An Expert Diagnosis System for Parkinson Disease Based on Genetic Algorithm-Wavelet Kernel-Extreme Learning Machine by Derya Avci, Akif Dogantekin

“…These parameters and the numbers of hidden neurons play a major role in the performance of ELM. …”
Get full text

Neural correlates of executive control in the avian brain. by Jonas Rose, Michael Colombo

“…When instructed to remember, many neurons showed sustained activation throughout the memory period. …”
Get full text

Presynaptic Ionotropic Receptors Controlling and Modulating the Rules for Spike Timing-Dependent Plasticity by Matthijs B. Verhoog, Huibert D. Mansvelder

“…Throughout life, activity-dependent changes in neuronal connection strength enable the brain to refine neural circuits and learn based on experience. …”
Get full text

Calcium Signalling in Neurological Disorders, with Insights from Miniature Fluorescence Microscopy by Dechuan Sun, Mona Amiri, Qi Meng, Ranjith R. Unnithan, Chris French

“…Growing evidence suggests that disrupted neuronal calcium signalling contributes to the pathophysiology of NDs. …”
Get full text

Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel by Victor I. Popov, Igor V. Kraev, Dmitri A. Ignat'ev, Michael G. Stewart

“…Our data suggest that doublecortin-labelled immature cells exist in a mitotic state and may represent a renewable pool for generation of new neurons within the dentate gyrus.…”
Get full text

Neuroprotective Activity of (-)-Epigallocatechin Gallate against Lipopolysaccharide-Mediated Cytotoxicity by Jin-Biao Liu, Li Zhou, Yi-Zhong Wang, Xu Wang, Yu Zhou, Wen-Zhe Ho, Jie-Liang Li

“…Furthermore, EGCG treatment of neurons could inhibit LPS-induced production of reactive oxygen species (ROS). …”
Get full text

Cardiac Dysrhythmias and Neurological Dysregulation: Manifestations of Profound Hypomagnesemia by Sagger Mawri, Edward Gildeh, Namita Joseph, Bobak Rabbani, Bryan Zweig

“…Among its various roles, magnesium modulates calcium entry and release from sarcoplasmic reticulum and regulates ATP pumps in myocytes and neurons, thereby regulating cardiac and neuronal excitability. …”
Get full text

Amniotic-Fluid Stem Cells: Growth Dynamics and Differentiation Potential after a CD-117-Based Selection Procedure by S. Arnhold, S. Glüer, K. Hartmann, O. Raabe, K. Addicks, S. Wenisch, M. Hoopmann

“…In contrast, in the unselected cell population neuronal differentiation is enhanced.…”
Get full text

Microglial Ion Channels as Potential Targets for Neuroprotection in Parkinson’s Disease by Jason R. Richardson, Muhammad M. Hossain

“…It is thought that the loss of neurons and development of inclusion bodies occur gradually over decades until they progress to the point where ~60% of the dopamine neurons are lost and patients present with motor dysfunction. …”
Get full text

A membrane-targeted photoswitch restores physiological ON/OFF responses to light in the degenerate retina by Gaia Ziraldo, Sara Cupini, Valentina Sesti, Emanuela Delfino, Guglielmo Lanzani, Chiara Bertarelli, Fabio Benfenati, Stefano Di Marco

“…However, visual restoration is poor due to the massive light-evoked activation of retinal neurons, regardless of the segregation of visual information in ON and OFF channels, which is essential for contrast sensitivity and spatial resolution. …”
Get full text

Role of nitric oxide synthase on brain GABA transaminase activity and GABA levels by Vega Rasgado Lourdes A., Reyes Guillermo Ceballos, Vega Díaz Fernando

“…Inhibition of endothelial and neuronal NOS (eNOS and nNOS) had opposite effects on GABA-T activity and GABA levels, even during seizures induced by pentylenetetrazole. …”
Get full text

Astrocytic heterogeneous nuclear ribonucleoprotein U is involved in scar formation after spinal cord injury by Lili Quan, Akiko Uyeda, Ichiro Manabe, Rieko Muramatsu

“…Inhibition of Hnrnpu in astrocytes impairs the formation of astrocytic glial scar, motor function recovery, and neuronal regeneration after spinal cord injury (SCI) in mice. …”
Get full text

Axon Guidance Mechanisms for Establishment of Callosal Connections by Mitsuaki Nishikimi, Koji Oishi, Kazunori Nakajima

“…In this paper, we review these guidance mechanisms during the development of the callosal neurons. Midline populations express and secrete guidance molecules, and “pioneer” axons as well as interactions between the medial and lateral axons are also involved in the axon pathfinding of the callosal neurons. …”
Get full text

Defects in hair cells disrupt the development of auditory peripheral circuitry by Riley T. Bottom, Yijun Xu, Caroline Siebald, Jinsei Jung, Ulrich Müller

“…Treatment modalities for deafness thus need to consider restoration of the function of both hair cells and neurons, even when the primary defect occurs in hair cells.…”
Get full text

Distinct role of primate DLPFC and LIP in hierarchical control of learned saccade sequences by Qingjun Wang, Binchao Shi, Jing Jia, Jingyu Hu, Haoran Li, Xin Jin, Aihua Chen

“…The electrophysiological recording revealed that sequence-level initiation information was mostly signaled by DLPFC neurons, whereas subsequence-level transition was largely encoded by LIP neurons. …”
Get full text

Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature by YuBing Y. Shen, Jyoti V. Jethe, Ashlan P. Reid, Jacob Hehir, Marcello Magri Amaral, Chao Ren, Senyue Hao, Chao Zhou, Jonathan A. N. Fisher

“…An increasing body of research has identified mechanosensitive ion channels that can be modulated by FUS and support acute electrical activity in neurons. However, neuromodulatory effects that persist from hours to days have also been reported. …”
Get full text

Effects of Methamphetamine on Single Unit Activity in Rat Medial Prefrontal Cortex In Vivo by Jinhwa Jang, Hee-Jin Ha, Yun Bok Kim, Young-Ki Chung, Min Whan Jung

“…To investigate how neuronal activity in the prefrontal cortex changes in an animal model of schizophrenia, we recorded single unit activity in the medial prefrontal cortex of urethane-anesthetized and awake rats following methamphetamine (MA) administration. …”
Get full text

Pleiotropic effects of mutant huntingtin on retinopathy in two mouse models of Huntington's disease by Hui Xu, Anakha Ajayan, Ralf Langen, Jeannie Chen

“…Furthermore, we show that the RPE cells from R6/1 mice contain mHTT nuclear inclusions, adding to the list of non-neuronal cells with mHTT aggregates and pathology. …”
Get full text

Network-wide effects of pallidal deep brain stimulation normalised abnormal cerebellar cortical activity in the dystonic animal model by Fabiana Santana Kragelund, Konstantinos Spiliotis, Marco Heerdegen, Tina Sellmann, Henning Bathel, Anika Lüttig, Angelika Richter, Jens Starke, Rüdiger Köhling, Denise Franz

“…This study explores how pallidal DBS alters spatiotemporal pattern formation of neuronal dynamics within the cerebellar cortex in a dystonic animal model, the dtsz hamster. …”
Get full text

MeHg Developing Exposure Causes DNA Double-Strand Breaks and Elicits Cell Cycle Arrest in Spinal Cord Cells by Fabiana F. Ferreira, Dib Ammar, Gilian F. Bourckhardt, Karoline Kobus-Bianchini, Yara M. R. Müller, Evelise M. Nazari

“…These results showed that in ovo MeHg exposure alters spinal cord development by disturbing the cell proliferation and death, also interfering in early neuronal differentiation.…”
Get full text