Rapid lightsheet fluorescence imaging of whole Drosophila brains at nanoscale resolution by potassium acrylate-based expansion microscopy by Xuejiao Tian, Tzu-Yang Lin, Po-Ting Lin, Min-Ju Tsai, Hsin Chen, Wen-Jie Chen, Chia-Ming Lee, Chiao-Hui Tu, Jui-Cheng Hsu, Tung-Han Hsieh, Yi-Chung Tung, Chien-Kai Wang, Suewei Lin, Li-An Chu, Fan-Gang Tseng, Yi-Ping Hsueh, Chi-Hon Lee, Peilin Chen, Bi-Chang Chen

“…Large-volume ExM is realized by using an axicon-based Bessel lightsheet microscope, featuring gentle multi-color fluorophore excitation and intrinsic optical sectioning capability, enabling visualization of Tm5a neurites and L3 lamina neurons with photoreceptors in the optic lobe. We also image nanometer-sized dopaminergic neurons across the same intact iteratively expanded Drosophila brain, enabling us to measure the 3D expansion ratio. …”
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The DNA Replication Stress Hypothesis of Alzheimer’s Disease by Yuri B. Yurov, Svetlana G. Vorsanova, Ivan Y. Iourov

“…A well-recognized theory of Alzheimer’s disease (AD) pathogenesis suggests ectopic cell cycle events to mediate neurodegeneration. Vulnerable neurons of the AD brain exhibit biomarkers of cell cycle progression and DNA replication suggesting a reentry into the cell cycle. …”
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Molecular and cellular mechanisms underlying peripheral nerve injury-induced cellular ecological shifts: Implications for neuroregeneration by Limao Wu, Jinglan He, Na Shen, Song Chen

“…Understanding the interactions between these cells and their mutual regulation with neurons is of great significance for the discovery of new neuroregenerative treatments and the identification of potential therapeutic targets.…”
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Intervention Models in Functional Connectivity Identification Applied to fMRI by João Ricardo Sato, Daniel Yasumasa Takahashi, Ellison Fernando Cardoso, Maria da Graça Morais Martin, Edson Amaro Júnior, Pedro Alberto Morettin

“…The development of functional magnetic resonance imaging (fMRI), based on the BOLD signal, is one of the most popular techniques related to the detection of neuronal activation. However, understanding the interactions between several neuronal modules is also an important task, providing a better comprehension about brain dynamics. …”
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Involvement of Thalamus in Initiation of Epileptic Seizures Induced by Pilocarpine in Mice by Yong-Hua Li, Jia-Jia Li, Qin-Chi Lu, Hai-Qing Gong, Pei-Ji Liang, Pu-Ming Zhang

“…The variation tendency of the peak values of cross-correlation function between neurons matched the variation tendency of the redundancy of LFPs. …”
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An Integrated Review of Psychological Stress in Parkinson’s Disease: Biological Mechanisms and Symptom and Health Outcomes by Kim Wieczorek Austin, Suzanne Weil Ameringer, Leslie Jameleh Cloud

“…Psychological stress may exacerbate biological mechanisms believed to contribute to neuronal loss in PD and lead to poorer symptom and health outcomes. …”
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Mitochondrial- and Endoplasmic Reticulum-Associated Oxidative Stress in Alzheimer's Disease: From Pathogenesis to Biomarkers by E. Ferreiro, I. Baldeiras, I. L. Ferreira, R. O. Costa, A. C. Rego, C. F. Pereira, C. R. Oliveira

“…Pathological changes in the AD brain include the presence of amyloid plaques, neurofibrillary tangles, loss of neurons and synapses, and oxidative damage. These changes strongly associate with mitochondrial dysfunction and stress of the endoplasmic reticulum (ER). …”
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Inhibition of Cathepsin S Produces Neuroprotective Effects after Traumatic Brain Injury in Mice by Jianguo Xu, Handong Wang, Ke Ding, Xinyu Lu, Tao Li, Jiawei Wang, Chunxi Wang, Jian Wang

“…Additionally, administration of LHVS led to a decrease in neuronal degeneration and improved neurobehavioral function. …”
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The impact of chronic intermittent hypoxia on enzymatic activity in memory-associated brain regions of male and female rats by Steve Mabry, Jessica L. Bradshaw, Jennifer J. Gardner, E. Nicole Wilson, Janak Sunuwar, Hannah Yeung, Sharad Shrestha, J. Thomas Cunningham, Rebecca L. Cunningham

