Complex Inflammation mRNA-Related Response in ALS Is Region Dependent by Sara Berjaoui, Mónica Povedano, Paula Garcia-Esparcia, Margarita Carmona, Ester Aso, Isidre Ferrer

“…Increased expression and abnormal distribution of IL-1β occurred in motor neurons of the lumbar spinal cord in ALS. Strong IL-10 immunoreactivity colocalizes with TDP-43-positive inclusions in motor neurons in ALS cases. …”
Get full text

Characterization of Neural Interaction During Learning and Adaptation from Spike-Train Data by Liqiang Zhu, Ying-Cheng Lai, Frank C. Hoppensteadt, Jiping He

“…Given that typical experimentaldata consist of spike trains recorded from individual neurons,probing the strength of neural interactions and their changes isextremely challenging. …”
Get full text

Expression of Neural Markers by Undifferentiated Mesenchymal-Like Stem Cells from Different Sources by Dana Foudah, Marianna Monfrini, Elisabetta Donzelli, Stefania Niada, Anna T. Brini, Monia Orciani, Giovanni Tredici, Mariarosaria Miloso

“…Our results suggest that the expression of βIII-tubulin and NeuN could be a common feature of stem cells and not exclusive to neuronal cells. This could result in a reassessment of the use of βIII-tubulin and NeuN as the only evidence proving neuronal differentiation. …”
Get full text

Intravenous Administration of Adipose-Derived Stem Cell Protein Extracts Improves Neurological Deficits in a Rat Model of Stroke by Kai Zhao, Rui Li, Changcong Gu, Long Liu, Yulong Jia, Xize Guo, Wanping Zhang, Chunying Pei, Linlu Tian, Bo Li, Jianrong Jia, Huakun Cheng, Hongwei Xu, Lixian Li

“…Treatment of adipose-derived stem cell (ADSC) substantially improves the neurological deficits during stroke by reducing neuronal injury, limiting proinflammatory immune responses, and promoting neuronal repair, which makes ADSC-based therapy an attractive approach for treating stroke. …”
Get full text

Enhanced Neuroprotective Effects of Coadministration of Tetrandrine with Glutathione in Preclinical Model of Parkinson’s Disease by Xiang-Yun Li, Guang-Hai Mei, Qiang Dong, Yu Zhang, Zhuang-Li Guo, Jing-Jing Su, Yu-Ping Tang, Xue-Hong Jin, Hou-Guang Zhou, Yan-Yan Huang

“…However, in the GSH + Tet group, we observed markedly decreased oxidative damage, inhibition of DA metabolism and enhanced DA synthesis, increased tyrosine hydroxylase- (TH-) immunopositive neuronal survival, and delayed apoptosis of dopaminergic neurons in the SN. …”
Get full text

N-Acetylcysteine in Combination with IGF-1 Enhances Neuroprotection against Proteasome Dysfunction-Induced Neurotoxicity in SH-SY5Y Cells by Benxu Cheng, Pinki Anand, Anxiu Kuang, Feroz Akhtar, Virginia L. Scofield

“…Ubiquitin proteasome system (UPS) dysfunction has been implicated in the development of many neuronal disorders, including Parkinson’s disease (PD). …”
Get full text

Mechanisms Underlying Adaptation of Respiratory Network Activity to Modulatory Stimuli in the Mouse Embryo by Marc Chevalier, Rafaël De Sa, Laura Cardoit, Muriel Thoby-Brisson

“…By combining electrophysiology and calcium imaging performed on embryonic brainstem slice preparations, we provide evidence showing that embryonic inspiratory pacemaker neurons are already intrinsically sensitive to neuromodulation and external conditions (i.e., temperature) affecting respiratory network activity, suggesting a potential role of pacemaker neurons in mediating rhythm adaptation to modulatory stimuli in the embryo.…”
Get full text

A Hybrid Approach for Modular Neural Network Design Using Intercriteria Analysis and Intuitionistic Fuzzy Logic by Sotir Sotirov, Evdokia Sotirova, Vassia Atanassova, Krassimir Atanassov, Oscar Castillo, Patricia Melin, Todor Petkov, Stanimir Surchev

“…On the other hand, a high number of neurons can slow down the learning process, which is not desired. …”
Get full text

Transcriptomic analysis reinforces the implication of spatacsin in neuroinflammation and neurodevelopment by Liriopé Toupenet Marchesi, Daniel Stockholm, Typhaine Esteves, Marion Leblanc, Nicolas Auger, Julien Branchu, Khalid Hamid El Hachimi, Giovanni Stevanin

“…Abstract Hereditary spastic paraplegia (HSP) encompasses a group of rare genetic diseases primarily affecting motor neurons. Among these, spastic paraplegia type 11 (SPG11) represents a complex form of HSP caused by deleterious variants in the SPG11 gene, which encodes the spatacsin protein. …”
Get full text

