Dysregulation of REST and its target genes impacts the fate of neural progenitor cells in down syndrome by Tan Huang, Sharida Fakurazi, Pike-See Cheah, King-Hwa Ling

“…Downregulation of REST may lead to defects in post-differentiation neuronal morphology in the brain of the DS fetal. This study aims to elucidate the role of REST in DS-derived NPCs using bioinformatics analyses and laboratory validations. …”
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Multifaceted neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) in Alzheimer’s disease: an overview of pre-clinical studies focused on β-amyloid peptide by Kumju Youn, Chi-Tang Ho, Mira Jun

“…Many lines of evidence indicate that excessive β-amyloid peptide (Aβ) generation and aggregation play pivotal roles in the initiation of AD, leading to various biochemical alteration including oxidative damage, mitochondrial dysfunction, neuroinflammation, signaling pathway and finally resulting in neuronal death. AD has a complex pathogenic mechanism, and a single-target approach for anti-AD strategy is thus full of challenges. …”
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Super-enhancers and efficacy of triptolide in small cell carcinoma of the ovary hypercalcemic type by Jessica D. Lang, William Selleck, Shawn Striker, Nicolle A. Hipschman, Rochelle Kofman, Anthony N. Karnezis, Felix K.F. Kommoss, Friedrich Kommoss, Jae Rim Wendt, Salvatore J. Facista, William P.D. Hendricks, Krystal A. Orlando, Patrick Pirrotte, Elizabeth A. Raupach, Victoria L. Zismann, Yemin Wang, David G. Huntsman, Bernard E. Weissman, Jeffrey M. Trent

“…This may further support neuronal cell-of-origin previously proposed. We found high sensitivity of SCCOHT cell lines to triptolide. …”
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The WAVE complex in developmental and adulthood brain disorders by Hyung-Goo Kim, Clara Berdasco, Angus C. Nairn, Yong Kim

“…Abstract Actin polymerization and depolymerization are fundamental cellular processes required not only for the embryonic and postnatal development of the brain but also for the maintenance of neuronal plasticity and survival in the adult and aging brain. …”
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Enhancing Convolutional Neural Network Robustness Against Image Noise via an Artificial Visual System by Bin Li, Yuki Todo, Sichen Tao, Cheng Tang, Yu Wang

“…In this study, we investigate the mechanism of neuron orientation selectivity and develop an artificial visual system (AVS) referring to the structure of the primary visual system. …”
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Proteomic profiling identifies muscle-invasive bladder cancers with distinct biology and responses to platinum-based chemotherapy by A. Contreras-Sanz, G. L. Negri, M. J. Reike, H. Z. Oo, J. M. Scurll, S. E. Spencer, K. Nielsen, K. Ikeda, G. Wang, C. L. Jackson, S. Gupta, M. E. Roberts, D. M. Berman, R. Seiler, G. B. Morin, P. C. Black

“…For example, MTOR and PARP are over-expressed at the protein level in tumours identified as neuronal-like. In addition, we determine that high intra-tumoural proteome heterogeneity in pre-neoadjuvant chemotherapy tissue is associated with worse prognosis. …”
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A Rare Case of Paraneoplastic Syndrome Presented with Severe Gastroparesis due to Ganglional Loss by Konstantinos N. Argyriou, Martin Peters, Javaid Ishtiaq, Santosh Enaganti

“…These syndromes can generally involve any organic system of the human body with gastroparesis being the commonest manifestation of the paraneoplastic involvement of the neuronal bodies of the gastrointestinal tract in cancer patients. …”
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Cognitive disorders: Potential astrocyte-based mechanism by Shiyu Li, Yeru Chen, Gang Chen

“…Neurodegenerative diseases are a common type of organic disease related to the pathology of neuronal death and disruption of glial cell balance, ultimately accompanied with cognitive impairment. …”
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Non‐Invasive Photoacoustic Cerebrovascular Monitoring of Early‐Stage Ischemic Strokes In Vivo by Jiwoong Kim, Joo Young Kweon, Seongwook Choi, Hyunseo Jeon, Minsik Sung, Rongkang Gao, Chengbo Liu, Chulhong Kim, Yong Joo Ahn

“…Abstract Early‐stage stroke monitoring enables timely intervention that is crucial to minimizing neuronal damage and increasing the extent of recovery. …”
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Integrating molecular photoswitch memory with nanoscale optoelectronics for neuromorphic computing by David Alcer, Nelia Zaiats, Thomas K. Jensen, Abbey M. Philip, Evripidis Gkanias, Nils Ceberg, Abhijit Das, Vidar Flodgren, Stanley Heinze, Magnus T. Borgström, Barbara Webb, Bo W. Laursen, Anders Mikkelsen

“…The dye acts as synaptic weights in the optical interconnects, while the nano-optoelectronics provide neuron reception, interpretation and emission of light signals. …”
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Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases by Leilei Chen, Qingqing Shen, Yingjuan Liu, Yunqi Zhang, Liping Sun, Xizhen Ma, Ning Song, Junxia Xie

