Modulation of brain glutamate dehydrogenase as a tool for controlling seizures by Rasgado Lourdes A. Vega, Reyes Guillermo Ceballos, Díaz Fernando Vega

“…GDH represents an important regulation point of neuronal excitability, and modulation of its activity represents a potential target for metabolic treatment of epilepsy and for the development of new AEDs.…”
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Rare Manifestation of a c.290 C>T, p.Gly97Glu VCP Mutation by Nivedita U. Jerath, Cameron D. Crockett, Steven A. Moore, Michael E. Shy, Conrad C. Weihl, Tsui-Fen Chou, Tiffany Grider, Michael A. Gonzalez, Stephan Zuchner, Andrea Swenson

“…Our patient reflects the clinical heterogeneity of VCP mutations, as his neurological localization is a spectrum between a lower motor neuron disorder and a hereditary axonal peripheral neuropathy such as CMT2. …”
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Alpha-Lipoic Acid Attenuates Cerebral Ischemia and Reperfusion Injury via Insulin Receptor and PI3K/Akt-Dependent Inhibition of NADPH Oxidase by Yinhua Dong, Hongxin Wang, Zefeng Chen

“…In the present study, administration of ALA (40 mg/kg, i.p.) for 3 days resulted in a significant decrease in neuronal deficit score and infarct volume and a significant increase in grip time and latency time in Morris water maze at 48 h after middle cerebral artery occlusion and reperfusion (MCAO/R) in rats. …”
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The Role of FRMD7 in Idiopathic Infantile Nystagmus by Rachel J. Watkins, Mervyn G. Thomas, Chris J. Talbot, Irene Gottlob, Sue Shackleton

“…Limited studies together with the knowledge of the function of other FERM domain containing proteins, suggest that FRMD7 may play a role in membrane extension during neuronal development through remodeling of the actin cytoskeleton.…”
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Perfusion Imaging in Autoimmune Encephalitis by Deepak Vallabhaneni, Muhammad Atif Naveed, Rajiv Mangla, Awss Zidan, Rashi I. Mehta

“…Autoimmune encephalitis is caused by antibodies against neuronal synaptic receptors, surface proteins, or intracellular proteins. …”
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The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms by Wenli Jiao, Jiayi Lin, Yanfang Deng, Yelin Ji, Chuoyi Liang, Sijia Wei, Xi Jing, Fengxia Yan

“…Within the central nervous system, aberrant microglial and astrocytes activation, cytokine imbalances, and compromised blood-brain barrier integrity propagate neuroinflammation, disrupting neurotransmission, impairing neuroplasticity, and promoting neuronal injury. The crosstalk between peripheral and central immunity creates a vicious cycle exacerbating depressive neuropathology. …”
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Identification of C-Kit-Positive Interstitial Cells in the Dog Lower Urinary Tract and Relationship with Smooth Muscle and Nerves. Hypotheses for a Likely Pacemaker Role. by Silvana Arrighi, Giampaolo Bosi, Debora Groppetti, Fausto Cremonesi

“…The roles of interstitial cells might include regulation of smooth muscle activity of the bladder detrusor, integrating neuronal signals during urine storage and voiding.…”
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Neural network-based robot localization using visual features by Felipe Trujillo-Romero

“…The map is modeled using a neural network, where each neuron corresponds to an absolute position in the room. …”
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Photoinduced hidden monoclinic metallic phase of VO2 driven by local nucleation by Feng-Wu Guo, Wen-Hao Liu, Zhi Wang, Shu-Shen Li, Lin-Wang Wang, Jun-Wei Luo

“…Abstract The insulator-to-metal transition in VO2 has garnered extensive attention for its potential applications in ultrafast switches, neuronal network architectures, and storage technologies. …”
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VDAC1: A Key Player in the Mitochondrial Landscape of Neurodegeneration by Shirel Argueti-Ostrovsky, Shir Barel, Joy Kahn, Adrian Israelson

“…The pivotal functions of VDAC1 in controlling mitochondrial membrane permeability, regulating calcium balance, and facilitating programmed cell death pathways, position it as a key determinant in the delicate balance between neuronal viability and degeneration. Accordingly, increasing evidence suggests that VDAC1 is implicated in the pathophysiology of neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and others. …”
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Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian Brain by Edoardo Parrella, Valter D. Longo

