Advances in Deep Brain Imaging with Quantum Dots: Structural, Functional, and Disease-Specific Roles by Tenesha Connor, Hemal Weerasinghe, Justin Lathia, Clemens Burda, Murat Yildirim

“…Beyond structural imaging, QDs facilitate functional imaging applications, such as high-resolution tracking of hemodynamic responses and neural activity, supporting investigations of neuronal dynamics and blood flow in vivo. Their stability enables long-term, targeted drug delivery and photodynamic therapy, presenting potential therapeutic applications in treating brain tumors, Alzheimer’s disease, and traumatic brain injury. …”
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Exploration and Verification of Prognostic Value of Endothelial Cells in Glioblastoma by Hengchao MA, Yuyang LIU, Jun XU, Bingyan TAO, Jun ZHANG

“…Seven groups of cells were obtained after GBM single-cell sequencing analysis, including AC-like tumor cells, endothelial cells, monocytes/macrophages, NB-like tumor cells, neurons, OC-like tumor cells, and OPC-like tumor cells. …”
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Action potential-like modes as modulated waves in an extended soliton model for biomembranes and nerves by J. A. Onana Inouga, S. E. Mkam Tchouobiap, M. Siewe Siewe, F. M. Moukam Kakmeni

“…Accordingly, the analytical theory uses a perturbative technique, and a damped cubic–quintic nonlinear Schrödinger equation is derived, which admits a single-pulse-type solitary solution that possesses different phase characteristics of the typical neuronal Appulse structure, representative of nerve impulse profiles. …”
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Molecular Imaging of Gliomas by A. H. Jacobs, C. Dittmar, A. Winkeler, G. Garlip, W. D. Heiss

“…First of all, the exact localization, extent, and metabolic activity of the glioma must be determined to identify the biologically active target tissue for a biological treatment regimen; this is usually performed by imaging the expression of up-regulated endogenous genes coding for glucose or amino acid transporters and cellular hexokinase and thymidine kinase genes, respectively. Second, neuronal function and functional changes within the surrounding brain tissue have to be assessed in order to save this tissue from therapy-induced damage. …”
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Comparison Of Glucagon Like Peptide/1 Levels In Diabetic Women With Ovarian Polycystic Syndrome And Healthy Women by Namra Iqtidar, Imran Ali Zaidi, Sobia Niaz, Javaria Latif, Amir Naveed, Ayesha Yousaf

“…Moreover, GLP-1 is required to significantly stimulate GnRH (Gonadotropin Hormone releasing hormone) secretion because of the presence of GLP-1 brain receptors located on the GnRH neurons which cause more LH (Luteinizing hormone) secretion.  …”
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NDUFA11 may be the disulfidptosis-related biomarker of ischemic stroke based on integrated bioinformatics, clinical samples, and experimental analyses by Sijun Li, Ningyuan Chen, Junrui He, Xibao Luo, Wei Lin

“…BackgroundProgrammed cell death plays an important role in neuronal injury and death after ischemic stroke (IS), leading to cellular glucose deficiency. …”
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Association of Tooth Loss with New-Onset Parkinson’s Disease: A Nationwide Population-Based Cohort Study by Ho Geol Woo, Yoonkyung Chang, Ji Sung Lee, Tae-Jin Song

“…Systemic inflammatory reaction may be related to the degeneration of dopamine neurons in the substantia nigra. We hypothesized that tooth loss is related to increased risk of new-onset Parkinson’s disease. …”
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Progress in the Application of Resting-State Functional Magnetic Resonance Imaging in Chronic Nonspecific Low Back Pain by XU Ting, XUE Qin, LÜ Ying, TU Jianchun, DAI Dechun

“…Resting-state functional magnetic resonance imaging (rs-fMRI) can reflect the intensity of neuronal activity to acertain extent and has unique advantages in the study of central mechanisms of CNLBP. …”
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NPT1220-312, a TLR2/TLR9 Small Molecule Antagonist, Inhibits Pro-Inflammatory Signaling, Cytokine Release, and NLRP3 Inflammasome Activation by Agata Habas, Srinivasa Reddy Natala, Jon K. Bowden-Verhoek, Emily M. Stocking, Diana L. Price, Wolfgang Wrasidlo, Douglas W. Bonhaus, Martin B. Gill

“…A growing body of evidence suggests that excessive TLR-mediated innate immune system activation can lead to neuronal damage and precipitate or perpetuate neurodegenerative diseases. …”
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Analysis of reservoir rock permeability changes due to solid precipitation during waterflooding using artificial neural network by Azizollah Khormali, Soroush Ahmadi, Aleksandr Nikolaevich Aleksandrov

“…Through the implementation of this algorithm in the network, it was determined that the optimal configuration consisted of three layers - comprising of two hidden layers with eight and four neurons in the first and second layer, respectively, along with one output layer. …”
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Lipidopathy disrupts peripheral and central amyloid clearance in Alzheimer's disease: Where are our knowledge by Shahram Darabi, Enam Alhagh Charkhat Gorgich, Fatemeh Moradi, Auob Rustamzadeh

“…Amyloid-beta (Aβ) production is a normal physiological process, essential for neuronal function. However, an imbalance in Aβ production and clearance is the central pathological feature of Alzheimer’s disease (AD), leading to the accumulation of Aβ plaques in the brain. …”
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Clothianidin and Thiacloprid Mixture Administration Induces Degenerative Damage in the Dentate Gyrus and Alteration in Short-Term Memory in Rats by Alejandra Mora-Gutiérrez, Jorge Guevara, Carmen Rubio, Minerva Calvillo-Velasco, Daniela Silva-Adaya, Socorro Retana-Márquez, Blanca Espinosa, Carmen Martínez-Valenzuela, Moisés Rubio-Osornio

