A Reinforcement-Learning Based Approach for Designing High-Voltage SiC MOSFET Guard Rings by Tejender Singh Rawat, Chia-Lung Hung, Yi-Kai Hsiao, Wei-Chen Yu, Surya Elangovan, Wei-Ting Lin, Yi-Rong Lin, Kai-Lin Yang, Nien-Yi Jan, Yung-Hui Li, Hao-Chung Kuo

“…The network architecture was kept at “auto” with 3 hidden layers of 128 neurons in each layer. Our method is practically feasible and easily implemented as compared to other works, and has been shown in this paper. …”
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An intein-split transactivator for intersectional neural imaging and optogenetic manipulation by Hao-Shan Chen, Xiao-Long Zhang, Rong-Rong Yang, Guang-Ling Wang, Xin-Yue Zhu, Yuan-Fang Xu, Dan-Yang Wang, Na Zhang, Shou Qiu, Li-Jie Zhan, Zhi-Ming Shen, Xiao-Hong Xu, Gang Long, Chun Xu

“…The IBIST-based Ca2+ imaging showed that the IBIST can intersect five features and that hippocampal neurons tune differently to distinct emotional stimuli depending on the pattern of projection targets. …”
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Role of Astrocytic Dysfunction in the Pathogenesis of Parkinson’s Disease Animal Models from a Molecular Signaling Perspective by Lucas Udovin, Cecilia Quarracino, María I. Herrera, Francisco Capani, Matilde Otero-Losada, Santiago Perez-Lloret

“…In PD animal models, Frizzled (Fzd) neuronal receptors’ activation by the Wnt-1 normally released by astrocytes following injuries leads to β-catenin-dependent gene expression, favoring neuron survival and viability. …”
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Guillain-Barré syndrome following falciparum malaria infection: a case report by Molla Asnake Kebede, Alemayehu Beharu Tekle, Misikir Alemu Eshetu, Erkyehun Pawlos Shash, Melaku Tsediew Berhanu, Elias Tabiet Ahmed, Hashime Meketa Negatie

“…This patient’s neurological symptoms pointed to paralysis of the lower motor neurons. Guillain-Barré Syndrome is also suggested by elevated protein levels and a lack of cells in the cerebrospinal fluid. …”
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Growth Arrest Specific Gene 6 Protein Concentration in Cerebrospinal Fluid Correlates with Relapse Severity in Multiple Sclerosis by P. P. Sainaghi, L. Collimedaglia, F. Alciato, R. Molinari, D. Sola, E. Ranza, P. Naldi, F. Monaco, M. Leone, M. Pirisi, G. C. Avanzi

“…Growth arrest specific gene 6 (Gas6) protein enhances survival of oligodendrocytes and neurons, and it is involved in autoimmunity. Therefore, we aimed to verify whether cerebrospinal-fluid (CSF) Gas6 concentration may represent a biomarker of disease activity in multiple sclerosis. …”
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Aging Alters Olfactory Bulb Network Oscillations and Connectivity: Relevance for Aging-Related Neurodegeneration Studies by A. Ahnaou, D. Rodriguez-Manrique, S. Embrechts, R. Biermans, N. V. Manyakov, S. A. Youssef, W. H. I. M. Drinkenburg

“…The OB of aged mice showed a significant increase in the number of histone H2AX-positive neurons, a marker of DNA damage. While the input-output relationship measure of basal synaptic activity was found not to differ between young and aged mice, a pronounced decline in the slope of field excitatory postsynaptic potential (fEPSP) and the population spike amplitude (PSA) were found in aged mice. …”
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Membrane-targeted push-pull azobenzenes for the optical modulation of membrane potential by Valentina Sesti, Arianna Magni, Matteo Moschetta, Chiara Florindi, Marlene E. Pfeffer, Mattia Lorenzo DiFrancesco, Michele Guizzardi, Giulia Folpini, Luca Sala, Alessandra Gilda Ritacca, Beatrice Campanelli, Paola Moretti, Giuseppe Maria Paternò, Luca Maragliano, Matteo Tommasini, Francesco Lodola, Elisabetta Colombo, Fabio Benfenati, Chiara Bertarelli, Guglielmo Lanzani

