Hyaluronidase-induced matrix remodeling contributes to long-term synaptic changes by Rostislav Sokolov, Rostislav Sokolov, Viktoriya Krut', Viktoriya Krut', Vsevolod Belousov, Vsevolod Belousov, Vsevolod Belousov, Vsevolod Belousov, Andrey Rozov, Andrey Rozov, Irina V. Mukhina, Irina V. Mukhina

“…The ECM is synthesized by neurons, astrocytes, and other types of cells. Hyaluronan, a hyaluronic acid polymer, is a key component of the ECM. …”
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DLK-dependent axonal mitochondrial fission drives degeneration after axotomy by Jorge Gómez-Deza, Matthew Nebiyou, Mor R. Alkaslasi, Francisco M. Nadal-Nicolás, Preethi Somasundaram, Anastasia L. Slavutsky, Wei Li, Michael E. Ward, Trent A. Watkins, Claire E. Le Pichon

“…Importantly, we show that CRISPR mediated Drp1 depletion protects mouse retinal ganglion neurons from degeneration after optic nerve crush. …”
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Syngap1 promotes cognitive function through regulation of cortical sensorimotor dynamics by Thomas Vaissiere, Sheldon D. Michaelson, Thomas Creson, Jessie Goins, Daniel Fürth, Diana Balazsfi, Camilo Rojas, Randall Golovin, Konstantinos Meletis, Courtney A. Miller, Daniel O’Connor, Lorenzo Fontolan, Gavin Rumbaugh

“…Here, we demonstrate in mice that expression of the autism/intellectual disability gene, Syngap1, in cortical excitatory neurons is required for the formation of somatomotor networks that promote SMI-mediated perception. …”
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Sub-cellular population imaging tools reveal stable apical dendrites in hippocampal area CA3 by Jason J. Moore, Shannon K. Rashid, Emmett Bicker, Cara D. Johnson, Naomi Codrington, Dmitri B. Chklovskii, Jayeeta Basu

“…Abstract Apical and basal dendrites of pyramidal neurons receive anatomically and functionally distinct inputs, implying compartment-level functional diversity during behavior. …”
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Immune System in the Brain: A Modulatory Role on Dendritic Spine Morphophysiology? by Oscar Kurt Bitzer-Quintero, Ignacio González-Burgos

“…In addition, astrocytes, oligodendrocytes, endothelial cells, and, to a lesser extent, neurons are implicated in the immune response in the central nervous system. …”
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The Impact of Electrophysiological Diversity on Pattern Completion in Lithium Nonresponsive Bipolar Disorder: A Computational Modeling Approach by Abraham Nunes, Selena Singh, Anouar Khayachi, Shani Stern, Thomas Trappenberg, Martin Alda

“…Induced pluripotent stem cell–derived CA3 pyramidal cell–like neurons show significant hyperexcitability in lithium‐responsive BD patients, while lithium nonresponders show marked variance in hyperexcitability. …”
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Subminute thermal damage to cell types present in the skin by Meagan Doppegieter, Ton G. van Leeuwen, Angela van Weert, Maurice C.G. Aalders, Erik N.T.P. Bakker

“…Especially within the range of 50–60 °C, survival of neuronal cells and keratinocytes was significantly less than that of endothelial and smooth muscle cells. …”
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Polysulfide and persulfide-mediated activation of the PERK-eIF2α-ATF4 pathway increases Sestrin2 expression and reduces methylglyoxal toxicity by Shin Koike, Hideo Kimura, Yuki Ogasawara

“…Here, we demonstrated that polysulfide treatment promoted the oligomerization of PERK and PTP1B in neuronal cells using western blotting under nonreducing conditions. …”
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Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms by Ali Mohammadkhanizadeh, Mohammad Sheibani, Soroush Taherkhani, Davood Nourabadi, Seyed Mahdi Mohamadi-Zarch, Farnaz Nikbakht, Yaser Azizi

“…Neurodegenerative diseases (NDs) are characterized by the progressive loss of neurons and neuronal connections, leading to cognitive decline, memory impairment, and motor dysfunction. …”
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Discriminating neural ensemble patterns through dendritic computations in randomly connected feedforward networks by Bhanu Priya Somashekar, Upinder Singh Bhalla

