Nitric Oxide in Cerebral Vasospasm: Theories, Measurement, and Treatment by Michael Siuta, Scott L. Zuckerman, J. Mocco

“…A second hypothesis focuses on the dysfunction of nitric oxide synthase, an enzyme that synthesizes NO, and subsequent generation of reactive nitrogen species. …”
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Monocyte-Derived Macrophages Are Impaired in Myelodysplastic Syndrome by Yu Han, Huaquan Wang, Zonghong Shao

“…CD206 and signal regulatory protein alpha (SIRPα) on macrophages were detected by flow cytometry. Inducible nitric oxide synthase (iNOS) was measured by ELISA method. …”
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Neurochemical Plasticity of the Coeliac-Superior Mesenteric Ganglion Complex Neurons Projecting to the Prepyloric Area of the Porcine Stomach following Hyperacidity by Katarzyna Palus, Jarosław Całka

“…An upregulated expression of GAL and NPY and the de novo synthesis of neuronal nitric oxide synthase (nNOS) and leu5-enkephalin (LENK) as well as downregulated expression of TH and DβH in the stomach-projecting neurons were observed. …”
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NOS2 as a prognostic biomarker for early-onset colorectal cancer based on public data and clinical validation analysis by Chaoqun Xing, Lipeng Zhao, Weiwei Zou, Xie Peng, Xiao-Liang Xing, Jie Li

“…The results showed the immune-related gene nitric oxide synthase 2 (NOS2) was independently associated with the poor prognosis of EOCRC patients in both TGCA and GEO database. …”
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Oscillatory Shear Stress Induces Oxidative Stress via TLR4 Activation in Endothelial Cells by Zhimei Wang, Feng Wang, Xiangquan Kong, Xiaofei Gao, Yue Gu, Junjie Zhang

“…OSS phosphorylated caveolin-1, promoted its binding with endothelial nitric oxide synthase (eNOS), and resulted in deactivation of eNOS. …”
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A Possible Novel Anti-Inflammatory Mechanism for the Pharmacological Prolyl Hydroxylase Inhibitor 3,4-Dihydroxybenzoate: Implications for Use as a Therapeutic for Parkinson’s Disea... by Shankar J. Chinta, Subramanian Rajagopalan, Abirami Ganesan, Julie K. Andersen

“…DHB significantly attenuated LPS-mediated induction of nitric oxide synthase and pro-inflammatory cytokines in murine BV2 microglial cells in vitro in conjunction with reduced ROS production and activation of NFκB and MAPK pathways possibly due to up-regulation of HO-1 levels. …”
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Protective Effects of Polydatin on Septic Lung Injury in Mice via Upregulation of HO-1 by Xiao-hui Li, Xia Gong, Li Zhang, Rong Jiang, Hong-zhong Li, Meng-jiao Wu, Jing-yuan Wan

“…In addition, PD inhibited CLP-induced serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) production, lung cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase isoform (iNOS) protein expressions and NF-κB activation. …”
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Subetta Treatment Increases Adiponectin Secretion by Mature Human Adipocytes In Vitro by Jim Nicoll, Evgeniy A. Gorbunov, Sergey A. Tarasov, Oleg I. Epstein

“…To investigate the mechanism of action in peripheral tissues of novel complex drug containing release-active dilutions of antibodies to the beta subunit of the insulin receptor and antibodies to endothelial nitric oxide synthase (Subetta), which has shown efficacy in animal models of diabetes. …”
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Glycogen Synthase Kinase 3β Promotes Postoperative Cognitive Dysfunction by Inducing the M1 Polarization and Migration of Microglia by Jingjin Li, Chonglong Shi, Zhengnian Ding, Wenjie Jin

“…Prophylactic administration of lithium chloride (2 mM/kg) can inhibit the expression of proinflammatory mediators in the hippocampus, reduce the hippocampal expression of NF-κB, and increase both the downregulation of M1 microglial-related genes (inducible nitric oxide synthase and CD86) and upregulation of M2 microglial-related genes (IL-10 and CD206), to alleviate the cognitive impairment caused by orthopedic surgery. …”
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Spatiotemporal Pattern of Neuroinflammation After Impact-Acceleration Closed Head Injury in the Rat by Servan Rooker, Sebastian Jander, Jos Van Reempts, Guido Stoll, Philippe G. Jorens, Marcel Borgers, Jan Verlooy

