Trigonelline exerts its neuroprotective effects in experimental spinal cord injury through modulation of inflammation, apoptosis, and neurotrophic factors by Zhi-Lan Ye, Yuan Cao

“…Histological examination of spinal cord tissue indicated that trigonelline significantly (P<0.05) ameliorated the histological damage caused by SCI, thereby improving neuronal degeneration, inflammatory cell infiltration, and necrosis. …”
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Do cytokines play a role in the transition from acute to chronic musculoskeletal pain? by Andrea Ebersberger, Hans-Georg Schaible

“…In numerous experimental non-human studies, cytokines have been shown to alter neuronal sensitivity in the peripheral and central nociceptive systems. …”
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The impact of apolipoprotein E, type ∊4 allele on Alzheimer's disease pathological biomarkers: a comprehensive post-mortem pilot-analysis. by Ziyu Wan, Tao Ma

“…Furthermore, our analysis does not observe dramatic neuronal changes in grey matter across the span of AD pathology. …”
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Palmitoylethanolamide, a Natural Retinoprotectant: Its Putative Relevance for the Treatment of Glaucoma and Diabetic Retinopathy by Jan M. Keppel Hesselink, Ciro Costagliola, Josiane Fakhry, David J. Kopsky

“…Since its discovery in 1957 as a biologically active component in foods and in many living organisms, around 500 scientific papers have been published on PEA’s anti-inflammatory and neuron-protective properties. PEA has been evaluated for glaucoma, diabetic retinopathy, and uveitis, pathological states based on chronic inflammation, respiratory disorders, and various pain syndromes in a number of clinical trials since the 70s of 20th century. …”
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实验性牙髓炎疼痛诱发c-fos 在中枢内的表达 by 林正梅, 程　斌, 凌均, 陈小华

“…诱痛后2 h 为Fos 免疫阳性神经元(Fos-like immunoreactivity neuron , FLN)的表达高峰, 4 h 左右开始减弱。FLN 除了密集分布在三叉 神经脊束核尾侧亚核(nucleus of the spinal tract of the trigeminal nerve , caudal par t, sp5c)的Ⅰ 、Ⅱ 层外, 极间核、口核、感觉主核、 躯体感觉皮层等可见FLN 的表达;臂旁核、室旁核、中央杏仁核等与痛调节有关的内脏中继核团亦可见FLN 的表达。…”
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Recursive seed amplification detects distinct α-synuclein strains in cerebrospinal fluid of patients with Parkinson’s disease by Stefan Bräuer, Iñaki Schniewind, Elisabeth Dinter, Björn H. Falkenburger

“…Pathologically, it is characterized by neuronal inclusions containing misfolded, fibrillar alpha-synuclein (aSyn). …”
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Tau phosphorylation suppresses oxidative stress-induced mitophagy via FKBP8 receptor modulation. by Michael O Isei, Meredith Crockett, Emily Chen, Joel Rodwell-Bullock, Trae Carroll, Peter A Girardi, Keith Nehrke, Gail V W Johnson

“…Here, we use immortalized mouse hippocampal neuronal cell lines to extend that result into mammalian cells. …”
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Decreased Hsp90 activity protects against TDP-43 neurotoxicity in a C. elegans model of amyotrophic lateral sclerosis. by Laura Garcia-Toscano, Heather N Currey, Joshua C Hincks, Jade G Stair, Nicolas J Lehrbach, Nicole F Liachko

“…Neuronal inclusions of hyperphosphorylated TDP-43 are hallmarks of disease for most patients with amyotrophic lateral sclerosis (ALS). …”
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Feasibility study of PET/CT for the detection and localization of nervous system damage caused by trimethyltin chloride by Anqing Liu, Qingqiang Tu, Ming Huang

“…Moreover, TMT induced neuronal damage within the cerebral cortex, hippocampal CA1, CA3 and DG regions as well as the cerebellum while also promoting gliosis surrounding the hippocampus. …”
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Application of Mild Therapeutic Hypothermia on Stroke: A Systematic Review and Meta-Analysis by Shaheen E. Lakhan, Fabricio Pamplona

“…Stroke occurs due to an interruption in cerebral blood supply affecting neuronal function. Body temperature on hospital admission is an important predictor of clinical outcome. …”
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Minimal presynaptic protein machinery governing diverse kinetics of calcium-evoked neurotransmitter release by Dipayan Bose, Manindra Bera, Christopher A. Norman, Yulia Timofeeva, Kirill E. Volynski, Shyam S. Krishnakumar

“…Under conditions mimicking sustained neuronal activity, the Synaptotagmin-7 fusion clamp is destabilized by the elevated basal calcium concentration, thereby enhancing the synchronous component of fusion. …”
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High-Affinity Detection of Alpha-Synuclein by Aptamer-Gold Conjugates on an Amine-Modified Dielectric Surface by Xuemei You, Subash C. B. Gopinath, Thangavel Lakshmipriya, Dingan Li