“…MTP2 was tested in different cell types, including HEK293T cells, primary neurons, and cardiomyocytes, and a steady depolarization is always recorded. …”
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Komparasi Metode Klasifikasi untuk Deteksi Ekspresi Wajah Dengan Fitur Facial Landmark by Fitra A. Bachtiar, Muhammad Wafi

“…The hyperparameter for ELM is 40 hidden neurons, SVM with  = 105 and 200 iteration, while k-NN used 3 k neighbors. …”
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An approach for accurate identification and monitoring of species in mangrove forests based on multi-source spectral data and deep learning by Monterrubio-Martínez Erandi, Trujillo-Acatitla Rubicel, Tuxpan-Vargas José, Moreno-Casasola Patricia

“…The computational experiments for MLP models involve different number of neurons and hidden layers. The best models for detecting mangrove forest achieved an accuracy of 99.95 % for training and 99.8 % for test, while for monospecific mangrove forest, at the species level, it attained an accuracy of 98.73 % for training and 96.84 % for test, in both cases the models demonstrated a great performance test for segmentation of different kind of mangrove forests. …”
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Secondary motor cortex tracks decision value during the learning of a non-instructed task by Elisabete Augusto, Vladimir Kouskoff, Nicolas Chenouard, Margaux Giraudet, Léa Peltier, Aron de Miranda, Alexy Louis, Lucille Alonso, Frédéric Gambino

“…We use in vivo microscopy and modeling to show that M2 neurons in male mice exhibit persistent activity-encoding decision values that predict action-selection probabilities. …”
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Development of the inner ear and regeneration of hair cells after hearing impairment by Xin Bing, Chengcheng Liu, Xue Cao, Chengzhilin Li, Xiaochen Gao, Fangyuan Zhu, Xinhao Wu, Na Guo, Houyang Hu, Ming Xia, Miaoqing Zhao

“…It is mainly caused by the damage of inner ear hair cells (HCs) or the degeneration of spiral ganglion neurons. In mammals, cochlear HCs cannot regenerate naturally after injury, leading to irreversible hearing loss. …”
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Aspirin inhibits proteasomal degradation and promotes α-synuclein aggregate clearance through K63 ubiquitination by Jing Gao, Yang Liu, Chenfang Si, Rui Guo, Shouqiao Hou, Xiaosong Liu, Houfang Long, Di Liu, Daichao Xu, Zai-Rong Zhang, Cong Liu, Bing Shan, Christoph W. Turck, Kaiwen He, Yaoyang Zhang

“…Accordingly, using the major pathological protein of Parkinson’s disease (PD), α-synuclein (α-syn), as an example of protein aggregates, we find that aspirin is able to reduce α-syn in cultured cells, neurons, and PD model mice with rescued locomotor ability. …”
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Drosophila ubiquitin-specific peptidase 14 stabilizes the PERIOD protein by regulating a ubiquitin ligase SLIMB by So Who Kang, Jung-Eun Park, Soonhyuck Ok, Minhui Um, Hyeonjeong Son, Seunghee Byun, Nayoung Park, Su Jin Lee, Thị Xuân Thùy Trần, Gyeongmin Kim, Jeonghun Yeom, Kyunggon Kim, Eun Young Kim, Min-Ji Kang

“…Interestingly, despite these alterations in PER levels, neither USP14 overexpression nor knockdown significantly impacts circadian behavioral rhythms, likely because of slight effects on PER levels in small ventral lateral neurons (sLNvs). Further analysis shows that USP14 physically interacts with Supernumerary Limbs (SLIMB), a protein involved in PER degradation. …”
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The Role of Neuroglial Crosstalk and Synaptic Plasticity-Mediated Central Sensitization in Acupuncture Analgesia by Zhongxi Lyu, Yongming Guo, Yinan Gong, Wen Fan, Baomin Dou, Ningcen Li, Shenjun Wang, Yuan Xu, Yangyang Liu, Bo Chen, Yi Guo, Zhifang Xu, Xiaowei Lin

