Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases by Maria H. Madeira, Raquel Boia, Paulo F. Santos, António F. Ambrósio, Ana R. Santiago

“…Retinal degenerative diseases are major causes of vision loss and blindness worldwide and are characterized by chronic and progressive neuronal loss. One common feature of retinal degenerative diseases and brain neurodegenerative diseases is chronic neuroinflammation. …”
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Ionotropic Glutamate Receptors and Voltage-Gated Ca2+ Channels in Long-Term Potentiation of Spinal Dorsal Horn Synapses and Pain Hypersensitivity by Dong-ho Youn, Gábor Gerber, William A. Sather

“…Mechanisms that underlie LTP of spinal DH neurons include changes in the numbers, activity, and properties of ionotropic glutamate receptors (AMPA and NMDA receptors) and of voltage-gated Ca2+ channels. …”
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Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches by Almudena Fuster-Matanzo, María Llorens-Martín, Félix Hernández, Jesús Avila

“…Furthermore, neuroinflammation has been demonstrated to affect important processes in the brain, such as the formation of new neurons, commonly known as adult neurogenesis. For this, many therapeutic approaches have been developed in order to avoid or mitigate the deleterious effects caused by the chronic activation of the immune response. …”
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The role of neurofilament light chain in the context of neurological disorders by V. Taluntienė, R. Motiekaitytė, R. Kizlaitienė, N. Giedraitienė, G. Kaubrys

“… Neurofilament light chain (NFL) is a structural neuronal protein highly expressed in large myelinated axons. …”
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A Quarter Century of Liver Transplantation: Learning from Livers by Paul C. Adams

“…Normal gallbladder motility in the denervated transplanted liver questions the role of neuronal influences on gallbladder function. Finally, experimental liver transplantation in animals has been used as a tool to study metabolic problems.…”
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Influence of the Neural Network Hyperparameters on its Numerical Conditioning by S. V. Sholtanyuk

“…Performance of the forecasting perceptron with various hyperparameters sets, with different amount of neurons and various activation functions in particular, has been considered. …”
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A Novel Design of a Neural Network-Based Fractional PID Controller for Mobile Robots Using Hybridized Fruit Fly and Particle Swarm Optimization by Ghusn Abdul Redha Ibraheem, Ahmad Taher Azar, Ibraheem Kasim Ibraheem, Amjad J. Humaidi

“…With suitable arrangements of the hidden layer neurons using nonlinear and linear activation functions in the hidden and output layers, respectively, and with appropriate connection weights between different hidden layer neurons, a new class of nonlinear neural fractional-order proportional integral derivative (NNFOPID) controller is proposed and designed. …”
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Sex reversal induced by 17β-estradiol may be achieved by regulating the neuroendocrine system of the Pacific white shrimp Penaeus vannamei by Tao Wang, Shihao Li, Yang Yu, Fuhua Li

“…The observed retardation in growth in the EM group may be attributed to the potential for neuronal damage and disruptions in the cell cycle and PI3K-Akt signaling pathways. …”
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Brief exposure to (-) THC affects zebrafish embryonic locomotion with effects that persist into the next generation by Md Ruhul Amin, Lakhan Khara, Joshua Szaszkiewicz, Andrew M. Kim, Trevor J. Hamilton, Declan W. Ali

“…Here we exposed zebrafish (Danio rerio) to a single exposure of (-)THC (0.001 mg/L (3.2 nM) to 20 mg/L (63.6 µM), for 5 h) during gastrulation (5.25 hpf to 10.75 hpf) when key neurons involved in locomotion such as the primary motor neurons and Mauthner cell first appear. …”
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Safety, Tolerability and Pharmacokinetic-Pharmacodynamic Relationship of NX210c Peptide in Healthy Elderly Volunteers: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascend... by Annette Janus, Daniël Dumas, Juliette Le Douce, Sébastien Marie, Giuseppe Pasculli, Pauline Bambury, Sighild Lemarchant, Philip Kremer, Yann Godfrin

“…Abstract Introduction Blood-brain barrier (BBB) integrity is fundamental to brain homeostasis, enabling control of substance exchange and safeguarding neurons against harmful toxins, pathogens, and immune cells that lead to dysregulation and inflammation involved in ageing and neurodegenerative diseases (NDD). …”
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Case Report: Targeted treatment by fluoxetine/norfluoxetine of a KCNC2 variant causing developmental and epileptic encephalopathy by Ping Li, Alice Butler, Yu Zhou, Karl L. Magleby, Christina A. Gurnett, Lawrence Salkoff

