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Phase II randomised, double-blind, placebo-controlled trial to assess the efficacy and safety of MLC1501 in patients with stroke: the MLC1501 study Assessing Efficacy in post-STrOk...
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602
The proof is in the pudding: patient engagement in studying cannabidiol in mild cognitive impairment
Published 2025-01-01“…Cannabidiol (CBD) shows potential in slowing MCI progression due to its neuroprotective and anti-inflammatory properties. In CBD research, PE is underutilized too. …”
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603
Pharmacokinetics of 7,8-dihydroxyflavone in neonatal mice with hypoxia-ischemia related brain injury
Published 2025-01-01“…Introduction7,8-Dihydroxyflavone (7,8-DHF) is a promising translational therapy in several brain injury models, including the neonatal hypoxia-ischemia (HI) model in mice. However, the neuroprotective effect of 7,8-DHF was only observed in female, but not male, neonatal mice with HI brain injury. …”
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604
evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomat...
Published 2025-01-01“…Semaglutide may have a disease-modifying, neuroprotective effect in AD through multimodal mechanisms including neuroinflammatory, vascular, and other AD-related processes. …”
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605
Emerging Implications of Serum Resolvin D2 as a Biochemical Marker for Severity Assessment and Prognosis Prediction Following Moderate-Severe Traumatic Brain Injury: A Prospective...
Published 2025-01-01“…Hua Zong,* Yaqiong Zong,* Jian Li, Shaoyun Zhao, Weipeng Wu, Runhong Chen, Guoan Zhao, Zhuolun Li Department of Neurosurgery, Changzhi People’s Hospital, Changzhi, Shanxi Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian Li, Department of Neurosurgery, Changzhi People’s Hospital, Changzhi, Shanxi Province, People’s Republic of China, Email lijian958801@163.comBackground: Resolvin D2 (RvD2), which exhibits anti-inflammatory properties, is neuroprotective. This study aimed to ascertain the potential of serum RvD2 level as a prognostic predictor of moderate-to-severe traumatic brain injury (msTBI).Methods: In this prospective cohort study, serum RvD2 levels were measured in 136 patients with msTBI and 100 healthy controls. …”
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606
Functional differentiation of human dental pulp stem cells into neuron-like cells exhibiting electrophysiological activity
Published 2025-01-01“…Unlike other human stem cells, hDPSCs can be differentiated, without genetic modification, to neural cells that secrete neuroprotective factors. However, a better understanding of their real capacity to give rise to functional neurons and integrate into synaptic networks is still needed. …”
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607
Electroacupuncture at Quchi and Zusanli Enhances the Proliferation of Cortex and SVZ-derived Neural Stem Cell in Cerebral Ischemia-Reperfusion Injured Rats Via Activation of Notch1...
Published 2015-10-01“…The findings of EA treatment for three days and seven days showed that EA could enhance proliferation of neural stem cells (<italic>P</italic><0.05). ④The expression of JAG1, NICD, Hes1, Hes5 in ischemic surrounding cortex and ischemic SVZ area were further increased after EA treatment for seven days in comparation with those in the model group (<italic>P</italic><0.05 or <italic>P</italic><0.01); and in the EA+GSI group, the expression of NICD, Hes1, Hes5 proteins were significantly decreased (<italic>P</italic><0.05), but the expression of JAG1 had no significant difference (<italic>P</italic>>0.05). ⑤In the EA+GSI group, the number of Nestin positive cells and Brdu co-localized with Nestin in ischemic SVZ region were increased (<italic>P</italic><0.01 or <italic>P</italic><0.05).Conclusions:EA at the Quchi and Zusanli acupints can reduce the infarct volume, improve the overall animal behavior and exert a neuroprotective effect in cerebral ischemia-reperfusion injured rats. …”
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608
αAsarone alleviates neuronal injury by facilitating autophagy via miR-499-5p/PDCD4/ATG5 signaling pathway in ischemia stroke
Published 2025-01-01“…IntroductionαAsarone, an essential oil derived from Acorus gramineus Aiton, which has been successfully used to treat epilepsy in traditional chinese medicine, and has also been reported to confer neuroprotective effects on stroke. However, its mechanism of action remains poorly understood.MethodsThe effects of αAsarone on autophagy were examined by WB, RT-qPCR, immunofluorescence colocalization, transmission electron microscope, and autophagic flux activity was measured by infecting HT22 cells with mRFP-GFP-LC3 adenovirus. …”
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609
Caribbean Consortium for Research in Environmental and Occupational Health (CCREOH) Cohort Study: influences of complex environmental exposures on maternal and child health in Suri...
Published 2020-09-01“…Effects of potentially beneficial neuroprotective factors in fish that may counter neurotoxic effects of Hg are being examined. …”
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610
Physiology and Pathophysiology of Marathon Running: A narrative Review
Published 2025-01-01“…It further positively affects hematopoiesis and cytotoxic abilities of natural killer cells, and may act neuroprotective on a long-term basis. After a marathon, changes in biomarkers suggesting pathological events in certain organ systems such as cardiovascular, renal, gastrointestinal, liver, hematological, immune, musculoskeletal, central nervous, and endocrine systems can often be observed. …”
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611
Effect of intravitreal injections on the progression and prognosis of primary open-angle glaucoma
Published 2021-12-01“…Studies on the effects and neuroprotective role of vascular endothelial growth factor (VEGF) and agents blocking its action in various organs and tissues on the retina have demonstrated some differences in the outcomes and their interpretation which potentially affect IVI management strategy and treatment efficacy. …”
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612
NPT100-18A rescues mitochondrial oxidative stress and neuronal degeneration in human iPSC-based Parkinson’s model
Published 2025-01-01“…In addition, we provide first mechanistic insights into how a compartment-specific antioxidant effect in mitochondria might contribute to the neuroprotective effects of NPT100-18A.…”
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613
Appearance of green tea compounds in plasma following acute green tea consumption is modulated by the gut microbiome in mice
Published 2025-02-01“…ABSTRACT Studies have suggested that phytochemicals in green tea have systemic anti-inflammatory and neuroprotective effects. However, the mechanisms behind these effects are poorly understood, possibly due to the differential metabolism of phytochemicals resulting from variations in gut microbiome composition. …”
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614
Examining the therapeutic potential and side effects of calcium channel blockers in mortality and morbidity of patients with stroke: A systematic review of pre-clinical and clinica...
Published 2025-06-01“…Among 24 studies, 11 reported favorable outcomes following CCB administration, and two studies reported neuroprotective effects for CCBs without any adverse outcome in stroke patients. …”
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615
Role of BDNF-TrkB signaling in the improvement of motor function and neuroplasticity after ischemic stroke in rats by transcranial direct current stimulation
Published 2025-01-01“…Conclusion: Our findings indicate that tDCS may exert a neuroprotective effect by activating the downstream key molecules of BDNF-TrkB expression, for instance, PLCγ/ CaMK IV/ CREB and ERK/ RSK pathway. …”
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616
Mechanism of Electroacupuncture at Baihui and Shenting Alleviating Cerebral Ischemia-reperfusion Injury via Regulating BNIP3L-Mediated Mitophagy
Published 2022-02-01“…The results of the electroacupuncture+3-MA group showed that the autophagy inhibitor 3-MA could reverse the neuroprotective effect of electroacupuncture in MCAO model rats.ConclusionElectroacupuncture at Baihui and Shenting acupoints can alleviate neurological damage in rats with cerebral ischemia-reperfusion. …”
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