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1341
Human lineage mutations regulate RNA-protein binding of conserved genes NTRK2 and ITPR1 involved in human evolution
Published 2024-06-01“…These HLMs enriched in a set of conserved genes highly expressed in adult excitatory neurons and prenatal Purkinje neurons, and were involved in synapse organisation and the GTPase pathway. …”
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1342
Recent Developments on Novel 2D Materials for Emerging Neuromorphic Computing Devices
Published 2025-02-01“…This comprehensive review provides an extensive study of the recent advancements in 2D materials‐based neuromorphic devices especially in multiterminal synaptic devices, two‐terminal synaptic devices, neuronal devices, and the integration of synaptic and neuronal devices. …”
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1343
Reactivation of mTOR signaling slows neurodegeneration in a lysosomal sphingolipid storage disease
Published 2025-01-01“…This accumulation occurs primarily in neurons, and leads to progressive neurodegeneration through a largely unknown process. …”
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1344
Inactivation of the CMAH gene and deficiency of Neu5Gc play a role in human brain evolution
Published 2025-02-01“…The inactivation of CMAH and the loss of endogenous Neu5Gc may have played a role in human brain evolution by affecting neural conduction, neuronal development, and aging.…”
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1345
Synaptic motility and functional stability in the whisker cortex
Published 2025-01-01“…The azimuthal position of a whisker can be estimated from the activity of whisking neurons that respond selectively to a preferred phase along the whisking cycle. …”
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1346
Botulinum Neurotoxin Application to the Severed Femoral Nerve Modulates Spinal Synaptic Responses to Axotomy and Enhances Motor Recovery in Rats
Published 2018-01-01“…Botulinum neurotoxin A (BoNT) and brain-derived neurotrophic factor (BDNF) are known for their ability to influence synaptic inputs to neurons. Here, we tested if these drugs can modulate the deafferentation of motoneurons following nerve section/suture and, as a consequence, modify the outcome of peripheral nerve regeneration. …”
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1347
Guidance Cue Netrin-1 and the Regulation of Inflammation in Acute and Chronic Kidney Disease
Published 2014-01-01“…One such paradigm exists in the developing nervous system, where neuronal migration is mediated by a balance between chemoattractive and chemorepulsive signals. …”
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1348
Glycyrrhizin as a potential disease-modifying therapy for epilepsy: insights into targeting pyroptosis to exert neuroprotective and anticonvulsant effects
Published 2025-01-01“…These patients experience progressive neuronal damage and poor outcomes. Therefore, there is an urgent need for disease-modifying therapy (DMT) that targets the pathogenesis of epilepsy. …”
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1349
Effects of (±) 3,4-Methylenedioxymethamphetamine (MDMA) on Sleep and Circadian Rhythms
Published 2007-01-01“…Certain stimulants, such as 3,4-methylenedioxymethamphetamine (MDMA), may also have the potential to produce persistent alterations in circadian regulation and sleep because they can be neurotoxic toward brain monoaminergic neurons involved in normal sleep regulation. In particular, MDMA has been found to damage brain serotonin (5-HT) neurons in a variety of animal species, including nonhuman primates, with growing evidence that humans are also susceptible to MDMA-induced brain 5-HT neurotoxicity. 5-HT is an important modulator of sleep and circadian rhythms and, therefore, individuals who sustain MDMA-induced 5-HT neurotoxicity may be at risk for developing chronic abnormalities in sleep and circadian patterns. …”
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1350
Calcitonin Gene-Related Peptide in Tension-Type Headache
Published 2002-01-01“…These findings indicate that ongoing activity in sensory neurons in the cranial muscles may be reflected in changes of plasma levels of neuropeptides in patients with chronic tension-type headache. …”
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1351
Study of Brain-derived Neurotrophic Factor in Drug-naive Patients with Schizophrenia
Published 2024-05-01“…Background and Aim: Brain-derived neurotrophic factor (BDNF) is a widely studied neurotrophin and is said to be involved in the regulation of many neuronal processes, including neurogenesis, neuronal differentiation, maturation, and survival. …”
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1352
Therapeutic Potential of 5-HT2C Receptor Ligands
Published 2010-01-01“…In addition, their expression in specific neuronal populations in the hypothalamus would be critical for their role in the regulation of feeding behavior. …”
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1353
Modeling the effect of extrusion parameters on density of biomass pellet using artificial neural network
Published 2024-02-01“…Results: The results showed that a four-layer perceptron network with training algorithm of back propagation, hyperbolic tangential activation function, and Delta training rule with ten neurons in the first hidden layer and four neurons in the second hidden layer had the best performance for the prediction of pellet density. …”
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1354
Haptic Perception with Self-Organizing ANNs and an Anthropomorphic Robot Hand
Published 2010-01-01“…For the mapping of the explored objects, one system uses a Self-Organizing Map (SOM), one uses a Growing Cell Structure (GCS), one uses a Growing Cell Structure with Deletion of Neurons (GCS-DN), and one uses a Growing Grid (GG). …”
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1355
Role of Fractalkine/CX3CL1 and Its Receptor in the Pathogenesis of Inflammatory and Malignant Diseases with Emphasis on B Cell Malignancies
Published 2014-01-01“…It is constitutively expressed in many hematopoietic and nonhematopoietic tissues such as endothelial and epithelial cells, lymphocytes, neurons, microglial osteoblasts. The biological activities of CX3CL1 are mediated by CX3CR1, that is expressed on different cell types such as NK cells, CD14+ monocytes, cytotoxic effector T cells, B cells, neurons, microglia, smooth muscle cells, and tumor cells. …”
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1356
Almost Periodic Solutions for Wilson-Cowan Type Model with Time-Varying Delays
Published 2013-01-01“…Wilson-Cowan model of neuronal population with time-varying delays is considered in this paper. …”
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1357
Single-cell chromatin accessibility landscape profiling reveals the diversity of epigenetic regulation in the rat nervous system
Published 2025-01-01“…We identified cell subtypes of both neuronal and non-neuronal cells with highly specific distributions and characterized gene regulatory elements associated with cell type-specific regions. …”
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1358
IGF-1 Restores Visual Cortex Plasticity in Adult Life by Reducing Local GABA Levels
Published 2012-01-01“…Insulin-like growth factor 1 (IGF-1) is a peptide implicated in prenatal and postnatal phases of brain development such as neurogenesis, neuronal differentiation, synaptogenesis, and experience-dependent plasticity. …”
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1359
Role of Thyroid Hormone in Neurodegenerative Disorders of Older People
Published 2025-01-01“…The pathophysiology of TH-related neurodegeneration include changes in the blood–brain barrier, increased cellular stress, altered processing of β-amyloid precursor protein and the effect of TH on neuronal cell viability. The neurotoxicity of TH is partially mediated by the thyroid hormone responsive protein (THRP). …”
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1360
Sliding Mode Real-Time Control of Photovoltaic Systems Using Neural Estimators
Published 2016-01-01“…In order to test the designed control system, a photovoltaic module model based on a second artificial neuronal network (ANN) has been obtained from experimental data gathered during 18 months in the Faculty of Engineering Vitoria-Gasteiz (Spain). …”
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