DA5-CH and Semaglutide Protect against Neurodegeneration and Reduce α-Synuclein Levels in the 6-OHDA Parkinson’s Disease Rat Model by Lingyu Zhang, Chun Li, Zijuan Zhang, Zhenqiang Zhang, Qian-Qian Jin, Lin Li, Christian Hölscher

“…In addition, both drugs protected dopaminergic neurons and increased TH expression in the substantia nigra. …”
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Modeling of CO2 solubility and partial pressure in blended diisopropanolamine and 2-amino-2-methylpropanol solutions via response surface methodology and artificial neural network by Zohreh Khoshraftar

“…The multilayer perceptron (MLP) architecture demonstrated strong correlation capabilities, featuring one hidden layer with 10 and 5 neurons, respectively. Its topology was structured as 4-10-1 for predicting CO2 solubility and 4-5-1 for predicting CO2 partial pressure. …”
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Theaflavin Ameliorates Cerebral Ischemia-Reperfusion Injury in Rats Through Its Anti-Inflammatory Effect and Modulation of STAT-1 by Fei Cai, Cai-Rong Li, Ji-Liang Wu, Jian-Guo Chen, Chao Liu, Qing Min, Wei Yu, Chang-Han Ouyang, Jin-He Chen

“…Our study demonstrated that theaflavin significantly protected neurons from cerebral ischemia-reperfusion injury by limiting leukocyte infiltration and expression of ICAM-1, and suppressing upregulation of inflammatory-related prooxidative enzymes (iNOS and COX-2) in ischemic brain via, at least in part, reducing the phosphorylation of STAT-1.…”
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Pivotal roles of melanopsin containing retinal ganglion cells in pupillary light reflex in photopic conditions by Jeremy Matthew Bohl, Abdul Rhman Hassan, Zachary J. Sharpe, Megi Kola, Angela Shehu, Deborah Langrill Beaudoin, Tomomi Ichinose

“…The intrinsically photosensitive retinal ganglion cells (ipRGCs) in the retina are neurons that are critical to generating the PLR, receiving rod/cone photoreceptor signals and directly sensing light through melanopsin. …”
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Early Neural Cell Death Is an Extensive, Dynamic Process in the Embryonic Chick and Mouse Retina by Teresa Chavarría, Jimena Baleriola, Raquel Mayordomo, Flora de Pablo, Enrique J. de la Rosa

“…We performed a parallel study in embryonic chick and mouse retinas, focusing on the period during which the first neurons, the retinal ganglion cells (RGCs), are generated. …”
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Downregulation of an Evolutionary Young miR-1290 in an iPSC-Derived Neural Stem Cell Model of Autism Spectrum Disorder by Dalia Moore, Brittney M. Meays, Lepakshe S. V. Madduri, Farah Shahjin, Subhash Chand, Meng Niu, Abrar Albahrani, Chittibabu Guda, Gurudutt Pendyala, Howard S. Fox, Sowmya V. Yelamanchili

“…We previously have identified an evolutionary young miRNA, miR-1290, to be essential in neural stem cell proliferation and neuronal differentiation. Here, we show that miR-1290 is significantly downregulated during neuronal differentiation in reprogrammed induced pluripotent stem cell- (iPSC-) derived neurons obtained from idiopathic autism spectrum disorder (ASD) patients. …”
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Application of psychobiotics in clinical treatment of mental disorders: Neurodevelopmental disorders, neurodegenerative diseases, depression and anxiety by Jingwei Cui, Wenxin Wang, Yue Tang, Siyuan Feng, Hong Liu, Zikai Hao

“…The gut microbiota influences bidirectional communication between the brain and the gastrointestinal (GI) system. Neurons in the enteric nervous system directly interact with neurotransmitters, short‐chain fatty acids (SCFAs), gut hormones, and anti‐inflammatory cytokines produced by the gut microbiota, thereby affecting signal transmission in the central nervous system. …”
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Altered Expression of NF-κB and SP1 after Exposure to Advanced Glycation End-Products and Effects of Neurotrophic Factors in AGEs Exposed Rat Retinas by Guzel Bikbova, Toshiyuki Oshitari, Takayuki Baba, Shuichi Yamamoto

“…These results demonstrate the potential of the NTFs as axoprotectants in AGEs exposed retinal neurons.…”
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Evaluating the predictive potential of RSM and ANN models in treatment of greywater-syrup mixture using Ekowe clay-PEM microbial fuel cell by Livinus A. Obasi, Cornelius O. Nevo

“…The ANN gave the best prediction with n = 10 neurons. The response variables (power density generation (mW/m2) and chemical oxygen demand (COD) removal efficiency (%)) were measured against four process input variables: mass of the clay component of the proton exchange membrane (PEM) (g), PEM preparation temperature (PPT), anolyte pH, and concentration. …”
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Traumatic Brain Injury and Stem Cell: Pathophysiology and Update on Recent Treatment Modalities by Cesar Reis, Vadim Gospodarev, Haley Reis, Michael Wilkinson, Josileide Gaio, Camila Araujo, Sheng Chen, John H. Zhang

