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2041
BACE1 Is Necessary for Experience-Dependent Homeostatic Synaptic Plasticity in Visual Cortex
Published 2014-01-01“…Here we demonstrate that mice lacking the major neuronal β-secretase, BACE1, exhibit a similar phenotype: stronger basal excitatory synaptic transmission and failure to adapt to changes in visual experience. …”
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2042
Drug resistant epilepsy as the consequence of inadequate control of type 1 diabetes
Published 2024-04-01“…In conclusion, glucose is one of the key metabolic agents for the proper brain function and any imbalances in its blood level may impair the neuronal computation. Thus, it is extremely important, especially among diabetic patients, to control glucose blood level and avoid any disturbances, as they may lead to severe consequences, such as HE and drug-resistant epilepsy.…”
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2043
A Computational Model of Attention-Guided Visual Learning in a High-Performance Computing Software System
Published 2024-12-01“…The feature-similarity gain model proposes that attention multiplicatively strengthens neuronal responses based on how similar their feature tuning is to the attended input. …”
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2044
A Case of Xanthoma of Bilateral Tendoachilles Reconstructed with Fascia Lata Graft X
Published 2024-01-01“…Deposition of cholestanol in the neurons causes atrophy and secondary demyelination. …”
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2045
An anatomical aspect on masseteric muscles in cattle rabies by real-time pcr
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2046
High-fat diet and neuroinflammation: The role of mitochondria
Published 2025-02-01“…More importantly, mitochondrial damage, neuroinflammation, and insulin resistance caused by HFD form a mutually reinforcing vicious cycle, ultimately leading to the death of neurons and promoting the progression of neurodegenerative diseases. …”
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2047
Differential Susceptibility to Propofol and Ketamine in Primary Cultures of Young and Senesced Astrocytes
Published 2024-01-01“…Previously, mechanistic and pathogenic investigations focused on neurons, and little is known about the effect of commonly used intravenous anesthetics such as propofol and ketamine on astrocytes. …”
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2048
Molecular Findings Before Vision Loss in the Streptozotocin-Induced Rat Model of Diabetic Retinopathy
Published 2025-01-01“…While redox imbalance, activation of microglia, secretion of pro-inflammatory cytokines, and neuronal cell death are also observed, the latter remains an emerging hypothesis requiring further exploration. …”
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2049
Idiopathic Intracranial Hypertension Papillopathy due to Hormonal Changes during Pregnancy
Published 2023-01-01“…Recent research revealed that, during pregnancy, hormones interact with the central nervous system, leading to an increase in the size of neurons which could potentially result in intracranial hypertension. …”
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2050
Differential Coding of Fruit, Leaf, and Microbial Odours in the Brains of <i>Drosophila suzukii</i> and <i>Drosophila melanogaster</i>
Published 2025-01-01“…We hypothesised that the basis for different behaviours is already formed at the level of the antennal lobe of <i>D. suzukii</i> and <i>D. melanogaster</i> by different neuronal responses to volatiles associated with ripe and fermenting fruit. …”
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2051
Research on Role of Connexin 36 in Pathogenesis of Rats with Levodopa-induced Dyskinesia
Published 2016-08-01“…The up-regulation of Cx36 expression may increase the oscillatory discharge of neurones, and enhance the unbalance of the direct and indirect pathways in the striatum, and promote the output of abnormal striatal signals, which leads to the formation of LID.…”
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2052
Measuring Measuring iron concentration in the blood samples of some autistic children from Baghdad City
Published 2025-01-01“…Without a doubt, toxic metal overload or key element shortages can cause epigenetic modifications that impair neuronal maturation and lead to neurodevelopmental abnormalities in the form of developmental disorders in children. …”
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2053
Alzheimer’s Disease and <i>Porphyromonas gingivalis</i>: Exploring the Links
Published 2025-01-01“…Virulence factors, such as gingipains and lipopolysaccharides, were shown to be implicated in blood–brain barrier disruption, neuroinflammation, and neuronal damage. <i>P. gingivalis</i>-derived outer membrane vesicles may serve to disseminate virulence factors to brain tissues. …”
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2054
Water quality assessment for aquaculture using deep neural network
Published 2025-01-01“…In this paper, optimal DNN model is developed by tuning the various parameters like number of hidden layers, hidden neurons and activation functions using Python programme in visual studio. …”
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2055
Characterisation of Pain Responses in the High Fat Diet/Streptozotocin Model of Diabetes and the Analgesic Effects of Antidiabetic Treatments
Published 2015-01-01“…Hindpaw mechanical withdrawal thresholds were significantly lowered in the model, but mechanically evoked responses of spinal neurones were unaltered, compared to HFD/vehicle rats. …”
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2056
Cannabis oil in treating Parkinson’s disease: improvement of motor and non-motor symptoms: a case report
Published 2025-01-01“…Abstract Parkinson’s disease (PD) is characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta, which leads to a reduction in the production of dopamine. …”
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2057
Medical foods in Alzheimer’s disease
Published 2019-03-01“…Improvements in symptomatology and regional brain atrophy in AD have been claimed for several medical foods, for example, those providing ketone bodies as alternative energy supply to neurons, those containing precursors believed to improve synaptic function, and those addressing oxidative stress related to memory loss. …”
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2058
A Possible Novel Anti-Inflammatory Mechanism for the Pharmacological Prolyl Hydroxylase Inhibitor 3,4-Dihydroxybenzoate: Implications for Use as a Therapeutic for Parkinson’s Disea...
Published 2012-01-01“…Parkinson’s disease (PD) is an age-related neurodegenerative disorder characterized in part by the preferential loss of nigrostriatal dopaminergic neurons. Although the precise etiology of PD is unknown, accumulating evidence suggests that PD involves microglial activation that exerts neurotoxic effects through production of proinflammatory cytokines and increased oxidative and nitrosative stress. …”
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2059
Overexpression of SFPQ Improves Cognition and Memory in AD Mice
Published 2025-01-01“…Splicing factor proline and glutamine rich (SFPQ) is known to play a crucial role in neurodegenerative diseases, including antioxidant-related functions and regulating gene expression within brain neurons. However, the specific role of SFPQ in AD pathology is not well understood. …”
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2060
Spinal Cord Lesion: Effects of and Perspectives for Treatment
Published 2001-01-01“…Electrophysiologicai and histological studies have shown that a transformation of motor units takes place following central motor lesions with the consequence that regulation of muscle tone is achieved at a lower level of neuronal organization which in turn enables the patient to walk. …”
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