“…We analyzed the spatiotemporal expression pattern of the proinflammatory key molecules: interleukin-1β, interleukin-6, tumor necrosis factor-α, and inducible nitric oxide synthase in a rat closed head injury (CHI) paradigm. 51 rats were used for RT-PCR analysis after CHI, and 18 for immunocytochemistry. …”
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Fucofuroeckol-A from Eisenia bicyclis Inhibits Inflammation in Lipopolysaccharide-Induced Mouse Macrophages via Downregulation of the MAPK/NF-κB Signaling Pathway by Sang-Hoon Lee, Sung-Hwan Eom, Na-Young Yoon, Moon-Moo Kim, Yong-Xin Li, Sang Keun Ha, Se-Kwon Kim

“…FF suppressed the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and the expression of inducible nitric oxide synthase and cyclooxygenase-2 dose dependently in lipopolysaccharide- (LPS-) induced RAW 264.7 mouse macrophages. …”
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Molecular Mechanisms Underlying Anti-Inflammatory Actions of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi (Wasabia japonica) by Takuhiro Uto, De-Xing Hou, Osamu Morinaga, Yukihiro Shoyama

“…We previously reported that 6-MSITC strongly suppresses cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and cytokines, which are important factors that mediate inflammatory processes. …”
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The Effect of Race and Shear Stress on CRP-Induced Responses in Endothelial Cells by Chenyi Ling, Marc D. Cook, Heather Grimm, Maitha Aldokhayyil, Dulce Gomez, Michael Brown

“…More than just a pure bystander, CRP directly interacts with endothelial cells to decrease endothelial nitric oxide synthase (eNOS) expression and bioactivity, decrease nitric oxide (NO) production, and increase the release of vasoconstrictors and adhesion molecules. …”
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The Efficacy of Processing Strategies on the Gastroprotective Potentiality of Chenopodium quinoa Seeds by Abdalbasit Adam Mariod, Suzy Munir Salama

“…All animals were sacrificed after an additional hour, and the stomach tissues were examined for histopathology of hematoxylin and eosin staining, immunohistochemistry of cyclooxygenase 2 (COX-2), and nitric oxide synthase (iNOS). Stomach homogenates were evaluated for oxidative stress parameters and prostaglandin E2 (PGE2). …”
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Anti-Inflammatory Strategy for M2 Microglial Polarization Using Retinoic Acid-Loaded Nanoparticles by Marta Machado-Pereira, Tiago Santos, Lino Ferreira, Liliana Bernardino, Raquel Ferreira

“…Our results show that RA-NP inhibited LPS-induced release of nitric oxide and the expression of inducible nitric oxide synthase and promoted arginase-1 and interleukin-4 production. …”
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Metabolomic profiling of amines in sepsis predicts changes in NOS canonical pathways. by Abel Tesfai, Niall MacCallum, Nicholas S Kirkby, Hime Gashaw, Nicola Gray, Elizabeth Want, Gregory J Quinlan, Sharon Mumby, James M Leiper, Mark Paul-Clark, Blerina Ahmetaj-Shala, Jane A Mitchell

“…<h4>Rationale</h4>Nitric oxide synthase (NOS) is a biomarker/target in sepsis. …”
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The protective effect of coadministration of coenzyme Q10 and vitamin E on myopathy induced by simvastatin in rats by Omar Ammar Hashim, Intesar Tarik Numan, Nadia Hameed Mohammed

“…At the end of the experiment, rats were euthanized by cervical dislocation, and blood and the collected tissue samples were collected to measure creatinine kinase (CKM), malondialdehyde (MDA), total antioxidant capacity (TAOC), inducible nitric oxide synthase-2 (iNOS2), and aldolase. In addition, gastrocnemius muscle histopathology was examined. …”
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Ultrasound-assisted extraction of peanut shell by-product: Chemical properties, antioxidant, and anti-inflammatory effects by Kang Jung Wook, Lee In Chul

“…Western blot analysis and reverse transcription polymerase chain reaction (RT-PCR) were used to evaluate the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). …”
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Computer Simulation on Analgesic Functional Chemome Characteristics of <italic>Radix Saposhnikoviae</italic> by Chunsong ZHENG, Xiaojie XU, Hongzhi YE, Jinxia YE, Guangwen WU, Xianxiang LIU

“…Tumor necrosis factor alpha (TNF-α), p38, inducible nitric oxide synthase (iNOS) and phosphodiesterase 4A (PDE-4A) were considered as analgesic targets. …”
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Nitric Oxide - Its Importance in Swallowing, Inflammatory Bowel Disease and Cirrhotic Cardiomyopathy by ABR Thomson

“…Nitric oxide is a neurotransmitter found in the central and peripheral nervous systems. Nitric oxide synthase (NOS) is localized in the central nervous system, including the nucleus of the solitary tract, nucleus ambiguus and dorsal motor nucleus of the vagus. …”
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