The Gut Microbiome Regulates the Psychomotor Effects and Context-Dependent Rewarding Responses to Cocaine in Germ-Free and Antibiotic-Treated Animal Models by Andrew D. Winters, Dina M. Francescutti, David J. Kracht, Diptaraj S. Chaudhari, Branislava Zagorac, Mariana Angoa-Perez

“…ABX-treated mice also showed significant declines in microbial diversity, shifts in bacterial structure, and dysregulation in metabolic, immune, and neurotransmitter pathways (<i>p</i> ≤ 0.0001), including alterations in short-chain fatty acids and gamma-aminobutyric acid metabolism. …”
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Maturation of the GABAergic Transmission in Normal and Pathologic Motoneurons by Anne-Emilie Allain, Hervé Le Corronc, Alain Delpy, William Cazenave, Pierre Meyrand, Pascal Legendre, Pascal Branchereau

“…γ-aminobutyric acid (GABA) acting on Cl−-permeable ionotropic type A (GABAA) receptors (GABAAR) is the major inhibitory neurotransmitter in the adult central nervous system of vertebrates. …”
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Limosilactobacillus reuteri fermented brown rice alleviates anxiety improves cognition and modulates gut microbiota in stressed mice by Akanksha Tyagi, Yu-Yeong Choi, Lingyue Shan, Annadurai Vinothkanna, Eun-Seok Lee, Ramachandran Chelliah, Kaliyan Barathikannan, Sivakumar Thasma Raman, Se Jin Park, Ai-Qun Jia, Geun Pyo Choi, Deog Hwan Oh

“…Anxiety was assessed through body weight, corticosterone levels, neurotransmitter profiles, and behavioral tests. A four-week FBR regimen reduced corticosterone, restored neurotransmitters like gamma-aminobutyric acid (GABA) and serotonin, and improved anxiety-related behaviors. …”
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The Effect of Strength Training on the Quality of Life and Cognitive Functions of Elderly People by Ernesta Klimavičiūtė, Sandra Naujalė, Lina Mickevičienė, Erika Krasinskė, Margarita Drozdova – Statkevičienė, Vida Janina Česnaitienė

“…Possible biological mechanisms that may underlie the effectiveness of physical exercise include increased blood flow in the brain, changes in neurotransmitter release, and the process of neurogenesis (Sumińska, 2021). …”
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Molecular Mechanisms Linking Omega-3 Fatty Acids and the Gut–Brain Axis by Anna Zinkow, Wojciech Grodzicki, Malwina Czerwińska, Katarzyna Dziendzikowska

“…Derived mainly from marine sources, these long-chain polyunsaturated fatty acids are integral to cell membrane structure, enhancing fluidity and influencing neurotransmitter function and signal transduction. Additionally, n-3 fatty acids modulate inflammation by altering eicosanoid production, reducing proinflammatory cytokines, and promoting anti-inflammatory mediators. …”
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A Single‐Center Retrospective Cohort Study of Biopterin Metabolism Disorders in the United Arab Emirates by Omar Jarrah, Mahmood Nouri, Aisha Al Shamsi

“…Four patients' cerebrospinal fluid neurotransmitter metabolites were evaluated. Blood for DHPR screening and urine pterin profile were done on eight patients. …”
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IUPHAR themed review: The gut microbiome in schizophrenia by Srinivas Kamath, Elysia Sokolenko, Kate Collins, Nicole S.L. Chan, Natalie Mills, Scott R. Clark, Francine Z. Marques, Paul Joyce

“…Gut microbial dysbiosis or altered gut microbial consortium, in schizophrenia suggests a pathogenic role through the gut-brain axis, influencing neuroinflammatory and neurotransmitter pathways critical to psychotic, affective, and cognitive symptoms. …”
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Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice by Mengjie He, Mengying Hu, Tingqiao Wang, Zeping Zuo, Hongkai Li, Zhiwei Zhao, Yunwen Hao, Xueling Dai, Jianfang Wang, Yaxuan Sun

“…The aim of this study was to investigate the potential effects of Morinda officinalis oligosaccharides (MOO) on depression and its concomitant symptom, sexual dysfunction.MethodsChronic unpredictable mild stress (CUMS)-induced depression model was constructed, and the effects of MOO on depression and sexual abilities were evaluated.ResultsThe results revealed that MOO was able to alleviate CUMS-induced depression-like behavior in mice, to inhibit hippocampal neuron apoptosis, to reverse monoamine neurotransmitter imbalance, increase Brain-derived neurotrophic factor (BDNF) expression levels in the hippocampus, to modulate the composition and distribution of gut microbiota, and to increase the abundance of probiotics after continuous gavage of MOO for 28 days. …”
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Cysteine Rich Intestinal Protein 2 is a copper-responsive regulator of skeletal muscle differentiation and metal homeostasis. by Odette Verdejo-Torres, David C Klein, Lorena Novoa-Aponte, Jaime Carrazco-Carrillo, Denzel Bonilla-Pinto, Antonio Rivera, Arpie Bakhshian, Fa'alataitaua M Fitisemanu, Martha L Jiménez-González, Lyra Flinn, Aidan T Pezacki, Antonio Lanzirotti, Luis Antonio Ortiz Frade, Christopher J Chang, Juan G Navea, Crysten E Blaby-Haas, Sarah J Hainer, Teresita Padilla-Benavides

“…Copper (Cu) is essential for respiration, neurotransmitter synthesis, oxidative stress response, and transcription regulation, with imbalances leading to neurological, cognitive, and muscular disorders. …”
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Conformational diversity in class C GPCR positive allosteric modulation by Giuseppe Cannone, Ludovic Berto, Fanny Malhaire, Gavin Ferguson, Aurelien Fouillen, Stéphanie Balor, Joan Font-Ingles, Amadeu Llebaria, Cyril Goudet, Abhay Kotecha, Vinothkumar K.R., Guillaume Lebon

