-
2061
Discriminative training of spiking neural networks organised in columns for stream‐based biometric authentication
Published 2022-09-01“…A network structure based on neuron columns is proposed, resembling cortical columns in the human cortex, and a new derivation of error backpropagation for the spiking neural networks that integrate the lateral inhibition in these structures. …”
Get full text
Article -
2062
Neuroinflammation and ALS: Transcriptomic Insights into Molecular Disease Mechanisms and Therapeutic Targets
Published 2017-01-01“…Despite the mechanism underlying motor neuron death is not yet clarified, multiple pathogenic processes have been proposed to account for ALS. …”
Get full text
Article -
2063
The consistency of vitamin B12 in marketed microalgae powders
Published 2024-12-01“…Vitamin B12 is a water nutrient that plays a key role, in DNA replication and the production of red blood cells as well as maintaining proper neuron function in the body system. Insufficient levels of this vitamin can result in health complications like megaloblastic anemia. …”
Get full text
Article -
2064
Using cortical organoids to understand the pathogenesis of malformations of cortical development
Published 2025-01-01“…Widespread abnormalities in neuronal formation or migration can lead to small head size or microcephaly with disorganized placement of cell types. …”
Get full text
Article -
2065
Transspieces Kitchen
Published 2025-02-01“…La arquitectura es la manera en que las diferentes formas de vida ejecutan su entrelazamiento físico, neuronal y metabólico - cómo se constituyen a sí mismas como algo inseparable. …”
Get full text
Article -
2066
Brain receptor dynamics in early and adult life stress: Gateways to maladaptive coping strategies
Published 2025-01-01“…The brain receptor molecules are key mediators of these processes, translating neuromodulatory signals into neuronal responses or circuit activity changes that ultimately shape behavioral outcomes. …”
Get full text
Article -
2067
Caffeine-Induced Suppression of GABAergic Inhibition and Calcium-Independent Metaplasticity
Published 2016-01-01“…GABAergic inhibition plays a critical role in the regulation of neuron excitability; thus, it is subject to modulations by many factors. …”
Get full text
Article -
2068
Forebrain Ischemia-Reperfusion Simulating Cardiac Arrest in Mice Induces Edema and DNA Fragmentation in the Brain
Published 2007-05-01“…This model is known to induce neuronal death in the hippocampus, striatum, and cortex. …”
Get full text
Article -
2069
Synaptic plasticity in fronto-insular circuits underlying stress susceptibility and resilience
Published 2025-02-01“…In the short term, stress effects on neuronal activity may be adaptive, but repeated engagement of these adaptations may lead to circuit dysfunction—a phenomenon known as allostatic load. …”
Get full text
Article -
2070
Cox-2 Plays a Vital Role in the Impaired Anxiety Like Behavior in Colchicine Induced Rat Model of Alzheimer Disease
Published 2016-01-01“…Results indicate that the parameters of anxiety were dependent on neuronal circuitries that were probably sensitive to etoricoxib induced blocking of neurodegeneration. …”
Get full text
Article -
2071
Aduhelm, a novel anti-amyloid monoclonal antibody, for the treatment of Alzheimer’s Disease: A comprehensive review
Published 2022-07-01“…Studies show Adulhelm may help to restore neurological function in patients with AD by reducing beta-amyloid plaques and reestablishing neuronal calcium permeability. At present, there is concern the magnitude of this drug's benefit may only be statistically significant, although not clinically significant. …”
Get full text
Article -
2072
Changes in Muscles and Tendons Due to Neural Motor Disorders: Implications for Therapeutic Intervention
Published 2001-01-01“…Patients with an upper motor neurone syndrome (CP) suffer from many disabling primary symptoms: spasms, weakness, and loss of dexterity. …”
Get full text
Article -
2073
A Novel Heterozygous De Novo MORC2 Missense Variant Causes an Early Onset and Severe Neurodevelopmental Disorder
Published 2024-01-01“…MORC2 may have a role in the development of neurones, and dominant variants in this gene have recently been linked with disorders including Charcot-Marie-Tooth type 2Z disease, spinal muscular atrophy and, more recently, a neurodevelopmental syndrome consisting of developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy (DIGFAN), presenting with hypotonia, microcephaly, brain atrophy, intellectual disability, hearing loss, faltering growth, and craniofacial dysmorphism. …”
Get full text
Article -
2074
The Neurobiological Pathogenesis of Poststroke Depression
Published 2014-01-01“…The pathogenesis of PSD is complicated, with some special neurobiological mechanism, which mainly involves neuroanatomical, neuron, and biochemical factors and neurogenesis which interact in complex ways. …”
Get full text
Article -
2075
A combination of topical and systemic administration of brimonidine is neuroprotective in the murine optic nerve crush model.
Published 2024-01-01“…Animals were sacrificed seven days post-ONC, and immunohistochemical staining of retinal whole mounts was performed using neuronal NeuN and GFAP staining. Microscopic pictures of the central, middle, and peripheral regions of the retina were taken. …”
Get full text
Article -
2076
Applications of Deep Learning in the Evaluation and Analysis of College Students’ Mental Health
Published 2022-01-01“…Secondly, through the expansion and utilization of multi-layer neuron self-coding neural network, the psychological health of college students is evaluated and analyzed in the psychological discipline, the discrete data structure is established by using the relevant psychological data, the psychological behavior of college students is analyzed, summarized, and classified, and the data model is filled to judge the mental health status of college students. …”
Get full text
Article -
2077
Rationale for the Use of Cord Blood in Hypoxic-Ischaemic Encephalopathy
Published 2022-01-01“…In several animal models of HIE, CB decreased oxidative stress, cell death markers, CD4+ T cell infiltration, and microglial activation; restored normal brain metabolic activity; promoted neurogenesis; improved myelination; and increased the proportion of mature oligodendrocytes, neuron numbers in the motor cortex and somatosensory cortex, and brain weight. …”
Get full text
Article -
2078
Translational Approach to Behavioral Learning: Lessons from Cerebellar Plasticity
Published 2013-01-01“…The privileged relationship between the cerebellum and the inferior olive offers an ideal circuit for attempting to integrate the numerous evidences of neuronal plasticity into a translational perspective. …”
Get full text
Article -
2079
Rodent Models of Developmental Ischemic Stroke for Translational Research: Strengths and Weaknesses
Published 2019-01-01“…Timing of the lesion occurrence seems to be critical, as it strongly interferes with neuronal circuit development and determines the way spontaneous plasticity takes place. …”
Get full text
Article -
2080
A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines
Published 2012-01-01“…An important factor in the onset of inflammatory process is the overexpression of interleukin (IL)-1, which produces many reactions in a vicious circle that cause dysfunction and neuronal death. Other important cytokines in neuroinflammation are IL-6 and tumor necrosis factor (TNF)-α. …”
Get full text
Article