Molecular Hydrogen Modulates T Cell Differentiation and Enhances Neuro-Regeneration in a Vascular Dementia Mouse Model by Dain Lee, Hyunjun Jo, Jong-Il Choi

“…Transcriptomic evaluations confirmed that VaD suppressed key neuroprotective and anti-inflammatory genes, while H₂ treatment restored or enhanced their expression. …”
Get full text

Hydrolase-Treated Royal Jelly Attenuates H2O2- and Glutamate-Induced SH-SY5Y Cell Damage and Promotes Cognitive Enhancement in a Rat Model of Vascular Dementia by Nualpun Sirinupong, Worrapanitch Chansuwan, Pratchaya Kaewkaen

“…In conclusion, RJH is the potential neuroprotective agent and cognitive enhancer for VaD.…”
Get full text

Dihydromyricetin inhibits injury caused by ischemic stroke through the lncRNA SNHG17/miR-452-3p/CXCR4 axis by Jiacheng Xie, Qiuyue Yang, Xueliang Zeng, Qi Zeng, Hai Xiao

“…Dihydromyricetin (DHM) has been reported to have neuroprotective potential, but its role and mechanism in IS have not been fully elucidated. …”
Get full text

Propofol Ameliorates Microglia Activation by Targeting MicroRNA-221/222-IRF2 Axis by Xi Xiao, Yuanyuan Hou, Wei Yu, Sihua Qi

“…Propofol is a widely used intravenous anesthetic drug with potential neuroprotective effect in diverse diseases of neuronal injuries such as traumatic brain injury and ischemic stroke. …”
Get full text

Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats by Tongxia Zhang, Tao Zhang, Han Yu, Lingyi Chi

“…Methods STVNa was given intraperitoneally after SCI to see if it had any neuroprotective benefits. On Days 7, 14, 21, and 28 post‐SCI, functional recovery was measured using the Basso, Beattie, and Bresnahan (BBB) scoring system along with the oblique plate test. …”
Get full text

Effect of Differently Polarized Human Macrophages on the SH-SY5Y Cells Damaged by Ischemia and Hypoxia In Vitro by Ivan Mikhailovich Rashchupkin, Ekaterina Yakovlevna Shevela, Aleksandra Aleksandrovna Maksimova, Marina Aleksandrovna Tikhonova, Aleksandr Anatolevich Ostanin, Elena Removna Chernykh

“…The aim of this study was to compare the neuroregenerative and neuroprotective activity of soluble factors secreted by variously activated human macrophages on the functions of neural progenitors in an in vitro model of ischemia or ischemia/hypoxia. …”
Get full text

Oxidative stress and dysregulated long noncoding RNAs in the pathogenesis of Parkinson’s disease by Jialu Wang, Meitong Liu, Jiuhan Zhao, Pan Hu, Lianbo Gao, Shen Tian, Jin Zhang, Huayan Liu, Xiaoxue Xu, Zhenwei He

“…Therefore, modulating the levels of specific lncRNAs may alleviate pathological oxidative damage and have neuroprotective effects. This review discusses the general mechanisms of oxidative stress, pathological mechanism underlying the role of oxidative stress in the pathogenesis of PD, and teases out the mechanisms through which lncRNAs regulate oxidative stress during PD pathogenesis, as well as identifies the possible neuroprotective mechanisms of lncRNAs. …”
Get full text

The Protective Effect of Docosahexaenoic Acid on Mitochondria in SH-SY5Y Model of Rotenone-Induced Toxicity by Britta Eggers, Jennifer Stepien, Anne-Katrin Reker, Svenja Esser, Kathy Pfeiffer, Magdalena Pawlas, Katalin Barkovits, Katrin Marcus

“…They are involved in various processes, including synaptic development, functionality, integrity, and plasticity, and are therefore thought to have general neuroprotective properties. Considerable research evidence further supports the beneficial effects of omega-3 fatty acids, specifically on mitochondria, through their antioxidant and anti-apoptotic properties, making them an attractive addition in treatment options for neurodegenerative disorders in which mitochondrial alterations are commonly observed. …”
Get full text

Hippocampal Neurogenesis and the Brain Repair Response to Brief Stereotaxic Insertion of a Microneedle by Shijie Song, Shuojing Song, Chuanhai Cao, Xiaoyang Lin, Kunyu Li, Vasyl Sava, Juan Sanchez-Ramos

“…This study describes immediate and early humoral and cellular mechanisms of the brain’s response to microinjury that will be useful for the investigation of potential neuroprotective and deleterious effects of deep brain stimulation in various neuropsychiatric disorders.…”
Get full text

