Pediatric Tuina for the treatment of functional dyspepsia: A systematic review and meta-analysis of randomized controlled trials by Na-Yeon Ha, Chang-Yul Keum, Jinsung Kim

“…There were no significant differences between the combined Tuina and CT groups regarding the four individual dyspeptic symptoms or neuropeptide Y levels. No adverse events were reported in the Tuina group. …”
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Somatostatin in inflammatory bowel disease by J. D. Van Bergeijk, J. H. P. Wilson

“…Intestinal inflammation is controlled by various immunomodulating cells, interacting by molecular mediators. Neuropeptides, released by enteric nerve cells and neuroendocrine mucosa cells, are able to affect several aspects of the general and intestinal immune system, with both pro- as well as anti-inflammatory activities. …”
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Blockade of Glutamate Release by Botulinum Neurotoxin Type A in Humans: A Dermal Microdialysis Study by Larissa Bittencourt da Silva, Ali Karshenas, Flemming W Bach, Sten Rasmussen, Lars Arendt-Nielsen, Parisa Gazerani

“…BACKGROUND: The analgesic action of botulinum neurotoxin type A (BoNTA) has been linked to the blockade of peripheral release of neuropeptides and neurotransmitters in animal models; however, there is no direct evidence of this in humans.…”
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Erratum to “The Role of Neurokinin-1 Receptor in the Microenvironment of Inflammation and Cancer” by Marisa Rosso

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Involvement of Mechanistic Target of Rapamycin (mTOR) in Valine Orexigenic Effects in Rainbow Trout by Sara Comesaña, Mauro Chivite, Ayelén M. Blanco, María Alborja-Valado, Jessica Calo, Marta Conde-Sieira, José L. Soengas

“…However, it is not clear which precise mechanisms link the activation of mTOR and the alteration in feed intake levels since we did not observe changes in mRNA levels of appetite-regulatory neuropeptides as well as in the phosphorylation status and levels of integrative proteins.…”
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The Role of Neurokinin-1 Receptor in the Microenvironment of Inflammation and Cancer by Marisa Rosso, Miguel Muñoz, Michael Berger

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Neuroimmunology of psoriasis: Possible roles for calcitonin gene-related peptide in its pathogenesis by Joshua Kotlyar, Richard D. Granstein

“…This allows it to play a role in a variety of cutaneous inflammatory disorders such as psoriasis, exerting effects on various immune cells via effector molecules such as neuropeptides. In this review, we discuss the role of calcitonin gene-related peptide in modulating the immune system and inflammation, with a focus on psoriasis.…”
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Novel Targets for Anti-Inflammatory Therapy in Inflammatory Bowel Disease by John L Wallace

“…This review focuses on the potential for developing therapy aimed at three targets: nerves and neuropeptides; coagulation and thrombosis; and adhesion molecules. …”
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First evidence of immunomodulation of the renin-angiotensin system through substance P/neurokinin 1 receptor: a case and control study in hypertension and cardiac patients by Ibrahim M. Alanazi, Riffat Mehboob, Ayesha Tariq, Sajid Hameed, Uzma Malik, Noreen Sarwar, Imran Shahid, Khurram Mehboob

“… Gaining knowledge about the differences in substance P (SP) and neurokinin 1 receptor (NK1R) levels between cardiac and hypertensive patients may help clarify how these neuropeptides could be involved in the pathophysiology of cardiovascular disorders. …”
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Hormonal Changes in Menopause and Orexin-A Action by Giovanni Messina, Andrea Viggiano, Vincenzo De Luca, Antonietta Messina, Sergio Chieffi, Marcellino Monda

“…Orexins are hypothalamic neuropeptides recently discovered, involved in the regulation of feeding behaviour, sleep-wakefulness rhythm, and neuroendocrine homeostasis. …”
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Pharmacological Treatment of Obesity in Children and Adolescents: Present and Future by Lorenzo Iughetti, Mariachiara China, Rossella Berri, Barbara Predieri

“…Considering that our knowledge on the physiological systems regulating food intake and body weight is considerably increased, many studies have underlined the scientific and clinical relevance of potential treatments based on management of peripheral or central neuropeptides signals by drugs. In this paper, we analyze the data on the currently approved obesity pharmacological treatment suggesting the new potential drugs.…”
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Depression as a Neuroendocrine Disorder: Emerging Neuropsychopharmacological Approaches beyond Monoamines by Mervin Chávez-Castillo, Victoria Núñez, Manuel Nava, Ángel Ortega, Milagros Rojas, Valmore Bermúdez, Joselyn Rojas-Quintero

