Targeting Mitochondrial Dysfunction in Cerebral Ischemia: Advances in Pharmacological Interventions by Igor Belenichev, Olena Popazova, Nina Bukhtiyarova, Victor Ryzhenko, Sergii Pavlov, Elina Suprun, Valentyn Oksenych, Oleksandr Kamyshnyi

“…Disruptions in mitochondrial function, driven by factors such as oxidative stress, excitotoxicity, and altered ion balance, lead to neuronal death and contribute to cognitive impairments in several brain diseases. …”
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Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia by Veronica Ghiglieri, Vincenza Bagetta, Valentina Pendolino, Barbara Picconi, Paolo Calabresi

“…In Parkinson’s disease (PD), alteration of dopamine- (DA-) dependent striatal functions and pulsatile stimulation of DA receptors caused by the discontinuous administration of levodopa (L-DOPA) lead to a complex cascade of events affecting the postsynaptic striatal neurons that might account for the appearance of L-DOPA-induced dyskinesia (LID). …”
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Advances in the Critical Care Management of Ischemic Stroke by Vineeta Singh, Nancy J. Edwards

“…In this paper, we will review the indications for specialized ICU care for an ischemic stroke patient, the treatment principles, and strategies employed by neurointensivists to minimize secondary neuronal injury, the literature in support of such strategies (and the questions to be addressed by future studies), all with the ultimate goal of increasing the likelihood of favorable neurologic outcomes in our ischemic stroke population.…”
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Multiple Approaches to Investigate the Transport and Activity-Dependent Release of BDNF and Their Application in Neurogenetic Disorders by David Hartmann, Jana Drummond, Erik Handberg, Sharday Ewell, Lucas Pozzo-Miller

“…Studies utilizing genetic and pharmacological manipulations in rodent models and neuronal cultures have revealed myriad roles of brain-derived neurotrophic factor (BDNF). …”
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An “Engram-Centric” Approach to Transient Global Amnesia (TGA) and Other Acute-Onset Amnesias by Andrew J. Larner

“…Here, TGA, TEA, and functional amnesia are considered in light of the historical engram conception of memory, now informed by recent experimental research, as disturbances in distributed ensembles of engram neurones active during memory formation and recall. …”
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Trends in Anti-Epileptic Drug Development by Lennart Gram

“…For a number of years efforts have been directed towards compounds which may augment neuronal inhibition, and these efforts have resulted in the development of several valuable drugs. …”
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Neuroinflammatory Mechanisms of Mitochondrial Dysfunction and Neurodegeneration in Glaucoma by Joao N. Duarte

“…The present review focuses on how mitochondrial dysfunction may overwhelm the ability of neurons and glial cells to adequately maintain homeostasis and how mitochondria-derived DAMPs trigger the immune system and induce neurodegeneration.…”
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Thermo‐TRP regulation by endogenous factors and its physiological function at core body temperature by Makiko Kashio

“…Thermo‐TRPs that detect temperature changes in peripheral sensory neurons possess indispensable functions in thermosensation, eliciting defensive behavior against noxious temperatures and driving autonomic/behavioral thermoregulatory responses to maintain body temperature in mammals. …”
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Cell Secretion: Current Structural and Biochemical Insights by Saurabh Trikha, Elizabeth C. Lee, Aleksandar M. Jeremic

“…The sizes of porosomes range from 150nm in diameter in acinar cells of the exocrine pancreas to 12nm in neurons. In recent years, significant progress has been made in our understanding of the porosome and the cellular activities required for cell secretion, such as membrane fusion and swelling of secretory vesicles. …”
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Mechanisms of Neuroprotection by Protein Disulphide Isomerase in Amyotrophic Lateral Sclerosis by Adam K. Walker, Julie D. Atkin

“…Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterised by the progressive loss of motor neurons, leading to paralysis and death within several years of onset. …”
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Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus by Pavel P. Tregub, Yulia K. Komleva, Maria V. Kukla, Anton S. Averchuk, Anna S. Vetchinova, Natalia A. Rozanova, Sergey N. Illarioshkin, Alla B. Salmina

“…The plasticity of synaptic transmission involves the expression of immediate early genes (IEGs) that regulate neuronal activity, thereby supporting learning and memory. …”
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What Is New in Glaucoma: From Treatment to Biological Perspectives by Raffaele Nuzzi, Paola Marolo, Alessia Nuzzi

