Tempol Attenuates Neuropathic Pain by Inhibiting Nitric Oxide Production by Donglin Jia, Huan Wang, Bin Han, Liping Zhang, Jianrong Guo

“…Spinal cord levels of nitric oxide, as well as activities of nitric oxide synthase and acetylcholinesterase, were tested in postoperative day 7. …”
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Ac2-26 Alleviates Brain Injury after Cardiac Arrest and Cardiopulmonary Resuscitation in Rats via the eNOS Pathway by Jing Gong, Qi-Hang Tai, Guang-Xiao Xu, Xue-Ting Wang, Jing-Li Zhu, Xiao-Qing Zhao, Hai-Bin Sun, Dan Zhu, Wei Gao

“…Ac2-26 and endothelial nitric oxide synthase (eNOS) have been shown to reduce neuroinflammation. …”
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Effect of Thrombolysis on Circulating Microparticles in Patients with ST-Segment Elevation Myocardial Infarction by Zhe Li, Wei Zhang, Qun-Rang Wang, Yu-juan Yang, Xin-Hong Liu, Gong Cheng, Feng-Jun Chang

“…After determining the concentration, the effects of MPs on endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) in rat myocardial tissue in vitro were detected by immunohistochemistry and western blotting. …”
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Effects of Resveratrol on the Kidney in Rats with Streptozotocin Induced Diabetic Nephropathy by Duygu Tozcu, Çiğdem Özer, Aydan Babül, Sevim Ercan, Ergin Dileköz, Gülnur Take Kaplanoğlu, Güleser Göktaş

“…In group D, decreased endothelial nitric oxide synthase uptake (weak immune reactivity) was observed, whereas this uptake increased with RSV treatment (moderate immune reactivity). …”
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Protection Effect of Endomorphins on Advanced Glycation End Products Induced Injury in Endothelial Cells by Jing Liu, Liping Yan, Ruilan Niu, Limin Tian, Qi Zhang, Jinxing Quan, Hua Liu, Suhong Wei, Qian Guo

“…Then, HUVEC survival rate was calculated by MTT assay, the levels of NO, endothelial nitric oxide synthase (eNOS), and inducible nitric oxide synthase (iNOS) were detected by colorimetric analysis, and the contents of endothelin-1 (ET-1) were detected by ELISA. …”
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Nitric oxide as a mediator of inflammation?—You had better believe it by Mark J. S. Miller, Matthew B. Grisham

“…Therapeutic benefit can be achieved by inhibition of inducible nitric oxide synthase and not the donation of additional nitric oxide. …”
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Nitric oxide function in atherosclerosis by K. E. Matthys, H. Bult

“…Atherosclerosis is a chronic inflammatory process in the intima of conduit arteries, which disturbs the endothelium-dependent regulation of the vascular tone by the labile liposoluble radical nitric oxide (NO) formed by the constitutive endothelial nitric oxide synthase (eNOS). This defect predisposes to coronary vasospasm and cardiac ischaemia, with anginal pain as the typical clinical manifestation. …”
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Study on Pharmacodynamic Material Basis and Molecular Mechanism of Wutou Tang in Pain Relief Based on Computer Simulation by Chunsong ZHENG, Jie LIN, Changlong FU, Jinxia YE, Xiaojie XU, Hongzhi YE

“…They could act on six targets including inducible nitric oxide synthase (iNOS), p38, C-Jun N-terminal Kinase 1 (JNK-1), tumor necrosis factor-α (TNF-α), phosphodiesterase 4A (PDE-4A) and Kappa-type opioid receptor. …”
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To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents by Isaac Arbeláez-Quintero, Mauricio Palacios

“…Most experiments done in the cerebral ischemia model, via middle cerebral artery occlusion in rodents (MCAO), had positive results favoring metformin’s neuroprotective role and involve several cellular pathways like oxidative stress, endothelial nitric oxide synthase activation, activation of angiogenesis and neurogenesis, autophagia, and apoptosis. …”
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The refractory form of gastroesophageal reflux disease: clinical and endoscopical, functional and morphofunctional criteria by M. A. Osadchuk, A. M. Osadchuk, D. V. Balashov, I. M. Kvetnoy

“…Contents of nephro-endocrine cells in mucosa of the esophagus, producing nitric oxide synthase, endothelin-1, melatonin, neurotensin and р53 was determined by immunehistochemical method.Results. …”
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Nanoparticles Containing Hyaluronan Acid and Astragalus Polysaccharides for Treating Osteoarthritis by Gongbiao Lu, Lin Du, Jishou Lu, Liuzhong Jin

