Neuromodulation of Attentional Control in Major Depression: A Pilot DeepTMS Study by Jodie Naim-Feil, John L. Bradshaw, Dianne M. Sheppard, Oded Rosenberg, Yechiel Levkovitz, Pinhas Dannon, Paul B. Fitzgerald, Moshe Isserles, Abraham Zangen

“…Deep transcranial magnetic stimulation (deepTMS), a noninvasive neuromodulatory technique, can modulate neural activity and induce neuroplasticity changes in brain regions recruited by attentional processes. …”
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Long-term memory plasticity in a decade-long connectivity study post anterior temporal lobe resection by Marine N. Fleury, Lawrence P. Binding, Peter Taylor, Fenglai Xiao, Davide Giampiccolo, Sarah Buck, Gavin P. Winston, Pamela J. Thompson, Sallie Baxendale, Andrew W. McEvoy, Matthias J. Koepp, John S. Duncan, Meneka K. Sidhu

“…We observe key adaptive changes in memory networks of a predominantly seizure-free cohort. Ongoing neuroplasticity in posterior medial temporal regions and contralesional cingulum or pallidum contribute to long-term verbal and visual memory recovery. …”
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High-intensive physical rehabilitation approach in children and adolescents with acquired brain injury during subacute phase (REHABILITY): a feasibility study protocol by Jan Willem Gorter, Christiaan Gmelig Meyling, Olaf Verschuren, Ingrid Rentinck, Irene van der Steen, Raoul Engelbert

“…Introduction While principles of neuroplasticity and motor learning emphasise the potential of high dosage of physical rehabilitation in children and adolescents with acquired brain injury (ABI) during the subacute phase, we lack empirical evidence to demonstrate its impact in terms of meaningful outcomes. …”
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Effects of long-term adapted physical training on functional capacity and quality of life in older adults with Parkinson's disease by Oussama Gaied Chortane, Elmoetez Magtouf, Wael Maktouf, Sabri Gaied Chortane

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Effects of Motor Training on Accuracy and Precision of Jaw and Finger Movements by Yinan Chen, Song Wu, Zhengting Tang, Jinglu Zhang, Lin Wang, Linfeng Yu, Kelun Wang, Peter Svensson

“…The accuracy and precision of standardized jaw and finger movements are dependent on visual feedback and appears to improve more by training in the trigeminal system possibly reflecting significant neuroplasticity in motor control mechanisms.…”
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MiR-18a-LncRNA NONRATG-022419 pairs targeted PRG-1 regulates diabetic induced cognitive impairment by regulating NGF\BDNF-Trkb signaling pathway by Qiong Xiang, Hu Lin, Jia-Sheng Tao, Chuan-Jun Fu, Li-Ni Liu, Jing Deng, Xian-Hui Li

“…Up to now, phospholipid phosphatase related 4 (Plppr4), also known as plasticity related gene 1 (PRG-1) has been revealed its important role in neuroplasticity. However, the underlying mechanisms of Plppr4 on the basis of diabetic-induced cognitive dysfunction (DCD) are still unknown. …”
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Pregnancy entails a U-shaped trajectory in human brain structure linked to hormones and maternal attachment by Camila Servin-Barthet, Magdalena Martínez-García, María Paternina-Die, Luis Marcos-Vidal, Daniel Martín de Blas, Anna Soler, Olha Khymenets, Daniel Bergé, Gemma Casals, Pilar Prats, Oscar J. Pozo, Clara Pretus, Susana Carmona, Oscar Vilarroya

“…Abstract Growing evidence places the gestational period as a unique moment of heightened neuroplasticity in adult life. In this longitudinal study spanning pre, during, and post pregnancy, we unveil a U-shaped trajectory in gray matter (GM) volume, which dips in late pregnancy and partially recovers during postpartum. …”
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Anger Emotional Stress Influences VEGF/VEGFR2 and Its Induced PI3K/AKT/mTOR Signaling Pathway by Peng Sun, Sheng Wei, Xia Wei, Jieqiong Wang, Yuanyuan Zhang, Mingqi Qiao, Jibiao Wu