“…However, an imbalance in metal ions, whether excessive or insufficient, is detrimental and can contribute to neuronal death through oxidative stress, ferroptosis, cuproptosis, cell senescence, or neuroinflammation. …”
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Designs of Biomaterials and Microenvironments for Neuroengineering by Yanru Yang, Yuhua Zhang, Renjie Chai, Zhongze Gu

“…In addition, we compose a conductive patterned compounded biomaterial, which could mimic neuronal microenvironment for neuroengineering by concentrating the advantage of such biomaterials.…”
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Neurotoxicological Effects of Some Mycotoxins on Humans Health and Methods of Neuroprotection by Aleksandra Kuć-Szymanek, Daria Kubik-Machura, Klaudia Kościelecka, Tomasz Męcik-Kronenberg, Lidia Radko

“…They are mainly related to the increase in oxidative stress in neuronal cells, which leads to higher levels of pro-inflammatory cytokines as IL-1β, IL-6 and TNF-α, enzymatic activity as GST, GPx, CAT and SOD and neurotransmitter dysfunction (5-HT, serotonin, dopamine and GABA). …”
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Direct‐Print 3D Electrodes for Large‐Scale, High‐Density, and Customizable Neural Interfaces by Pingyu Wang, Eric G. Wu, Hasan Uluşan, Eric Tianjiao Zhao, A.J. Phillips, Alexandra Kling, Madeline Rose Hays, Praful Krishna Vasireddy, Sasidhar Madugula, Ramandeep Vilkhu, Andreas Hierlemann, Guosong Hong, E.J. Chichilnisky, Nicholas A. Melosh

“…This approach enables customizable electrode shape, height, and positioning for precise targeting of neuron populations distributed in 3D. The effectiveness of this approach is demonstrated in tackling the critical challenge of interfacing with the retina—specifically, selectively targeting retinal ganglion cell (RGC) somas while avoiding the axon bundle layer. 6,600‐microelectrode, 35 µm pitch, tissue‐penetrating arrays are fabricated to obtain high‐fidelity, high‐resolution, and large‐scale retinal recording that reveals little axonal interference, a capability previously undemonstrated. …”
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Cortical Reorganization following Injury Early in Life by Moran Artzi, Shelly Irene Shiran, Maya Weinstein, Vicki Myers, Ricardo Tarrasch, Mitchell Schertz, Aviva Fattal-Valevski, Elka Miller, Andrew M. Gordon, Dido Green, Dafna Ben Bashat

“…Brain reorganization of the gray matter within the CLH, while not necessarily indicating better outcome, is suggested as a response to neuronal deficits following injury early in life.…”
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A multi-channel bioimpedance-based device for Vietnamese hand gesture recognition by Nhat-Minh Than, Son-Thuy Nguyen, Dang-Nguyen Huynh, Thao-Nguyen Tran, Nguyen-Khoa Le, Huu-Xuan Mai, Cao-Dang Le, Tan-Thi Pham, Quang-Linh Huynh, Trung-Hau Nguyen

“…To categorize hand gestures, Convolutional Neuron Network (CNN), XGBoost, and Random Forest were used. …”
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Sleep in Genetically Confirmed Pantothenate Kinase-Associated Neurodegeneration: A Video-Polysomnographic Study by Maria Livia Fantini, Giovanni Cossu, Andrea Molari, Monia Cabinio, Ozlem Uyanik, Roberto Cilia, Maurizio Melis, Angelo Antonini, Luigi Ferini-Strambi

“…Patients show iron accumulation in the basal ganglia, with neuronal loss and gliosis. A mutation of pantothenate kinase (PANK2) gene localized on chromosome 20p13 has been described in familiar forms, as well as in sporadic patients. …”
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Effet de l'illumination proche infra-rouge intracérébrale chez des primates MPTP by Fannie Darlot, Cécile Moro, Napoléon Torres‑Martinez, Claude Chabrol, Florian Reinhart, Diane Agay, Thomas Costecalde, John Mitrofanis, Alim‑Louis Benabid

“…La maladie de Parkinson (MP) est une maladie neurodégénérative chronique affectant le système dopaminergique et se traduisant par une perte des neurones dopaminergiques (DA) de la substance noire compacta (SNc) et des faisceaux nigro-striés. …”
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Intracalvariosseous injection: an approach for central nervous system drug delivery through skull bone marrow with a preclinical research in strokeResearch in context by Wenqian Liu, Mo Yang, Nanxing Wang, Xiangrong Liu, Chaoyu Wang, Kaibin Shi, Fu-Dong Shi, Yuesong Pan, Mingjun Zhang, Zhiwei Sun, Yongjun Wang, Yilong Wang

“…In the treatment of stroke with neuroprotective agents, although the drug dosage of ICO injection was lower than intravenous injection, drug accumulation in the brain increased after ICO injection, which helped repair nerve damage, reduce neuronal apoptosis, and decrease the expression of inflammatory factors. …”
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Response Features Determining Spike Times by Barry J. Richmond, Mike W. Oram, Matthew C. Wiener

“…Interpreting messages encoded in single neuronal responses requires knowing which features of the responses carry information. …”
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