Protective Effect of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) against Vascular Dysfunction in Hyperglycemic Rats by Nurul Paramita, Brilliant C. Puspasari, Randika Arrody, Neng T. Kartinah, Trinovita Andraini, Julfiana Mardatillah, Hardiyanti Rusli, Dewi I. S. Santoso

“…An enzyme-linked immunosorbent assay (ELISA) was used to measure the glucagon-likepeptide-1 (GLP-1), endothelial nitric oxide synthase (eNOS), and tumor necrosis factor-alpha (TNFα) levels. …”
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Preventive Effect of Salicylate and Pyridoxamine on Diabetic Nephropathy by Tarek Kamal Abouzed, Seiichi Munesue, Ai Harashima, Yusuke Masuo, Yukio Kato, Khaled Khailo, Hiroshi Yamamoto, Yasuhiko Yamamoto

“…Male mice overexpressing inducible nitric oxide synthase in pancreatic β-cells were employed as a diabetic model. …”
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Binding affinity screening of polyphenolic compounds in Stachys affinis extract (SAE) for their potential antioxidant and anti-inflammatory effects by Hun Hwan Kim, Se Hyo Jeong, Min Yeong Park, Pritam Bhangwan Bhosale, Abuyaseer Abusaliya, Sang Joon Lee, Jeong Doo Heo, Hyun Wook Kim, Je Kyung Seong, Dong Il Kim, Kwang Il Park, Gon Sup Kim

“…Inflammation caused by LPS is an endotoxin found in the outer membrane of Gram-negative bacteria, which induces immune cells to produce inflammatory cytokines such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase. Based on this, the antioxidant and anti-inflammatory effects of plant extracts were investigated. …”
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Neurotrophic Effect of Adipose Tissue-Derived Stem Cells on Erectile Function Recovery by Pigment Epithelium-Derived Factor Secretion in a Rat Model of Cavernous Nerve Injury by Xin Chen, Qiyun Yang, Tao Zheng, Jun Bian, Xiangzhou Sun, Yanan Shi, Xiaoyan Liang, Guoquan Gao, Guihua Liu, Chunhua Deng

“…Moreover, the neuronal nitric oxide synthase (nNOS) and S100 expression in penile dorsal nerves and the smooth muscle content to collagen ratio in penile tissues significantly increased. …”
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High Glucose Induces Endothelial COX2 and iNOS Expression via Inhibition of Monomethyltransferase SETD8 Expression by Jie Qi, Qichao Wu, Qian Cheng, Xiangyuan Chen, Minmin Zhu, Changhong Miao

“…Cyclooxygenase 2 (COX2) and inducible nitric oxide synthase (iNOS) overexpression results in endothelial apoptosis, thus mediating vascular endothelial injury in hyperglycaemia. …”
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Differences in cNOS/iNOS Activity during Resistance to Trypanosoma cruzi Infection in 5-Lipoxygenase Knockout Mice by Carolina Panis, Vanessa Jacob Victorino, Vera Lúcia Hideko Tatakihara, Rubens Cecchini, Luiz Vicente Rizzo, Lucy Megumi Yamauchi, Sueli Fumie Yamada-Ogatta, Marli Cardoso Martins-Pinge, Phileno Pinge-Filho

“…We used infected 5-lipoxygenase-deficient mice (5-LO−/−) to explore the participation of nitric oxide synthase isoforms, inducible (iNOS) and constitutive (cNOS), in heart injury, cytokine profile, and oxidative stress during the early stage of T. cruzi infection. …”
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Phenolic compounds from Chaenomeles speciosa alleviate inflammation in lipopolysaccharide-treated RAW264.7 macrophages via the NF-κB and MAPK pathways by Fuxia Hu, Chao Liu, Fengqin Wang, Changxin Zhou, Maotong Zhu, Dongxiao Sun-Waterhouse, Zhaosheng Wang

