Autoregulation of the glial gene reversed polarity in Drosophila by Jamie L. Wood, Saroj Nepal, Bradley W. Jones

“…Abstract During development, cells of the nervous system begin as unspecified precursors and proceed along one of two developmental paths to become either neurons or glia. Work in the fruit fly Drosophila melanogaster has established the role of the transcription factor Glial cells missing (Gcm) in directing neuronal precursor cells to assume a glial cell fate. …”
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Transcriptomic analysis reinforces the implication of spatacsin in neuroinflammation and neurodevelopment by Liriopé Toupenet Marchesi, Daniel Stockholm, Typhaine Esteves, Marion Leblanc, Nicolas Auger, Julien Branchu, Khalid Hamid El Hachimi, Giovanni Stevanin

“…Previous studies have described several potential roles for spatacsin, including its involvement in lysosome and autophagy mechanisms, neuronal and neurites development or mitochondria function. …”
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Effect of the Iridoid-rich Fraction from <italic>Valeriana jatamansi</italic> Jones on Oxidative Stress in Rats with Spinal Cord Injury by Jiaojuan HUANG, Wenchun WANG, Deqi XIONG, Hao LU, Wu XIANG, Xiaohua ZHAO, Ruihan ZHOU, Anren ZHANG

“…The results of the HE staining showed that the structure of gray matter and white matter of the spinal cord tissue in the sham-operated group were normal at the perilesional area, the structure of the neurons was also clear, and no significant spinal cord injured was found; compared with the sham-operated group, the spinal cord structure was severely damaged in the model group: the gray matter of the central part of the spinal cord and the white matter of the surrounding part of the spinal cord turned into blur because of injury and a large number of neurons degenerated, a number of nerve cells even appeared necrosis, and the cell structure was seriously destroyed at the same time, and in addition, the nuclear turned into shrinkage or dissolution and passed away, accompanying with varying degrees of neutrophil infiltration and a large number of microglia proliferation; compared with the model group, the spinal cord structure of the treatment group with iridoid-rich fraction from <italic>Valeriana jatamansi</italic> Jones significantly improved, and there were only small areas presenting a neuronal necrosis, a small amount of eosinophils increasing and a small number of eosinophils microglia infiltration in the spinal cord tissue at the perilesional area, and at the same time, the histopathological scores in tissue sections were lower(<italic>P</italic>&lt; 0.05). …”
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Amyotrophic Lateral Sclerosis, a Multisystem Pathology: Insights into the Role of TNFα by Massimo Tortarolo, Daniele Lo Coco, Pietro Veglianese, Antonio Vallarola, Maria Teresa Giordana, Gabriella Marcon, Ettore Beghi, Marco Poloni, Michael J. Strong, Anand M. Iyer, Eleonora Aronica, Caterina Bendotti

“…Our group and others have recently reported opposite involvements of TNFR1 and TNFR2 in motor neuron death. TNFR2 mediates TNFα toxic effects on these neurons presumably through the activation of MAP kinase-related pathways. …”
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Learning enhances behaviorally relevant representations in apical dendrites by Sam E Benezra, Kripa B Patel, Citlali Perez Campos, Elizabeth MC Hillman, Randy M Bruno

“…We used both two-photon and SCAPE microscopy to longitudinally track tuft-wide calcium spikes in apical dendrites of layer 5 pyramidal neurons in barrel cortex as mice learned a tactile behavior. …”
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Intelligent classification of computer vulnerabilities and network security management system: Combining memristor neural network and improved TCNN model. by Zhenhui Liu

“…The MNN, by simulating the memory effect of biological neurons, effectively captures the complex nonlinear relationships within vulnerability data, thereby enhancing the data insight capabilities of the network security management system. …”
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Electrical stimulation of the sciatic nerve restores inspiratory diaphragm function in mice after spinal cord injury by Ian Walling, Ian Walling, Sarah Baumgartner, Mitesh Patel, Steven A. Crone, Steven A. Crone, Steven A. Crone

“…IntroductionSpinal cord injury in the high cervical cord can impair breathing due to disruption of pathways between brainstem respiratory centers and respiratory motor neurons in the spinal cord. Electrical stimulation of limb afferents can increase ventilation in healthy humans and animals, but it is not known if limb afferent stimulation can improve breathing following a cervical injury.MethodsWe stimulated the sciatic nerve while using electromyography to measure diaphragm function in anesthetized mice following a cervical (C2) hemisection spinal cord injury, as well as in uninjured controls. …”
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ID3RSNet: cross-subject driver drowsiness detection from raw single-channel EEG with an interpretable residual shrinkage network by Xiao Feng, Xiao Feng, Zhongyuan Guo, Zhongyuan Guo, Sam Kwong

“…In addition, a fully connected layer with weight freezing is utilized to effectively suppress the negative influence of neurons on the model classification. With the global average pooling (GAP) layer incorporated in the residual shrinkage network structure, we introduce an EEG-based Class Activation Map (ECAM) interpretable method to enable visualization analysis of sample-wise learned patterns to effectively explain the model decision. …”
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A red pomegranate fruit extract-based formula ameliorates anxiety/depression-like behaviors via enhancing serotonin (5-HT) synthesis in C57BL/6 male mice by Xiping Zhu, Dongxiao Sun-Waterhouse, Chun Cui

“…The RPFE formula exhibited the abilities to normalize the levels of serum inflammatory cytokines (NF-κB, TNF-α, IL-6, IL-1β and IFN-γ) and malondialdehyde (MDA), and activities of superoxide dismutase (SOD), catalase (CAT) and nitric oxide synthase (NOS), as well as relieve the injury of hippocampal neurons. The serotonin (5-HT) levels in hippocampus were increasingly enhanced, which might be mediated by reducing the activity of indoleamine-2,3-dioxygenase (IDO) and increasing the activity of tryptophan hydroxylase (TPH). …”
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Feature Representations Using the Reflected Rectified Linear Unit (RReLU) Activation by Chaity Banerjee, Tathagata Mukherjee, Eduardo Pasiliao Jr.

