Biochemical analysis to study wild-type and polyglutamine-expanded ATXN3 species. by Grégoire Quinet, María Cristina Paz-Cabrera, Raimundo Freire

“…The main hallmark of SCA3 is the expansion of a polyglutamine tract located in the C-terminal of Ataxin-3 (or ATXN3) protein, that triggers the mis-localization and toxic aggregation of ATXN3 in neuronal cells. The propensity of wild type and polyglutamine-expanded ATXN3 proteins to aggregate has been extensively studied over the last decades. …”
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Olfactory dysfunction as potential biomarker in neurodegenerative diseases: a narrative review by Nicolas De Cleene, Katarína Schwarzová, Samuel Labrecque, Clancy Cerejo, Atbin Djamshidian, Klaus Seppi, Beatrice Heim

“…Neurodegenerative diseases represent a group of disorders characterized by progressive degeneration of neurons in the central nervous system, leading to a range of cognitive, motor, and sensory impairments. …”
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Emergence of Prediction by Reinforcement Learning Using a Recurrent Neural Network by Kenta Goto, Katsunari Shibata

“…In a task where an agent gets a reward when it catches a moving object that can possibly become invisible, it was observed that the agent learned to detect the necessary factors of the object velocity before it disappeared, to relay the information among some hidden neurons, and finally to catch the object at an appropriate position and timing, considering the effects of bounces off a wall after the object became invisible.…”
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Electroacupuncture attenuates ferroptosis by promoting Nrf2 nuclear translocation and activating Nrf2/SLC7A11/GPX4 pathway in ischemic stroke by Xi-chen Yang, Ya-ju Jin, Rong Ning, Qiu-yue Mao, Peng-yue Zhang, Li Zhou, Cheng-cai Zhang, Yi-chen Peng, Na Chen

“…The infarct volume was detected by TTC staining, and the neuronal damage was observed by Nissl staining. The levels of Fe2+, reactive oxygen species (ROS), superoxide dismutase (SOD), and malondialdehyde (MDA) were measured by ELISA. …”
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Learning enhances behaviorally relevant representations in apical dendrites by Sam E Benezra, Kripa B Patel, Citlali Perez Campos, Elizabeth MC Hillman, Randy M Bruno

“…We used both two-photon and SCAPE microscopy to longitudinally track tuft-wide calcium spikes in apical dendrites of layer 5 pyramidal neurons in barrel cortex as mice learned a tactile behavior. …”
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Viruses and neurodegeneration: a growing concern by S. Shouman, N. Hesham, T. Z. Salem

“…Abstract Neurodegenerative diseases (NDDs) cause a progressive loss of neurons. Since NDDs are multifactorial, the precise etiology varies on the basis of the type of disease and patient history. …”
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Symmetry breaking organizes the brain’s resting state manifold by Jan Fousek, Giovanni Rabuffo, Kashyap Gudibanda, Hiba Sheheitli, Spase Petkoski, Viktor Jirsa

“…These include spontaneous high-amplitude co-activations, neuronal cascades, spectral cortical gradients, multistability, and characteristic functional connectivity dynamics. …”
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A mouse model of Bardet-Biedl Syndrome has impaired fear memory, which is rescued by lithium treatment. by Thomas K Pak, Calvin S Carter, Qihong Zhang, Sunny C Huang, Charles Searby, Ying Hsu, Rebecca J Taugher, Tim Vogel, Christopher C Cychosz, Rachel Genova, Nina N Moreira, Hanna Stevens, John A Wemmie, Andrew A Pieper, Kai Wang, Kai Wang, Val C Sheffield

“…Two-week treatment with lithium chloride partially restores the proliferation of hippocampal neurons which leads to a rescue of context fear conditioning. …”
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Fast and sensitive multivalent spatial pattern-recognition for circular RNA detection by Zhixin Zhou, Bing Han, Yu Wang, Nina Lin, Zhongqiu Zhou, Yuan Zhang, Ying Bai, Ling Shen, Yanfei Shen, Yuanjian Zhang, Honghong Yao

“…Using this sensor, we visualize the real-time response of endogenous circRNA expression in vitro neuronal cells and in vivo brain between pre-stroke and post-stroke male mice, identify the patients with acute ischemic stroke in clinical samples, as well as track the delivery of circRNA in photochromic stroked animal model. …”
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Sodium Butyrate Protects N2a Cells against Aβ Toxicity In Vitro by Jingxuan Sun, Boyu Yuan, Yancheng Wu, Yuhong Gong, Wenjin Guo, Shoupeng Fu, Yongxin Luan, Wei Wang