“…The extract suppressed the levels of nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β), and the mRNA and protein expressions of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). …”
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Berberine Protects against Palmitate-Induced Endothelial Dysfunction: Involvements of Upregulation of AMPK and eNOS and Downregulation of NOX4 by Ming Zhang, Chun-Mei Wang, Jing Li, Zhao-Jie Meng, Sheng-Nan Wei, Ji Li, Richard Bucala, Yu-Lin Li, Li Chen

“…The mRNA level of endothelial nitric oxide synthase (eNOS) was measured by RT-PCR, and the protein levels of eNOS, p-eNOS, Akt, p-Akt, AMPK, p-AMPK, and NADPH oxidase (NOX4) were analyzed. …”
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Protective role of 3-mercaptopyruvate sulfurtransferase (MPST) in the development of metabolic syndrome and vascular inflammation by Paraskevas Zampas, Zhen Li, Antonia Katsouda, Aimilia Varela, Stelios Psarras, Constantinos H. Davos, David J. Lefer, Andreas Papapetropoulos

“…Mice were fed a high-fat diet (HFD) for 15 weeks to induce obesity and hyperglycemia and administrated a nitric oxide synthase inhibitor, during the last 5 weeks to induce hypertension and MetS. …”
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Anesthetic Isoflurane Posttreatment Attenuates Experimental Lung Injury by Inhibiting Inflammation and Apoptosis by Jun-tang Li, Hui Wang, Wei Li, Li-feng Wang, Li-chao Hou, Jing-lan Mu, Xin Liu, Hui-juan Chen, Ke-lang Xie, Nan-lin Li, Chun-fang Gao

“…ISO also inhibited ZY-induced expression and activation of nuclear factor-kappaB p65 and inducible nitric oxide synthase in pulmonary tissue. ZY administration also resulted in the upregulation of heme oxygenase-1 expression and activity in the lung, which was further enhanced by ISO treatment. …”
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Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Ameliorates the Development of Periodontitis by Noritaka Sawada, Kei Adachi, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Shuichiro Kobayashi, Shin-ichi Miyajima, Yuki Suzuki, Takeshi Kikuchi, Makoto Mizutani, Taku Toriumi, Masaki Honda, Akio Mitani, Tatsuaki Matsubara, Keiko Naruse

“…Periodontitis increased inflammatory cell infiltration, macrophage accumulation, and gene expressions of tumor necrosis factor-α and inducible nitric oxide synthase in the gingiva, all of which were ameliorated by liraglutide. …”
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Solitary Nitric Oxide Signaling Mediates Mild Stress-Induced Anxiety and Norepinephrine Release in the Bed Nucleus of the Stria Terminalis during Protracted Ethanol Withdrawal by Zhenglin Zhao, Sang Chan Kim, Yu Jiao, Yefu Wang, Bong Hyo Lee, Hee Young Kim, Chul Won Lee, Chae Ha Yang, Rongjie Zhao

“…Increased noradrenergic signaling from the nucleus tractus solitarius (NTS) to the bed nucleus of the stria terminalis (BNST) during EtOHW underlies withdrawal-induced anxiety, while nitric oxide synthase (NOS) inhibitors injected into the periaqueductal area attenuate EtOHW-induced anxiety. …”
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The research progress and prospects of circadian rhythm in obesity: a bibliometric analysis by Ye Dou, Xiaojin Guo, Xuefei Wang, Aolong He, Fanghe Li, Kuo Gao

“…The gene expression of obesity is an early hotspot in the study of circadian rhythm and obesity, and emerging research areas such as intermittent fasting, restricted feeding, endothelial nitric oxide synthase and gut microbiota will become significant hotspots and trends in the field of circadian rhythm and obesity. …”
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Nucleotide sequence variants, gene expression and serum profile of immune and antioxidant markers associated with brucellosis resistance/susceptibility in Shami goat by Ahmed A. Elsayed, Ahmed M. Sallam