“…One important aspect of designing a neural network is the choice of the activation function to be used at the neurons of the different layers. In this work, we introduce a four-output activation function called the Reflected Rectified Linear Unit (RReLU) activation which considers both a feature and its negation during computation. …”
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Optimizing Breast Cancer Mammogram Classification Through a Dual Approach: A Deep Learning Framework Combining ResNet50, SMOTE, and Fully Connected Layers for Balanced and Imbalanc... by Abdullah Fahad A. Alshamrani, Faisal Saleh Zuhair Alshomrani

“…The model architecture was iteratively refined to combat overfitting, with the final version incorporating three dense layers (128, 256, and 128 neurons) with dropout rates of 0.5. Our model achieved 99% accuracy on a balanced dataset and 90% on an imbalanced portion. …”
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Enhanced glycolysis-derived lactate promotes microglial activation in Parkinson’s disease via histone lactylation by Qixiong Qin, Danlei Wang, Yi Qu, Jiangting Li, Ke An, Zhijuan Mao, Jingyi Li, Yongjie Xiong, Zhe Min, Zheng Xue

“…Here, we demonstrated that inhibiting glycolysis with 2-deoxy-d-glucose alleviates microgliosis, neuroinflammation and dopaminergic neurons damage by reducing lactate accumulation in PD mice. …”
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Modeling the modulation of beta oscillations in the basal ganglia by dual-target optogenetic stimulation by Xiaomin Wang, Ying Yu, Qingyun Wang

“…Optogenetic techniques provide precise control over the activity of specific neurons within the nucleus, offering more accurate regulatory effects compared to deep brain stimulation. …”
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Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer’s disease by administration through an intranasal route by Anne-Claire Groo, Thomas Curel, Aurélie Malzert-Fréon, Line Séguy, Ophélie Bento, Sophie Corvaisier, Thomas Culerier, Romain Legrand, Noëlle Callizot, Alexandre Henriques, Georgia Culley, Sylvie Claeysen, Christophe Rochais, Patrick Dallemagne

“…Finally, intranasal administration of low doses of bambuterol gel in mice intoxicated with Aβ peptides, prevented long-term spatial memory impairment and showed beneficial effects on the survival of neurons and on synapse preservation.…”
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Cyanin Chloride Inhibits Hyperbaric Pressure-Induced Decrease of Intracellular Glutamate-Aspartate Transporter in Rat Retinal Müller Cells by Xiaomin Chen, Yue Wang, Fangfang Han, Min Ke

“…Anthocyanin has been reported to protect retinal neurons. We hypothesize that cyanin chloride, a type of anthocyanin, can inhibit hyperbaric pressure-induced GLAST decreases in cultured rat retinal Müller cells and may serve as a potential neuroprotective agent in glaucoma treatment. …”
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Electroacupuncture Alleviates Neuropathic Pain through Regulating miR-206-3p Targeting BDNF after CCI by Wenzhan Tu, Jingjing Yue, Xuqing Li, Qiaoyun Wu, Guanhu Yang, Shengcun Li, Qiangsan Sun, Songhe Jiang

“…Nissl staining was measured to observe morphological changes in neurons. Transmission electron microscopy (TEM) was employed to evaluate microscopic changes in dorsal horn synapses. …”
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Effect of a Traditional Chinese Herbal Medicine Formulation on Cell Survival and Apoptosis of MPP+-Treated MES 23.5 Dopaminergic Cells by Shuifen Ye, Ho Kee Koon, Wen Fan, Yihui Xu, Wei Wei, Chuanshan Xu, Jing Cai

“…Progressive degeneration of dopaminergic neurons in the substantia nigra (SN) is implicated in Parkinson’s disease (PD). …”
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A software system for modeling evolution in a population of organisms with vision, interacting with each other in 3D simulator by A. P. Devyaterikov, A. Yu. Palyanov

“…For a system of hundreds or thousands of neurons, one can still hope to determine the necessary parameters and get the functioning of the nervous system more or less similar to that of a living organism – as, for example, in a recent work on the modeling of the Xenopus tadpole. …”
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Enhanced bioavailability of Quercetin-loaded niosomal in situ gel for the management of Parkinson’s disease by Abhishek A. Revankar, Archana S. Patil, Reshma Karishetti, Krutuja R. Chougule, Priyanka Patil, Abhijit Salokhe

“…Male Wistar rats were utilized to assess the effects of quercetin-loaded niosomes on motor function, dopaminergic neuron protection, and oxidative stress alleviation.ResultsThe optimized niosomal formulation exhibited a particle size of 195 nm, a polydispersity index (PDI) of 0.29, a zeta potential (ZP) of −30.63 mV, and an entrapment efficiency (EE) of 82.77%. …”
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Beyond modular and non-modular states: theoretical considerations, exemplifications, and practical implications by Francesco Benso, Carlo Chiorri, Eleonora Ardu, Paola Venuti, Angela Pasqualotto, Angela Pasqualotto

“…We also evaluate recent discoveries, such as mirror neurons and the neural reuse hypothesis, and their implications for traditional modularity models. …”
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