“…Abstract The metabotropic glutamate receptors (mGlus) are class C G protein-coupled receptors (GPCR) that form obligate dimers activated by the major excitatory neurotransmitter L-glutamate. The architecture of mGlu receptor comprises an extracellular Venus-Fly Trap domain (VFT) connected to the transmembrane domain (7TM) through a Cysteine-Rich Domain (CRD). …”
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Inclusion of hypocretin-1 improved performance of poor sleep quality prediction for elderly patients with acute ischemic stroke: a prospective cohort study by Ting Fu, Weiwei Zhang, Rongrong Guo, Shuang He, Saiying Yu, Huiying Wang, Yunfeng Zhang, Ying Wu

“…BackgroundHypocretin-1 is a vital neurotransmitter in regulating the sleep–wake cycle and provides neuroprotection against cerebral ischemia. …”
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SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation by Izabella A. Pena, Jeffrey S. Shi, Sarah M. Chang, Jason Yang, Samuel Block, Charles H. Adelmann, Heather R. Keys, Preston Ge, Shveta Bathla, Isabella H. Witham, Grzegorz Sienski, Angus C. Nairn, David M. Sabatini, Caroline A. Lewis, Nora Kory, Matthew G. Vander Heiden, Myriam Heiman

“…These include enzymes important for amino acid metabolism, one-carbon metabolism, polyamine synthesis, erythropoiesis, and neurotransmitter metabolism. A third of all mammalian pyridoxal 5’-phosphate-dependent enzymes are localized in the mitochondria; however, the molecular machinery involved in the regulation of mitochondrial pyridoxal 5’-phosphate levels in mammals remains unknown. …”
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Trace amine-associated receptors (TAARs)2-9 knockout mice exhibit reduced wakefulness and disrupted REM sleep by Sunmee Park, Jasmine Heu, Gavin Scheldrup, Ryan K. Tisdale, Yu Sun, Meghan Haire, Shun-Chieh Ma, Marius C. Hoener, Thomas S. Kilduff

“…IntroductionThis study aimed to investigate the role of TAAR2-9 in sleep/wake regulation, given TAAR1's known involvement in modulating neurotransmitter release and sleep patterns.MethodsMale TAAR2-9 knockout (KO) and wild-type (WT) mice were compared using baseline sleep/wake patterns, responses to sleep deprivation, effects of TAAR1 agonists, and dopaminergic markers. …”
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Pathogenetic Substantiation of the Therapeutic Impact on Microbiota in Irritable Bowel Syndrome by Yu. O. Shulpekova, G. H. Babaeva, V. Yu. Rusyaev

“…Intestinal bacteria demonstrate a significant humoral effect due to signalling molecules, some of which exhibit neurotransmitter properties. The study of the bacterial cross-feeding for various species, i.e. mutual use of nutrient substrates produced by bacteria of various species, is of a great interest. …”
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Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review by Andrada Pintea, Andrei Manea, Cezara Pintea, Robert-Alexandru Vlad, Magdalena Bîrsan, Paula Antonoaea, Emöke Margit Rédai, Adriana Ciurba

“…Based on their mechanism of action, they can be classified into signal peptides, carrier peptides, neurotransmitter inhibitor peptides, and enzyme inhibitor peptides. …”
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Toxicodynamic insights of 2C and NBOMe drugs – Is there abuse potential? by Eva Gil-Martins, Daniel José Barbosa, Fernanda Borges, Fernando Remião, Renata Silva

“…This manuscript provides a comprehensive review of the psychedelic pathways underlying 2C and NBOMe designer drugs, focusing on their interactions with serotonergic and other neurotransmitter systems, shedding light on their potential for abuse.…”
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Altered resting-state cerebral blood flow and its relationship with molecular architecture in tremor dominant Parkinson’s disease by Shangpei Wang, Yajie Cai, Yibin Zhao, Yongqiang Yu, Xianwen Chen, Longsheng Wang

“…Perfusion alterations of the TD subtype were related to dopamine, serotonin, other excitatory neurotransmitters such as glutamate and opioid, which may provide novel insights into pathophysiological processes and guide new therapeutic targets.…”
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Effects of Functional Red Pine Seed Direct-Drinking Oil on Constipation and Intestinal Barrier Function in Mice by Jie Li, Haonan Zheng, Jiahui Liu, Jie Ding, Qingqi Guo, Na Zhang

“…Results showed that, compared to normal mice, constipated mice exhibited symptoms of dry stools, difficulty defecating, abnormal neurotransmitter levels, oxidative stress, and colonic tissue damage. …”
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Gut Microbiota and Its Impact on Brain Function and Mental Health by Zofia Martyna Wójcik, Katarzyna Kamińska-Omasta, Bartosz Omasta, Olga Krupa, Paulina Dorota Pietrukaniec, Kuba Borys Romańczuk, Kinga Furtak, Szymon Przemysław Stolarczyk, Magdalena Agata Czerska, Daria Rybak

“…The gut-brain axis modulates neurotransmitter production (e.g., serotonin, GABA), immune responses, and interacts through bacterial metabolites. …”
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Effect and Mechanism of Soluble Dietary Fiber from Corn Bran on Loperamide-induced Constipation in Mice by Xiangrui ZENG, Caixia JIANG, Xiaolan LIU, Xiqun ZHENG, Xuyao WEI

“…Compared to that of the model group, the levels of gastrointestinal tract-related neurotransmitters (motilin, 5-hydroxytryptamine, etc.) were elevated in mice that received CSDF, suggesting that CSDF could alleviate constipation in enteric nervous system disorders. …”
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