“…The aim of this study is to research the protective effects of NaB on neurons against Aβ toxicity and to uncover the underlying mechanisms. …”
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The Batten disease gene Cln3 is required for the activation of intestinal stem cell during regeneration via JAK/STAT signaling in Drosophila by Zihua Yu, Zihua Yu, Jinhua Yan, Zhiming Liu, Haiyan Wang, Guanzheng Luo, Haiyang Chen

“…CLN3 mutation causes Juvenile neuronal ceroid lipofuscinosis (JNCL, also known as Batten disease), an early onset neurodegenerative disorder. …”
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Maintenance of Synaptic Stability Requires Calcium-Independent Phospholipase A2 Activity by Julie Allyson, Xiaoning Bi, Michel Baudry, Guy Massicotte

“…This paper mainly focuses on brain calcium-independent PLA2 (iPLA2) and on the mechanisms by which they influence neuronal function and regulate synaptic plasticity. …”
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Emotional and Motivational Pain Processing: Current State of Knowledge and Perspectives in Translational Research by Susanne Becker, Edita Navratilova, Frauke Nees, Stefaan Van Damme

“…In this review, we discuss the psychophysiological and neuronal factors that may be associated with the transition to chronic pain. …”
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The emerging role of 12/15-lipoxygenase in ischemic stroke by Xuening Wang, Qiuji Shao, Yuan Gao

“…In this review, we elaborate on the key pathological mechanisms that unfold following ischemic stroke, including neuroinflammation, oxidative stress, neuronal apoptosis, and blood-brain barrier disruption, and present evidence demonstrating that 12/15-LOX inhibition could be used to treat ischemic stroke through various avenues. …”
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Anti-N-Methyl-D-Aspartate Encephalitis as Paraneoplastic Manifestation of Germ-Cells Tumours: A Cases Report and Literature Review by Claudia Geraldine Rita, Israel Nieto Gañan, Adriano Jimenez Escrig, Ángela Carrasco Sayalero

“…Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is the most common form of autoimmune encephalitis, caused by the interaction between an antibody and its target, located on glutamate receptor type N-methyl-D-aspartate (NMDA) of neuronal surface. There is a wide spectrum of clinical features starting by a viral-like prodrome, followed by symptoms such as psychosis, aggressive behaviour, memory loss, seizures, movement disorders, and autonomic instability. …”
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Ferroptosis: A New Pathway in the Interaction between Gut Microbiota and Multiple Sclerosis by Junjie Jian, Jun Wei

“…Multiple sclerosis (MS) is a chronic autoimmune disorder marked by neuroinflammation, demyelination, and neuronal damage. Recent advancements highlight a novel interaction between iron-dependent cell death, known as ferroptosis, and gut microbiota, which may significantly influences the pathophysiology of MS. …”
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Does SIRT-1 Mediate Calorie Restriction and Prolong Life? – A Mini Review by Kordala Anna, Pietrzak Bogusława

“…SIRT1 increases glucose production, enhances fat mobilization, stimulates angiogenesis, prevents neuronal degeneration and rises insulin sensitivity. …”
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Identification of an additional periplanone receptor family gene preferentially expressed in the male antennae of the American cockroach by Takayuki Watanabe, Atsushi Ugajin, Kosuke Tateishi, Hidehiro Watanabe, Makoto Mizunami

“…Fluorescent in situ hybridization revealed that PameOR1 and PameOR1-like are co-expressed in the periplanone-A-responsive sensory neurons within the single walled-B sensilla on the male adult antennae. …”
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Modulation of brain glutamate dehydrogenase as a tool for controlling seizures by Rasgado Lourdes A. Vega, Reyes Guillermo Ceballos, Díaz Fernando Vega

“…GDH represents an important regulation point of neuronal excitability, and modulation of its activity represents a potential target for metabolic treatment of epilepsy and for the development of new AEDs.…”
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Dopaminergic Modulation of Striatal Inhibitory Transmission and Long-Term Plasticity by Elizabeth Nieto Mendoza, Elizabeth Hernández Echeagaray

“…This work focused on the analysis of both dopaminergic modulation of inhibitory synapses and the synaptic plasticity established between GABAergic afferents to medium spiny neurons (MSNs). Our results showed that low and high DA concentrations mainly reduced the amplitude of inhibitory synaptic response; however detailed analysis of the D1 and D2 participation in this modulation displayed a wide variability in synaptic response. …”
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