“…DNA was extracted and selected parts the immunity; solute carrier family 11 member 1 (SLC11A1), toll-like receptor 1 (TLR1), toll-like receptor 9 (TLR9), SP110 nuclear body protein (SP110), the adenosine A3 receptor (ADORA3), caspase activating recruitment domain 15 (CARD15) and interferon regulatory factor 3 (IRF3), antioxidant glutathione peroxidase 1 (GPX1), nitric oxide synthase (NOS), NAD(P)H dehydrogenase [quinone] 1 (NQO1) and transcription factor NF-E2-related factor 2 (Nrf2) and erythritol related transketolase (TKT), ribose 5-phosphate isomerase (RPIA) and Adenosine monophosphate deaminase (AMPD) genes were sequenced. …”
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Exploratory Investigation of Intestinal Structure and Function after Stroke in Mice by Diya Ye, Yuting Hu, Ning Zhu, Weizhong Gu, Gao Long, Enfu Tao, Marong Fang, Mizu Jiang

“…Myeloperoxidase (MPO) activity and inflammatory proteins (nuclear factor kappa-B (NF-κB), inducible nitric oxide synthase (iNOS)) in the small intestine were significantly increased in mice after stroke. …”
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Protective Effects of Two Safflower Derived Compounds, Kaempferol and Hydroxysafflor Yellow A, on Hyperglycaemic Stress-Induced Podocyte Apoptosis via Modulating of Macrophage M1/M... by Yuanping Li, Dan Zheng, Dayue Shen, Xilan Zhang, Xiaoyun Zhao, Hui Liao

“…The expressions of inducible nitric oxide synthase (iNOS), tumor necrosis factor- (TNF-) α, mannose receptor (CD206), and arginase- (Arg-) 1 were quantified by Western blotting and real-time quantitative PCR. …”
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Midgut immune profiling and functional characterization of Aedes aegypti ABC transporter gene(s) using systemic and local bacterial challenges by Vikas Kumar, Shilpi Garg, Diksha Sisodia, Lalita Gupta, Sanjeev Kumar, Vishal Saxena

“…The AaeABCG3 gene silencing exhibited a significant reduction of midgut bacterial load through the induction of nitric oxide synthase (NOS) in sugar-fed and systemic bacterial-challenged mosquitoes. …”
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Liraglutide Enhances the Activity of the ACE-2/Ang(1–7)/Mas Receptor Pathway in Lungs of Male Pups from Food-Restricted Mothers and Prevents the Reduction of SP-A by J. Fandiño, A. A. Vaz, L. Toba, M. Romaní-Pérez, L. González-Matías, F. Mallo, Y. Diz-Chaves

“…Liraglutide also increased endothelial nitric oxide synthase (eNOS) expression in MPFR lungs, reflecting the activation of MasR by angiotensin 1–7. …”
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Gedunin Mitigates <i>Cutibacterium acnes</i>-Induced Skin Inflammation by Inhibiting the NF-κB Pathway by Ju Kyoung Sim, Ye Ji Heo, Jin Hak Shin, Seon Sook Kim, Su Ryeon Seo

“…Key inflammatory mediators, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and interleukin-6 (IL-6), were evaluated. …”
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iNOS-Produced Nitric Oxide from Cancer Cells as an Intermediate of Stemness Regulation by PARP-1 in Colorectal Cancer by María del Moral-Martinez, Paula Sánchez-Uceta, Ruben Clemente-Gonzalez, Sara Moreno-SanJuan, Jose D. Puentes-Pardo, Huda Khaldy, David Lopez-Perez, Javier Arnedo, Jorge Casado, Luis Martínez-Heredia, Angel Carazo, Josefa León

“…In this study, we propose that nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) could act as a mediator. We evaluated the expression of iNOS in a cohort of patients previously used to analyze the effects of PARP-1 on CRC in relation to p53 status. …”
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