“…., the p38, extracellular signal-regulated kinases, and c-Jun-N-terminal kinase pathways), which contribute to the activation of nociceptive neurons. However, the responses of chemokines to acupuncture vary among the types of pain models, acupuncture methods, and stimulation parameters. …”
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Hyaluronic Acid-Based Hybrid Nanoparticles as Promising Carriers for the Intranasal Administration of Dimethyl Fumarate by Serri C, Piccioni M, Guarino V, Santonicola P, Cruz-Maya I, Crispi S, Di Cagno MP, Ferraro L, Dalpiaz A, Botti G, Giunchedi P, Rassu G, Gavini E

“…In particular, LPNs appear able to enter neurons and monolayers of epithelial cells, allowing to promote the nose-to-brain DMF delivery. …”
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Altered functional brain connectivity in Dyt1 knock-in mouse models by R. Z. Adury, B. J. Wilkes, P. Girdhar, Y. Li, D. E. Vaillancourt, D. E. Vaillancourt, D. E. Vaillancourt

“…In this study, we aimed to elucidate the impact of the GAG TorsinA mutation present globally and when restricted to the cortical and hippocampal neurons. To accomplish this, we generated two distinct Dyt1 mouse models, one with Dyt1 dGAG knock-in throughout the body (dGAG) and another with a cerebral cortex-specific Dyt1 dGAG knock-in using Emx1 promoter (EMX). …”
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Platelet-derived HMGB1 induces NETosis, exacerbating brain damage in the photothrombotic stroke model by Sang-A. Oh, Song-I. Seol, Dashdulam Davaanyam, Seung-Woo Kim, Ja-Kyeong Lee

“…Immunofluorescence staining revealed initial localization of HMGB1 in neurons, followed by its accumulation within activated neutrophils and platelets within blood vessels. …”
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Insufficient gene expression and lost gene regulatory network may underlie the mechanism of Hirschsprung Disease in 5p–syndrome by Yizhao Luan, Peng Li, Yuanyuan Luo, Hong Zhang, Xiaochun Zhu, Yan Zhang, Aihua Yin, Qiang Wu, Chengwei Chai

“…On the other hand, integrating gene regulatory relationship estimated from single cell chromatin accessibility omics of enteric neurons, we found that the 5p deletion regions contained key cis-regulatory regions for HSCR-related gene GDNF. …”
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MetaboLINK is a novel algorithm for unveiling cell-specific metabolic pathways in longitudinal datasets by Jared Lichtarge, Gerarda Cappuccio, Gerarda Cappuccio, Soumya Pati, Soumya Pati, Alfred Kwabena Dei-Ampeh, Alfred Kwabena Dei-Ampeh, Senghong Sing, Senghong Sing, Senghong Sing, LiHua Ma, Zhandong Liu, Zhandong Liu, Mirjana Maletic-Savatic, Mirjana Maletic-Savatic, Mirjana Maletic-Savatic

“…., MetaboLINK) to metabolomics data derived from Nuclear Magnetic Resonance (NMR) spectroscopy performed on neural cells at various developmental stages, from human embryonic stem cells to neurons.ResultsThe MetaboLINK analysis of longitudinal metabolomics data has revealed distinct pathways related to amino acids, lipids, and energy metabolism, uniquely associated with specific cell progenies. …”
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Total flavonoids of Astragalus membranaceus protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice by inhibiting ferroptosis through SLC7A11/GPX... by Zitian Gao, Gaorui Wang, Yujie Chen, Wuke Yuan, Jun Cai, Aiping Feng, Jie Fang, Qi Xu, Xiaojun Wu

“…TFA offered neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse model of Parkinsonism, by improving behavior performance in the gait analysis and pole test, and inhibiting the decline of tyrosine hydroxylase (TH) positive neurons and TH protein expression in substantia nigra of mice. …”
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