Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats by Madhavan Nampoothiri, Jessy John, Nitesh Kumar, Jayesh Mudgal, Gopalan Kutty Nampurath, Mallikarjuna Rao Chamallamudi

“…To conclude, the present study suggests that simvastatin per se protects the neurons in hippocampus and frontal cortex from AlCl3, an environmental toxin.…”
Get full text

Microwave Drying Modelling of Stevia rebaudiana Leaves Using Artificial Neural Network and Its Effect on Color and Biochemical Attributes by Baldev Singh Kalsi, Sandhya Singh, Mohammed Shafiq Alam, Surekha Bhatia

“…The result showed that the ANN model with 15 neurons in 1 hidden layer could predict the MR with a high R2 value (0.999). …”
Get full text

GFRα1 Promotes Axon Regeneration after Peripheral Nerve Injury by Functioning as a Ligand by Tomoaki Suzuki, Ken Kadoya, Takeshi Endo, Miwako Yamasaki, Masahiko Watanabe, Norimasa Iwasaki

“…GFRα1 bound to a receptor complex consisting of NCAM and integrin α7β1 of dorsal root ganglion neurons in a GDNF‐RET independent manner. This is further confirmed by the Ret Y1062F knock‐in mice, which cannot transmit most of GDNF‐RET signaling. …”
Get full text

Integrated multi-omics analysis reveals the underlying molecular mechanism for the neurotoxicity of triclosan in zebrafish by Shasha Zhao, Yuhang Ling, Baohua Zhang, Danting Wang, Limei Sun

“…Histopathological investigations and neural ultrastructural observations demonstrated that TCS could induce variable levels of pyknosis and vacuolation in the cytoplasm of neurons as well as torn mitochondrial membranes, shrinkage and broken or absent cristae. …”
Get full text

The Leech Nervous System: A Valuable Model to Study the Microglia Involvement in Regenerative Processes by Françoise Le Marrec-Croq, Francesco Drago, Jacopo Vizioli, Pierre-Eric Sautière, Christophe Lefebvre

“…Those questions aim to better understand the mechanisms of microglial cell recruitment and their crosstalk with damaged neurons. The study of this dialog is necessary to elucidate the balance of the inflammation leading to the leech CNS repair.…”
Get full text

Electroacupuncture Improved Hippocampal Neurogenesis following Traumatic Brain Injury in Mice through Inhibition of TLR4 Signaling Pathway by Yuqin Ye, Yongxiang Yang, Chen Chen, Ze Li, Yanfeng Jia, Xinhong Su, Chaoxian Wang, Xiaosheng He

“…BrdU/NeuN immunofluorescence was performed to label newborn neurons in the hippocampus after EA treatment. Water maze test and neurological severity score were used to evaluate neurological function posttrauma. …”
Get full text

Effect of Maternal Administration of Edible Bird’s Nest on the Learning and Memory Abilities of Suckling Offspring in Mice by Yong Xie, Hongliang Zeng, Zhiji Huang, Hui Xu, Qunyan Fan, Yi Zhang, Baodong Zheng

“…Moreover, BDNF levels for CA1, CA2, and CA3 regions in hippocampi and the numbers of dyed neurons in CA1, CA2, CA3, and DG regions among the offspring were significantly enhanced due to the intake of EBN by the maternal mice. …”
Get full text

Understanding retinal tau pathology through functional 2D and 3D iPSC-derived in vitro retinal models by Lorenza Mautone, Federica Cordella, Alessandro Soloperto, Silvia Ghirga, Giorgia Di Gennaro, Ylenia Gigante, Silvia Di Angelantonio

“…These changes are associated with impaired synaptic development, reduced neuronal connectivity, and enhanced cellular stress responses, including the increased formation of stress granules, markers of apoptosis and autophagy, and the presence of intracellular toxic tau aggregates. …”
Get full text

“…They were just treating her Symptom by Symptom”: maternal experiences of having a child with spinal muscular atrophy in Ghana by Esther Doe-Yo Tawiah, Jacob Owusu Sarfo

“…Abstract Background Children with Spinal Muscular Atrophy (SMA) face the challenges of a rare condition impacting their motor neurons, placing substantial caregiving burdens on their mothers. …”
Get full text

Melatonin attenuates MPP+-induced autophagy via heat shock protein in the Parkinson’s disease mouse model by Yinli Guo, Chengbo Liu

“…Conclusion Melatonin exerts a protective effect against MPP+-induced damage to dopaminergic neurons, presumably by upregulating HSP70, which inhibits neuronal autophagy.…”
Get full text

