Subetta Treatment Increases Adiponectin Secretion by Mature Human Adipocytes In Vitro by Jim Nicoll, Evgeniy A. Gorbunov, Sergey A. Tarasov, Oleg I. Epstein

“…To investigate the mechanism of action in peripheral tissues of novel complex drug containing release-active dilutions of antibodies to the beta subunit of the insulin receptor and antibodies to endothelial nitric oxide synthase (Subetta), which has shown efficacy in animal models of diabetes. …”
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Glycogen Synthase Kinase 3β Promotes Postoperative Cognitive Dysfunction by Inducing the M1 Polarization and Migration of Microglia by Jingjin Li, Chonglong Shi, Zhengnian Ding, Wenjie Jin

“…Prophylactic administration of lithium chloride (2 mM/kg) can inhibit the expression of proinflammatory mediators in the hippocampus, reduce the hippocampal expression of NF-κB, and increase both the downregulation of M1 microglial-related genes (inducible nitric oxide synthase and CD86) and upregulation of M2 microglial-related genes (IL-10 and CD206), to alleviate the cognitive impairment caused by orthopedic surgery. …”
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Spatiotemporal Pattern of Neuroinflammation After Impact-Acceleration Closed Head Injury in the Rat by Servan Rooker, Sebastian Jander, Jos Van Reempts, Guido Stoll, Philippe G. Jorens, Marcel Borgers, Jan Verlooy

“…We analyzed the spatiotemporal expression pattern of the proinflammatory key molecules: interleukin-1β, interleukin-6, tumor necrosis factor-α, and inducible nitric oxide synthase in a rat closed head injury (CHI) paradigm. 51 rats were used for RT-PCR analysis after CHI, and 18 for immunocytochemistry. …”
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Fucofuroeckol-A from Eisenia bicyclis Inhibits Inflammation in Lipopolysaccharide-Induced Mouse Macrophages via Downregulation of the MAPK/NF-κB Signaling Pathway by Sang-Hoon Lee, Sung-Hwan Eom, Na-Young Yoon, Moon-Moo Kim, Yong-Xin Li, Sang Keun Ha, Se-Kwon Kim

“…FF suppressed the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and the expression of inducible nitric oxide synthase and cyclooxygenase-2 dose dependently in lipopolysaccharide- (LPS-) induced RAW 264.7 mouse macrophages. …”
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Molecular Mechanisms Underlying Anti-Inflammatory Actions of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi (Wasabia japonica) by Takuhiro Uto, De-Xing Hou, Osamu Morinaga, Yukihiro Shoyama

“…We previously reported that 6-MSITC strongly suppresses cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and cytokines, which are important factors that mediate inflammatory processes. …”
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The Effect of Race and Shear Stress on CRP-Induced Responses in Endothelial Cells by Chenyi Ling, Marc D. Cook, Heather Grimm, Maitha Aldokhayyil, Dulce Gomez, Michael Brown

“…More than just a pure bystander, CRP directly interacts with endothelial cells to decrease endothelial nitric oxide synthase (eNOS) expression and bioactivity, decrease nitric oxide (NO) production, and increase the release of vasoconstrictors and adhesion molecules. …”
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The Efficacy of Processing Strategies on the Gastroprotective Potentiality of Chenopodium quinoa Seeds by Abdalbasit Adam Mariod, Suzy Munir Salama

“…All animals were sacrificed after an additional hour, and the stomach tissues were examined for histopathology of hematoxylin and eosin staining, immunohistochemistry of cyclooxygenase 2 (COX-2), and nitric oxide synthase (iNOS). Stomach homogenates were evaluated for oxidative stress parameters and prostaglandin E2 (PGE2). …”
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Anti-Inflammatory Strategy for M2 Microglial Polarization Using Retinoic Acid-Loaded Nanoparticles by Marta Machado-Pereira, Tiago Santos, Lino Ferreira, Liliana Bernardino, Raquel Ferreira

“…Our results show that RA-NP inhibited LPS-induced release of nitric oxide and the expression of inducible nitric oxide synthase and promoted arginase-1 and interleukin-4 production. …”
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The protective effect of coadministration of coenzyme Q10 and vitamin E on myopathy induced by simvastatin in rats by Omar Ammar Hashim, Intesar Tarik Numan, Nadia Hameed Mohammed

“…At the end of the experiment, rats were euthanized by cervical dislocation, and blood and the collected tissue samples were collected to measure creatinine kinase (CKM), malondialdehyde (MDA), total antioxidant capacity (TAOC), inducible nitric oxide synthase-2 (iNOS2), and aldolase. In addition, gastrocnemius muscle histopathology was examined. …”
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Ultrasound-assisted extraction of peanut shell by-product: Chemical properties, antioxidant, and anti-inflammatory effects by Kang Jung Wook, Lee In Chul

“…Western blot analysis and reverse transcription polymerase chain reaction (RT-PCR) were used to evaluate the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). …”
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Nitric Oxide - Its Importance in Swallowing, Inflammatory Bowel Disease and Cirrhotic Cardiomyopathy by ABR Thomson