“…On the other hand, the most recent approaches to treat glaucoma outcomes in its advanced stages include electrical stimulation, stem cells, exosomes, extracellular vesicles, and growth factors. Finally, neuronal plasticity-based rehabilitation methods are being studied to reeducate patients in order to stimulate their residual visual capacity. …”
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Immune Privilege as an Intrinsic CNS Property: Astrocytes Protect the CNS against T-Cell-Mediated Neuroinflammation by Ulrike Gimsa, N. Avrion Mitchison, Monika C. Brunner-Weinzierl

“…They support differentiation and homeostasis of neurons and influence synaptic activity. They are responsible for formation of the blood-brain barrier (BBB) and make up the glia limitans. …”
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Neural Mechanisms of Temporomandibular Joint and Masticatory Muscle Pain: A Possible Role for Peripheral Glutamate Receptor Mechanisms by David K Lam, Barry J Sessle, Brian E Cairns, James W Hu

“…A peripheral mechanism involving autocrine and/or paracrine regulation of nociceptive neuronal excitability via injury or inflammation-induced release of glutamate into peripheral tissues that may contribute to the development of craniofacial pain is proposed.…”
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Marijuana Compounds: A Nonconventional Approach to Parkinson’s Disease Therapy by Mariana Babayeva, Haregewein Assefa, Paramita Basu, Sanjeda Chumki, Zvi Loewy

“…Neurologically, it is characterized by the selective degeneration of a unique population of cells, the nigrostriatal dopamine neurons. The current treatment is symptomatic and mainly involves replacement of dopamine deficiency. …”
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A Report on a Family with TMTC3-Related Syndrome and Review by Sayeeda Hana, Deepak karthik, Jingxuan Shan, Stephany El Hayek, Lotfi Chouchane, André Megarbane

“…Recessive mutations in the TMTC3 gene have been reported in thirteen patients to date exhibiting development delay, intellectual disability (ID), seizures, and muscular hypotonia, accompanied occasionally by neuronal migration defects expressed as either cobblestone lissencephaly or periventricular hypertopia. …”
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Zinc Metalloproteinases and Amyloid Beta-Peptide Metabolism: The Positive Side of Proteolysis in Alzheimer's Disease by Mallory Gough, Catherine Parr-Sturgess, Edward Parkin

“…Alzheimer's disease is a neurodegenerative condition characterized by an accumulation of toxic amyloid beta- (A𝛽-)peptides in the brain causing progressive neuronal death. A𝛽-peptides are produced by aspartyl proteinase-mediated cleavage of the larger amyloid precursor protein (APP). …”
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Structural, Synaptic, and Epigenetic Dynamics of Enduring Memories by Ossama Khalaf, Johannes Gräff

“…In this review, we highlight three of the greatly addressed mechanisms that play a central role for a given memory to endure: the allocation of the memory to a given neuronal population and what brain areas are recruited for its storage; the structural changes that underlie memory persistence; and finally the epigenetic control of gene expression that might regulate and support memory perseverance. …”
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Bilateral Iris Mammillations in Amblyopic Eyes without Oculodermal Melanocytosis or Neurofibromatosis by Megumi Yamamoto, Tatsuya Mimura, Koichi Matsumoto, Shigeki Hamano, Hisataka Nanba, Shoko Ubukata, Emiko Watanabe, Atsushi Mizota

“…We report a rare case of bilateral simple iris mammillations without ocular melanosis or systemic neuronal disorders. Case Report. A healthy 10-year-old Japanese girl was found incidentally to have bilateral iris mammillations while being treated for amblyopia. …”
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Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology by Rupal Dhariwal, Rupal Dhariwal, Mukul Jain, Mukul Jain, Yaser Rafiq Mir, Abhayveer Singh, Bhavik Jain, Pankaj Kumar, Mohd Tariq, Mohd Tariq, Devvret Verma, Khemraj Deshmukh, Virendra Kumar Yadav, Tabarak Malik, Tabarak Malik

“…Neurodegenerative diseases, characterized by progressive neuronal loss and cognitive impairments, pose a significant global health challenge. …”
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