A Differential Evolution-Oriented Pruning Neural Network Model for Bankruptcy Prediction by Yajiao Tang, Junkai Ji, Yulin Zhu, Shangce Gao, Zheng Tang, Yuki Todo

“…Inspired by the mechanism of biological neurons, we propose an evolutionary pruning neural network (EPNN) model to conduct financial bankruptcy analysis. …”
Get full text

SYMBOLIC ANALYSIS OF CLASSICAL NEURAL NETWORKS FOR DEEP LEARNING by Vladimir Milićević, Igor Franc, Maja Lutovac Banduka, Nemanja Zdravković, Nikola Dimitrijević

“…In this paper, we propose, as a proof of concept, to start the system design by drawing a single neuron. A more complex scheme of the neural network is obtained by using the copy, move, and paste commands for the simplest unit. …”
Get full text

Advances in Stem Cell Therapy for Huntington’s Disease: A Comprehensive Literature Review by Siddharth Shah, Hadeel M. Mansour, Brandon Lucke-Wold

“…A key feature of HD is the loss of striatal neurons and cortical atrophy. Although there is no cure at present, the discovery of the gene causing HD has brought us into a new DNA era and therapeutic advances for several neurological disorders. …”
Get full text

Uncertainty-aware deep learning in healthcare: A scoping review. by Tyler J Loftus, Benjamin Shickel, Matthew M Ruppert, Jeremy A Balch, Tezcan Ozrazgat-Baslanti, Patrick J Tighe, Philip A Efron, William R Hogan, Parisa Rashidi, Gilbert R Upchurch, Azra Bihorac

“…The predominant method for quantifying uncertainty was Monte Carlo dropout, producing predictions from multiple networks for which different neurons have dropped out and measuring variance across the distribution of resulting predictions. …”
Get full text

Monocarboxylate Transporters: Role and Regulation in Corneal Diabetes by Pawan Shrestha, Amy E. Whelchel, Sarah E. Nicholas, Wentao Liang, Jian-Xing Ma, Dimitrios Karamichos

“…Changes appeared dependent on neuronal density, suggesting that MCTs are very likely critical to the neuronal defects observed in diabetic keratopathy/neuropathy. …”
Get full text

Spatiotemporal Expression and Molecular Characterization of miR-344b and miR-344c in the Developing Mouse Brain by Jia-Wen Leong, Syahril Abdullah, King-Hwa Ling, Pike-See Cheah

“…Further investigation on the locality of miR-344b and miR-344c showed that both miRNAs were localized in nuclei of immature neurons. In conclusion, miR-344b and miR-344c were expressed spatiotemporally during mouse brain developmental stages.…”
Get full text

Neurodegeneration in Patients with Type 2 Diabetes Mellitus without Diabetic Retinopathy by Elena Garcia-Martin, Marta Cipres, Isabel Melchor, Laura Gil-Arribas, Elisa Vilades, Vicente Polo, Maria Jesus Rodrigo, Maria Satue

“…Patients with type 2 DM without diabetic retinopathy and good metabolic control present neurodegeneration affecting neurons in the macular area and axons in different sectors of the optic disc. …”
Get full text

Comparative mRNA Expression of eEF1A Isoforms and a PI3K/Akt/mTOR Pathway in a Cellular Model of Parkinson’s Disease by Kawinthra Khwanraj, Suriyat Madlah, Khwanthana Grataitong, Permphan Dharmasaroja

“…Recently, gene profiling on dopaminergic neurons from postmortem PD patients showed both upregulation and downregulation of some PI3K and mTOR genes. …”
Get full text

Gestational stress disrupts dopamine and oxytocin signaling in the postpartum reward system of rats: implications for mood, motivation and mothering by Achikam Haim, Christopher Albin-Brooks, Holly Brothers, Michaela Breach, Benedetta Leuner

“…Lastly, we assessed mRNA expression of OT and OT receptors (OTR) and found that gestational stress increased OT expression in the hypothalamus but reduced OTR expression in the postpartum ventral tegmental area (VTA), a target of hypothalamic OT neurons. In the VTA, a reduction in OT-immunoreactive fibers following gestational stress was also seen. …”
Get full text

Effect of Centella asiatica Leaf Extract on the Dietary Supplementation in Transgenic Drosophila Model of Parkinson’s Disease by Yasir Hasan Siddique, Falaq Naz, Smita Jyoti, Ambreen Fatima, Saba Khanam, Rahul, Fahad Ali, Syed Faiz Mujtaba, Mohammad Faisal

“…The role of Centella asiatica L. leaf extract was studied on the transgenic Drosophila model flies expressing normal human alpha synuclein (h-αS) in the neurons. The leaf extract was prepared in acetone and was subjected to GC-MS analysis. …”
Get full text