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81
Serotonin Receptors in Hippocampus
Published 2012-01-01“…Serotonin is an ancient molecular signal and a recognized neurotransmitter brainwide distributed with particular presence in hippocampus. …”
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82
Serotonergic Dysfunction in Parkinson's Disease and Its Relevance to Disability
Published 2011-01-01“…Results from biochemical, animal, postmortem, and functional imaging studies have revealed that other neurotransmitter systems are affected as well, including the serotonergic system. …”
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83
Hypothalamus-pituitary-adrenal and gut-brain axes in biological interaction pathway of the depression
Published 2025-02-01“…This allows endotoxins to enter the bloodstream, contributing to neuroinflammation and altering neurotransmitter production, including serotonin. Since the majority of serotonin is produced in the gut, disruptions in this pathway may be linked to depressive symptoms. …”
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84
Development of Tinnitus at a Low Dose of Sertraline: Clinical Course and Proposed Mechanisms
Published 2016-01-01“…Cochlear input is processed through complex interactions between serotonergic, glutamatergic, and GABAergic neurotransmitter systems. Options for treatment of tinnitus include selective serotonin reuptake inhibitors (SSRIs); however in rare instances this symptom may occur as a side effect of this class of medications. …”
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85
Genetics of Nonsyndromic Congenital Hearing Loss
Published 2016-01-01“…Mutations in genes that control the adhesion of hair cells, intracellular transport, neurotransmitter release, ionic hemeostasis, and cytoskeleton of hair cells can lead to malfunctions of the cochlea and inner ear. …”
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87
Intestinal microbiome as effective regulator of enteral and central nervous system activity
Published 2018-08-01“…However the fact of neurotransmitter production in close proximity to intestinal wall creates a basis for the further studies. …”
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88
Assortment of GABAergic Plasticity in the Cortical Interneuron Melting Pot
Published 2011-01-01“…Cortical structures of the adult mammalian brain are characterized by a spectacular diversity of inhibitory interneurons, which use GABA as neurotransmitter. GABAergic neurotransmission is fundamental for integrating and filtering incoming information and dictating postsynaptic neuronal spike timing, therefore providing a tight temporal code used by each neuron, or ensemble of neurons, to perform sophisticated computational operations. …”
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89
Olfactory dysfunction as potential biomarker in neurodegenerative diseases: a narrative review
Published 2025-01-01“…We summarize the most common methods used to measure olfactory function and delve into neuropathological correlations and the alterations in neurotransmitter systems associated with OD in those neurodegenerative diseases, including differences in genetic variants if applicable, and cater to current pitfalls and shortcomings in the research.…”
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90
Potential Adverse Consequences of Combination Therapy with Gabapentin and Pregabalin
Published 2021-01-01“…These were designed to not only look chemically like the central inhibitory neurotransmitter gamma-aminobutyric acid (GABA) but also act like it. …”
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91
Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration
Published 2025-02-01“…Additionally, we mapped neurotransmitter receptor/transporter density maps to the cortical thickness maps, to uncover different correlation patterns for each genetic form. …”
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92
The Neurometabolic Function of the Dopamine–Aminotransferase System
Published 2025-01-01“…Results: The dopamine–aminotransferase system of the energy metabolism regulation is a separate, independent, regulatory and diagnostically significant biochemical pathway controlled by the hormonal system, the key hormone is cortisol, the key neurotransmitter is dopamine, the key transcription factor is CREB, and the key regulatory enzymes are alanine aminotransferase, aspartate aminotransferase, and tyrosine aminotransferase. …”
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93
Identification of Molecular Substrate for the Attenuation of Anxiety: A Step Toward the Development of Better Anti-Anxiety Drugs
Published 2001-01-01“…Benzodiazepines augment the action of the inhibitory neurotransmitter g-aminobutyric acid (GABA) at contact points between two nerve cells called synapses, points at which information is transmitted from one nerve cell to the next. …”
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94
Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity
Published 2011-01-01“…The sign of synaptic plasticity depends on the spike order of presynaptic and postsynaptic neurons. Ionotropic neurotransmitter receptors, such as NMDA receptors and nicotinic acetylcholine receptors, are intimately involved in setting the rules for synaptic strengthening and weakening. …”
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95
Probiotics in Depression Management: Efficacy, Mechanisms and Future Directions
Published 2025-01-01“…The pathophysiology is often attributed to neurotransmitter imbalances, hypothalamic-pituitary-adrenal (HPA) axis dysfunction, and inflammation. …”
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96
The Impact of Antidepressants on Gut Microbiome and Depression Management
Published 2024-07-01“…However, their influence extends beyond neurotransmitter modulation in the brain to significant effects on gastrointestinal physiology. …”
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97
Impact of Exposure to Fenitrothion on Vital Organs in Rats
Published 2016-01-01“…This study also showed an impairment in brain neurotransmitter (elevated 5-HT, glutamate, GABA, and reduced dopamine and norepinephrine level). …”
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98
1,5-Dichloroethanoanthracene Derivatives As Antidepressant Maprotiline Analogs: Synthesis, DFT Computational Calculations, and Molecular Docking
Published 2022-01-01“…Molecular docking simulation showed that all the compounds (1, 2, 5, and 6) have high antidepressant activities and form stable complexes with LeuT by inhibiting the neurotransmitter reuptake at the synapse and hence are good candidates as antidepressant drugs.…”
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99
Distinct mechanisms of electroacupuncture and manual acupuncture in modulating hypothalamic GnRH–tanycyte unit function of polycystic ovary syndrome
Published 2025-02-01“…MA primarily functions through neurotransmitter regulation. These findings highlight potential hypothalamic targets and provide new insights into the distinct mechanisms of EA and MA.…”
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100
Neuronal heterogeneity in the ventral tegmental area: Distinct contributions to reward circuitry and motivated behavior
Published 2025-03-01“…Distinct subtypes of DA neurons can be identified across the VTA and substantia nigra pars compacta (SNc) by characteristics that include gene expression patterns (molecular identity), connectivity motifs (network identity), and patterns of task-linked activity and neurotransmitter release (computational identity). This review aims to synthesize current knowledge of diverse neuronal populations in the VTA, including distinct subtypes of DA, glutamate (GLUT), and GABAergic neurons and combinatorial cells alongside well-characterized markers of these neuronal subclasses. …”
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