A cortico-subcortical loop for motor control via the pontine reticular formation by Emília Bősz, Viktor M. Plattner, László Biró, Kata Kóta, Marco A. Diana, László Acsády

“…Summary: Movement and locomotion are controlled by large neuronal circuits like the cortex-basal ganglia (BG)-thalamus loop. …”
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Development of Microneedle Patch Loaded with Bacopa monnieri Solid Lipid Nanoparticles for the Effective Management of Parkinson’s Disease by Delna Joy, Jobin Jose, Shabana Bibi, Akshay Bandiwadekar, Gopika Gopan, Clara Mariana Gonçalves Lima, Talha Bin Emran, Fahad A. Alhumaydhi, Harsha Ashtekar, Sandeep D. S, Carlos Adam Conte-Junior

“…Herbal products for PD have been shown to have antioxidant effects in reducing dopaminergic neurons from degeneration. Here, we attempted to incorporate solid lipid nanoparticles (SLNs) of Bacopa monnieri into dissolvable microneedle arrays and evaluate its neuroprotective activity. …”
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Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model by Hyun Ho Jung, Jaewoo Shin, Jinhyung Kim, Seung-Hee Ahn, Sung Eun Lee, Chin Su Koh, Jae Sung Cho, Chanho Kong, Hyung-Cheul Shin, Sung June Kim, Jin Woo Chang

“…Also, we simultaneously recorded neuronal activity (NP; n=9) in the thalamus of the ventral posterolateral nucleus and RAIC to evaluate electrophysiological changes from MCS. …”
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Enhanced glycolysis-derived lactate promotes microglial activation in Parkinson’s disease via histone lactylation by Qixiong Qin, Danlei Wang, Yi Qu, Jiangting Li, Ke An, Zhijuan Mao, Jingyi Li, Yongjie Xiong, Zhe Min, Zheng Xue

“…Here, we demonstrated that inhibiting glycolysis with 2-deoxy-d-glucose alleviates microgliosis, neuroinflammation and dopaminergic neurons damage by reducing lactate accumulation in PD mice. …”
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Prosthetic Hand Based on Human Hand Anatomy Controlled by Surface Electromyography and Artificial Neural Network by Larisa Dunai, Isabel Seguí Verdú, Dinu Turcanu, Viorel Bostan

“…These signals were used for feature extraction and classification using an artificial neuronal network. The model converges after 10 sessions, achieving 98% accuracy. …”
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A Muscle-Specific Rehabilitation Training Method Based on Muscle Activation and the Optimal Load Orientation Concept by Zhibin Song, Chao Nie, Shuyang Li, Paolo Dario, Jian S. Dai

“…In this paper, a muscle-specific rehabilitation training method based on the optimal load orientation concept (OLOC) was proposed for patients whose motor neurons are injured, but whose muscles and tendons are intact, to implement high-efficiency resistance training for the shoulder muscles, which is one of the most complex joints in the human body. …”
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Co-targeting of glial activation and inflammation by tsRNA-Gln-i-0095 for treating retinal ischemic pathologies by Ying Zhang, Yan Ma, Yu-Ke Ji, Yi-Fei Jiang, Duo Li, Wan Mu, Mu-Di Yao, Jin Yao, Biao Yan

“…These effects led to reduced structural and functional damage, inhibited glial activation and inflammation, and enhanced neuronal function. Mechanistically, tsRNA-Gln-i-0095 downregulated the expression of NFIA and TGFBR2 through a miRNA-like mechanism. …”
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USP14 is crucial for proteostasis regulation and α-synuclein degradation in human SH-SY5Y dopaminergic cells by Vignesh Srinivasan, Rabah Soliymani, Larisa Ivanova, Ove Eriksson, Nina Peitsaro, Maciej Lalowski, Mati Karelson, Dan Lindholm

“…USP14 is a promising factor to consider in PD to target α-syn through its regulation of proteasomes and oxidative stress in dopaminergic neurons.…”
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Intermittent Vibration Induces Sleep via an Allatostatin A‐GABA Signaling Pathway and Provides Broad Benefits in Alzheimer's Disease Models by Yang Mou, Yan Zhang, Yuxian Zheng, Guang He, Zhi‐Xiang Xu, Xiao Xiao, Yong Ping

“…A clear evidence is further provided that allatostatin A (AstA)‐GABA signaling mediates short‐term intermittent vibration‐induced sleep (iVIS) by inhibiting octopaminergic arousal neurons through activating GABAA receptors. The existence of iVIS in mice is corroborated, implicating the GABAergic system in this process. …”
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Electroencephalogram biomarkers as predictors of mortality and functional recovery in patients with severe traumatic brain injury: Protocol study by Walter Gomes da Silva Filho, Layza Julhia do Nascimento Moura, Arthur Barcelos Massariol Nascimento, Gabrielle Cristina Tessmann, Fabricia Silva Miranda, Vitória Caroline Reinoso de Almeida, Bárbara Vargens Broedel, Miller Lucas de Faria, Fernando Zanela da Silva Arêas

“…The trauma triggers inflammatory and neurochemical changes that exacerbate neuronal damage, resulting in neuropsychiatric complications. …”
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Citrulline – The Powerhouse Nutrient for Cardiometabolic and Brain Health by Daria Pedrycz, Mateusz Drabczyk, Emilia Pedrycz, Karolina Karoń, Grzegorz Drapała, Wojciech Grabowski, Łukasz Karoń, Anna Zygmunt, Sławomir Karoń

