CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics, Regulating Growth Cone Development and Axon Elongation by Minghui Tan, Caihui Cha, Yongheng Ye, Jifeng Zhang, Sumei Li, Fengming Wu, Sitang Gong, Guoqing Guo

“…Collapsin response mediator proteins (CRMPs) are highly expressed in the developing nervous system, mediating growth cone guidance, neuronal polarity, and axonal elongation. However, whether and how CRMPs associate with microtubules and actin coordinated cytoskeletal dynamics remain unknown. …”
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Review on dietary supplements as an effective improvement of Alzheimer’s disease: focus on structures and mechanisms by Sheng Li, Yinling Wei, Zhenzhen Liang, Lingli Guo, Xiaojiang Hao, Yu Zhang

“…Especially with the widespread use of DSs, DSs containing polyphenols, alkaloids, terpenes, polysaccharides and other bioactive components can prevent AD by reducing Aβ deposition, inhibiting tau protein hyperphosphorylation, reconstructing synaptic dysfunction, weakening cholinesterase activity, regulating mitochondrial oxidative stress, neuronal inflammation and apoptosis. This review summarizes the anti-AD effects of the main DSs and their bioactive constituents, as well as the potential molecular mechanisms covers from 2017 to 2023. …”
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The Role of “Mixed” Orexigenic and Anorexigenic Signals and Autoantibodies Reacting with Appetite-Regulating Neuropeptides and Peptides of the Adipose Tissue-Gut-Brain Axis: Releva... by Kvido Smitka, Hana Papezova, Karel Vondra, Martin Hill, Vojtech Hainer, Jara Nedvidkova

“…Parasympathetic, sympathetic, and serotoninergic systems are required for communication between brain satiety centre, gut, and AT. These neuronal circuits include neuropeptides ghrelin, neuropeptide Y (NPY), peptide YY (PYY), cholecystokinin (CCK), leptin, putative anorexigen obestatin, monoamines dopamine, norepinephrine (NE), serotonin, and neutralizing autoantibodies. …”
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The role of KLF4 in human primordial germ cell development by Sun-Min Lee, Merrick Pierson Smela, M. Azim Surani

“…Cut-and-run and transcriptomic analyses reveal that KLF4 represses somatic markers involved in neuronal and endodermal differentiation while promoting the expression of genes associated with PGC specification, such as PAX5, and epigenetic regulators, including DNMT3L and REST. …”
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Molecular logic for cellular specializations that initiate the auditory parallel processing pathways by Junzhan Jing, Ming Hu, Tenzin Ngodup, Qianqian Ma, Shu-Ning Natalie Lau, M. Cecilia Ljungberg, Matthew J. McGinley, Laurence O. Trussell, Xiaolong Jiang

“…Abstract The cochlear nuclear complex (CN), the starting point for all central auditory processing, encompasses a suite of neuronal cell types highly specialized for neural coding of acoustic signals. …”
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Effect of the Entorhinal Cortex on Ictal Discharges in Low-Mg2+-Induced Epileptic Hippocampal Slice Models by Ye-Jun Shi, Xin-Wei Gong, Hai-Qing Gong, Pei-Ji Liang, Pu-Ming Zhang, Qin-Chi Lu

“…Here, multielectrode recording techniques were used to study the spatiotemporal characteristics of epileptiform discharges in adult mouse hippocampal slices and combined EC-hippocampal slices and determine whether and how the EC affects the hippocampal neuron discharge patterns. The results showed that low-Mg2+ artificial cerebrospinal fluid induced interictal discharges in hippocampal slices, whereas, in combined EC-hippocampal slices the discharge pattern was alternated between interictal and ictal discharges, and ictal discharges initiated in the EC and propagated to the hippocampus. …”
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Advances in synaptic PET imaging and intervention with synapse-targeted small-molecular drugs for dementia diagnosis and therapy by Xiuhong Lu, Bin Ji, Gang Huang, Hong Ding

“…Dementia is characterized by synaptic and neuronal dysfunction in disease-specific brain regions. …”
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Técnicas de planificación para optimizar el rendimiento de los sistemas de tiempo real multiprocesador by José María Aceituno, Ana Guasque, Patricia Balbastre, José Simó, Carlos Eduardo Pereira, Alfons Crespo

“…Además, se propone una red neuronal artificial para predecir qué política de alojamiento se debe aplicar para minimizar la longitud de los intervalos que forman el plan temporal y así reducir la complejidad de planificación de cada intervalo.…”
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MT-100, a human Tie2-agonistic antibody, improves penile neurovasculature in diabetic mice via the novel target Srpx2 by Fang-Yuan Liu, Young-Lai Cho, Fitri Rahma Fridayana, Lashkari Niloofar, Minh Nhat Vo, Yan Huang, Anita Limanjaya, Mi-Hye Kwon, Jiyeon Ock, Seon-Jin Lee, Guo Nan Yin, Nam-Kyung Lee, Ji-Kan Ryu

