Cell Secretion: Current Structural and Biochemical Insights by Saurabh Trikha, Elizabeth C. Lee, Aleksandar M. Jeremic

“…The sizes of porosomes range from 150nm in diameter in acinar cells of the exocrine pancreas to 12nm in neurons. In recent years, significant progress has been made in our understanding of the porosome and the cellular activities required for cell secretion, such as membrane fusion and swelling of secretory vesicles. …”
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Mechanisms of Neuroprotection by Protein Disulphide Isomerase in Amyotrophic Lateral Sclerosis by Adam K. Walker, Julie D. Atkin

“…Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterised by the progressive loss of motor neurons, leading to paralysis and death within several years of onset. …”
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Gene Therapy for Parkinson's Disease by Rachel Denyer, Michael R. Douglas

“…More radically, gene therapy could be used to correct the imbalances in basal ganglia circuitry associated with the symptoms of Parkinson's disease, or to preserve or restore dopaminergic neurons lost during the disease process itself. The latter neuroprotective approach is the most exciting, as it could theoretically be disease modifying rather than simply symptom alleviating. …”
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Prediction Study on PCI Failure of Reactor Fuel Based on a Radial Basis Function Neural Network by Xinyu Wei, Jiashuang Wan, Fuyu Zhao

“…For the purpose of the appropriate network complexity and overall computational efficiency, the hidden neurons in the RBFNN can be changed online based on the neuron activity and mutual information. …”
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Single Photon Emission Tomography Imaging in Parkinsonian Disorders: A Review by Paul D. Acton, P. David Mozley

“…Pathological evidence has shown clearly that these disorders are associated with a loss of neurons, particularly in the nigrostriatal dopaminergic pathway. …”
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Morphological and functional decline of the SNc in a model of progressive parkinsonism by Jacob M. Muñoz, John T. Williams, Joseph J. Lebowitz

“…Abstract The motor symptoms of Parkinson’s Disease are attributed to the degeneration of dopamine neurons in the substantia nigra pars compacta (SNc). …”
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Analysis of the Severity of Accidents on Rural Roads Using Statistical and Artificial Neural Network Methods by Mohammad Habibzadeh, Pooyan Ayar, Mohammad Hassan Mirabimoghaddam, Mahmoud Ameri, Seyede Mojde Sadat Haghighi

“…In addition, two artificial neural network (ANN) models were developed using two kinds of learning methods to train neurons to select the best result. The results of modeling and analysis of accidents using various techniques revealed that each technique, depending on its purpose, examined the severity of accidents from a different point of view and represented various outcomes. …”
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P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction by Segundo J. Guzman, Zoltan Gerevich

“…ATP released from neurons and astrocytes during neuronal activity or under pathophysiological circumstances is able to influence information flow in neuronal circuits by activation of ionotropic P2X and metabotropic P2Y receptors and subsequent modulation of cellular excitability, synaptic strength, and plasticity. …”
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Toll-Like Receptors Expression and Signaling in Glia Cells in Neuro-Amyloidogenic Diseases: Towards Future Therapeutic Application by Dorit Trudler, Dorit Farfara, Dan Frenkel

“…It was recently suggested that TLRs have an important role in the crosstalk between neurons and glial cells in the central nervous system (CNS). …”
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Cellular Origin of Spontaneous Ganglion Cell Spike Activity in Animal Models of Retinitis Pigmentosa by David J. Margolis, Peter B. Detwiler

“…Patch-clamp recordings from identified types of ON and OFF retinal ganglion cells in the adult (36–210 d old) rd1 mouse show that the ongoing oscillatory spike activity in both cell types is driven by strong rhythmic synaptic input from presynaptic neurons that is blocked by CNQX. The recurrent synaptic activity may arise in a negative feedback loop between a bipolar cell and an amacrine cell that exhibits resonant behavior and oscillations in membrane potential when the normal balance between excitation and inhibition is disrupted by the absence of photoreceptor input.…”
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Emerging Roles of Immune Cells in Postoperative Cognitive Dysfunction by Yue Liu, Yiqing Yin

“…After surgery, alarmins are leaked from the injury sites and proinflammatory cytokines are increased in the peripheral circulation. Neurons in the hippocampus, which is responsible for learning and memory, can be damaged by cytokines transmitted to the brain parenchyma. …”
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Purinergic Receptors of the Central Nervous System: Biology, PET Ligands, and Their Applications by Hamideh Zarrinmayeh PhD, Paul R. Territo PhD

“…These receptors are involved in cellular neuroinflammatory responses that regulate functions of neurons, microglial and astrocytes. Based on their endogenous ligands, purinergic receptors are classified into P1 or adenosine, P2X and P2Y receptors. …”
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Skin Acute Wound Healing: A Comprehensive Review by Luis Cañedo-Dorantes, Mara Cañedo-Ayala

“…The first step of the inflammatory phase is an immediate response to injury; primary sensory neurons sense injury and send danger signals to the brain, to stop bleeding and start inflammation. …”
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Analysis of Artificial Neural Network: Architecture, Types, and Forecasting Applications by Manogaran Madhiarasan, Mohamed Louzazni

“…The performances of the proposed neural network-based forecasting models are analyzed with various hidden neurons and validated using the acquired real-time meteorological data. …”
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The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation by Ekta Bajwa, Caitlin B. Pointer, Andis Klegeris

“…Mitochondrial molecules released into the extracellular space following neuronal damage or death may also play a role in these diseases by acting as signaling molecules called damage-associated molecular patterns (DAMPs). …”
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MODELING OF SOLAR RADIATION WITH A NEURAL NETWORK by VALENTIN STOYANOV, IVAYLO STOYANOV, TEODOR ILIEV

“…The possible ANN structure, the size of training data set, the number of hidden neurons, and the type of training algorithms were analyzed in order to identify the most appropriate model. …”
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Potential of ultrasound stimulation and sonogenetics in vision restoration: a narrative review by Jie Ji, Chen Gong, Gengxi Lu, Junhang Zhang, Baoqiang Liu, Xunan Liu, Junhao Lin, Patrick Wang, Biju B. Thomas, Mark S. Humayun, Qifa Zhou

“…We also address how methods such as viral transcription can be utilized to render specific neurons or organs highly responsive to ultrasound, leading to significantly improved therapeutic outcomes.…”
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Recurrences Reveal Shared Causal Drivers of Complex Time Series by William Gilpin

“…Unmeasured causal forces influence diverse experimental time series, such as the transcription factors that regulate genes or the descending neurons that steer motor circuits. Combining the theory of skew-product dynamical systems with topological data analysis, we show that simultaneous recurrence events across multiple time series reveal the structure of their shared unobserved driving signal. …”
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Genetic Rat Models of Parkinson's Disease by Ryan M. Welchko, Xavier T. Lévêque, Gary L. Dunbar

“…Parkinson’s disease (PD) is a neurodegenerative disease characterized by a specific loss of dopaminergic neurons. Although the vast majority of PD cases are idiopathic in nature, there is a subset that contains genetic links. …”
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Chronic pain in a family doctor practice – meaning, assessment, and therapeutic options by Dominika Prokop, Mikołaj Borek, Jan Baran, Dawid Rowiński, Oliwia Sikora, Katarzyna Chamera-Cyrek, Aneta Podczerwińska, Clara Kuzminski

“…Appropriately tailored therapeutic management is crucial because insufficient pain relief negatively affects the central nervous system, potentially leading to behavioural changes, emotional and psychological disorders, cognitive dysfunctions, abnormalities in cerebral blood flow, and a decrease in the number of neurons.…”
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