“…We created a rat model of induced anger (anger-out and anger-in) emotional response using social isolation and resident-intruder paradigms and assessed changes in hippocampus’ VEGF content, neuroplasticity, and the PI3K/AKT/mTOR signaling pathway. …”
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Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling by Ginetta Collo, Laura Cavalleri, Federica Bono, Cristina Mora, Stefania Fedele, Roberto William Invernizzi, Massimo Gennarelli, Giovanna Piovani, Tilo Kunath, Mark J. Millan, Emilio Merlo Pich, PierFranco Spano

“…While the exact antidepressant mechanism of action remains uncertain, a role for D3R in the restoration of impaired neuroplasticity occurring in TRD has been proposed. Since D3R agonists are highly expressed on DA neurons in humans, we studied the effect of ropinirole and pramipexole on structural plasticity using a translational model of human-inducible pluripotent stem cells (hiPSCs). …”
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Next generation bioelectronic medicine: making the case for non-invasive closed-loop autonomic neuromodulation by Imanuel Lerman, Yifeng Bu, Rahul Singh, Harold A. Silverman, Anuj Bhardwaj, Alex J. Mann, Alik Widge, Joseph Palin, Christopher Puleo, Hubert Lim

“…Knowledge gaps remain and likely contribute to the lack of available closed loop autonomic neuromodulation systems, namely, (1) significant exogenous and endogenous noise that must be filtered out, (2) potential drift in the signal due to temporal change in disease severity and/or therapy induced neuroplasticity, and (3) confounding effects of exogenous therapies (e.g., concurrent medications that dysregulate autonomic nervous system functions). …”
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Sex reversal induced by 17β-estradiol may be achieved by regulating the neuroendocrine system of the Pacific white shrimp Penaeus vannamei by Tao Wang, Shihao Li, Yang Yu, Fuhua Li

“…In contrast, the negatively regulated pathways of neuroactive ligand-receptor interaction and the dopaminergic synapse in the NF group suggest a potential impact of E2 on neuroplasticity through the modulation of neuroregulator binding and signaling, which affects the establishment of morphological differences and gender identity. …”
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The Effect of Physical Activity on Alzheimer’s Disease - Systematic Review by Julia Lachowska, Karolina Senior, Jerzy Smandek, Maja Mielczarek, Paulina Sroczyńska, Jan Sroczyński

“…Evidence suggests that regular physical activity enhances cognitive function, reduces neuroinflammation, improves brain structure, and supports neuroplasticity. Both RET and aerobic exercise have been shown to delay the onset of cognitive decline, with RET also reducing amyloid plaque formation and promoting neuroprotection. …”
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Early life microbial succession in the gut follows common patterns in humans across the globe by Guilherme Fahur Bottino, Kevin S. Bonham, Fadheela Patel, Shelley McCann, Michal Zieff, Nathalia Naspolini, Daniel Ho, Theo Portlock, Raphaela Joos, Firas S. Midani, Paulo Schüroff, Anubhav Das, Inoli Shennon, Brooke C. Wilson, Justin M. O’Sullivan, Robert A. Britton, Deirdre M. Murray, Mairead E. Kiely, Carla R. Taddei, Patrícia C. B. Beltrão-Braga, Alline C. Campos, Guilherme V. Polanczyk, Curtis Huttenhower, Kirsten A. Donald, Vanja Klepac-Ceraj

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Hot and cold exposure triggers distinct transcriptional and behavioral responses in laboratory-inbred pond snails by Veronica Rivi, Anuradha Batabyal, Cristina Benatti, Fabio Tascedda, Johanna Maria Catharina Blom, Ken Lukowiak

