Showing 601 - 616 results of 616 for search '"neuroprotection"', query time: 0.05s Refine Results
  1. 601

    Phase II randomised, double-blind, placebo-controlled trial to assess the efficacy and safety of MLC1501 in patients with stroke: the MLC1501 study Assessing Efficacy in post-STrOk... by Narayanaswamy Venketasubramanian, Deidre Anne De Silva, Christopher P L H Chen, Cyrus G Escabillas, John Harold Hiyadan, Johnny K Lokin, Romulo U Esagunde, Joel M Advincula, Christian Oliver C Co, Maria Epifania V Collantes, Annabelle Y Lao, Yeow-Hoay Koh, Carol Huilian Tham

    “…Background MLC1501, consisting of four herbs, that is, Radix Astragali, Radix Angelicae sinensis, Rhizoma Chuanxiong, Radix Polygalae, has the same pharmacological properties as its precursors MLC601 and MLC901 which contain extracts of nine herbs and showed neuroprotective, anti-inflammatory and neurorestorative properties in non-clinical models, as well as clinical benefits in improving functional and neurological recovery after brain injuries.Aims To determine the efficacy of MLC1501 on motor recovery as measured by Fugl-Meyer motor Assessment (FMA) total score at 24 weeks in patients with ischaemic stroke (IS).Design A total of 300 patients aged >18 years, diagnosed with IS in the prior 2–10 days, with National Institute of Health Stroke Scale (NIHSS) total score of 8–18 and a combined score of ≥3 on NIHSS motor items 5A, 5B, 6A and/or 6B, will be randomised in a 1:1:1 ratio to receive oral placebo, MLC1501 low dose or MLC1501 high dose for 6 months. …”
    Get full text
    Article
  2. 602

    The proof is in the pudding: patient engagement in studying cannabidiol in mild cognitive impairment by Antonia Keck, Julia-Sophia Scheuermann, Petra Scheerbaum, Elmar Graessel, Kirsten R. Müller-Vahl

    Published 2025-01-01
    “…Cannabidiol (CBD) shows potential in slowing MCI progression due to its neuroprotective and anti-inflammatory properties. In CBD research, PE is underutilized too. …”
    Get full text
    Article
  3. 603

    Pharmacokinetics of 7,8-dihydroxyflavone in neonatal mice with hypoxia-ischemia related brain injury by Sin Yin Lim, Cameron O. Scarlett, Sefer Yapici, Peter Ferrazzano, Peter Ferrazzano, Pelin Cengiz, Pelin Cengiz

    Published 2025-01-01
    “…Introduction7,8-Dihydroxyflavone (7,8-DHF) is a promising translational therapy in several brain injury models, including the neonatal hypoxia-ischemia (HI) model in mice. However, the neuroprotective effect of 7,8-DHF was only observed in female, but not male, neonatal mice with HI brain injury. …”
    Get full text
    Article
  4. 604

    evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomat... by Jeffrey L. Cummings, Alireza Atri, Howard H. Feldman, Oskar Hansson, Mary Sano, Filip K. Knop, Peter Johannsen, Teresa León, Philip Scheltens

    Published 2025-01-01
    “…Semaglutide may have a disease-modifying, neuroprotective effect in AD through multimodal mechanisms including neuroinflammatory, vascular, and other AD-related processes. …”
    Get full text
    Article
  5. 605

    Emerging Implications of Serum Resolvin D2 as a Biochemical Marker for Severity Assessment and Prognosis Prediction Following Moderate-Severe Traumatic Brain Injury: A Prospective... by Zong H, Zong Y, Li J, Zhao S, Wu W, Chen R, Zhao G, Li Z