Rutin via Increase in the CA3 Diameter of the Hippocampus Exerted Antidepressant-Like Effect in Mouse Model of Maternal Separation Stress: Possible Involvement of NMDA Receptors by Maryam Anjomshoa, Shakiba Nasiri Boroujeni, Sorayya Ghasemi, Zahra Lorigooini, Ahmad Amiri, Shima Balali-dehkordi, Hossein Amini-khoei

“…Rutin, partially, through a neuroprotective effect on the hippocampus exerted antidepressant-like effect. …”
Get full text

Protocol for investigating astrocytic mitochondria in neurons of adult mice using two-photon microscopy by Jian Zhou, Fengling Du, Fan Zhang, Xianhui Zhang, Yuanyuan Wu, Lifang Zhang, Ping Liao, Tianqi Tu, Jianhua Peng, Tao Li, Yong Jiang

“…Summary: Under pathological conditions, astrocytes can transfer mitochondria to neurons, where they exert neuroprotective effects. In this context, we present a protocol for capturing astrocytic mitochondria in neurons of adult mice using a two-photon microscope. …”
Get full text

Novel Poly-Arginine Peptide R18D Reduces α-Synuclein Aggregation and Uptake of α-Synuclein Seeds in Cortical Neurons by Emma C. Robinson, Anastazja M. Gorecki, Samuel R. Pesce, Vaishali Bagda, Ryan S. Anderton, Bruno P. Meloni

“…Cationic arginine-rich peptides (CARPs) are an emerging class of molecule with multiple neuroprotective mechanisms of action, including protein stabilisation. …”
Get full text

The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment by Fan Chen, Na Wang, Xinyan Tian, Juan Su, Yan Qin, Rongqiao He, Xiaping He

“…Mangiferin (MGF) is a natural C-glucosyl-xanthone with promising neuroprotective effects, and is considered to have potential in the treatment of AD. …”
Get full text

Stress assessment instruments for hospitalized preterm newborns: scoping review by Mónica Costa, Maria Filomena Gaspar, Maria Alice Curado, Ana Brantes

“…Expanding validated tools and prioritizing individualized, neuroprotective care are essential for improving outcomes. …”
Get full text

Motor Learning Deficits in a Neonatal Mouse Model of Hypoxic-Ischemic Injury by Maria Marlicz, Weronika Matysik, Emily Zucker, Sarah Lee, Hannah Mulhern, Jennifer Burnsed

“…This HI model exhibits subtle motor deficits relevant to findings in humans and may be a useful tool in testing further neuroprotective strategies.…”
Get full text

Human Umbilical Cord Mesenchymal Stem Cells Attenuate Ocular Hypertension-Induced Retinal Neuroinflammation via Toll-Like Receptor 4 Pathway by Shangli Ji, Jie Xiao, Jian Liu, Shibo Tang

“…Our previous study has shown that the intravitreal transplantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) reveals a neuroprotective role in microsphere injection-induced ocular hypertension (OHT) rat models. …”
Get full text

S100A8-CAMKK2-AMPK axis confers the protective effects of mild hypothermia against cerebral ischemia-reperfusion injury in rats by Dandan Zhang, Yuting Dai, Xiaoyan Xu, Fuguo Ma, Mingshan Wang, Weiwei Qin

“…Abstract To investigate the neuroprotective mechanism of mild hypothermia (MH) in ameliorating cerebral ischemia reperfusion (IR) injury. …”
Get full text

Microalgae, a Potential Natural Functional Food Source – a Review by Villarruel-López Angélica, Ascencio Felipe, Nuño Karla

“…The importance of algal lipids is based on their polyunsaturated fatty acids, their anti-inflammatory effects, their modulation of lipid pathways, and their neuroprotective action. Microalgae peptides can bind or inhibit specific receptors in cardiovascular diseases and cancer, while carotenoids can act as potent antioxidants. …”
Get full text

Prebiotic Properties of Dates and Their Impact on Health by Ahmad Alhomsi, Mukaddes Kılıç Bayraktar

“…Beyond gut health, dates offer additional benefits, including anti-inflammatory, antioxidant, cardiovascular, neuroprotective, and blood sugar-regulating effects. This review synthesizes recent findings on the prebiotic effects and broader health impacts of dates, suggesting their potential in dietary strategies for promoting health and preventing gastrointestinal disorders.…”
Get full text

Melatonin and its physiological and therapeutic effects: A review by Stefanović Bojana V., Spasojević Nataša M., Ferizović Harisa N., Janković Milica D., Virijević Kristina M., Dronjak Slađana S.

“…It has been proven that melatonin exerts neuroprotective and antidepressant like effects. Also, many researchers have found that melatonin plays an important role in various cardiovascular diseases. …”
Get full text