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221
Exosome in Crosstalk between Inflammation and Angiogenesis: A Potential Therapeutic Strategy for Stroke
Published 2022-01-01“…Angiogenesis is essential for neuroprotection and neural repair following stroke. The neuroinflammatory reaction plays a vital role in stroke, and inhibition of inflammation contributes to establishing an appropriate external environment for angiogenesis. …”
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222
The link between optic neuritis and multiple sclerosis. Literature review
Published 2021-03-01“…Thereby, new substances are being researched recently to evaluate their significance in the processes of remyelination and neuroprotection. Some aspects of epidemiology, etiology, pathogenesis, clinical signs, possibilities of diagnosis and treatment of optic neuritis together with the evaluation of the risk of multiple sclerosis development are discussed in this article. …”
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223
The Endotoxin-Induced Neuroinflammation Model of Parkinson's Disease
Published 2011-01-01“…Furthermore, we summarize the recent experimental therapeutic strategies targeting endotoxin-induced neuroinflammation to elicit neuroprotection in the nigrostriatal dopaminergic system. …”
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224
Research Progress on the GIP/GLP-1 Receptor Coagonist Tirzepatide, a Rising Star in Type 2 Diabetes
Published 2023-01-01“…Ongoing trials (NCT04166773) and evidence suggest that it appears to be a promising drug in the areas of NAFLD, renal, and neuroprotection. Based on preclinical studies and clinical trials, the aim of this article is to discuss the latest clinical developments in tirzepatide, to focus on its differences with other incretin therapies, and to suggest future possibilities and mechanisms of tirzepatide therapy.…”
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225
Brain-Derived Neurotrophic Factor and Nerve Growth Factor Therapeutics for Brain Injury: The Current Translational Challenges in Preclinical and Clinical Research
Published 2022-01-01“…Neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) serve as potential therapeutic options to increase neural repair and recovery as they promote neuroprotection and regeneration. BDNF and NGF have demonstrated the ability to improve functional recovery in preclinical and to a lesser extent clinical studies. …”
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226
Neurocranial Pharmacodialysis Device for subarachnoid hemorrhage treatment—a perspective
Published 2024-02-01“…The RESULTS showed the following four facts: (1) high-grade SAH requiring decompressive craniectomy readily offers, as the last step of the neurosurgical procedure, the safe closure of the opened cranium with the NPD while leaving the efficacy of the decompressive intervention intact. (2) The neurocranially attached NPD can automatically execute, as long as it is necessary, subarachnoid polypharmacy to prevent post-SAH vasospasm, reduce the risk of rebleeding, and provide neuroprotection in delayed cerebral ischemia (DCI), bypassing the blood-brain barrier (BBB) via connected subarachnoid strips. (3) These effects of drug delivery can be optimized with NPD-controlled long-term cleaning of the CSF and drainage of cellular debris, hydrocephalus, and interstitial edema accompanied by the subarachnoid dialysis of potentially neurotoxic extracellular molecules. (4) Safety and efficacy of these NPD operations are monitored, and possible epileptiform EEG is detected, via the wireless EEG system of the device. …”
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227
Circuitry and Synaptic Dysfunction in Alzheimer’s Disease: A New Tau Hypothesis
Published 2020-01-01“…Confronting this leading hypothesis, a few years ago, we reported that the increase in phosphorylation levels of dendritic Tau, at its microtubule domain (MD), acts as a neuroprotective mechanism that prevents N-methyl-D-aspartate receptor (NMDAr) overexcitation, which allowed us to propose that Tau protein phosphorylated near MD sites is involved in neuroprotection, rather than in neurodegeneration. …”
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228
The biological and functional restoration of spinal cord injury
Published 2024-12-01“…Restoration of the anatomical structure and microenvironment of the damaged region can be obtained by molecular drug modulation, neuroprotection, neuroregeneration, stem cell therapy, and biomaterial‐based tissue engineering. …”
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229
Critical Aspects of Clinical Trial Design for Novel Cell and Gene Therapies
Published 2011-01-01“…Beyond the provision of symptomatic efficacy and safety data, it also remains to be identified whether the possibilities offered by stem cell and gene therapy technological advances might translate to meaningful neuroprotection and/or disease-modifying effects or alleviate the nonmotor aspects of PD and thus offer additional benefits beyond those achieved through conventional pharmacotherapy or deep brain stimulation (DBS).…”
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230
Widespread Striatal Delivery of GDNF from Encapsulated Cells Prevents the Anatomical and Functional Consequences of Excitotoxicity
Published 2019-01-01“…Stereological estimates of striatal neuron number and volume of lesion size revealed that GDNF delivery resulted in near complete neuroprotection. Conclusions. Delivery of neurotrophic molecules such as GDNF using encapsulated cells has reached a technological point where clinical evaluation is justified. …”
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231
Diabetic Retinopathy and BDNF: A Review on Its Molecular Basis and Clinical Applications
Published 2020-01-01“…Impairment of neuroprotection and vasculopathy are the main reasons for the progression of diabetic retinopathy. …”
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232
Do PPAR-Gamma Agonists Have a Future in Parkinson's Disease Therapy?