    Published 2025-01-01
    “…Hua Zong,* Yaqiong Zong,* Jian Li, Shaoyun Zhao, Weipeng Wu, Runhong Chen, Guoan Zhao, Zhuolun Li Department of Neurosurgery, Changzhi People’s Hospital, Changzhi, Shanxi Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian Li, Department of Neurosurgery, Changzhi People’s Hospital, Changzhi, Shanxi Province, People’s Republic of China, Email lijian958801@163.comBackground: Resolvin D2 (RvD2), which exhibits anti-inflammatory properties, is neuroprotective. This study aimed to ascertain the potential of serum RvD2 level as a prognostic predictor of moderate-to-severe traumatic brain injury (msTBI).Methods: In this prospective cohort study, serum RvD2 levels were measured in 136 patients with msTBI and 100 healthy controls. …”
    Get full text
    Article
  6. 606

    Functional differentiation of human dental pulp stem cells into neuron-like cells exhibiting electrophysiological activity by B. Pardo-Rodríguez, A. M. Baraibar, I. Manero-Roig, J. Luzuriaga, J. Salvador-Moya, Y. Polo, R. Basanta-Torres, F. Unda, S. Mato, Gaskon Ibarretxe, Jose Ramon Pineda

    Published 2025-01-01
    “…Unlike other human stem cells, hDPSCs can be differentiated, without genetic modification, to neural cells that secrete neuroprotective factors. However, a better understanding of their real capacity to give rise to functional neurons and integrate into synaptic networks is still needed. …”
    Get full text
    Article
  7. 607

    Electroacupuncture at Quchi and Zusanli Enhances the Proliferation of Cortex and SVZ-derived Neural Stem Cell in Cerebral Ischemia-Reperfusion Injured Rats Via Activation of Notch1... by Jing TAO, Weilin LIU, Jia HUANG, Xiehua XUE, Shanli YANG, Yi ZHENG, Yunjiao LIN, Xiaoqian YE, Meiqin LIN, Lidian CHEN

    Published 2015-10-01
    “…The findings of EA treatment for three days and seven days showed that EA could enhance proliferation of neural stem cells (<italic>P</italic>&lt;0.05). ④The expression of JAG1, NICD, Hes1, Hes5 in ischemic surrounding cortex and ischemic SVZ area were further increased after EA treatment for seven days in comparation with those in the model group (<italic>P</italic>&lt;0.05 or <italic>P</italic>&lt;0.01); and in the EA+GSI group, the expression of NICD, Hes1, Hes5 proteins were significantly decreased (<italic>P</italic>&lt;0.05), but the expression of JAG1 had no significant difference (<italic>P</italic>&gt;0.05). ⑤In the EA+GSI group, the number of Nestin positive cells and Brdu co-localized with Nestin in ischemic SVZ region were increased (<italic>P</italic>&lt;0.01 or <italic>P</italic>&lt;0.05).Conclusions:EA at the Quchi and Zusanli acupints can reduce the infarct volume, improve the overall animal behavior and exert a neuroprotective effect in cerebral ischemia-reperfusion injured rats. …”
    Get full text
    Article
  8. 608

    αAsarone alleviates neuronal injury by facilitating autophagy via miR-499-5p/PDCD4/ATG5 signaling pathway in ischemia stroke by Yonghuan Yan, Linfang Wu, Lu Wang, Dandan Wang, Mengting Huang, Jinyong Peng, Jinyong Peng, Yingying Huang, Yingying Huang, Yingying Huang

    Published 2025-01-01
    “…IntroductionαAsarone, an essential oil derived from Acorus gramineus Aiton, which has been successfully used to treat epilepsy in traditional chinese medicine, and has also been reported to confer neuroprotective effects on stroke. However, its mechanism of action remains poorly understood.MethodsThe effects of αAsarone on autophagy were examined by WB, RT-qPCR, immunofluorescence colocalization, transmission electron microscope, and autophagic flux activity was measured by infecting HT22 cells with mRFP-GFP-LC3 adenovirus. …”
    Get full text
    Article
  9. 609
  10. 610