“…Local convergence of such patterned activity as synaptic clusters on dendrites could help single neurons harness the potential of dendritic nonlinearities to decode neural activity patterns. …”
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The role of neurotrophic factors in retinal ganglion cell resiliency by Alan K. Abraham, Alan K. Abraham, Michael Telias, Michael Telias

“…The death of RGCs in either case will irreversibly cause loss of vision, as RGCs are the sole output neurons of the retina. RGC neurodegeneration affects certain neurons preferentially, resulting in subpopulations of resilient and susceptible cells. …”
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Mitochondrial transplantation: a promising strategy for the treatment of retinal degenerative diseases by Jing Chi, Bin Fan, Yulin Li, Qing Jiao, Guang-Yu Li

“…Mitochondria, the primary powerhouses of the cell, play an integral role in retinal physiology by fulfilling the high-energy requirements of photoreceptors and secondary neurons through oxidative phosphorylation. In a healthy state, mitochondria ensure proper visual function by facilitating efficient conversion and transduction of visual signals. …”
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Application of Artificial Neural Network in the Baking Process of Salmon by Pengfei Jiang, Kaiyue Zhu, Shan Shang, Wengang Jin, Wanying Yu, Shuang Li, Shen Wang, Xiuping Dong

“…The best network topology occurred with 5 input layer neurons, 17 hidden layer neurons, and 2 output layer neurons, and the MSE was 0.00153, and Rall was 0.99661. …”
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Revealing and mitigating the inhibitory effect of serotonin on HRP-mediated protein labelling by Zora Chui-Kuen Chan, Cheng Qi, Yuanhong Cai, Xin Li, Jing Ren

“…Profiling proteins at this detailed level is essential for understanding the molecular mechanisms of neuronal connectivity and transmission. Despite its recent successful application to various neuronal types, proximity labelling has yet to be employed to study the serotonin system. …”
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The Contribution of α-Synuclein Spreading to Parkinson’s Disease Synaptopathy by Francesca Longhena, Gaia Faustini, Cristina Missale, Marina Pizzi, PierFranco Spano, Arianna Bellucci

“…Indeed, α-synuclein accumulation can impair synaptic dopamine release and induces the death of nigrostriatal neurons. While in physiological conditions the protein can interact with and modulate synaptic vesicle proteins and membranes, numerous experimental evidences have confirmed that its pathological aggregation can compromise correct neuronal functioning. …”
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Action Selection and Operant Conditioning: A Neurorobotic Implementation by André Cyr, Frédéric Thériault

“…We base our AS process on a simple central pattern generator (CPG), decision neurons, sensory neurons, and motor neurons as the main circuit components. …”
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Blockade of NR2A-Containing NMDA Receptors Induces Tau Phosphorylation in Rat Hippocampal Slices by Julie Allyson, Eve Dontigny, Yves Auberson, Michel Cyr, Guy Massicotte

“…From a mechanistic perspective, our study revealed that blockade of NR2A-containing receptors influences Tau phosphorylation probably by increasing calcium influx into neurons, which seems to rely on accumulation of new NR1/NR2B receptors in neuronal membranes and could involve the cyclin-dependent kinase 5 pathway.…”
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Noradrenergic inputs from the locus coeruleus to anterior piriform cortex and the olfactory bulb modulate olfactory outputs by Chi Geng, Ruochen Li, Shan Li, Penglai Liu, Yuxin Peng, Changyu Liu, Zhen Wang, Hongxing Zhang, Anan Li

“…Abstract Norepinephrine (NE) released from locus coeruleus (LC) noradrenergic (NAergic) neurons plays a pivotal role in the regulation of olfactory behaviors. …”
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Hippocampal Dendritic Spines Are Segregated Depending on Their Actin Polymerization by Nuria Domínguez-Iturza, María Calvo, Marion Benoist, José Antonio Esteban, Miguel Morales

“…Using FRAP, we have reexamined the actin dynamics of individual spines from pyramidal hippocampal neurons, both in cultures and in hippocampal organotypic slices. …”
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Early Neural Cell Death Is an Extensive, Dynamic Process in the Embryonic Chick and Mouse Retina by Teresa Chavarría, Jimena Baleriola, Raquel Mayordomo, Flora de Pablo, Enrique J. de la Rosa

“…We performed a parallel study in embryonic chick and mouse retinas, focusing on the period during which the first neurons, the retinal ganglion cells (RGCs), are generated. …”
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