“…Furthermore, nano elevated the expression of osteopontin (OPN) and attenuated inducible nitric oxide synthase (iNOS) protein. Our data indicated the protective role of HA and APS-capsuled nanoparticles in OA treatment.…”
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Zeatin Elicits Premature Erythrocyte Senescence Through Calcium and Oxidative Stress Mediated by the NOS/PKC/CK1α Signaling Axis by Iman A. Alajeyan, Jawaher Alsughayyir, Mohammad A. Alfhili

“…The hemolytic potential of ZTN, mediated through nitric oxide synthase/protein kinase C/casein kinase 1α signaling axis, is sensitive to isosmotic urea, sucrose, and PEG availability. …”
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Nutraceutical COMP-4 confers protection against endothelial dysfunction through the eNOS/iNOS-NO-cGMP pathway. by Monica G Ferrini, Andrea Abraham, Revecca Millán, Leslie Graciano, Sriram V Eleswarapu, Jacob Rajfer

“…NO intracellular content, nitrite formation and cGMP content in culture media, nitric oxide synthase (NOS) isoforms and mRNA content, pro-inflammatory cytokines, and PAI-1 expression and activity were measured. …”
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Effect of Static Magnetic Field on Oxidant/Antioxidant Parameters in Cancerous and Noncancerous Human Gastric Tissues by Bahadır Öztürk, Zahide Esra Durak, Süleyman Büber, Ender Hilmi Kocaoğlu

“…There were no differences between nitric oxide (NO) and nitric oxide synthase (NOS) parameters in or among the cancerous and noncancerous tissues. …”
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Anti-Inflammation Property of Syzygium cumini (L.) Skeels on Indomethacin-Induced Acute Gastric Ulceration by Lanchakon Chanudom, Jitbanjong Tangpong

“…Indomethacin induced inflammation by activated inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-α) proinflammatory cytokines to release large amount of ROS/RNS which were ameliorated in mice pretreatment with SCC. …”
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Can Chronic Nitric Oxide Inhibition Improve Liver and Renal Dysfunction in Bile Duct Ligated Rats? by Mona Fouad Mahmoud, Sara Zakaria, Ahmed Fahmy

“…In conclusion, inhibition of NO production by constitutive nitric oxide synthase (cNOS) plays a crucial role in liver injury and renal dysfunction while inhibition of iNOS by AG has beneficial effect. …”
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Spatiotemporal Pattern of Neuroinflammation After Impact-Acceleration Closed Head Injury in the Rat

“…We analyzed the spatiotemporal expression pattern of the proinflammatory key molecules: interleukin-1<mml:math alttext="$eta$"> <mml:mi>&#x03B2;</mml:mi> </mml:math>, interleukin-6, tumor necrosis factor-<mml:math alttext="$alpha$"> <mml:mi>&#x03B1;</mml:mi> </mml:math>, and inducible nitric oxide synthase in a rat closed head injury (CHI) paradigm. 51 rats were used for RT-PCR analysis after CHI, and 18 for immunocytochemistry. …”
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Effect of Arginine Vasopressin on Intraoperative Hypotension Caused by Oral Administration of 5-Aminolevulinic Acid by Gen Owada, Hideo Nishizawa, Yuki Matoyama, Eri Watanabe, Keigo Mitsuda, Naoki Kaneko, Yasuhiro Kimura, Taikan Nanao, Junichi Fujimoto

“…However, after starting a continuous administration of AVP, the systolic blood pressure increased, and the hemodynamic parameters remained stable during the remainder of the operation. 5-ALA administration may lower blood pressure by inducing nitric oxide production, and AVP inhibits inducible nitric oxide synthase messenger RNA expression and interleukin-1β-stimulated nitric oxide production. …”
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Force-Induced Nitric Oxide Promotes Osteogenic Activity during Orthodontic Tooth Movement in Mice by Yuqing Sun, Jingfei Fu, Feiran Lin, Shengnan Li, Juan Du, Yi Liu, Yuxing Bai

“…The production of NO and the expression level of nitric oxide synthase (NOS) were detected after mechanical stimulation. …”
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Asthma in Sickle Cell Disease by Manisha Newaskar, Karen A. Hardy, Claudia R. Morris

“…While the pathophysiologic mechanism in atopic asthma involves up-regulation of Th2 cytokines, mast cell– and eosinophil-driven inflammation, plus increased activity of inducible nitric oxide synthase (iNOS) and arginase in airway epithelium resulting in obstructive changes and AHR, the exact mechanisms of AHR, obstructive and restrictive lung disease in SCD is unclear. …”
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