“…The Kv3.2 subfamily of voltage activated potassium channels encoded by the KCNC2 gene is abundantly expressed in neurons that fire trains of fast action potentials that are a major source of cortical inhibition. …”
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Different rs-fMRI Data Processing Methods in the Study of Vascular Cognitive Impairment by Ying GUAN, Luwen ZHU, Feng WANG, Danna CAO, Xiaoling LI, Qiang TANG

“…The technique mainly reflects the spontaneous activity of neurons by reflecting the spontaneous activity of the brain's blood oxygen level-dependent signal, which is closer to the physiological state than the task-state functional magnetic resonance imaging. …”
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Markers of vascular autoregulation in primary open-angle glaucoma by N.E. Fomin, A.V. Kuroyedov

“…VEGF is involved in the development of optic nerve and retinal neurons by promoting neuronal proliferation and stimulating endothelial cells. …”
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Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications by Pharaoh Fellow Mwale, Cheng-Ta Hsieh, Ting-Lin Yen, Jing-Shiun Jan, Rajeev Taliyan, Chih-Hao Yang, Wen-Bin Yang

“…This review explores the role of CHI3L1 in the pathogenesis of these disorders, with a focus on its contributions to neuroinflammation, immune cell infiltration, and neuronal degeneration. As a key regulator of neuroinflammation, CHI3L1 modulates microglia and astrocyte activity, driving the release of proinflammatory cytokines that exacerbate disease progression. …”
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Significance of single-nucleotide variants of anorexigenic hormone genes in childhood obesity by A.O. Nikulina

“…Obesity-induced dysregulation of hypothalamic neurons is not completely eliminated by restoring body weight, therefore the most urgent task of modern precision medicine is to predict the trajectory of development of metabolic disorders associated with obesity in children. …”
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Generation and characterization of two induced pluripotent stem cell lines (ICGi052-A and ICGi052-B) from a patient with frontotemporal dementia with parkinsonism-17 associated wit... by E. V. Grigor’eva, A. A. Malakhova, E. S. Yarkova, J. M. Minina, Y. V. Vyatkin, J. A. Nadtochy, E. A. Khabarova, J. A. Rzaev, S. P. Medvedev, S. M. Zakian

“…Frontotemporal dementia with parkinsonism-17 is a neurodegenerative disease characterised by pathological aggregation of the tau protein with the formation of neurofibrillary tangles and subsequent neuronal death. The inherited form of frontotemporal dementia can be caused by mutations in several genes, including the MAPT gene on chromosome 17, which encodes the tau protein. …”
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Tau oligomers impair memory and synaptic plasticity through the cellular prion protein by Claudia Balducci, Franca Orsini, Milica Cerovic, Marten Beeg, Beatrice Rocutto, Letizia Dacomo, Antonio Masone, Eleonora Busani, Ilaria Raimondi, Giada Lavigna, Po-Tao Chen, Susanna Leva, Laura Colombo, Chiara Zucchelli, Giovanna Musco, Nicholas M. Kanaan, Marco Gobbi, Roberto Chiesa, Luana Fioriti, Gianluigi Forloni

“…Abstract Deposition of abnormally phosphorylated tau aggregates is a central event leading to neuronal dysfunction and death in Alzheimer’s disease (AD) and other tauopathies. …”
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Bindarit attenuates neuroinflammation after subarachnoid hemorrhage by regulating the CCL2/CCR2/NF-κB pathway by Yanting Yao, Qiaowei Wu, Kaikun Yuan, Pei Wu, Chao Xu, Zhiyong Ji, Weishi Xu, Hongli Yu, Anyu Xu, Yanchen Liu, Huaizhang Shi

“…In vitro, Bindarit significantly reduced neuronal inflammation. Conclusion: Endogenous CCL2 expression was upregulated in the rat SAH model. …”
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Distinct mechanisms of electroacupuncture and manual acupuncture in modulating hypothalamic GnRH–tanycyte unit function of polycystic ovary syndrome by Yu Wang, Yicong Wang, Yuning Chen, Wenhan Lu, Xiaoyu Tong, Jiajia Li, Wenhao Gao, Rui Huang, Wei Hu, Yi Feng

“…Tissue clearing and three-dimensional (3D) imaging were employed to visualize the hypothalamic GnRH neuronal network and assess postacupuncture modifications. …”
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Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury by Jingying Zhou, Xue Huo, Benson O. A. Botchway, Luyao Xu, Xiaofang Meng, Songou Zhang, Xuehong Liu

“…The inhibition of the mTOR pathway by resveratrol has the potential of serving as a neuronal restorative mechanism following SCI.…”
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