Adenosine deficiency facilitates CA1 synaptic hyperexcitability in the presymptomatic phase of a knockin mouse model of Alzheimer disease by Mattia Bonzanni, Alice Braga, Takashi Saito, Takaomi C. Saido, Giuseppina Tesco, Philip G. Haydon

“…Both pharmacologic (adenosine kinase inhibitor) and non-pharmacologic (ketogenic diet) restorations of the adenosine tone successfully normalize hippocampal neuronal activity. Our results demonstrated that neuronal hyperexcitability during the asymptomatic stage of a KI model of Alzheimer disease originated at the synaptic compartment and is associated with adenosine deficient tone. …”
Get full text

Microglial C/EBPβ-Fcgr1 regulatory axis blocking inhibits microglial pyroptosis and improves neurological recovery by Jing Li, Yubing Yang, Chenguang Zhao, Jinghao Zhao, Xiaohui Wang, Shengshou Ye, Dong Wang, Chengdong Zhou, Jie Li, Shuang Wang, Ke Li, Chunmiao Liu, Xijing He, Jie Qin

“…In both in-vivo and in-vitro experiments, knocking down Cebpb or Fcgr1, or the pyroptosis inhibitor VX765 inhibited neuronal apoptosis and improved neurological recovery in mice. …”
Get full text

Brain injury biomarkers and applications in neurological diseases by Han Zhang, Jing Wang, Yang Qu, Yi Yang, Zhen-Ni Guo, Yanjie Yin

“…In this review, we described biomarkers for neuronal cell body injury (neuron-specific enolase, ubiquitin C-terminal hydrolase-L1, αII-spectrin), axonal injury (neurofilament proteins, tau), astrocyte injury (S100β, glial fibrillary acidic protein), demyelination (myelin basic protein), autoantibodies, and other emerging biomarkers (extracellular vesicles, microRNAs). …”
Get full text

Exploring Azithromycin’s Neuroprotective Role in Traumatic Brain Injury: Insights into Cognitive and Motor Recovery and Neuroinflammatory Modulation by Mohannad A. Almikhlafi, Nehad A. Abdallah, Aakash Kumar, Tarun Sharma, Zuber Khan, Haifa A. Fadil, Sultan Althagfan, Ahmed K. B. Aljohani, Sara A. Almadani, Samar F. Miski, Tahani Saeedi, Rayan S. Alharbi, Abdulrahman M. Al-Harthe, Mohammed H. Alsubhi, Hanaa Wanas, Ahmed Aldhafiri, Sidharth Mehan, Hossein M. Elbadawy

“…Histological evaluations focused on neuronal integrity in the cortex, hippocampus, and striatum. …”
Get full text

Modulation by NPY/NPF-like receptor underlies experience-dependent, sexually dimorphic learning by Sonu Peedikayil-Kurien, Rizwanul Haque, Asaf Gat, Meital Oren-Suissa

“…Here, we reveal sexual dimorphism in learning: C. elegans males do not learn to avoid the pathogenic bacteria PA14 as efficiently and rapidly as hermaphrodites. Notably, neuronal activity following pathogen exposure was dimorphic: hermaphrodites generate robust representations, while males, in line with their behavior, exhibit contrasting representations. …”
Get full text

Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog. by Eric Dessaud, Vanessa Ribes, Nikolaos Balaskas, Lin Lin Yang, Alessandra Pierani, Anna Kicheva, Bennett G Novitch, James Briscoe, Noriaki Sasai

“…Here we address how Shh signalling assigns the positional identities of distinct neuronal subtype progenitors throughout the ventral neural tube. …”
Get full text

Connectome-based prediction of functional impairment in experimental stroke models. by Oliver Schmitt, Peter Eipert, Yonggang Wang, Atsushi Kanoke, Gratianne Rabiller, Jialing Liu

“…Experimental rat models of stroke and hemorrhage are important tools to investigate cerebrovascular disease pathophysiology mechanisms, yet how significant patterns of functional impairment induced in various models of stroke are related to changes in connectivity at the level of neuronal populations and mesoscopic parcellations of rat brains remain unresolved. …”
Get full text

Spinal Cord Injury and Bladder Dysfunction: New Ideas about an Old Problem by Célia Duarte Cruz, Francisco Cruz

“…Spinal cord injury (SCI) interrupts these neuronal circuits and jeopardizes the voluntary control of bladder function. …”
Get full text

Differential microvascular endothelial cell responses in the retina in diabetes compared to the heart and kidneys, a spatial transcriptomic analysis. by Eric Wang, Biao Feng, Shali Chen, Zhaoliang Su, Subrata Chakrabarti

“…We found minimal similarities between retinal MECs and neuronal cells. Our findings show considerable heterogeneity across retinal, renal, and cardiac MECs, both at the basal state and in their responses to hyperglycemia in diabetes. …”
Get full text