Published 2011-01-01“…In the last decade, PPAR-γ agonists have received increasing attention for their neuroprotective properties displayed in a variety of neurodegenerative diseases, including Parkinson's disease (PD), likely related to the anti-infammatory activity of these compounds. …”
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233
Biochemical Factors Modulating Cellular Neurotoxicity of Methylmercury
Published 2011-01-01“…This paper emphasizes that the protection against oxidative stress offered by these biochemical factors is among one of the major mechanisms responsible for conferring neuroprotection. It is therefore critical to ascertain the cellular mechanisms associated with various dietary nutrients as well as to determine the potential effects of neurotoxic exposures for accurately assessing the risks and benefits associated with fish consumption.…”
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234
Structural Characters and Pharmacological Activity of Protopanaxadiol-Type Saponins and Protopanaxatriol-Type Saponins from Ginseng
Published 2024-01-01“…This paper provides an overview of PDS and PTS, mainly focusing on their chemical profile, pharmacokinetics, hydrolytic metabolism, and pharmacological activities including antioxidant, antifatigue, antiaging, immunodulation, antitumor, cardiovascular protection, neuroprotection, and antidiabetes. It is intended to contribute to an in-depth study of the relationship between PDS and PTS.…”
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235
Targeting Mitochondrial Dysfunction in Cerebral Ischemia: Advances in Pharmacological Interventions
Published 2025-01-01“…This article highlights the critical role of mitochondrial dysfunction in the progression of neurodegenerative diseases and discusses the need for targeted therapeutic strategies to attenuate cellular damage, restore mitochondrial function, and enhance neuroprotection.…”
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236
Molecular Circuits of Resolution in the Eye
Published 2010-01-01“…Protective endogenous roles of LXA4 and NPD1 have been established utilizing lipidomic analysis, knockout mice, and pharmacological, genetic, and dietary manipulation, providing compelling evidence that these intrinsic lipid autacoid circuits play essential roles in restraining inflammation, promoting wound healing, inhibiting pathological angiogenesis, and providing neuroprotection in the delicate visual axis.…”
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237
The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease
Published 2011-01-01“…Here, the current knowledge about the role of mitochondrial dysfunction in PD, Nrf2/ARE stress-response mechanisms, and the evidence for specific links between this pathway and PD are summarized. The neuroprotection of nigral dopaminergic neurons by the activation of Nrf2 through several inducers in PD is also emphasized as a promising therapeutic approach.…”
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238
Thiamine and Thiamine Pyrophosphate as Non-Competitive Inhibitors of Acetylcholinesterase—Experimental and Theoretical Investigations
Published 2025-01-01“…It has been proven that supportive therapy with vitamin B<sub>1</sub> can not only provide neuroprotection but also has a positive effect on advanced neurodegenerative diseases, such as Parkinson’s disease, Alzheimer’s disease, Wernicke–Korsakoff syndrome, or Huntington’s disease. …”
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239
Application of Mild Therapeutic Hypothermia on Stroke: A Systematic Review and Meta-Analysis
Published 2012-01-01“…Therapeutic hypothermia is promising in clinical settings for stroke neuroprotection. Methods. MEDLINE/PubMed, CENTRAL, Stroke Center, and ClinicalTrials.gov were systematically searched for hypothermia intervention induced by external or endovascular cooling for acute stroke. …”
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240
Preparation of Ginsenoside Rg3 and Protection against H2O2-Induced Oxidative Stress in Human Neuroblastoma SK-N-SH Cells
Published 2014-01-01“…These findings are expected to provide some implication for further research and application of ginsenoside Rg3 in neuroprotection.…”
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