    Physiology and Pathophysiology of Marathon Running: A narrative Review by Lorin Braschler, Pantelis T. Nikolaidis, Mabliny Thuany, Daniela Chlíbková, Thomas Rosemann, Katja Weiss, Matthias Wilhelm, Beat Knechtle

    Published 2025-01-01
    “…It further positively affects hematopoiesis and cytotoxic abilities of natural killer cells, and may act neuroprotective on a long-term basis. After a marathon, changes in biomarkers suggesting pathological events in certain organ systems such as cardiovascular, renal, gastrointestinal, liver, hematological, immune, musculoskeletal, central nervous, and endocrine systems can often be observed. …”
    Get full text
    Article
  11. 611

    Effect of intravitreal injections on the progression and prognosis of primary open-angle glaucoma by A.B. Movsisyan, N.G. Glazko, A.Yu. Brezhnev, A.V. Kuroyedov

    Published 2021-12-01
    “…Studies on the effects and neuroprotective role of vascular endothelial growth factor (VEGF) and agents blocking its action in various organs and tissues on the retina have demonstrated some differences in the outcomes and their interpretation which potentially affect IVI management strategy and treatment efficacy. …”
    Get full text
    Article
  12. 612

    NPT100-18A rescues mitochondrial oxidative stress and neuronal degeneration in human iPSC-based Parkinson’s model by Julian E. Alecu, Veronika Sigutova, Razvan-Marius Brazdis, Sandra Lörentz, Marios Evangelos Bogiongko, Anara Nursaitova, Martin Regensburger, Laurent Roybon, Kerstin M. Galler, Wolfgang Wrasidlo, Beate Winner, Iryna Prots

    Published 2025-01-01
    “…In addition, we provide first mechanistic insights into how a compartment-specific antioxidant effect in mitochondria might contribute to the neuroprotective effects of NPT100-18A.…”
    Get full text
    Article
  13. 613

    Appearance of green tea compounds in plasma following acute green tea consumption is modulated by the gut microbiome in mice by John D. Sterrett, Kevin D. Quinn, Katrina A. Doenges, Nichole M. Nusbacher, Cassandra L. Levens, Mike L. Armstrong, Richard M. Reisdorph, Harry Smith, Laura M. Saba, Kristine A. Kuhn, Catherine A. Lozupone, Nichole A. Reisdorph

    Published 2025-02-01
    “…ABSTRACT Studies have suggested that phytochemicals in green tea have systemic anti-inflammatory and neuroprotective effects. However, the mechanisms behind these effects are poorly understood, possibly due to the differential metabolism of phytochemicals resulting from variations in gut microbiome composition. …”
    Get full text
    Article
  14. 614
  15. 615

    Role of BDNF-TrkB signaling in the improvement of motor function and neuroplasticity after ischemic stroke in rats by transcranial direct current stimulation by Yu Chen, Lin Mao, Qinxiang Zhou, Dingqun Bai, Yuhan Kong

    Published 2025-01-01
    “…Conclusion: Our findings indicate that tDCS may exert a neuroprotective effect by activating the downstream key molecules of BDNF-TrkB expression, for instance, PLCγ/ CaMK IV/ CREB and ERK/ RSK pathway. …”
    Get full text
    Article
  16. 616

    Mechanism of Electroacupuncture at Baihui and Shenting Alleviating Cerebral Ischemia-reperfusion Injury via Regulating BNIP3L-Mediated Mitophagy by ZHONG Xiaoyong, LI Cheng, WANG Fang, CHEN Bin, LIANG Hui, RUAN Su

    Published 2022-02-01
    “…The results of the electroacupuncture+3-MA group showed that the autophagy inhibitor 3-MA could reverse the neuroprotective effect of electroacupuncture in MCAO model rats.ConclusionElectroacupuncture at Baihui and Shenting acupoints can alleviate neurological damage in rats with cerebral ischemia-reperfusion. …”
    Get full text
    Article