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Effects of Chronic Dopamine D2R Agonist Treatment and Polysialic Acid Depletion on Dendritic Spine Density and Excitatory Neurotransmission in the mPFC of Adult Rats
Published 2016-01-01“…Chronic treatment with D2R agonists modifies the expression of molecules implicated in neuronal structural plasticity, synaptic function, and inhibitory neurotransmission, which are also altered in schizophrenia. …”
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Mouse-derived Synaptosomes Trypsin Cleavage Assay to Characterize Synaptic Protein Sub-localization
Published 2025-01-01“…Neurons communicate through neurotransmission at highly specialized junctions called synapses. …”
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Stress Response and Perinatal Reprogramming: Unraveling (Mal)adaptive Strategies
Published 2016-01-01“…Here, we discuss recent findings about stress remodeling of excitatory neurotransmission and brain morphology in animal models of behavioral stress. …”
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The GABA-Withdrawal Syndrome: A Model of Local Status Epilepticus
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Depression as a Neuroendocrine Disorder: Emerging Neuropsychopharmacological Approaches beyond Monoamines
Published 2019-01-01“…Innovative pharmacological targets beyond monoamines include glutamatergic and GABAergic neurotransmission, brain-derived neurotrophic factor, various endocrine axes, as well as several neurosteroids, neuropeptides, opioids, endocannabinoids and endovanilloids. …”
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Alterations of Amino Acids and Monoamine Metabolism in Male Fmr1 Knockout Mice: A Putative Animal Model of the Human Fragile X Mental Retardation Syndrome
Published 2001-01-01“…The results presented here provide the first evidence that lack of FMRP expression in FMRP knockout mice is accompanied by age-dependent, region-specific alterations in neurotransmission.…”
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Ion Channels and Zinc: Mechanisms of Neurotoxicity and Neurodegeneration
Published 2012-01-01“…Ionotropic glutamate receptors, such as NMDA, AMPA and kainate receptors, are ligand-gated ion channels that mediate much of the excitatory neurotransmission in the brain. Not only do these receptors bind glutamate, but they are also regulated by and facilitate the postsynaptic uptake of the trace metal zinc. …”
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Fatigue in Liver Disease: Pathophysiology and Clinical Management
Published 2006-01-01“…Specifically, experimental findings suggest that fatigue associated with liver disease likely occurs as a result of changes in neurotransmission within the brain. In conclusion, a reasonable approach to help guide in the management of the fatigued patient with liver disease is presented.…”
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Gastrointestinal myofibroblasts: role in regulation of physiological activity and reparation of gastro-intestinal tract
Published 2010-06-01“…Intestinal myofibroblasts are pacemakers for smooth myocytes of GIT, they modulate neurotransmission, participate in modulation of immune response, playing a critical role in reparation of erosions and ulcers of GIT.…”
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Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators
Published 2017-01-01“…The N-methyl-D-aspartate receptors (NMDARs) are subtype glutamate receptors that play important roles in excitatory neurotransmission and synaptic plasticity. Their hypo- or hyperactivation are proposed to contribute to the genesis or progression of various brain diseases, including stroke, schizophrenia, depression, and Alzheimer’s disease. …”
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The Effect of Glucocorticoid and Glucocorticoid Receptor Interactions on Brain, Spinal Cord, and Glial Cell Plasticity
Published 2017-01-01“…Stress/GCs induce structural plasticity in neurons, Schwann cells, microglia, oligodendrocytes, and astrocytes as well as affect neurotransmission by changing the release and reuptake of glutamate. …”
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Cell Secretion: Current Structural and Biochemical Insights
Published 2010-01-01“…Essential physiological functions in eukaryotic cells, such as release of hormones and digestive enzymes, neurotransmission, and intercellular signaling, are all achieved by cell secretion. …”
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Pathogenesis of Hepatic Encephalopathy
Published 2012-01-01“…The brain-blood barrier disturbances, changes in neurotransmission, neuroinflammation, oxidative stress, GABA-ergic or benzodiazepine pathway abnormalities, manganese neurotoxicity, brain energetic disturbances, and brain blood flow abnormalities are considered to be involved in the development of hepatic encephalopathy. …”
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The Adenosinergic System in Diabetic Retinopathy
Published 2016-01-01“…The adenosinergic system is widely regarded as a significant modulator of neurotransmission and the inflammatory response, through the actions of the four types of adenosine receptors (A1R, A2AR, A2BR, and A3R), and thus could be revealed as a potential player in the events unfolding in the early stages of diabetic retinopathy. …”
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Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology
Published 2015-01-01“…Many of these effects result from acute increases in dopamine and serotonin neurotransmission. Subsequent to these acute effects, METH produces persistent damage to dopamine and serotonin release in nerve terminals, gliosis, and apoptosis. …”
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The endocannabinoid system and ophthalmic pathologies: a review of molecular mechanisms and its implications for clinical practice
Published 2025-02-01“…It is known that this widespread cell-signaling system is involved in retinal neurobiological processes, including visual signal processing, as well as neurotransmission. Furthermore, various research indicated the involvement of ECS in the molecular basis of various pathologies, mostly glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD). …”
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INTERMOLECULAR INTERACTIONS IN NEURONAL FUNCTIONAL SYSTEMS
Published 2015-01-01“…The model represents activity-dependent changes of the synaptic transmission efficiency, integration of excitation in the local dendritic network of a neuron, and prolonged maintenance of the new level of neurotransmission.…”
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The Neuropathology of Autism
Published 2012-01-01“…Abnormalities include cytoarchitectonic laminar differences, excess white matter neurons, decreased numbers of GABAergic cerebellar Purkinje cells, and other events that can be traced developmentally and cause anomalies in circuitry. Problems with neurotransmission are evident by recent receptor and binding site studies especially in the inhibitory GABA system likely contributing to an imbalance of excitatory/inhibitory transmission. …”
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Male Sexual Dysfunction
Published 2022-08-01“…Risk factors for male sexual dysfunction include age, diabetes mellitus (DM), cancer, stroke, hypertension, penile trauma, depression, anxiety, and disturbance in central serotonin neurotransmission and 5-HT postsynaptic receptor functioning. …”
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