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1681
Functional characteristics of serotoninergic nerves stimulating stomach and intestinal contractions
Published 2018-08-01“…The stimulatory effect is amplified at block of sympathetic nerve by Ornidum, and is eliminated by block of serotoninergic receptors of autonomic ganglia neurons by trimeperidine hydrochloride. It demonstrates that ST partially consists of serotoninergic nerves. …”
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1682
Neurotrophic Receptor Tyrosine Kinase 2 (NTRK2) Alterations in Low-Grade Gliomas: Report of a Novel Gene Fusion Partner in a Pilocytic Astrocytoma and Review of the Literature
Published 2020-01-01“…NTRK2 encodes for the protein tropomyosin receptor kinase B (TrkB), which is a neurotrophin receptor with high affinity for Brain-Derived Neurotrophic Factor (BDNF), and plays a role in several physiological functions of neurons, including cell survival and differentiation. …”
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1683
Absence of Rybp Compromises Neural Differentiation of Embryonic Stem Cells
Published 2016-01-01“…We found that rybp null mutant ESCs formed less matured neurons, astrocytes, and oligodendrocytes from existing progenitors than wild type cells. …”
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1684
From Mechanisms to Medicine: Neurovascular Coupling in the Diagnosis and Treatment of Cerebrovascular Disorders: A Narrative Review
Published 2024-12-01“…Neurovascular coupling (NVC) refers to the process of local changes in cerebral blood flow (CBF) after neuronal activity, which ensures the timely and adequate supply of oxygen, glucose, and substrates to the active regions of the brain. …”
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1685
Spindle Bursts in Neonatal Rat Cerebral Cortex
Published 2016-01-01“…Together with early gamma oscillations, spindle bursts synchronize the activity of a local neuronal network organized in a cortical column. Disturbances in spindle burst activity during corticogenesis may contribute to disorders in cortical architecture and in the activity-dependent control of programmed cell death. …”
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1686
A Bayesian regularization intelligent computing scheme for the fractional dengue virus model
Published 2025-03-01“…The computing stochastic BRNNs approach is presented for three variations with the selection of the data as testing 13%, authentication 11% and training 76% together with sixteen hidden neurons. The result’s comparison is accessible in the form of overlapping, which is based on the BRNNs approach and reference Adam solutions. …”
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1687
Anti-HSV-1 agents: an update
Published 2025-01-01“…HSV-1 is well known for its lytic infections at the primary sites and for establishing latency in the sensory neuronal ganglia, with occasional recurrent infections. …”
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1688
Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats
Published 2025-02-01“…In contrast, female rats with hAPOEε4 genotype showed increased new adult-born neurons, but no changes in the other cell types, suggesting a possible compensatory response to the effects of hAPOEε4 at this time point. …”
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1689
Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies
Published 2011-01-01“…Parkinson's disease (PD) is the second most common neurodegenerative disorder and is mainly characterized by the selective and progressive loss of dopaminergic neurons, accompanied by locomotor defects. Although most PD cases are sporadic, several genes are associated with rare familial forms of the disease. …”
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1690
A guide to selecting high-performing antibodies for Huntingtin (UniProt ID: P42858) for use in western blot, immunoprecipitation, and immunofluorescence [version 2; peer review: 2...
Published 2025-01-01“…Expansion of this repeat tract above a pathogenic threshold of 36 repeats is the causative mutation of Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. Here we have characterized twenty Huntingtin commercial antibodies for western blot, immunoprecipitation, and immunofluorescence using a standardized experimental protocol based on comparing read-outs in knockout cell lines and isogenic parental controls. …”
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1691
Established Principles and Emerging Concepts on the Interplay between Mitochondrial Physiology and S-(De)nitrosylation: Implications in Cancer and Neurodegeneration
Published 2012-01-01“…In this paper we aim at summarizing the current knowledge of mitochondria-related proteins undergoing S-nitrosylation and how this redox modification might impact on mitochondrial functions, whose impairment has been correlated to tumorigenesis and neuronal cell death. In particular, emphasis will be given to the possible, but still neglected implication of denitrosylation reactions in the modulation of mitochondrial SNOs and how they can affect mitochondrion-related cellular process, such as oxidative phosphorylation, mitochondrial dynamics, and mitophagy.…”
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1692
Late-Onset Ornithine Carbamoyltransferase Deficiency Accompanying Acute Pancreatitis and Hyperammonemia
Published 2013-01-01“…Left undiagnosed, this condition may manifest irreversible neuronal damage. However, timely diagnosis and treatment initiation can be facilitated simply by increased awareness of the ICU staff. …”
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1693
An optimized LSTM-based equalizer for 100 Gigabit/s-class short-range fiber-optic communications
Published 2024-09-01“…An optimization of a long short-term memory (LSTM) structure in terms of network depth and distribution of neurons in hidden layers leads to an enhancement of the overall performance of the 50 Gbaud PAM4 communications. …”
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1694
Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury
Published 2016-01-01“…Spinal cord injury is a devastating disease which disrupts the connections between the brain and spinal cord, often resulting in the loss of sensory and motor function below the lesion site. Most injured neurons fail to regenerate in the central nervous system after injury. …”
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1695
Role of Zinc Signaling in the Regulation of Mast Cell-, Basophil-, and T Cell-Mediated Allergic Responses
Published 2018-01-01“…Its deficiency causes growth retardation, immunodeficiency, and neuronal degeneration. Zinc homeostasis is tightly regulated by zinc transporters and metallothioneins that control zinc concentration and its distribution in individual cells and contributes to zinc signaling. …”
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1696
Application of neurotoxin- and pesticide-induced animal models of Parkinson’s disease in the evaluation of new drug delivery systems
Published 2022-03-01“…It is characterized by motor symptoms such as akinesia, bradykinesia, tremor, rigidity, and postural abnormalities, due to the loss of nigral dopaminergic neurons and a decrease in the dopa-mine contents of the caudate-putamen structures. …”
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1697
Neutrophils, NETs and multiple sclerosis: a mini review
Published 2025-01-01“…Multiple sclerosis (MS), a chronic inflammatory and degenerative autoimmune disease characterized by the activation of various inflammatory cells, leads to demyelination and neuronal injury. Neutrophils, often underestimated in MS, are gaining increased attention for their significant functions in MS patients and the experimental autoimmune encephalomyelitis (EAE) animal model. …”
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1698
Molecular Mechanisms Underlying Hypothermia-Induced Neuroprotection
Published 2011-01-01“…There is now compelling clinical evidence that prolonged, moderate cerebral hypothermia initiated within a few hours after severe ischemia can reduce subsequent neuronal death and improve behavioral recovery. The neuroprotective role of hypothermia is also well established in experimental animals. …”
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1699
Brain-derived tau oligomer polymorphs: distinct aggregations, stability profiles, and biological activities
Published 2025-01-01“…Our results indicate that the aBDTOs possess different structural and morphological features that impact neuronal function, gene regulation, and ultimately disease progression. …”
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1700
The impact of glycolysis on ischemic stroke: from molecular mechanisms to clinical applications
Published 2025-01-01“…However, in the ischemia–reperfusion state, neuronal cells show a particular reliance on aerobic glycolysis. …”
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