Showing 321 - 340 results of 2,514 for search '"neuron"', query time: 0.07s Refine Results
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    Deciphering the interactome of Ataxin-2 and TDP-43 in iPSC-derived neurons for potential ALS targets. by Yuan Tian, Nicolette Heinsinger, Yinghui Hu, U-Ming Lim, Yi Wang, Aaron Zefrin Fernandis, Sophie Parmentier-Batteur, Becky Klein, Jason M Uslaner, Sean M Smith

    Published 2024-01-01
    “…Co-immunoprecipitation demonstrated that Ataxin-2 and TDP-43 interact, that their interaction is mediated through the RNA recognition motif (RRM) of TDP-43, and knocking down Ataxin-2 or mutating the RRM domains rescued TDP-43 toxicity in an iPSC-derived neuronal model with TDP-43 overexpression. To decipher the Ataxin-2 and TDP-43 interactome, we used co-immunoprecipitation followed by mass spectrometry to identify proteins that interacted with Ataxin-2 and TDP-43 under conditions of endogenous or overexpressed TDP-43 in iPSC-derived neurons. …”
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  3. 323

    Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus by Natalia Avaliani, Ulrich Pfisterer, Andreas Heuer, Malin Parmar, Merab Kokaia, My Andersson

    Published 2017-01-01
    “…Direct conversion of human somatic cells to induced neurons (iNs), using lineage-specific transcription factors has opened new opportunities for cell therapy in a number of neurological diseases, including epilepsy. …”
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  4. 324

    Study of the neuronal response to olfactory stimuli in control and LPS-stimulated mice by functional magnetic resonance imaging by A. E. Akulov, A. V. Romashchenko, O. B. Shevelev, D. V. Petrovski, A. A. Savelov, M. P. Moshkin

    Published 2015-12-01
    “…Olfactory stimulus type affected neuronal response rate in an olfactory bulb but did not affect response parameters in other brain regions studied. …”
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    The Dissemination of Rift Valley Fever Virus to the Eye and Sensory Neurons of Zebrafish Larvae Is Stat1-Dependent by Sebastiaan ter Horst, Aleksandra Siekierska, Ann-Sofie De Meulemeester, Arno Cuvry, Laura Cools, Johan Neyts, Peter de Witte, Joana Rocha-Pereira

    Published 2025-01-01
    “…Thus, RVFV-induced blindness likely occurs due to direct damage to the eye and peripheral neurons, rather than the brain. Treatment with the JAK-inhibitor ruxolitinib, as well as knockout of <i>stat1a</i> but not <i>stat1b</i>, enhanced RVFV replication to ~6 log<sub>10</sub> viral RNA copies/larva and ultra-bright livers, although without dissemination to sensory neurons or the eye, thereby confirming the critical role of <i>stat1</i> in RVFV pathogenesis.…”
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  8. 328

    Intrathecal Resiniferatoxin Modulates TRPV1 in DRG Neurons and Reduces TNF-Induced Pain-Related Behavior by M. Leo, M. Schulte, L.-I. Schmitt, M. Schäfers, C. Kleinschnitz, T. Hagenacker

    Published 2017-01-01
    “…Transient receptor potential vanilloid-1 (TRPV1) is a nonselective cation channel, predominantly expressed in sensory neurons. TRPV1 is known to play an important role in the pathogenesis of inflammatory and neuropathic pain states. …”
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    Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via α2-Adrenoceptors in Trigeminal Ganglion Neurons by Sang-Taek Im, Youn Yi Jo, Gayoung Han, Hyun Jung Jo, Yong Ho Kim, Chul-Kyu Park

    Published 2018-01-01
    “…Two types of voltage-gated sodium channels, Nav1.7 and Nav1.8, as well as α2-adrenoceptors are expressed in primary sensory neurons of the trigeminal ganglion (TG). Using whole-cell patch-clamp recordings, we investigated the effects of dexmedetomidine on voltage-gated sodium channel currents (INa) via α2-adrenoceptors in dissociated, small-sized TG neurons. …”
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    Potential Protection of Coeloglossum viride var. Bracteatum Extract against Oxidative Stress in Rat Cortical Neurons by Zhe Guo, Rui-Yuan Pan, Xiao-Yan Qin

    Published 2013-01-01
    “…The present study explored the neuroprotective effect of Coeloglossum viride var. bracteatum extract (CE) against oxidative stress in rat cortical neurons. The results demonstrated that administration of CE inhibited hydrogen peroxide-induced neurotoxicity tested by MTT, LDH release, and TUNEL assays. …”
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    Effect of age and sex differences on the abundances of neuronal, glial, and endothelial cells in non-diseased brain tissue. by Arttu Autio-Kimura, Tapio Nevalainen, Mikko Hurme

    Published 2024-01-01
    “…Neuroinflammatory and neurodegenerative diseases are influenced by the complex interplay of different cell types within the brain, and understanding the proportions and dynamics of neuronal, glial, and endothelial cells is crucial for deciphering the mechanisms of these diseases. …”
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    Fate erasure logic of gene networks underlying direct neuronal conversion of somatic cells by microRNAs by Kitra Cates, Luorongxin Yuan, Yan Yang, Andrew S. Yoo

    Published 2025-01-01
    “…Summary: Neurogenic microRNAs 9/9∗ and 124 (miR-9/9∗-124) drive the direct reprogramming of human fibroblasts into neurons with the initiation of the fate erasure of fibroblasts. …”
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    Differentiation of Human Embryonic Stem Cells to Sympathetic Neurons: A Potential Model for Understanding Neuroblastoma Pathogenesis by Jane Carr-Wilkinson, Nilendran Prathalingam, Deepali Pal, Mohammad Moad, Natalie Lee, Aishwarya Sundaresh, Helen Forgham, Peter James, Mary Herbert, Majlinda Lako, Deborah A. Tweddle

    Published 2018-01-01
    “…Previous studies modelling human neural crest differentiation from stem cells have resulted in a low yield of sympathetic neurons. Our aim was to optimise a method for the differentiation of human embryonic stem cells (hESCs) to sympathetic neuron-like cells (SN) to model normal human SNS development. …”
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