“…There is evidence that alterations in protease activity and neuronal activation are associated with cognitive dysfunction, are dependent on sex, and may be brain region-specific. …”
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The Vibrio type VI secretion system induces intestinal macrophage redistribution and enhanced intestinal motility by Julia S. Ngo, Piyush Amitabh, Jonah G. Sokoloff, Calvin Trinh, Travis J. Wiles, Karen Guillemin, Raghuveer Parthasarathy

“…Given known crosstalk between macrophages and enteric neurons, our observations suggest that macrophage redistribution forms a key link between Vibrio activity and intestinal motility. …”
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Effects of exercise training on the nigrostriatal glutamatergic pathway and receptor interactions in Parkinson’s disease: a systematic review by Shahid Ishaq, Iqbal Ali Shah, Shin-Da Lee, Shin-Da Lee, Bor-Tsang Wu

“…BackgroundThe excitatory imbalance of glutamatergic neurons, caused by insufficient input from dopaminergic neurons, contributes the pathogenesis of Parkinson’s disease (PD). …”
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Comprehensive Insight of Neurodegenerative Diseases and The Role of Neurotoxin Agents — Glutamate by Hui-Min Yap, Kwan-Liang Lye, Loh Teng-Hern Tan

“…Glutamate toxicity, which can be caused by excessive intake of monosodium glutamate (MSG), is the major contributor to pathological neuronal cell death. It causes neuronal dysfunction and degeneration in the central nervous system (CNS). …”
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Augmentation of Tonic GABAA Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABAA Receptors by Adam C. Errington, David W. Cope, Vincenzo Crunelli

“…It is well established that impaired GABAergic inhibition within neuronal networks can lead to hypersynchronous firing patterns that are the typical cellular hallmark of convulsive epileptic seizures. …”
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Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum by Katharine L. Dobson, Tomas C. Bellamy

“…Pharmacological activation of adenylyl cyclase by forskolin caused LTP at Purkinje neurons, but only transient potentiation at Bergmann glia, reinforcing the concept that ectopic sites lack the capacity to express sustained cAMP-dependent potentiation. …”
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Searching for the cellular underpinnings of the selective vulnerability to tauopathic insults in Alzheimer’s disease by Justin Torok, Pedro D. Maia, Chaitali Anand, Ashish Raj

“…We found that hippocampal glutamatergic neurons as a whole were significantly positively associated with regional tau deposition, suggesting vulnerability, while cortical glutamatergic and GABAergic neurons were negatively associated. …”
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Distinct cellular toxicity of two mutant huntingtin mRNA variants due to translation regulation. by Haifei Xu, Juan Ji An, Baoji Xu

“…We found that the long HTT 3'UTR was capable of guiding mRNA to neuronal dendrites, suggesting that some long-form HTT mRNA is transported to dendrites for local protein synthesis. …”
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Principled neuromorphic reservoir computing by Denis Kleyko, Christopher J. Kymn, Anthony Thomas, Bruno A. Olshausen, Friedrich T. Sommer, E. Paxon Frady

“…While the memory buffer can be realized with standard reservoir networks, computing higher-order features requires networks of ‘Sigma-Pi’ neurons, i.e., neurons that enable both summation as well as multiplication of inputs. …”
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Neurophysiology of Drosophila Models of Parkinson’s Disease by Ryan J. H. West, Rebecca Furmston, Charles A. C. Williams, Christopher J. H. Elliott

“…Finally, the strong neuronal phenotypes permit relevant first in vivo drug testing.…”
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A multi-base harmonic balance method applied to Hodgkin-Huxley model by Aymen Balti, Valentina Lanza, Moulay Aziz-Alaoui

“…Our case test is the Hodgkin-Huxley model, one of the most realistic neuronal models in literature. This system, depending on the value of the external stimuli current, exhibits periodic solutions, both stable and unstable.…”
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The NeuroML ecosystem for standardized multi-scale modeling in neuroscience by Ankur Sinha, Padraig Gleeson, Bóris Marin, Salvador Dura-Bernal, Sotirios Panagiotou, Sharon Crook, Matteo Cantarelli, Robert C Cannon, Andrew P Davison, Harsha Gurnani, Robin Angus Silver

“…Data-driven models of neurons and circuits are important for understanding how the properties of membrane conductances, synapses, dendrites, and the anatomical connectivity between neurons generate the complex dynamical behaviors of brain circuits in health and disease. …”
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