“…Furthermore, citrulline's antioxidant properties counteract oxidative stress by modulating reactive oxygen species (ROS), reducing lipid peroxidation, and protecting neuronal integrity. Emerging evidence suggests its potential in delaying endothelial senescence and preventing ferroptosis, establishing its role in vascular and neuroprotective strategies. …”
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SDF-1/CXCR4 Signaling Maintains Stemness Signature in Mouse Neural Stem/Progenitor Cells by Shih-Yin Ho, Thai-Yen Ling, Hsing-Yu Lin, Jeffrey Tsai-Jui Liou, Fei-Chih Liu, I-Chun Chen, Sue-Wei Lee, Yu Hsu, Dar-Ming Lai, Horng-Huei Liou

“…Moreover, Notch and RE1 silencing transcription factor (REST) both play an essential role in NSCs/NPCs maintenance and neuronal differentiation and were dramatically downregulated following SDF-1/CXCR4 cascade inhibition. …”
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Ruminal Acidosis in Feedlot: From Aetiology to Prevention by Joaquín Hernández, José Luis Benedito, Angel Abuelo, Cristina Castillo

“…Animals will show ruminal hypotony/atony with hydrorumen and a typical parakeratosis-rumenitis liver abscess complex, associated with a plethora of systemic manifestations such as diarrhea and dehydration, liver abscesses, infections of the lung, the heart, and/or the kidney, and laminitis, as well as neurologic symptoms due to both cerebrocortical necrosis and the direct effect of D-lactate on neurons. In feedlots, warning signs include decrease in chewing activity, weight, and dry matter intake and increase in laminitis and diarrhea prevalence. …”
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Long Course Hyperbaric Oxygen Stimulates Neurogenesis and Attenuates Inflammation after Ischemic Stroke by Ying-Sheng Lee, Chung-Ching Chio, Ching-Ping Chang, Liang-Chao Wang, Po-Min Chiang, Kuo-Chi Niu, Kuen-Jer Tsai

“…These effects may help in neuronal repair after ischemic stroke, and increasing the course of HBO therapy might enhance therapeutic effects on ischemic stroke.…”
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Direct Reprogramming of Mouse Fibroblasts to Neural Stem Cells by Small Molecules by Yan-Chuang Han, Yoon Lim, Michael D. Duffieldl, Hua Li, Jia Liu, Nimshitha Pavathuparambil Abdul Manaph, Miao Yang, Damien J. Keating, Xin-Fu Zhou

“…Furthermore, the SMINS cells are able to differentiate into astrocytes, functional neurons, and oligodendrocytes in vitro and in vivo. …”
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Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss by Lijuan Shi, Ying Chang, Xiaowei Li, Steve Aiken, Lijie Liu, Jian Wang

“…Disruption of these synapses not only disables the innervated ANFs but also results in the slow degeneration of spiral ganglion neurons if the synapses are not reestablished. Such a loss of ANFs should result in signal coding deficits, which are exacerbated by the bias of the damage toward synapses connecting low-spontaneous-rate (SR) ANFs, which are known to be vital for signal coding in noisy background. …”
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High order expression dependencies finely resolve cryptic states and subtypes in single cell data by Abel Jansma, Yuelin Yao, Jareth Wolfe, Luigi Del Debbio, Sjoerd V Beentjes, Chris P Ponting, Ava Khamseh

“…Among cryptically homogeneous embryonic cells, for example, Stator finds 34 distinct radial glia states whose gene expression forecasts their future GABAergic or glutamatergic neuronal fate. Further, Stator’s fine resolution of liver cancer states reveals expression programmes that predict patient survival. …”
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CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics, Regulating Growth Cone Development and Axon Elongation by Minghui Tan, Caihui Cha, Yongheng Ye, Jifeng Zhang, Sumei Li, Fengming Wu, Sitang Gong, Guoqing Guo

“…Collapsin response mediator proteins (CRMPs) are highly expressed in the developing nervous system, mediating growth cone guidance, neuronal polarity, and axonal elongation. However, whether and how CRMPs associate with microtubules and actin coordinated cytoskeletal dynamics remain unknown. …”
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Review on dietary supplements as an effective improvement of Alzheimer’s disease: focus on structures and mechanisms by Sheng Li, Yinling Wei, Zhenzhen Liang, Lingli Guo, Xiaojiang Hao, Yu Zhang

“…Especially with the widespread use of DSs, DSs containing polyphenols, alkaloids, terpenes, polysaccharides and other bioactive components can prevent AD by reducing Aβ deposition, inhibiting tau protein hyperphosphorylation, reconstructing synaptic dysfunction, weakening cholinesterase activity, regulating mitochondrial oxidative stress, neuronal inflammation and apoptosis. This review summarizes the anti-AD effects of the main DSs and their bioactive constituents, as well as the potential molecular mechanisms covers from 2017 to 2023. …”
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Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis by Diego Moncada, Fabricio Ballarini, Haydée Viola

“…Similar molecular machinery is activated in neurons following an electrical stimulus that induces synaptic changes and after learning sessions that trigger memory formation. …”
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