“…In the acute phase, brain tissue destroyed upon impact includes neurons, glia, and endothelial cells, the latter of which makes up the blood-brain barrier. …”
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Sufentanil enhances the cortical neurogenesis of rats with traumatic brain injury via PI3K/AKT signal pathway by Wei Gu, Mimi Wu, Ruocui Zhang, Peiyu Liu, Yang Jiao, Hui Rong

“…The oxidative stress, inflammation, nerve cell damage, melatonin, brain-derived neurotrophic factor (BDNF), neuron regeneration and p-AKT protein level in the cortex were detected with ELISA, TUNEL, qRT-PCR, immunofluorescence and Western blot. …”
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Human induced pluripotent stem cell–derived therapies for regeneration after central nervous system injury by Stephen Vidman, Yee Hang Ethan Ma, Nolan Fullenkamp, Giles W. Plant

“…Cells of the neuroectodermal lineage, such as neuronal subpopulations and glia, have been explored with varying degrees of success. …”
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Exploration and Verification of Prognostic Value of Endothelial Cells in Glioblastoma by Hengchao MA, Yuyang LIU, Jun XU, Bingyan TAO, Jun ZHANG

“…Seven groups of cells were obtained after GBM single-cell sequencing analysis, including AC-like tumor cells, endothelial cells, monocytes/macrophages, NB-like tumor cells, neurons, OC-like tumor cells, and OPC-like tumor cells. …”
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Comparison Of Glucagon Like Peptide/1 Levels In Diabetic Women With Ovarian Polycystic Syndrome And Healthy Women by Namra Iqtidar, Imran Ali Zaidi, Sobia Niaz, Javaria Latif, Amir Naveed, Ayesha Yousaf

“…Moreover, GLP-1 is required to significantly stimulate GnRH (Gonadotropin Hormone releasing hormone) secretion because of the presence of GLP-1 brain receptors located on the GnRH neurons which cause more LH (Luteinizing hormone) secretion.  …”
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Association of Tooth Loss with New-Onset Parkinson’s Disease: A Nationwide Population-Based Cohort Study by Ho Geol Woo, Yoonkyung Chang, Ji Sung Lee, Tae-Jin Song

“…Systemic inflammatory reaction may be related to the degeneration of dopamine neurons in the substantia nigra. We hypothesized that tooth loss is related to increased risk of new-onset Parkinson’s disease. …”
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Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer’s disease by Phoebe Valdes, Andrew B. Caldwell, Qing Liu, Michael Q. Fitzgerald, Srinivasan Ramachandran, Celeste M. Karch, Dominantly Inherited Alzheimer Network (DIAN), Douglas R. Galasko, Shauna H. Yuan, Steven L. Wagner, Shankar Subramaniam

“…Methods We examined whether common disease endotypes exist across these mutations with a later AAO (~ 55 years) using hiPSC-derived neurons from familial Alzheimer’s disease (FAD) patients harboring mutations in PSEN1 A79V , PSEN2 N141I , and APP V717I and mechanistically characterized by integrating RNA-seq and ATAC-seq. …”
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Analysis of reservoir rock permeability changes due to solid precipitation during waterflooding using artificial neural network by Azizollah Khormali, Soroush Ahmadi, Aleksandr Nikolaevich Aleksandrov

“…Through the implementation of this algorithm in the network, it was determined that the optimal configuration consisted of three layers - comprising of two hidden layers with eight and four neurons in the first and second layer, respectively, along with one output layer. …”
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The Role of Neuroglia in the Development and Progression of Schizophrenia by Neha S. Rawani, Allen W. Chan, Kathryn G. Todd, Glen B. Baker, Serdar M. Dursun

“…Although glia were originally thought to be present in the brain only to support neurons in a physical, metabolic and nutritional capacity, it has become apparent that these cells have a variety of important physiological roles and that abnormalities in their function may make significant contributions to the symptoms of schizophrenia. …”
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Neural Mass Modeling in the Cortical Motor Area and the Mechanism of Alpha Rhythm Changes by Yuanyuan Zhang, Zhaoying Li, Hang Xu, Ziang Song, Ping Xie, Penghu Wei, Guoguang Zhao

“…The findings suggest that increasing grip force activates more motor neurons in the motor cortex and raises their firing rate. …”
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Electrophysiologically calibrated optogenetic stimulation of dentate granule cells mitigates dendritic spine loss in denervated organotypic entorhino-hippocampal slice cultures by Tijana Hanauske, Carolin Christina Koretz, Tassilo Jungenitz, Jochen Roeper, Alexander Drakew, Thomas Deller

“…Abstract Organotypic slice cultures (OTCs) are versatile tools for studying long-term structure-function relationships of neurons within a defined network (e.g. hippocampus). …”
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