“…Alpha-synuclein is a biomarker closely correlated with the CNS and PD. The loss of neuronal cells in the substantia nigra leads to the aggregation of alpha-synuclein in the form of Lewy bodies, and Lewy neuritis is a neuropathological hallmark. …”
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Neostigmine Attenuates Proinflammatory Cytokine Expression in Preoptic Area but Not Choroid Plexus during Lipopolysaccharide-Induced Systemic Inflammation by Andrzej P. Herman, Dorota Tomaszewska-Zaremba, Marta Kowalewska, Aleksandra Szczepkowska, Małgorzata Oleszkiewicz, Agata Krawczyńska, Maciej Wójcik, Hanna Antushevich, Janina Skipor

“…It was found that this structure seems to not express the neuronal acetylcholine (ACh) receptor subunit alpha-7, required for anti-inflammatory action of ACh. …”
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Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo by Liam Kempthorne, Deniz Vaizoglu, Alexander J. Cammack, Mireia Carcolé, Martha J. Roberts, Alla Mikheenko, Alessia Fisher, Pacharaporn Suklai, Bhavana Muralidharan, François Kroll, Thomas G. Moens, Lidia Yshii, Stijn Verschoren, Benedikt V. Hölbling, Francisco C. Moreira, Eszter Katona, Rachel Coneys, Paula de Oliveira, Yong-Jie Zhang, Karen Jansen, Lillian M. Daughrity, Alexander McGown, Tennore M. Ramesh, Ludo Van Den Bosch, Gabriele Lignani, Ahad A. Rahim, Alyssa N. Coyne, Leonard Petrucelli, Jason Rihel, Adrian M. Isaacs

“…In C9orf72 patient-derived iPSC-neuron lines, CRISPR-CasRx reduces endogenous sense and antisense repeat RNAs and DPRs and protects against glutamate-induced excitotoxicity. …”
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Neural mechanisms of self-processing in autism: An ALE-based meta-analysis by Yue Yuan, Mingda Tao, Aibao Zhou, Xiangli Guan, Jiaomei Zhang

“…The findings revealed the following: (1) The capacity to make self-other distinctions and mirroring in social interactions is impacted by inadequate activation of brain areas of the mirror neuron system in ASD, which in turn impairs social interactions. (2) ASD activated more brain regions in self-processing than typically developing (TD) individuals. …”
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Mechano-gated iontronic piezomemristor for temporal-tactile neuromorphic plasticity by Xiao Wei, Zhixin Wu, Hanfei Gao, Shiqi Cao, Xue Meng, Yuqun Lan, Huixue Su, Zhenglian Qin, Hang Liu, Wenxin Du, Yuchen Wu, Mingjie Liu, Ziguang Zhao

“…Abstract In bioneuronal systems, the synergistic interaction between mechanosensitive piezo channels and neuronal synapses can convert and transmit pressure signals into complex temporal plastic pulses with excitatory and inhibitory features. …”
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Técnicas de control inteligente para el seguimiento del punto de máxima potencia en turbinas eólicas by Eduardo Muñoz-Palomeque, Jesús Enrique Sierra-García, Matilde Santos

“…Se ejemplifican dos estrategias de control inteligente: una red neuronal y un controlador de lógica borrosa. Estos enfoques se enmarcan en la regulación del par electromagnético del generador y, en consecuencia, de la velocidad angular del sistema, mejorando la generación de potencia. …”
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A multiscale model for glioma spread including cell-tissue interactions and proliferation by Christian Engwer, Markus Knappitsch, Christina Surulescu

“…Our current accounting for two subpopulations of cells to accomodate proliferation according to the go-or-grow dichtomotyis an extension of the setting in [16].As in that paper, we assume that cancer cells use neuronal fiber tracts as invasive pathways. Hence, the individualstructure of brain tissue seems to be decisive for the tumor spread. …”
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Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinoc... by Izabella Sall, Randi Foxall, Lindsey Felth, Soren Maret, Zachary Rosa, Anirudh Gaur, Jennifer Calawa, Nadia Pavlik, Jennifer L. Whistler, Cheryl A. Whistler

“…Mice that did not develop tolerance maintained a higher capacity for production of the short-chain fatty acid (SCFA) butyrate known to bolster intestinal barriers and promote neuronal homeostasis. Both fecal microbial transplantation (FMT) from donor mice that did not develop tolerance and dietary butyrate supplementation significantly reduced the development of tolerance independently of suppression of systemic inflammation. …”
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The Effect of Visual Feedback on Writing Size in Parkinson’s Disease by Adriaan R. E. Potgieser, Elizabeth Roosma, Martijn Beudel, Bauke M. de Jong

“…Both groups wrote larger without visual feedback, which adds insight in general neuronal mechanisms underlying the balance between feed-forward and feedback in visuomotor control, mechanisms that also hold for grasping movements.…”
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