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2341
Action potential-like modes as modulated waves in an extended soliton model for biomembranes and nerves
Published 2025-01-01“…Accordingly, the analytical theory uses a perturbative technique, and a damped cubic–quintic nonlinear Schrödinger equation is derived, which admits a single-pulse-type solitary solution that possesses different phase characteristics of the typical neuronal Appulse structure, representative of nerve impulse profiles. …”
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2342
Molecular Imaging of Gliomas
Published 2002-10-01“…First of all, the exact localization, extent, and metabolic activity of the glioma must be determined to identify the biologically active target tissue for a biological treatment regimen; this is usually performed by imaging the expression of up-regulated endogenous genes coding for glucose or amino acid transporters and cellular hexokinase and thymidine kinase genes, respectively. Second, neuronal function and functional changes within the surrounding brain tissue have to be assessed in order to save this tissue from therapy-induced damage. …”
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2343
NDUFA11 may be the disulfidptosis-related biomarker of ischemic stroke based on integrated bioinformatics, clinical samples, and experimental analyses
Published 2025-01-01“…BackgroundProgrammed cell death plays an important role in neuronal injury and death after ischemic stroke (IS), leading to cellular glucose deficiency. …”
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2344
Pregnancy Promotes Maternal Hippocampal Neurogenesis in Guinea Pigs
Published 2019-01-01“…Time-pregnant primigravidas (3-5 months old) and age-matched nonpregnant females were examined, with neurogenic potential evaluated via immunolabeling of Ki67, Sp8, doublecortin (DCX), and neuron-specific nuclear antigen (NeuN) combined with bromodeoxyuridine (BrdU) birth-dating. …”
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2345
GsMTx-4 combined with exercise improves skeletal muscle structure and motor function in rats with spinal cord injury.
Published 2025-01-01“…On histology of rat spinal tissue, compared with SCI rats, the combined treatment significantly increased neuron counts and BDNF levels, and significantly reduced the percentage of TUNEL-positive cells (all P<0.0001). …”
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2346
Progress in the Application of Resting-State Functional Magnetic Resonance Imaging in Chronic Nonspecific Low Back Pain
Published 2025-01-01“…Resting-state functional magnetic resonance imaging (rs-fMRI) can reflect the intensity of neuronal activity to acertain extent and has unique advantages in the study of central mechanisms of CNLBP. …”
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2347
NPT1220-312, a TLR2/TLR9 Small Molecule Antagonist, Inhibits Pro-Inflammatory Signaling, Cytokine Release, and NLRP3 Inflammasome Activation
Published 2022-01-01“…A growing body of evidence suggests that excessive TLR-mediated innate immune system activation can lead to neuronal damage and precipitate or perpetuate neurodegenerative diseases. …”
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2348
Visual Outcome Ambliopia Refraktif Yang Mendapat Cam Vision Stimulator Di RS. M. Djamil Padang Januari-Desember 2017
Published 2019-09-01“…The Cambridge Amblyopic (CAM) Vision stimulator merupakan salah satu teknik pengobatan ambliopia yang bekerja sesuai teori neurofisiologi oleh Hubel dan Wiesel, dimana seluruh neuron dari kortek visual dapat diaktivasi dan pulih dengan stimulasi grating sensitivitas kontras tinggi yang berputar dengan besar spatial frequency yang berbeda. …”
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2349
Lipidopathy disrupts peripheral and central amyloid clearance in Alzheimer's disease: Where are our knowledge
Published 2025-06-01“…Amyloid-beta (Aβ) production is a normal physiological process, essential for neuronal function. However, an imbalance in Aβ production and clearance is the central pathological feature of Alzheimer’s disease (AD), leading to the accumulation of Aβ plaques in the brain. …”
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2350
Biomaterial-based strategies: a new era in spinal cord injury treatment
Published 2025-12-01“…Ideal biomaterial scaffolds should not only provide structural support for neuron migration, adhesion, proliferation, and differentiation but also mimic the mechanical properties of natural spinal cord tissue. …”
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2351
Analysis of Upper Facial Weakness in Central Facial Palsy Following Acute Ischemic Stroke
Published 2025-01-01“…Background: Central facial palsy (CFP), resulting from upper motor neuron lesions in the corticofacial pathway, is traditionally characterized by the sparing of the upper facial muscles. …”
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2352
Effect of Electroacupuncture at Shenting and Baihui Acupoints on Ability of Learning and Memory and Expression of Autophagy Related Genes and Proteins in Cerebral Ischemia-reperfus...