“…Likewise, the brains of these animals showed tissue architecture loss, nucleosomal retraction, and a significant increase in the pycnosis of the granular neurons of the dentate gyrus analyzed at 72 h after the last dose (P=0.0125). …”
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Immunohistochemistry for (Pro)renin Receptor in Humans by Satoshi Morimoto, Noriko Morishima, Daisuke Watanabe, Yoichiro Kato, Noriyuki Shibata, Atsuhiro Ichihara

“…In the brain, (pro)renin receptor staining was detected in neurons throughout all areas, especially in the medulla oblongata, paraventricular nucleus and supraoptic nucleus of the hypothalamus, cerebrum, granular layer of the hippocampus, Purkinje cell layer of the cerebellum, and the pituitary anterior and posterior lobes. …”
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Dysregulation of Metabolic Peptides Precedes Hyperinsulinemia and Inflammation Following Exposure to Rotenone in Rats by Vandana Zaman, Denise Matzelle, Naren L. Banik, Azizul Haque

“…While prodromal symptoms, such as loss of smell, constipation, sleep disorder, anxiety/depression, and the loss of dopaminergic neurons in the substantia nigra of rotenone-treated animals, have been reported, alterations of metabolic hormones and hyperinsulinemia remain largely unknown and need to be investigated. …”
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Effect of Electroacupuncture at Shenting and Baihui Acupoints on Ability of Learning and Memory and Expression of Autophagy Related Genes and Proteins in Cerebral Ischemia-reperfus... by Lingli GAO, Xiaodong FENG

“…Morris water maze experiment was used to observe learning and memory ability of rats, TTC staining was used to observe the change of brain infarction area of rats, RT-PCR and Western Blot were used to detect the expression of autophagy related genes and proteins in hippocampus.Results:④Morris water maze outcomes showed that compared with the model group, the escape latency time of rats in the EA group was obviously shortened, the number of across-platform was increased and the distance was shortened (<italic>P</italic>&lt;0.05).④Compared with the model group, the nerve defect scale of brain ischemia-reperfusion injury rats in the EA group was decreased (<italic>P</italic>&lt;0.05).④TTC staining results showed that the area of brain infarction in the EA group and model group was respectively higher than that in the sham operation group, and the volume of brain infarction in the EA group was reduced compared with the model group (<italic>P</italic>&lt;0.05).④Compared with the model group, the levels of Beclin 1, LC3Ⅰ/Ⅱand PI3K mRNA and protein in the left side of hippocampus in the EA group were increased (<italic>P</italic>&lt;0.05).Conclusion:EA at the DU24 and DU20 acupoints can reduce the cerebral infarction, and improve animal behaviors, and protect the neuronal injury. Regulation of autophagy network system may be one of the biologic mechanisms of EA improving cognitive impairment after stroke.…”
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Vitamin B6 Deficiency Induces Autism-Like Behaviors in Rats by Regulating mTOR-Mediated Autophagy in the Hippocampus by Lijuan Chen, Jing Li, Xinglian Liu, Zhiwei Zhao, Yan Jin, Yikun Fu, Aiqin Zhou, Chengqun Wang, Yan Zhou

“…Gamma-aminobutyric acid (GABA) generation and synaptic inhibition of neurons in the hippocampus of rat were detected via immunofluorescence staining, followed by the measurement of GABA concentration through high-performance liquid chromatography (HPLC). …”
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Cognitive enhancing effect of an extract of Swertia chirata against memory impairment induced by aluminum chloride by Reena Deshmukh, Manisha Jaiswal, Anshita Shukla, Umesh Patil, Mukesh Sharma

“…Numerous studies have demonstrated that certain flavonoid antioxidants reduce oxidative stress-induced neuronal apoptosis. Results: Swertia chirata ethanolic extract exhibited longer exploration times for unfamiliar objects compared to familiar ones. …”
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Investigating Feed-Forward Back-Propagation Neural Network with Different Hyperparameters for Inverse Kinematics of a 2-DoF Robotic Manipulator: A Comparative Study by Rania Bouzid, Jyotindra Narayan, Hassène Gritli

“…Thereafter, we train the FFBP-NN with the generated datasets using the MATLAB Neural Network Toolbox and investigate its potential by altering the hyperparameters (e.g., number of hidden neurons, number of hidden layers, and training optimizer). …”
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Multi-channel microelectrode arrays for detection of single-cell level neural information in the hippocampus CA1 under general anesthesia induced by low-dose isoflurane by Ruilin Hu, Penghui Fan, Yiding Wang, Jin Shan, Luyi Jing, Wei Xu, Fan Mo, Mixia Wang, Yan Luo, Ying Wang, Xinxia Cai, Jinping Luo

“…Isoflurane caused an inhibition of spike firing rate in hippocampal CA1 neurons, while inducing low-frequency oscillations in CA1, thus enhancing the low-frequency power of local field potentials. …”
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Population genetics of spinoсerebellar ataxias caused by polyglutamine expansions by A. N. Shuvaev, O. S. Belozor, M. V. Smolnikova, D. A. Yakovleva, Andr. N. Shuvaev, O. M. Kazantseva, E. A. Pozhilenkova, O. I. Mozhei, S. Kasparov

“…Hereditary disorders of the neuronal system are some of the most important problems of medicine in the XXI century. …”
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