“…This regulation led to the survival of vascular and neuronal cells, a reduction in the production of reactive oxygen species (ROS), activation of the PI3K/AKT/eNOS signaling pathway, increased expression of neurotrophic factors, and ultimately alleviation of ED in diabetic mice. …”
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Cardiorespiratory dynamics in the brain: Review on the significance of cardiovascular and respiratory correlates in functional MRI signal by Mahathi Kandimalla, Seokbeen Lim, Jay Thakkar, Sannidhi Dewan, Daehun Kang, Myung-Ho In, Hang Joon Jo, Dong Pyo Jang, Zuzana Nedelska, Maria I. Lapid, Yunhong Shu, Cheon-Pyung, Petrice M. Cogswell, Val J. Lowe, Jeyeon Lee, Hoon-Ki Min

“…We also discuss the complexities of distinguishing these signals from neuronal activity in fMRI data, given their significant contribution to signal variability and interactions with cerebrospinal fluid (CSF). …”
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Stress-Induced Changes in the Gastrointestinal Motor System by Victor Plourde

“…These various responses to stress are presumably attributed to the preferential activation of specific neuronal pathways under the influence of a given stimulus or its intensity. …”
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Effect of Hemin on Brain Alterations and Neuroglobin Expression in Water Immersion Restraint Stressed Rats by Merhan Ragy, Fatma Ali, Maggie M. Ramzy

“…Hemin as HO-1 inducer has been shown to attenuate neuronal injury so the goal of this study was to assess the effect of hemin therapy on the acute stress and how it would modulate neurological outcome. …”
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CREB Regulates Experience-Dependent Spine Formation and Enlargement in Mouse Barrel Cortex by Annabella Pignataro, Antonella Borreca, Martine Ammassari-Teule, Silvia Middei

“…Experience modifies synaptic connectivity through processes that involve dendritic spine rearrangements in neuronal circuits. Although cAMP response element binding protein (CREB) has a key function in spines changes, its role in activity-dependent rearrangements in brain regions of rodents interacting with the surrounding environment has received little attention so far. …”
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Botulinum Therapy for Pain Caused by Spasticity in Advanced Stages of Brain Tumor in Adolescents: A Case Report by Tomoo Mano, Toshiharu Murakami, Haruki Mori, Takashi Masuda

“…Background: Spasticity is an upper motor neuron syndrome that exacerbates motor paralysis and is rarely associated with pain. …”
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Trimethyltin-Induced Microglial Activation via NADPH Oxidase and MAPKs Pathway in BV-2 Microglial Cells by Da Jung Kim, Yong Sik Kim

“…Trimethyltin (TMT) is known as a potent neurotoxicant that causes neuronal cell death and neuroinflammation, particularly in the hippocampus. …”
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Comparison of Two Classifiers; K-Nearest Neighbor and Artificial Neural Network, for Fault Diagnosis on a Main Engine Journal-Bearing by A. Moosavian, H. Ahmadi, A. Tabatabaeefar, M. Khazaee

“…Variable K value and hidden neuron count (N) were used in the range of 1 to 20, with a step size of 1 for KNN and ANN to gain the best classification results. …”
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Possible Involvement of TLRs and Hemichannels in Stress-Induced CNS Dysfunction via Mastocytes, and Glia Activation by Adam Aguirre, Carola J. Maturana, Paloma A. Harcha, Juan C. Sáez

“…Consequently, activated microglia and astrocytes release ATP and glutamate, affecting myelinization, neuronal development, and survival. Binding of ligands to TLRs induces a cascade of intracellular events leading to activation of several transcription factors that regulate the expression of many genes involved in inflammation. …”
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Parkinson’s disease and exosomes: from pathogenesis to diagnosis and treatment by A. Mišeikaitė, P. Vaitkienė

“…Although the clinical symptoms, neuronal changes, and various molecular mechanisms involved in this neuropathological disorder have been studied for many years, the diagnosis and treatment of the disease remain challenging. …”
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Dynamic Network-Based Relevance Score Reveals Essential Proteins and Functional Modules in Directed Differentiation by Chia-Chou Wu, Che Lin, Bor-Sen Chen

“…During the differentiation process, the proteins and functional modules with higher relevance scores also became more specific to the neuronal identity. Ultimately, the essential components revealed by the relevance scores may play a role in controlling the direction of differentiation. …”
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The Tao of Hematopoietic Stem Cells: Toward a Unified Theory of Tissue Regeneration by Kevin D. Bunting, Robert G. Hawley

“…However, recent studies have suggested that a subpopulation of HSCs may have the ability to contribute to diverse cell types such as hepatocytes, myocytes, and neuronal cells, especially following induced tissue damage. …”
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