“…Innovative pharmacological targets beyond monoamines include glutamatergic and GABAergic neurotransmission, brain-derived neurotrophic factor, various endocrine axes, as well as several neurosteroids, neuropeptides, opioids, endocannabinoids and endovanilloids. …”
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New Therapeutic Targets for Mood Disorders by Rodrigo Machado-Vieira, Giacomo Salvadore, Nancy DiazGranados, Lobna Ibrahim, David Latov, Cristina Wheeler-Castillo, Jacqueline Baumann, Ioline D. Henter, Carlos A. Zarate

“…These include: (1) glycogen synthase kinase-3 (GSK-3) and protein kinase C (PKC), (2) the purinergic system, (3) histone deacetylases (HDACs), (4) the melatonergic system, (5) the tachykinin neuropeptides system, (6) the glutamatergic system, and (7) oxidative stress and bioenergetics. …”
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Calcium/Calmodulin-Dependent Kinases in the Hypothalamus, Pituitary, and Pineal Gland: An Overview by Vincenzo Cimini, Susan Van Noorden, Cristina Terlizzi, Giovanna Giuseppina Altobelli

“…In rats and humans, CaMKIVs have been associated with gonadotropes and thyrotropes and CaMKII with several types of human tumor cells and with a specific signaling pathway. Neuropeptides such as vasopressin and endothelin are also involved in the CaMKII signaling chain, as is the CaMKIIδ isoform which participates in generating the circadian rhythms of the suprachiasmatic nucleus. …”
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The role of social isolation stress in escalated aggression in rodent models by Aki Takahashi

“…Social isolation during adulthood affects the levels of neurosteroids and neuropeptides and increases aggressive behavior. These changes are ethologically relevant for the adaptation to changes in local environmental conditions in the natural habitats. …”
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Neurobiological Mechanism of Acupuncture for Relieving Visceral Pain of Gastrointestinal Origin by Fang Zhang, Luyi Wu, Jimeng Zhao, Tingting Lv, Zhihai Hu, Zhijun Weng, Shuoshuo Wang, Huangan Wu, Huirong Liu

“…Numerous peripheral neurotransmitters, neuropeptides, and cytokines participate in the analgesic process of EA in visceral pain. …”
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Skin Matters: Identifying Pain Mechanisms and Predicting Treatment Outcomes by Edward A. Shipton

“…Epidermal cells (such as keratinocytes, Langerhans cells, and Merkel cells) express sensor proteins and neuropeptides; these regulate the neuroimmunocutaneous system and participate in nociception and neurogenic inflammation. …”
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Sleeve gastrectomy reveals the plasticity of the human gastric epithelium by Amit Elad, Botros Moalem, Dana Sender, Aya Bardugo, Ki-Suk Kim, Yhara Arad, Haya Benhayon, Ayelet Gal Etzyoni, Nehemia Greenstein, Aviv Halfon, Sarah Knapp, Michelle Malis, Bailey Peck, Itia Samuel, Amram Kupietzky, Saleh Daher, Esther Forkosh, David Hakimian, Tiberiu Hershcovici, Nadav Ilani, Lior Katz, Moshe Rottenstreich, Elez Vainer, Yuval Ishay, Eitan Zlotnick, Abed Nasereddin, Idid Shiff, Ariel Benson, Ronit Grinbaum, Siddhartha Mishra, Shlomi Kotler, Linda C. Samuelson, Darleen A. Sandoval, Rachel Ben-Haroush Schyr, Danny Ben-Zvi

“…ECLs of SG-operated patients overexpressed genes coding for biosynthesis of neuropeptides and serotonin. Mathematical modeling showed that pH homeostasis by gastrin is analogous to non-linear proportional and integral control, that drives adaptation of the epithelium to acid-secretion demand. …”
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Mice with Catalytically Inactive Cathepsin A Display Neurobehavioral Alterations by O. Y. Calhan, V. Seyrantepe

“…Previous in vitro studies have shown that CathA has specific activity against vasoactive peptides and neuropeptides, including endothelin-1 and oxytocin. A mutant mouse with catalytically inactive CathA enzyme (CathAS190A) shows increased levels of endothelin-1. …”
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Spinal NGF Restores Opioid Sensitivity in Neuropathic Rats: Possible Role of NGF as a Regulator of CCK-Induced Anti-Opioid Effects by Catherine M Cahill, Terence J Coderre

“…The implications for central NGF in the expression and regulation of spinal neuropeptides that are involved in pain mechanisms are reviewed. …”
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