State-of-the-Art Techniques to Causally Link Neural Plasticity to Functional Recovery in Experimental Stroke Research by Anna-Sophia Wahl

“…Here, we review current state-of the art techniques for the examination of cortical reorganization and for the manipulation of neuronal circuits as well as techniques which combine anatomical changes with molecular profiling. …”
Get full text

Multifocal motor neuropathy. A clinical case and literature review by O. Laucius, V. Danielius, T. Vanagas, P. Valiukevičius

“… Multifocal motor neuropathy is a rare motor neuron disease characterised by a progressive, gradual loss of muscle strength, although sensory functions are preserved. …”
Get full text

Linking Mitochondria to Synapses: New Insights for Stress-Related Neuropsychiatric Disorders by Freddy Jeanneteau, Margarita Arango-Lievano

“…Signaling loops between the mitochondria and synapses scale neuronal connectivity with bioenergetics capacity. …”
Get full text

fMRI Evidence of Magnitude Manipulation during Numerical Order Processing in Congenitally Deaf Signers by Josefine Andin, Peter Fransson, Jerker Rönnberg, Mary Rudner

“…We found the neuronal networks recruited in the two tasks to be generally similar across groups, with significant activation in the dorsal visual stream for the letter order task, suggesting letter identification and position encoding. …”
Get full text

Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats by Mira Chamoun, Elena G. Sergeeva, Petra Henrich-Noack, Shaobo Jia, Lisa Grigartzik, Jing Ma, Qing You, Frédéric Huppé-Gourgues, Bernhard A. Sabel, Elvire Vaucher

“…Since acetylcholine plays an important role in attention and neuronal plasticity, we explored whether potentiation of the cholinergic transmission has an effect on the visual function restoration. …”
Get full text

Spindle Activity Orchestrates Plasticity during Development and Sleep by Christoph Lindemann, Joachim Ahlbeck, Sebastian H. Bitzenhofer, Ileana L. Hanganu-Opatz

“…While NSBs have been proposed to coordinate the refinement of the maturating neuronal network, ASSs are associated with the implementation of acquired information within existing networks. …”
Get full text

Could Proteomic Research Deliver the Next Generation of Treatments for Pneumococcal Meningitis? by U. R. Goonetilleke, S. A. Ward, S. B. Gordon

“…Using proteomic techniques, neuronal death pathways could be described in CSF samples. …”
Get full text

Mining the Virgin Land of Neurotoxicology: A Novel Paradigm of Neurotoxic Peptides Action on Glycosylated Voltage-Gated Sodium Channels by Zhirui Liu, Jie Tao, Pin Ye, Yonghua Ji

“…Voltage-gated sodium channels (VGSCs) are important membrane protein carrying on the molecular basis for action potentials (AP) in neuronal firings. Even though the structure-function studies were the most pursued spots, the posttranslation modification processes, such as glycosylation, phosphorylation, and alternative splicing associating with channel functions captured less eyesights. …”
Get full text

Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer’s disease model by Jiqing Xu, Fred de Winter, Catherine Farrokhi, Edward Rockenstein, Michael Mante, Anthony Adame, Jonathan Cook, Xin Jin, Eliezer Masliah, Kuo-Fen Lee

“…Decreased expression of the neuronal marker MAP2 and synaptic markers PSD95 and synaptophysin in AD mice was significantly reversed. …”
Get full text

The multifaceted role of the inferior colliculus in sensory prediction, reward processing, and decision-making by Xinyu Du, Haoxuan Xu, Peirun Song, Yuying Zhai, Hangting Ye, Xuehui Bao, Qianyue Huang, Hisashi Tanigawa, Zhiyi Tu, Pei Chen, Xuan Zhao, Josef P Rauschecker, Xiongjie Yu

“…Further analysis revealed a direct correlation between IC neuronal activity and behavioral choices, suggesting its involvement in decision-making processes. …”
Get full text

Crisdesalazine alleviates inflammation in an experimental autoimmune encephalomyelitis multiple sclerosis mouse model by regulating the immune system by Su-Min Park, Yong-Hun Oh, Ga-Hyun Lim, Ju-Hyun An, Jin-Hwan Lee, Byoung-Joo Gwag, So-Jung Won, Kyoung-Won Seo, Hwa-Young Youn

“…We evaluated the efficacy of crisdesalazine (a novel microsomal prostaglandin E2 synthase-1 inhibitor) in an EAE model, including its immune-regulating potency in lipopolysaccharide-stimulated macrophages, and its neuroprotective effects in a macrophage-neuronal co-culture system. Crisdesalazine significantly alleviated clinical symptoms, inhibited inflammatory cell infiltration and demyelination in the spinal cord, and altered the phase of microglial/macrophage and regulatory T cells. …”
Get full text