Published 2016-08-01“…Morris water maze experiment was used to observe learning and memory ability of rats, TTC staining was used to observe the change of brain infarction area of rats, RT-PCR and Western Blot were used to detect the expression of autophagy related genes and proteins in hippocampus.Results:④Morris water maze outcomes showed that compared with the model group, the escape latency time of rats in the EA group was obviously shortened, the number of across-platform was increased and the distance was shortened (<italic>P</italic><0.05).④Compared with the model group, the nerve defect scale of brain ischemia-reperfusion injury rats in the EA group was decreased (<italic>P</italic><0.05).④TTC staining results showed that the area of brain infarction in the EA group and model group was respectively higher than that in the sham operation group, and the volume of brain infarction in the EA group was reduced compared with the model group (<italic>P</italic><0.05).④Compared with the model group, the levels of Beclin 1, LC3Ⅰ/Ⅱand PI3K mRNA and protein in the left side of hippocampus in the EA group were increased (<italic>P</italic><0.05).Conclusion:EA at the DU24 and DU20 acupoints can reduce the cerebral infarction, and improve animal behaviors, and protect the neuronal injury. Regulation of autophagy network system may be one of the biologic mechanisms of EA improving cognitive impairment after stroke.…”
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2353
Cognitive enhancing effect of an extract of Swertia chirata against memory impairment induced by aluminum chloride
Published 2025-03-01“…Numerous studies have demonstrated that certain flavonoid antioxidants reduce oxidative stress-induced neuronal apoptosis. Results: Swertia chirata ethanolic extract exhibited longer exploration times for unfamiliar objects compared to familiar ones. …”
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2354
Population genetics of spinoсerebellar ataxias caused by polyglutamine expansions
Published 2019-07-01“…Hereditary disorders of the neuronal system are some of the most important problems of medicine in the XXI century. …”
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2355
Upregulating Nonneuronal Cholinergic Activity Decreases TNF Release from Lipopolysaccharide-Stimulated RAW264.7 Cells
Published 2014-01-01“…It has been proved that endogenous neuronal acetylcholine (ACh) could play an anti-inflammatory role, and exogenous cholinergic agonists could weaken macrophages inflammatory response to lipopolysaccharide (LPS) stimulation through activation of α7 subunit-containing nicotinic acetylcholine receptor (α7nAChR). …”
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2356
Evaluation of transcriptomic changes after photobiomodulation in spinal cord injury
Published 2025-01-01“…Key pathways were significantly enriched, including 8.6-fold enrichment of “neuron projection morphogenesis” (adjusted p = 8.10 × 10− 14), with upregulation of Notch3, Slit1/Robo2 and Sema3g pathways. …”
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2357
Evolution of Functional and Paraclinical Markers as Predictive Factors in Pediatric Late-Onset SMA Under Nusinersen Treatment: The Role of CSF pNF-H
Published 2025-12-01“…We assessed pNF-H levels in CSF and serum—neuronal proteins associated with neurodegeneration—as well as serum creatinine levels, a marker of muscle activity, and motor skill scores to evaluate pNF-H’s potential as a predictor of motor development. …”
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2358
Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trial
Published 2025-01-01“…Abstract In vitro and animal studies have suggested that inoculation with herpes simplex virus 1 (HSV-1) can lead to amyloid deposits, hyperphosphorylation of tau, and/or neuronal loss. Here, we studied the association between HSV-1 and Alzheimer’s disease biomarkers in humans. …”
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2359
Oxidative stress and dysregulated long noncoding RNAs in the pathogenesis of Parkinson’s disease
Published 2025-01-01“…Oxidative stress and lncRNAs also affect other processes associated with neurodegeneration, including mitochondrial dysfunction and increased neuroinflammation that lead to neuronal death. Therefore, modulating the levels of specific lncRNAs may alleviate pathological oxidative damage and have neuroprotective effects. …”
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2360
The Protective Effect of Docosahexaenoic Acid on Mitochondria in SH-SY5Y Model of Rotenone-Induced Toxicity
Published 2025-01-01“…<b>Methods:</b> We utilized the most common neuronal cell line (SH-SY5Y) and induced mitochondrial oxidative stress through the addition of rotenone. …”
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