The GABA-Withdrawal Syndrome: A Model of Local Status Epilepticus by Carmen Silva-Barrat, Jean Champagnat, Christian Menini

“…In neocorticai slices obtained from GWS rats, most neurons recorded in the GABA-infused area are pyramidal neurons presenting bursting properties. …”
Get full text

Development of the early fetal human thalamus: from a protomap to emergent thalamic nuclei by Maznah Alhesain, Ayman Alzu’bi, Ayman Alzu’bi, Ayman Alzu’bi, Niveditha Sankar, Niveditha Sankar, Charles Smith, Charles Smith, Janet Kerwin, Ross Laws, Susan Lindsay, Gavin J. Clowry

“…The migration of GABAergic neurons into the thalamus occurs over a protracted period, first from the midbrain. …”
Get full text

Behavior Changes in Quinpirole Obsessive-Compulsive Disorder Rats Treated with 6-Hydroxydopamine and the Corresponding Dopaminergic Compulsive Loop Mechanism by Haowen Zheng, Rui He, Yang Ming, Haiping He, Wei Wang, Ligang Chen, Feilong Gong

“…Conclusions: 6-OHDA selectively damages the targets of dopaminergic neurons or nerve fibers within the OCD loop, which somewhat alleviates compulsive behaviours. …”
Get full text

Unbiased identification of cell identity in dense mixed neural cultures by Sarah De Beuckeleer, Tim Van De Looverbosch, Johanna Van Den Daele, Peter Ponsaerts, Winnok H De Vos

“…In mixed iPSC-derived neuronal cultures, microglia could be unequivocally discriminated from neurons, regardless of their reactivity state, and a tiered strategy allowed for further distinguishing activated from non-activated cell states, albeit with lower accuracy. …”
Get full text

Graphene oxide scaffolds promote functional improvements mediated by scaffold-invading axons in thoracic transected rats by Marta Zaforas, Esther Benayas, Raquel Madroñero-Mariscal, Ana Domínguez-Bajo, Elena Fernández-López, Yasmina Hernández-Martín, Ankor González-Mayorga, Elena Alonso-Calviño, Eduardo R. Hernández, Elisa López-Dolado, Juliana M. Rosa, Juan Aguilar, María C. Serrano

“…These neurons are located in the Gigantocellular nucleus of reticular formation and vestibular nuclei, both regions directly related to motor functions. …”
Get full text

Maladaptive changes in the homeostasis of AEA-TRPV1/CB1R induces pain-related hyperactivity of nociceptors after spinal cord injury by JiaQi Hu, WenYong Fan, Yue Xu, XiaoFei Li, HaoYang Zhang, Shun Li, Lei Xue

“…Anandamide (AEA) has been reported to modulate neuronal excitability and synaptic transmission through activation of cannabinoid type-1 receptors (CB1Rs) and transient receptor potential vanilloid 1 (TRPV1). …”
Get full text

Exploring Azithromycin’s Neuroprotective Role in Traumatic Brain Injury: Insights into Cognitive and Motor Recovery and Neuroinflammatory Modulation by Mohannad A. Almikhlafi, Nehad A. Abdallah, Aakash Kumar, Tarun Sharma, Zuber Khan, Haifa A. Fadil, Sultan Althagfan, Ahmed K. B. Aljohani, Sara A. Almadani, Samar F. Miski, Tahani Saeedi, Rayan S. Alharbi, Abdulrahman M. Al-Harthe, Mohammed H. Alsubhi, Hanaa Wanas, Ahmed Aldhafiri, Sidharth Mehan, Hossein M. Elbadawy

“…Histological evaluations focused on neuronal integrity in the cortex, hippocampus, and striatum. …”
Get full text

Identification of candidate genes involved in Zika virus-induced reversible paralysis of mice by John D. Morrey, Venkatraman Siddharthan, Hong Wang, Alexandre L. R. Oliveira, Keiichiro Susuki, Rakesh Kaundal, Sara M. Freeman, Aaron J. Thomas, Naveen Duhan, Nathan G. Corry

“…Using Zikv and Chat chromogenic and fluorescence in situ RNA hybridization, electron microscopy, immunohistochemistry, and ZIKV RT-qPCR, we determined that some paralyzed mice had infected motor neurons, but motor neurons are not reduced in number and the infection was not present in all paralyzed mice; hence infection of motor neurons were not strongly correlated with paralysis. …”
Get full text

Gap junction intercellular communications regulates activation of SARM1 and protects against axonal degeneration by Wen Jie Zhu, Jun Liu, Wan Hua Li, Zhi Ying Zhao, Chongquan Huang, Jian Yuan Yang, Hon Cheung Lee, Yong Juan Zhao

“…The gap junction involved was identified as Cx36 instead. This neuronal GJIC was demonstrated to be functional, enabling healthy neurons to protect adjacent axotomized axons from degeneration. …”
Get full text

DYRK1A (Dual-Specificity Tyrosine-Phosphorylated and -Regulated Kinase 1A): A Gene with Dosage Effect During Development and Neurogenesis by M. Dierssen, M. Martínez de Lagrán