Estimación del estado de carga de una batería de litio con redes neuronales y validación con FPGA-en-lazo by Erik Martínez-Vera, Alfredo Rosado-Muñoz, Pedro Bañuelos-Sánchez

“…En este trabajo, se utiliza un conjunto de datos de ciclado de una batería de Litio para entrenar una red neuronal para la estimación del estado de carga. Se realiza una optimización bayesiana para establecer la mejor arquitectura de red neuronal y se valida el comportamiento frente a las mediciones reales que ofrece el conjunto de datos. …”
Get full text

Multi-modal investigation reveals pathogenic features of diverse DDX3X missense mutations. by Federica Mosti, Mariah L Hoye, Carla F Escobar-Tomlienovich, Debra L Silver

“…Notably, clinically severe mutations exhibit excessive DNA damage in neurons, associated with increased cytoplasmic DNA:RNA hybrids and formation of stress granules. …”
Get full text

Unravelling a mechanistic link between mitophagy defect, mitochondrial malfunction, and apoptotic neurodegeneration in Mucopolysaccharidosis VII by Nishan Mandal, Apurba Das, Rupak Datta

“…Energy depletion triggered apoptosis in neuronal as well as non-neuronal cells of the CG2135−/− fly brain, where apoptotic dopaminergic neurons were also detected. …”
Get full text

Exploring the Mechanism on the Medullary Visceral Zone Inhibiting the Cholinergic Anti-inflammatory Pathway Induced by Sepsis by H. B. Li, Y. Zhou, A. H. Zhao, L. L. Guo

“…In MVZ of septic rats, many cholinergic and catecholaminergic neurons showed apoptotic, with low expressions of tyrosine hydroxylase and choline acetyltransferase. …”
Get full text

The role of the corticotropin-releasing hormone and its receptors in the regulation of stress response by E. V. Sukhareva

“…The activation of the hypothalamic-pituitary-adrenal axis (HPA axis) by neurons of the paraventricular hypothalamic nucleus (PVN), the primary site of synthesis CRH, triggers stress reactions. …”
Get full text

HyQ2: A Hybrid Quantum Neural Network for NextG Vulnerability Detection by Yifeng Peng, Xinyi Li, Zhiding Liang, Ying Wang

“…We propose the HyQ2 method to overcome these challenges, which constructs quantum neurons by selecting random neurons' outputs from a classical neural network. …”
Get full text

GABA Metabolism and Transport: Effects on Synaptic Efficacy by Fabian C. Roth, Andreas Draguhn

“…GABAergic inhibition is an important regulator of excitability in neuronal networks. In addition, inhibitory synaptic signals contribute crucially to the organization of spatiotemporal patterns of network activity, especially during coherent oscillations. …”
Get full text

Protocol to study inter-tissue communication between the hypothalamus and white adipose tissue and lifespan using a chemogenetic approach in aged mice by Kyohei Tokizane, Shin-ichiro Imai

“…Summary: Here, we present a protocol for assessing the impact of a chemogenetic manipulation in a subpopulation of the hypothalamic neurons on aging and lifespan control using a mouse model developed specifically for this purpose. …”
Get full text

Protocol to study the role of medial entorhinal cortex-basolateral amygdala circuit in context-induced retrieval of morphine withdrawal memory in mice by Yali Fu, Ting Ye, Ming Chen, Bin Lai, Ping Zheng

“…Here, we present a protocol to evaluate the importance of projection neurons from the MEC to the basolateral amygdala (BLA) (MEC-BLA neurons) in mice during context-induced retrieval of morphine withdrawal memory using a conditioned place aversion (CPA) model. …”
Get full text

Parkinson's Disease: Clinical Signs and Symptoms, Neural Mechanisms, Positron Emission Tomography, and Therapeutic Interventions by K. L. Leenders, W. H. Oertel

“…Its time course is slow and is characterized by progressive loss of dopaminergic and other brainstem neurons resulting in malfunctioning of the cerebral neuronal systems responsible for motor functions. …”
Get full text

Biomarkers and Their Possible Functions in the Intestinal Microenvironment of Chagasic Megacolon: An Overview of the (Neuro)inflammatory Process by José Rodrigues do Carmo Neto, Yarlla Loyane Lira Braga, Arthur Wilson Florêncio da Costa, Fernanda Hélia Lucio, Thais Cardoso do Nascimento, Marlene Antônia dos Reis, Mara Rubia Nunes Celes, Flávia Aparecida de Oliveira, Juliana Reis Machado, Marcos Vinícius da Silva

“…The association between inflammatory processes and intestinal neuronal destruction during the progression of Chagasic megacolon is well established. …”
Get full text