Effect of Astaxanthin on Immune Function and Myocardial Injury in Mice with Chronic Sleep Deprivation by FENG Biyun, LI Lingyan, LI Ming, ZHANG Jiayuan, QI Huanyang, CHEN Pingping, XU Guanghui

“…Moreover, the levels of serum creatine kinase (CK), superoxide dismutase (SOD), tumor necrosis factor-α (TNF-α), glutathione peroxidase (GSH-Px), interleukin (IL)-1β, IL-6, nitric oxide synthase (NOS) and γ-glutamyl transpeptidase (γ-GT) rose markedly in each treatment group, and the level of malondialdehyde (MDA) significantly declined. …”
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Withaferin A Inhibits Nuclear Factor-κB-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes by Francesca Martorana, Giulia Guidotti, Liliana Brambilla, Daniela Rossi

“…Here we demonstrate that the activation of astrocytic TLR4 by bacterial lipopolysaccharide (LPS) challenge can promote nuclear factor κB (NF-κB)-dependent induction of pro-inflammatory and stress response mediators, particularly Tumor Necrosis Factor α (TNFα), cyclooxygenase 2 (COX-2), and inducible nitric oxide synthase (iNOS). Since the steroid lactone Withaferin A was described to inhibit NF-κB activity in different cell types, we next determined the impact of this natural compound towards the identified astrocytic signalling pathway. …”
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Effect of Ultrafine Powderization and Solid Dispersion Formation via Hot-Melt Extrusion on Antioxidant, Anti-Inflammatory, and the Human Kv1.3 Channel Inhibitory Activities of Ange... by Yunyao Jiang, Jingpei Piao, Nan Liu, Jincai Hou, Jianxun Liu, Weicheng Hu

“…In addition, AGN-SD inhibited the production of prostaglandin E2 and intracellular reactive oxygen species and the mRNA expression of inducible nitric oxide synthase, cyclooxygenase-2, interleukin 1β, and interleukin 6. …”
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Genetic Deletion of Soluble Epoxide Hydrolase Attenuates Inflammation and Fibrosis in Experimental Obstructive Nephropathy by Chin-Wei Chiang, Hsueh-Te Lee, Der-Cherng Tarng, Ko-Lin Kuo, Li-Ching Cheng, Tzong-Shyuan Lee

“…Moreover, sEH−/− mice with UUO showed lower levels of inflammation-related and fibrosis-related protein such as monocyte chemoattractant protein-1, macrophage inflammatory protein-2, interleukin-1β (IL-1β), IL-6, inducible nitric oxide synthase, collagen 1A1, and α-actin. The levels of superoxide anion radical and hydrogen peroxide as well as NADPH oxidase activity were also decreased in UUO kidneys of sEH−/− mice compared to that observed in WT mice. …”
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Neuroprotective Effect of DAHP via Antiapoptosis in Cerebral Ischemia by Yanhua Qin, Weiming Hu, Yang Yang, Zhiying Hu, Weiyun Li, Marong Fang

“…Aberrant production of nitric oxide following inducible nitric oxide synthase (iNOS) expression has been implicated in cell death and contributes to ischemic brain injury. …”
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Long Noncoding RNA uc001pwg.1 Is Downregulated in Neointima in Arteriovenous Fistulas and Mediates the Function of Endothelial Cells Derived from Pluripotent Stem Cells by Lei Lv, Haozhe Qi, Xiangjiang Guo, Qihong Ni, Zezhen Yan, Lan Zhang

“…Further studies revealed that uc001pwg.1 overexpression could increase nitric oxide synthase (eNOS) phosphorylation and nitric oxide (NO) production in endothelial cells (ECs) derived from human-induced pluripotent stem cells (HiPSCs). …”
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Allogeneic Adipose-Derived Mesenchymal Stromal Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Regulating Self-Reactive T Cell Responses and Dendritic Cell Function by Per Anderson, Elena Gonzalez-Rey, Francisco O’Valle, Francisco Martin, F. Javier Oliver, Mario Delgado

“…We found that murine ASCs (mASCs) suppress T cell proliferation in vitro via inducible nitric oxide synthase (iNOS) and cyclooxygenase- (COX-) 1/2 activities. mASCs also prevented the lipopolysaccharide- (LPS-) induced maturation of dendritic cells (DCs) in vitro. …”
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A red pomegranate fruit extract-based formula ameliorates anxiety/depression-like behaviors via enhancing serotonin (5-HT) synthesis in C57BL/6 male mice by Xiping Zhu, Dongxiao Sun-Waterhouse, Chun Cui

“…The RPFE formula exhibited the abilities to normalize the levels of serum inflammatory cytokines (NF-κB, TNF-α, IL-6, IL-1β and IFN-γ) and malondialdehyde (MDA), and activities of superoxide dismutase (SOD), catalase (CAT) and nitric oxide synthase (NOS), as well as relieve the injury of hippocampal neurons. …”
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Role of Rutin on Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells by Azizah Ugusman, Zaiton Zakaria, Kien Hui Chua, Nor Anita Megat Mohd Nordin, Zaleha Abdullah Mahdy