“…The research in the last years suggests a relevant conserved function during neuronal development, related to proliferation and/or differentiation for DYRK1A. …”
Get full text

Is Parkinson’s Disease Truly a Prion-Like Disorder? An Appraisal of Current Evidence by Aneesha Chauhan, Alexander F. Jeans

“…Characterised by a loss of dopaminergic neurons and the development of intraneuronal inclusions known as Lewy bodies, it has classically been thought of as a cell-autonomous disease. …”
Get full text

Copyright protection algorithm based on differential privacy deep fake fingerprint detection model by Chengsheng YUAN, Qiang GUO, Zhangjie FU

“…A copyright protection algorithm based on differential privacy for deep fake fingerprint detection model (DFFDM) was proposed, realizing active copyright protection and passive copyright verification of DFFDM without weakening the performance of the original task.In the original task training, noise was added to introduce randomness, and the expected stability of the differential privacy algorithm was used to make classification decisions to reduce the sensitivity to noise.In passive verification, FGSM was used to generate adversarial samples, the decision boundary was fine-adjusted to establish a backdoor, and the mapping was used as an implanted watermark to realize passive verification.To solve the copyright confusion caused by multiple backdoors, a watermark verification framework was designed, which stamped the trigger backdoors and identified the copyright with the help of time order.In active protection, to provide users with hierarchical services, the key neurons in the task were frozen by probabilistic selection strategy, and the access rights were designed to realize the thawing of neurons, so as to obtain the right to use the original task.Experimental results show that the backdoor verification is still effective under different model performance, and the embedded backdoor shows a certain robustness to the model modification.Also, the proposed algorithm can resist not only the collusion attack by the attacker to recruit legitimate users, but also the fine-tuning and compression attacks caused by the model modification.…”
Get full text

Modulation by NPY/NPF-like receptor underlies experience-dependent, sexually dimorphic learning by Sonu Peedikayil-Kurien, Rizwanul Haque, Asaf Gat, Meital Oren-Suissa

“…Here, we reveal sexual dimorphism in learning: C. elegans males do not learn to avoid the pathogenic bacteria PA14 as efficiently and rapidly as hermaphrodites. Notably, neuronal activity following pathogen exposure was dimorphic: hermaphrodites generate robust representations, while males, in line with their behavior, exhibit contrasting representations. …”
Get full text

Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog. by Eric Dessaud, Vanessa Ribes, Nikolaos Balaskas, Lin Lin Yang, Alessandra Pierani, Anna Kicheva, Bennett G Novitch, James Briscoe, Noriaki Sasai

“…Here we address how Shh signalling assigns the positional identities of distinct neuronal subtype progenitors throughout the ventral neural tube. …”
Get full text

Connectome-based prediction of functional impairment in experimental stroke models. by Oliver Schmitt, Peter Eipert, Yonggang Wang, Atsushi Kanoke, Gratianne Rabiller, Jialing Liu

“…Experimental rat models of stroke and hemorrhage are important tools to investigate cerebrovascular disease pathophysiology mechanisms, yet how significant patterns of functional impairment induced in various models of stroke are related to changes in connectivity at the level of neuronal populations and mesoscopic parcellations of rat brains remain unresolved. …”
Get full text

Operation of Hydroelectric Power Plants, Dam Reservoirs, and Energy Trade Using Artificial Neural Networks by Sibel Akkaya Oy, Serkan İnal, Ali Ekber Özdemir

“…In this study, the next-day energy production of the HEPP was estimated using a neural network with two hidden layers, each with 10 neurons. A neural network with a hidden layer of 20 neurons was used to estimate future electricity prices and the best hours for market clearing price (MCP). …”
Get full text

Spinal Cord Injury and Bladder Dysfunction: New Ideas about an Old Problem by Célia Duarte Cruz, Francisco Cruz

“…Control of the lower urinary tract (LUT) requires complex neuronal circuits that involve elements located at the peripheral nervous system and at different levels of the central nervous system. …”
Get full text

Differential microvascular endothelial cell responses in the retina in diabetes compared to the heart and kidneys, a spatial transcriptomic analysis. by Eric Wang, Biao Feng, Shali Chen, Zhaoliang Su, Subrata Chakrabarti

“…We found minimal similarities between retinal MECs and neuronal cells. Our findings show considerable heterogeneity across retinal, renal, and cardiac MECs, both at the basal state and in their responses to hyperglycemia in diabetes. …”
Get full text

State-of-the-Art Techniques to Causally Link Neural Plasticity to Functional Recovery in Experimental Stroke Research by Anna-Sophia Wahl

“…Here, we review current state-of the art techniques for the examination of cortical reorganization and for the manipulation of neuronal circuits as well as techniques which combine anatomical changes with molecular profiling. …”
Get full text

What is “Hyper” in the ALS Hypermetabolism? by Alberto Ferri, Roberto Coccurello

“…The progressive and fatal loss of upper (brain) and lower (spinal cord) motor neurons and muscle denervation concisely condenses the clinical picture of amyotrophic lateral sclerosis (ALS). …”
Get full text