultrasound evaluation, serum beta-human chorionic gonadotropin determination is recommended before laparotomy. …”
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Deep Vein Thrombosis Provoked by Inferior Vena Cava Agenesis by Raad A. Haddad, Mazin Saadaldin, Binay Kumar, Ghassan Bachuwa

“…Inferior vena cava agenesis (IVCA) is a rare congenital anomaly that can be asymptomatic or present with vague, nonspecific symptoms, such as abdominal or lower back pain, or deep vein thrombosis (DVT). …”
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Asymptomatic elevation of serum aminotransferase activity: stages of diagnostic search by Yu. A. Tereshchenko, S. Yu. Tereshchenko

“…The majority of such patients present either no health-related complaints at all, or nonspecific symptoms. Data of common clinical examination and routine laboratory and instrumental tests frequently do not allow to determine satisfactory diagnostic hypothesis. …”
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Enteric Duplication Cyst Containing Squamous and Respiratory Epithelium: An Interesting Case of a Typically Pediatric Entity Presenting in an Adult Patient by Jessica Leigh Baumann, Charmi Patel

“…We present a rare case of a 21-year-old male who presented with nonspecific symptoms of abdominal discomfort and weight loss and was later found to have a 9 cm nonenhancing mass in the distal ileum on CT imaging. …”
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The utilization of microbial cell-free DNA next-generation sequencing for the detection of human herpesvirus-8 in a quaternary care center by Rebecca Berger, Jennifer Jacobe, Fernando H. Centeno, Todd Lasco, Mayar Al Mohajer

“…While violaceous skin lesions characterize cutaneous Kaposi sarcoma, extracutaneous HHV8 is challenging to diagnose due to nonspecific symptoms. Objectives: We evaluated the role of microbial cell-free DNA next-generation sequencing (mcfDNA NGS) in diagnosing HHV8-related illness. …”
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Crossed Renal Ectopia without Fusion: An Uncommon Cause of Abdominal Mass by Ana Ratola, Maria Miguel Almiro, Rita Lacerda Vidal, Nuno Neves, Adelaide Bicho, Sofia Figueiredo

“…In this case, the associated nonspecific symptoms were a coincidence.…”
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Low-Grade Endometrial Stromal Sarcoma in a 22-Year-Old Maiden Female: A Rare Case Report from Syria by Lana Nseir, Georget Mansour, Junior Makhoul, Luna Skaf, Mohammad Ziad Dahhan, Zuheir AlShehabi

“…They both have nonspecific symptoms, which makes the diagnosis of ESS difficult to achieve. …”
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Acute Renal Failure due to Obstructive Uropathy Secondary to Ureteral Endometriosis by Jeong In Choi, Jee Geun Yoo, Sa Jin Kim, Hae Nam Lee, Min Jeong Kim

“…Differential diagnosis is important to confirm diagnosis for patients with ureteral obstruction presenting nonspecific symptoms.…”
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Primary intracranial malignant melanoma in an adolescent: case report and literature review by Nyoman Golden, I Gusti Ketut Agung Surya Kencana, Christopher Lauren, Angky Saputra, Denny Japardi

“…As PIMM presents with nonspecific symptoms, awareness among clinicians is essential for early detection and appropriate intervention, warranting further research to develop standardized treatment protocols and enhance understanding of this rare tumor's pathophysiology.…”
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Ovarian Torsion in the Third Trimester of Pregnancy Leading to Iatrogenic Preterm Delivery by Evangelia Vlachodimitropoulou Koumoutsea, Manish Gupta, Antony Hollingworth, Anwen Gorry

“…As the woman is likely to present with nonspecific symptoms of lower abdominal pain, nausea, and vomiting, ovarian torsion can often be misdiagnosed as appendicitis or preterm labour. …”
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Pneumatosis Intestinalis as the Initial Presentation of Systemic Sclerosis: A Case Report and Review of the Literature by Farshid Ejtehadi, Nikolaos A. Chatzizacharias, Hugh Kennedy

“…The patient, a 75-year-old female, presented with an 8-month history of worsening dysphagia and epigastric pain, as well as other nonspecific symptoms. Initial investigations with an oesophagogastroduodenoscopy diagnosed Candida oesophagitis and also identified an extrinsic compression of the gastric antrum. …”
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Should miliary tuberculosis be considered as a possible cause of infertility in the new era: a case report and literature review by Aleksandra Cvetkovic, Ana Blanka Protic, Jelena Jovanovic, Tatjana Adzic Vukicevic, Tatjana Adzic Vukicevic

“…It should be taken into consideration as a possible risk for infertility in the presence of nonspecific symptoms. Screening methods for latent tuberculosis in IVF patients are needed even in a low-burden TB country.…”
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Early Detection of Pancreatic Cancer: Opportunities Provided by Cancer-induced Paraneoplastic Phenomena and Artificial Intelligence by Wei-Chih Liao

“…The difficulty in early detection is attributed to the fact that early PDACs cause few or nonspecific symptoms and are frequently obscure or even invisible in imaging studies such as computed tomography (CT). …”
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