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The approximate lag and anticipating synchronization between two unidirectionally coupled Hindmarsh-Rose neurons with uncertain parameters
Published 2024-10-01Subjects: Get full text
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322
Deciphering the interactome of Ataxin-2 and TDP-43 in iPSC-derived neurons for potential ALS targets.
Published 2024-01-01“…Co-immunoprecipitation demonstrated that Ataxin-2 and TDP-43 interact, that their interaction is mediated through the RNA recognition motif (RRM) of TDP-43, and knocking down Ataxin-2 or mutating the RRM domains rescued TDP-43 toxicity in an iPSC-derived neuronal model with TDP-43 overexpression. To decipher the Ataxin-2 and TDP-43 interactome, we used co-immunoprecipitation followed by mass spectrometry to identify proteins that interacted with Ataxin-2 and TDP-43 under conditions of endogenous or overexpressed TDP-43 in iPSC-derived neurons. …”
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323
Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus
Published 2017-01-01“…Direct conversion of human somatic cells to induced neurons (iNs), using lineage-specific transcription factors has opened new opportunities for cell therapy in a number of neurological diseases, including epilepsy. …”
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324
Study of the neuronal response to olfactory stimuli in control and LPS-stimulated mice by functional magnetic resonance imaging
Published 2015-12-01“…Olfactory stimulus type affected neuronal response rate in an olfactory bulb but did not affect response parameters in other brain regions studied. …”
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325
LIM-kinase 1 effects on memory abilities and male courtship song in Drosophila depend on the neuronal type
Published 2023-06-01Subjects: Get full text
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326
Prefrontal cortex neuronal ensembles dynamically encode task features during associative memory and virtual navigation
Published 2025-01-01“…Summary: Neuronal populations expand their information-encoding capacity using mixed selective neurons. …”
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327
The Dissemination of Rift Valley Fever Virus to the Eye and Sensory Neurons of Zebrafish Larvae Is Stat1-Dependent
Published 2025-01-01“…Thus, RVFV-induced blindness likely occurs due to direct damage to the eye and peripheral neurons, rather than the brain. Treatment with the JAK-inhibitor ruxolitinib, as well as knockout of <i>stat1a</i> but not <i>stat1b</i>, enhanced RVFV replication to ~6 log<sub>10</sub> viral RNA copies/larva and ultra-bright livers, although without dissemination to sensory neurons or the eye, thereby confirming the critical role of <i>stat1</i> in RVFV pathogenesis.…”
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328
Intrathecal Resiniferatoxin Modulates TRPV1 in DRG Neurons and Reduces TNF-Induced Pain-Related Behavior
Published 2017-01-01“…Transient receptor potential vanilloid-1 (TRPV1) is a nonselective cation channel, predominantly expressed in sensory neurons. TRPV1 is known to play an important role in the pathogenesis of inflammatory and neuropathic pain states. …”
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329
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Blood biomarkers for vascular cognitive impairment based on neuronal function: a systematic review and meta-analysis
Published 2025-02-01Subjects: Get full text
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331
Dexmedetomidine Inhibits Voltage-Gated Sodium Channels via α2-Adrenoceptors in Trigeminal Ganglion Neurons
Published 2018-01-01“…Two types of voltage-gated sodium channels, Nav1.7 and Nav1.8, as well as α2-adrenoceptors are expressed in primary sensory neurons of the trigeminal ganglion (TG). Using whole-cell patch-clamp recordings, we investigated the effects of dexmedetomidine on voltage-gated sodium channel currents (INa) via α2-adrenoceptors in dissociated, small-sized TG neurons. …”
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Modeling and correction of protein conformational disease in iPSC-derived neurons through personalized base editing
Published 2025-03-01Subjects: Get full text
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334
Gal-3 activates Tyro3 to ameliorate ferroptosis of hippocampal neurons after traumatic brain injury
Published 2025-03-01Subjects: Get full text
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335
Potential Protection of Coeloglossum viride var. Bracteatum Extract against Oxidative Stress in Rat Cortical Neurons
Published 2013-01-01“…The present study explored the neuroprotective effect of Coeloglossum viride var. bracteatum extract (CE) against oxidative stress in rat cortical neurons. The results demonstrated that administration of CE inhibited hydrogen peroxide-induced neurotoxicity tested by MTT, LDH release, and TUNEL assays. …”
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336
Neuronal Ceroid Lipofuscinosis in Border Collie Dogs in Japan: Clinical and Molecular Epidemiological Study (2000–2011)
Published 2012-01-01“…Neuronal ceroid lipofuscinosis (NCL) is an inherited, neurodegenerative lysosomal disease that causes premature death. …”
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Effect of age and sex differences on the abundances of neuronal, glial, and endothelial cells in non-diseased brain tissue.
Published 2024-01-01“…Neuroinflammatory and neurodegenerative diseases are influenced by the complex interplay of different cell types within the brain, and understanding the proportions and dynamics of neuronal, glial, and endothelial cells is crucial for deciphering the mechanisms of these diseases. …”
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339
Fate erasure logic of gene networks underlying direct neuronal conversion of somatic cells by microRNAs
Published 2025-01-01“…Summary: Neurogenic microRNAs 9/9∗ and 124 (miR-9/9∗-124) drive the direct reprogramming of human fibroblasts into neurons with the initiation of the fate erasure of fibroblasts. …”
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340
Differentiation of Human Embryonic Stem Cells to Sympathetic Neurons: A Potential Model for Understanding Neuroblastoma Pathogenesis
Published 2018-01-01“…Previous studies modelling human neural crest differentiation from stem cells have resulted in a low yield of sympathetic neurons. Our aim was to optimise a method for the differentiation of human embryonic stem cells (hESCs) to sympathetic neuron-like cells (SN) to model normal human SNS development. …”
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