“…While both cold and heat shock upregulated the HSP levels in the snail's central ring ganglia, cold exposure did not affect the expression levels of the neuroplasticity genes LymGRIN1 and LymCREB1, contrasting with heat shock's neurogenic effects. …”
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Effect of Transcranial Direct-Current Stimulation and Task-Oriented Training on Electroencephalography-Based Motor Recovery Chronic Stroke: A Randomized Clinical Trial by Maryam Zolghadr, Shohreh Noorizadeh Dehkordi, Javad Sarrafzadeh, Saeed Talebian, Hassan Haddadzade Niri, Marzieh Yassin

“…Adopting top-down and bottom-up interventions may enhance neuroplasticity and improve upper limb function. This study aims to determine the effect of motor cortical transcranial direct-current stimulation (tDCS) as a top-down approach combined with task-oriented training (TOT) as a bottom-up intervention on changes in electroencephalography (EEG) spectral power in chronic stroke patients. …”
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The Role of Mature Brain-Derived Neurotrophic Factor and Its Precursor in Predicting Early-Onset Insomnia in Stroke Patients Experiencing Early Neurological Deterioration by Shi G, Yu P, Wang Z, Xu M, Guo M, Wang X, Zhou R

“…Brain-derived neurotrophic factor (mBDNF) and its precursor, proBDNF, play essential roles in neuroplasticity and may be involved in the pathophysiological mechanisms underlying EOI. …”
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Diabetic Ephrin-B2-Stimulated Peripheral Blood Mononuclear Cells Enhance Poststroke Recovery in Mice by Rose Hilal, Marine Poittevin, Adrien Pasteur-Rousseau, Adrien Cogo, Gabrielle Mangin, Marie Chevauché, Yasmine Ziat, José Vilar, Jean-Marie Launay, Jean-François Gautier, Dong Broquères-You, Bernard I. Levy, Tatyana Merkulova-Rainon, Nathalie Kubis

“…At D14, microvessel density was decreased and functional recovery was enhanced compared to PBS-treated mice, whereas plasma levels of BDNF, a major regulator of neuroplasticity, were increased in mice treated with PB-MNC+ compared to the other two groups. …”
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Future risk of falls induced by ankle-foot sprains history: An observational and mendelian randomization study by Xiao'ao Xue, Weichu Tao, Qianru Li, Yi Li, Yiran Wang, Le Yu, Xicheng Gu, Tian Xia, Rong Lu, Ru Wang, He Wang, Yinghui Hua

“…Finally, genetically predicated cerebellar neuroimaging features were used to explore the mediating role of maladaptive neuroplasticity between ankle-foot sprains and falls by two-step MR analyses. …”
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Exploring the Therapeutic Role of Physical Activity in Psychotic Disorders: Cognitive, Somatic, and Mental Health Impacts by Klaudia Fikas, Kamil Chwaliszewski, Dorota Waz, Michał Mazur, Jakub Szarłowicz, Zofia Goliszek, Karolina Łucja Sobek, Wiktoria Tabin-Barczak, Aldona Sokołowska, Sebastian Samuła

“…Studies should investigate the neurobiological mechanisms behind the beneficial effects of physical activity in psychosis, such as stress responses and neuroplasticity. Integrating physical activity into standard treatment regimens could significantly improve patient outcomes in this population. …”
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Protocol of an open-label safety and feasibility pilot study of ketamine-assisted psychotherapy for methamphetamine use disorder (the KAPPA trial) by Jonathan Brett, Celia Morgan, Nadine Ezard, Brendan Clifford, Krista J Siefried, Robert May, Liam Acheson, Kathryn Fletcher, Harriet MacDonald, Gillinder Bedi, Alexandre Guerin, Elizabeth Knock, Michael Millard, Jess Doumany

“…In addition to direct antidepressant properties, ketamine is hypothesised to increase synaptogenesis and facilitate neuroplasticity, in turn prolonging and enhancing the effects of psychotherapy. …”
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