“…Nitric oxide is a neurotransmitter found in the central and peripheral nervous systems. Nitric oxide synthase (NOS) is localized in the central nervous system, including the nucleus of the solitary tract, nucleus ambiguus and dorsal motor nucleus of the vagus. …”
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Possible erythropoietin pharmacotherapeutic targets on painful diabetic neuropathy in rats by SAMUEL SUAREZ-MENDEZ, DEYSI Y. BERMÚDEZ-OCAÑA

“…To determine the action mechanisms of erythropoietin, levels of NF-κB in serum were measured with ELISA and was used L-NAME (Nω-nitro-L-arginine methyl ester hydrochloride, non-selective nitric oxide synthase inhibitor; 0.1-1 mg/kg, i.p.), glibenclamide (ATP-sensitive K+ channels blocker; 1-10 mg/kg, i.p.), methiothepin (non-selective 5-HT receptor antagonist; 0.01-0.1 mg/kg, i.p.) and naloxone (non-selective opioid receptor antagonist; 1 mg/kg). …”
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Metabolite-Sensing Receptors: Emerging Targets for Modulating Chronic Pain Pathways by Ciprian Pușcașu, Corina Andrei, Octavian Tudorel Olaru, Anca Zanfirescu

“…Butyrate-activated GPR43 inhibits inflammatory mediators like nitric oxide synthase-2 and cyclooxygenase-2, mitigating inflammation. …”
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Identification and characterization of a novel tetrapeptide from enzymatic hydrolysates of Baijiu byproduct by Qiang Wu, Changqing Zhong, Guirong Zeng, Xu Zhang, Liping Xiang, Chang Wan, Yougui Yu

“…Moreover, it showed no significant cytotoxicity toward human umbilical vein endothelial cells (HUVECs), and significantly induced phosphorylation of endothelial nitric oxide synthase (p-eNOS) and decreased endothelin 1 (END1) expression in angiotensin I (Ang I)-treated HUVECs, demonstrating the potential antihypertensive effect. …”
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Reducing oxidative stress and hepatoprotective effect of water extracts from Pu-erh tea on rats with high-fat diet by Jingjing Su, Xueqing Wang, Wenjun Song, Xiaoli Bai, Changwen Li

“…The malondialdehyde (MDA) and glucose (Glu) levels and the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), nitric oxide synthase (NOS), and pyruvate kinase (PK) in serum were determined. …”
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iNOS Promotes the Development of Osteosarcoma via Wnt/β-Catenin Pathway by Wei Chu, Lirong Cao, Gui Daokun, Jiali Zhao

“…Inducible nitric oxide synthase (iNOS), accompanied with protumor and antitumor activity, has been studied in multiple cancers. …”
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A Chinese Traditional Therapy for Bleomycin-Induced Pulmonary Fibrosis in Mice by Lifang Sun, Minjie Mao, Zhisheng Yan, Cuiyun Zuo, Xiaojie Zhang

“…Western blotting and real-time quantitative PCR were performed to determine the abundance of inducible nitric oxide synthase (iNOS), connective tissue growth factor (CTGF), alpha smooth muscle actin (α-SMA), and fibronectin (FN). …”
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Role of HO/CO in the Control of Peripheral Circulation in Humans by David Sacerdoti, Despina Mania, Paola Pesce, Silvia Gaiani, Angelo Gatta, Massimo Bolognesi

“…We evaluated the effects of inhibition of HO with stannous mesoporphyrin IX (SnMP) (200 𝜇M) locally administered by iontophoresis, on human skin blood flow, evaluated by laser-Doppler flowmetry, in the presence and absence of nitric oxide synthase (NOS) inhibition with L-NG-Nitroarginine methyl ester (L-NAME) (100 𝜇M). …”
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Garlic and Onion Attenuates Vascular Inflammation and Oxidative Stress in Fructose-Fed Rats by Marcela Alejandra Vazquez-Prieto, Cecilia Rodriguez Lanzi, Carina Lembo, Claudio Rómulo Galmarini, Roberto Miguel Miatello

“…At the end of the study, FFR had developed insulin resistance, aortic NADPH oxidase activity, increased SBP, plasma TBARS and vascular cell adhesion molecule-1 (VCAM-1) expression in mesenteric arteries, and a decrease in heart endothelial nitric oxide synthase (eNOS). Garlic and onion administration to F rats reduced oxidative stress, increased eNOS activity, and also attenuated VCAM-1 expression. …”
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Caffeine's Vascular Mechanisms of Action by Darío Echeverri, Félix R. Montes, Mariana Cabrera, Angélica Galán, Angélica Prieto

“…In endothelial cells, it increases intracellular calcium stimulating the production of nitric oxide through the expression of the endothelial nitric oxide synthase enzyme. Nitric oxide is diffused to the vascular smooth muscle cell to produce vasodilation. …”
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