“…Nitric oxide (NO), produced by endothelial nitric oxide synthase (eNOS), is a major antiatherogenic factor in the blood vessel. …”
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The ERK1/2 Inhibitor U0126 Attenuates Diabetes-Induced Upregulation of MMP-9 and Biomarkers of Inflammation in the Retina by Ghulam Mohammad, Mohammad Mairaj Siddiquei, Mohammad Imtiaz Nawaz, Ahmed M. Abu El-Asrar

“…The expression of inducible nitric oxide synthase (iNOS), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) was examined by Western blot analysis. …”
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Magnesium Lithospermate B Downregulates the Levels of Blood Pressure, Inflammation, and Oxidative Stress in Pregnant Rats with Hypertension by Kaixiang Xu, Xiaohong Zang, Mian Peng, Qian Zhao, Binbin Lin

“…The decreased expressions of vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), and NO observed in PIH rats were increased by MLB. …”
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Regulatory Role of GSK-3β on NF-κB, Nitric Oxide, and TNF-α in Group A Streptococcal Infection by Yu-Tzu Chang, Chia-Ling Chen, Chiou-Feng Lin, Shiou-Ling Lu, Miao-Huei Cheng, Chih-Feng Kuo, Yee-Shin Lin

“…The results revealed that GAS could activate NF-κB, followed by an increased expression of inducible nitric oxide synthase (iNOS) and NO production in a murine macrophage cell line. …”
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GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents by Qian-Feng Xiong, Shao-Hua Fan, Xue-Wen Li, Yu Niu, Jing Wang, Xin Zhang, Yi-Fan Chen, Ya-Wei Shi, Li-Hui Zhang

“…Vasorelaxation was attenuated by denuding the endothelium, L-NAME (nitric oxide synthase inhibitor), and glyburide (KATP channel blocker) but was not affected by indomethacin (cyclooxygenase inhibitor), iberiotoxin [Ca2+-activated K+ channel (KCa) blocker], or 4-aminopyridine (KV channel blocker). …”
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Betaine Treatment Attenuates Chronic Ethanol-Induced Hepatic Steatosis and Alterations to the Mitochondrial Respiratory Chain Proteome by Kusum K. Kharbanda, Sandra L. Todero, Adrienne L. King, Natalia A. Osna, Benita L. McVicker, Dean J. Tuma, James L. Wisecarver, Shannon M. Bailey

“…This protection by betaine was associated with normalization of SAM : S-adenosylhomocysteine (SAH) ratios and the attenuation of the ethanol-induced increase in inducible nitric oxide synthase and nitric oxide generation in the liver. …”
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Knockdown of PTEN promotes colon cancer progression and induces M2 macrophage polarization in the colon cancer cell environment by Xu Han, Ting Yan, Lina Wang, Bin He, Huaxu Yu

“…Si-PTEN reduced the expression of tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), and inducible nitric oxide synthase (iNOS), which upregulated the expression of Arg-1, CD206, CD163, p-p38, JNK, and AP-1 (P-values < 0.05). …”
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Anti-Inflammatory Effects of Adrenomedullin on Acute Lung Injury Induced by Carrageenan in Mice by Talero Elena, Di Paola Rosanna, Mazzon Emanuela, Emanuela Esposito, Motilva Virginia, Cuzzocrea Salvatore

“…Moreover, AM inhibited the induction of inducible nitric oxide synthase (iNOS), thereby abating the generation of nitric oxide (NO) and prevented the oxidative and nitroxidative lung tissue injury, as shown by the reduction of nitrotyrosine, malondialdehyde (MDA), and poly (ADP-ribose) polymerase (PARP) levels. …”
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Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson’s Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo by Chien-Wei Feng, Nan-Fu Chen, Te-Fu Chan, Wu-Fu Chen

“…It could significantly attenuate the interferon-gamma-induced upregulation of proinflammatory cytokines, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). …”
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CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases by Arthur I. Cederbaum, Lili Yang, Xiaodong Wang, Defeng Wu

“…Increased oxidative stress from induction of CYP2E1 sensitizes hepatocytes to LPS and TNFα toxicity and oxidants, activation of inducible nitric oxide synthase and p38 and JNK MAP kinases, and mitochondrial dysfunction are downstream mediators of this CYP2E1-LPS/TNFα-potentiated hepatotoxicity. …”
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Selenoprotein S Attenuates Tumor Necrosis Factor-α-Induced Dysfunction in Endothelial Cells by Siyuan Cui, Lili Men, Yu Li, Yingshuo Zhong, Shanshan Yu, Fang Li, Jianling Du

“…We first demonstrated that the upregulation of SelS enhances the levels of nitric oxide and endothelial nitric oxide synthase in tumor necrosis factor- (TNF-) α-treated human umbilical vein endothelial cells (HUVECs). …”
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Impact of Endurance Exercise Training on Biomarkers of Aortic Endothelial Damage in Diabetic Rats by Mahtab Fouladi, Maryam Mahmoudabady, Zahra Gholamnezhad, Sadegh Shabab, Saeed Niazmand, Hossein Salmani

“…After 6 weeks, biochemical parameters in serum and oxidative stress markers and mRNA expression of endothelial nitric oxide synthase (eNOS), lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), and intercellular adhesion molecule-1 (ICAM-1) in aorta tissue were assessed. …”
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