Phenolic Compounds and Pharmacological Potential of <em>Lavandula angustifolia</em> Extracts for the Treatment of Neurodegenerative Diseases by Olha Mykhailenko, Viktoriia Hurina, Nataliia Herbina, Yuliia Maslii, Liudas Ivanauskas, Inna Vladymyrova, Dmytro Lytkin, Zigmantas Gudžinskas, Hanna Severina, Olena Ruban, Victoriya Georgiyants

“…Lavender’s potential to protect neurons is based on its calming, anti-stress properties, which increase the brain’s resistance to neurodegeneration. …”
Get full text

Long-Term Voluntary Physical Exercise Exerts Neuroprotective Effects and Motor Disturbance Alleviation in a Rat Model of Parkinson’s Disease by Wan-Ling Tsai, Hsin-Yung Chen, Ying-Zu Huang, Yuan-Hao Chen, Chi-Wei Kuo, Kai-Yun Chen, Tsung-Hsun Hsieh

“…The pathologic hallmark of PD is nigrostriatal dopaminergic neuron loss, leading to several motor and nonmotor disturbances, such as akinesia, gait disturbance, depression, and anxiety. …”
Get full text

Sugemule-7 alleviates oxidative stress, neuroinflammation, and cell death, promoting synaptic plasticity recovery in mice with postpartum depression by Qiang Fu, Rui Qiu, Jiaquan Liang, Shuai Wu, Dezhi Huang, Yuxiang Qin, Qiaosheng Li, Xiaojie Shi, Xiyue Xiong, Zhongyong Jiang, Yuewen Chen, Yong Cheng

“…Overall, our study confirms the efficacy of Sugemule-7 in treating PPD at different concentrations, potentially alleviating depressive behaviors by enhancing synaptic plasticity, mitigating oxidative stress, reducing inflammation, and protecting neurons.…”
Get full text

Neuroanatomical and functional substrates of the short video addiction and its association with brain transcriptomic and cellular architecture by Yuanyuan Gao, Ying Hu, Jinlian Wang, Chang Liu, Hohjin Im, Weipeng Jin, Wenwei Zhu, Wei Ge, Guang Zhao, Qiong Yao, Pinchun Wang, Manman Zhang, Xin Niu, Qinghua He, Qiang Wang

“…Transcriptomic and cellular analyses also showed specific genes linked to gray matter volume (GMV) associated with SVA, with predominant expression in excitatory and inhibitory neurons. These genes showed distinct spatiotemporal expression patterns in the cerebellum during adolescence. …”
Get full text

CRISPR-based epigenetic editing of Gad1 improves synaptic inhibition and cognitive behavior in a Tauopathy mouse model by Lei Wan, Ping Zhong, Pei Li, Yong Ren, Wei Wang, Mingjun Yu, Henry Y. Feng, Zhen Yan

“…GABAergic signaling in the brain plays a key role in regulating synaptic transmission, neuronal excitability, and cognitive processes. Large-scale sequencing has revealed the diminished expression of GABA-related genes in Alzheimer's disease (AD), however, it is largely unclear about the epigenetic mechanisms that dysregulate the transcription of these genes in AD. …”
Get full text

Dynamic Changes in the Nigrostriatal Pathway in the MPTP Mouse Model of Parkinson’s Disease by Dongping Huang, Jing Xu, Jinghui Wang, Jiabin Tong, Xiaochen Bai, Heng Li, Zishan Wang, Yulu Huang, Yufei Wu, Mei Yu, Fang Huang

“…Pathophysiological events, such as reductions in the striatal dopamine (DA) concentrations and levels of the tyrosine hydroxylase (TH) protein, depletion of TH-positive nerve fibers, a decrease in the number of TH-positive neurons in the substantia nigra pars compacta (SNpc), and glial activation, are addressed. …”
Get full text

SCN10A gene polymorphism is associated with pain sensitivity and postoperative analgesic effects in patients undergoing gynecological laparoscopy by Yang Gao, Jing Li, Lin Gan, Meng Cai, Xiaofeng Lei, Jin Yu

“…The SCN10A gene encodes the Nav1.8 sodium channel protein, which is crucial for pain signal transmission in peripheral sensory neurons. Objectives This study aims to investigate the relationship between genetic mutations in the SCN10A gene (rs6795970) and postoperative analgesic effects following gynecological laparoscopic surgery. …”
Get full text