“…We will discuss how the “molecular strategy” responsible for life span extension in response to dietary and genetic manipulations appears to be remarkably conserved in various organisms and cells, including neuronal cells in different organisms. Taken together, these studies indicate that simple model systems will contribute to our comprehension of aging of the mammalian nervous system and will stimulate novel neurotherapeutic strategies in humans.…”
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Regulation of Posttranscriptional Modification as a Possible Therapeutic Approach for Retinal Neuroprotection by Yoko Ozawa, Toshihide Kurihara, Kazuo Tsubota, Hideyuki Okano

“…This latter effect may decrease synaptic activity, in turn adversely affecting neuronal survival. Both mechanisms involve increased UPS activity and the subsequent excessive degradation of a protein required for visual function. …”
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Novel Strategies for the Improvement of Stem Cells’ Transplantation in Degenerative Retinal Diseases by Simona Delia Nicoară, Sergiu Șușman, Oana Tudoran, Otilia Bărbos, Gabriela Cherecheș, Simion Aștilean, Monica Potara, Olga Sorițău

“…The main sources of SCs for the treatment of retinal diseases are the embryo, the bone marrow, the region of neuronal genesis, and the eye. The success of transplantation depends on the origin of cells, the route of administration, the local microenvironment, and the proper combinative formula of growth factors. …”
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Toll-Like Receptor 4: A Promising Therapeutic Target for Alzheimer’s Disease by Linyu Wu, Xiaohui Xian, Guangyu Xu, Zixuan Tan, Fang Dong, Min Zhang, Feng Zhang

“…Activation of TLR4 induces downstream signaling pathways and promotes the generation of proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β), which also trigger the activation of astrocytes and influence amyloid-dependent neuronal death. Therefore, TLR4 may be an important molecular target for treating AD by regulating neuroinflammation. …”
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Glucose metabolism impairment in major depressive disorder by Fanhao Meng, Jing Wang, Long Wang, Wei Zou

“…These impairments may result from mechanisms including insulin resistance, hyperglycemia-induced damage, oxidative stress, astrocyte abnormalities, and mitochondrial dysfunction, leading to insufficient energy supply, altered synaptic plasticity, neuronal cell death, and functional and structural damage to reward networks. …”
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Distinct patterns of prion strain deposition and toxicity in a novel whole brain organotypic slice culture system by Hailey Pineau, Valerie L. Sim

“…We have adapted this approach to a coronally sliced whole brain organotypic culture and demonstrate distinct profiles of cytotoxicity and neuronal loss upon exposure to four mouse-adapted scrapie strains. …”
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Autoimmune encephalitis: case reports of anti-NMDAR and anti-CASPR2 encephalitides and literature review by J. Kazlauskaitė, N. Giedraitienė, R. Masaitienė, A. Klimašauskienė

“…In clinical practice, neuronal antibodies remain the most significant diagnostic marker currently available. …”
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Identification of Molecular Substrate for the Attenuation of Anxiety: A Step Toward the Development of Better Anti-Anxiety Drugs by Uwe Rudolph

“…Synaptically released GABA binds to postsynaptic GABAA receptors, thus causing an influx of negatively charged chloride ions into the postsynaptic neuron. This leads to a hyperpolarization and thus functional inhibition of the postsynaptic cell. …”
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Aetiology of Vertigo as Seen at the Federal Medical Center Lokoja, North Central Nigeria by Stephen Agbomhekhe Ogah

“…Bengin Paroxysmal Positional Vertigo (BPPV) 22(44%) was the commonest aetiology found followed by Meniere's disease 8(16%), trauma 7(14%) and Vestibular Neuronitis 5(10%) respectively. Keywords: Aetiology, vertigo, BPPV, Meniere's disease.…”
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Guillain–Barre syndrome: An atypical presentation of IRIS on initiation of antiretroviral therapy in a newly diagnosed HIV infected by Hardik Patel, Debajyoti Majumdar, Dolanchampa Modak

“…On evaluation, he had symmetrical quadriparesis in the form of motor weakness, loss of posterior column sense, bulbar involvement and bilateral facial lower motor neuron nerve palsy with areflexia. Elevated protein was detected in cerebrospinal fluid. …”
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