Roles for Prlhr/GPR10 and Npffr2/GPR74 in feeding responses to PrRP by Yi Wang, Weiwei Qiu, Stace Kernodle, Carly Parker, Marc-Antonio Padilla, Jiaao Su, Abigail J. Tomlinson, Stephanie Oldham, Joss Field, Elise Bernard, David Hornigold, Christopher J. Rhodes, David P. Olson, Randy J. Seeley, Martin G. Myers, Jr

“…Not only does the artificial activation of NTSPrlh cells decrease feeding, but also the expression of Prlh (which encodes the neuropeptide PrRP) and neurotransmission by NTSPrlh neurons contributes to the restraint of food intake and body weight, especially in animals fed a high fat diet (HFD). …”
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Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk by Junjie Wang, Yingying Tang, Tianhong Zhang, Huiru Cui, Lihua Xu, Botao Zeng, Yu Li, Gaiying Li, Chunbo Li, Hui Liu, Zheng Lu, Jianye Zhang, Jijun Wang

“…Altered γ-aminobutyric acid (GABA), glutamate (Glu) levels, and an imbalance between GABAergic and glutamatergic neurotransmissions have been involved in the pathophysiology of schizophrenia. …”
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MMP-9 Contributes to Dendritic Spine Remodeling Following Traumatic Brain Injury by Barbara Pijet, Marzena Stefaniuk, Leszek Kaczmarek

“…On neuronal level, TBI may lead to circuitry remodeling and in effect imbalance between excitatory and inhibitory neurotransmissions. Such change in brain homeostasis may often lead to brain disorders. …”
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Molecular switch of the dendrite-to-spine transport of TDP-43/FMRP-bound neuronal mRNAs and its impairment in ASD by Pritha Majumder, Biswanath Chatterjee, Khadiza Akter, Asmar Ahsan, Su Jie Tan, Chi-Chen Huang, Jen-Fei Chu, Che-Kun James Shen

“…Conclusions This study, for the first time, highlights the importance of posttranslational modification of RBPs, such as the neurodevelopmental disease-related protein FMRP, as the molecular switch regulating the dendrite-to-spine transport of specific mRNAs under mGluR1-mediated neurotransmissions. The misregulation of this switch could contribute to the pathogenesis of FMRP-related neurodisorders including the autism spectrum disorder (ASD). …”
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