Repetitive Mild but Not Single Moderate Brain Trauma Is Associated with TAR DNA-Binding Protein 43 Mislocalization and Glial Activation in the Mouse Spinal Cord by Tamara Janković, Jelena Rajič Bumber, Nika Gržeta Krpan, Petra Dolenec, Marc Jaeger, Jasna Kriz, Gordana Župan, Kristina Pilipović

“…The progression of pathophysiological changes to the spinal cord motor neurons has been detected after repetitive TBI, while such changes have been less investigated after single TBI. …”
Get full text

The histological development of the fetal human inferior colliculus during the second trimester by Reetuparna Nanda, Mihail Bota, Jaikishan Jayakumar, Jaikishan Jayakumar, Suresh S, S. Lata, E. Harish Kumar, Chitra Srinivasan, Sudha Vasudevan, Kumutha Jayaraman, Mohanasankar Sivaprakasam, Mohanasankar Sivaprakasam, Mohanasankar Sivaprakasam, Richa Verma

“…We identify stellate-like and round neurons in the central nucleus of the IC (CNIC) at 24 GW and 27 GW, comparable to the adult human IC. …”
Get full text

Nociceptor-localized KCC2 suppresses brachial plexus avulsion-induced neuropathic pain and related central sensitization by Hang Xian, Huan Guo, Yuan-Ying Liu, Sui-Bin Ma, Rui Zhao, Jian-Lei Zhang, Hang Zhang, Rou-Gang Xie, Xu-Cheng Guo, Jie Ren, Sheng-Xi Wu, Ceng Luo, Rui Cong

“…Overexpression of KCC2 in DRG could reverse the hyperexcitability of DRG neurons and alleviate the pain of BPA mice synchronously. …”
Get full text

Complementary cognitive roles for D2-MSNs and D1-MSNs during interval timing by Robert A Bruce, Matthew Weber, Alexandra Bova, Rachael Volkman, Casey Jacobs, Kartik Sivakumar, Hannah Stutt, Youngcho Kim, Rodica Curtu, Kumar Narayanan

“…We harnessed optogenetic tagging to record from striatal D2-dopamine receptor-expressing medium spiny neurons (D2-MSNs) in the indirect pathway and from D1-dopamine receptor-expressing MSNs (D1-MSNs) in the direct pathway. …”
Get full text

Mechanism of Swimming Exercise Intervention on Rats with Vascular Dementia Based on PERK/ATF4/CHOP Pathway by LIU Fang, LI Mengxing, WANG Yu, TANG Wei

“…After four weeks of intervention, Morris water maze experiment was used to observe behavioral changes of rats; transmission electron microscopy was used to observe the ultrastructure of neurons in the hippocampal CA1 region of rats; real-time fluorescent quantitative PCR (RT-qPCR) and Western blot were used to detect the relative expression levels of protein kinase R-like endoplasmic reticulum kinase (PERK), activating transcription factor 4 (ATF4), and C/EBP homologous protein (CHOP) mRNA and protein.Results(1) Behavioral changes: compared with the sham operation group, the average escape latency in the model group was significantly prolonged, and the number of platform crossing significantly reduced, and the differences were statistically significant (<italic>P</italic>&lt;0.05). …”
Get full text

Intravenous Administration of Adipose-Derived Stem Cell Protein Extracts Improves Neurological Deficits in a Rat Model of Stroke by Kai Zhao, Rui Li, Changcong Gu, Long Liu, Yulong Jia, Xize Guo, Wanping Zhang, Chunying Pei, Linlu Tian, Bo Li, Jianrong Jia, Huakun Cheng, Hongwei Xu, Lixian Li

“…Treatment of adipose-derived stem cell (ADSC) substantially improves the neurological deficits during stroke by reducing neuronal injury, limiting proinflammatory immune responses, and promoting neuronal repair, which makes ADSC-based therapy an attractive approach for treating stroke. …”
Get full text

Neural activity responsiveness by maturation of inhibition underlying critical period plasticity by Ibuki Matsumoto, Sou Nobukawa, Sou Nobukawa, Sou Nobukawa, Sou Nobukawa, Takashi Kanamaru, Takashi Kanamaru, Yusuke Sakemi, Yusuke Sakemi, Nina Sviridova, Nina Sviridova, Tomoki Kurikawa, Nobuhiko Wagatsuma, Kazuyuki Aihara, Kazuyuki Aihara

“…However, the neural response to external stimuli and neuronal oscillations at the neural population level during CPs has not yet been fully clarified. …”
Get full text

Gestational diabetes induces autistic-like behaviors in offspring by disrupting the GABAergic system by Xuan-Qi Liu, Tian-li Huang, Shu-Yu Zhang, Yu-Tong Huang, Jia-Ying Mo, Yi-Shang Yan, Yi-Ning Cao, Yue-Ran Cai, Jian-Zhong Sheng, Hong Zhu, He Feng Huang

“…Behavioral analyses were conducted to assess social novelty and stereotypic behaviors. Neuronal excitability in the prefrontal cortex (PFC) was evaluated using c-Fos staining after social behavior stimulation. …”
Get full text

Electroacupuncture Pretreatment Elicits Tolerance to Cerebral Ischemia/Reperfusion through Inhibition of the GluN2B/m-Calpain/p38 MAPK Proapoptotic Pathway by Bao-yu Zhang, Guan-ran Wang, Wen-hua Ning, Jian Liu, Sha Yang, Yan Shen, Yang Wang, Meng-xiong Zhao, Li Li

“…This EA pretreatment regime could improve neurofunction, decrease cerebral infarction volume, and reduce neuronal apoptosis 24 hours after cerebral I/R injury. …”
Get full text

Behavioral Improvement and Regulation of Molecules Related to Neuroplasticity in Ischemic Rat Spinal Cord Treated with PEDF by Chary Marquez Batista, Leonardo Luis Torres Bianqui, Bruno Bonganha Zanon, Mauricio Menezes Aben Athar Ivo, Gabriela Pintar de Oliveira, Jessica Ruivo Maximino, Gerson Chadi

“…Eph receptors and ephrins were found in specific populations of neurons and astrocytes. PEDF treatment to SC injury triggered neuroplasticity in lumbar CPG and regulation of neurotrophic factors, extracellular matrix molecules, and ephrins.…”
Get full text

G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis by Morgan G. Stykel, Shehani V. Siripala, Eric Soubeyrand, Carla L. Coackley, Ping Lu, Suelen Camargo, Sharanya Thevasenan, Gerardo Balderas Figueroa, Raphaella W.L. So, Erica Stuart, Rachi Panchal, Elissavet-Kalliopi Akrioti, Jeffery T. Joseph, Omid Haji-Ghassemi, Era Taoufik, Tariq A. Akhtar, Joel C. Watts, Scott D. Ryan

“…Summary: Loss of dopaminergic neurons in Parkinson’s disease (PD) is preceded by loss of synaptic dopamine (DA) and accumulation of proteinaceous aggregates. …”
Get full text

ATF3 Knockdown Exacerbates Astrocyte Activation by Inhibiting Phosphorylation of Drp1 in Ischemic Stroke by Huang R, Huang X, Yang H, Wu H, Liu F, Saw PE, Cao M

“…Rong Huang,1 Xiaoyan Huang,1 Hongmei Yang,1 Haixuan Wu,1 Fan Liu,1 Phei Er Saw,2,3 Minghui Cao1,4 1Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 2Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 3Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 4Department of Anesthesiology, Shenshan Medical Center, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Shanwei, 516600, People’s Republic of ChinaCorrespondence: Phei Er Saw; Minghui Cao, Email caipeie@mail.sysu.edu.cn; caomh@mail.sysu.edu.cnIntroduction: ATF3, a stress-induced transcription factor, has been implicated in the injury processes of various cell types, including neurons. It is recognized as a common marker for neuronal damage following neurotrauma. …”
Get full text

CD2AP deficiency aggravates Alzheimer’s disease phenotypes and pathology through p38 MAPK activation by Yan-Yan Xue, Zhe-Sheng Zhang, Rong-Rong Lin, Hui-Fen Huang, Ke-Qing Zhu, Dian-Fu Chen, Zhi-Ying Wu, Qing-Qing Tao

“…Results CD2AP is widely expressed in various regions of the mouse brain, with predominant expression in neurons and vascular endothelial cells. In APP/PS1 mice, neuronal knockout of Cd2ap significantly aggravated tau pathology, synaptic impairments and cognitive deficits. …”
Get full text