ROS-regulated SUR1-TRPM4 drives persistent activation of NLRP3 inflammasome in microglia after whole-brain radiation by Yuan Chang, Yihua He, Di Wang, Kunxue Zhang, Yuzhen Zhang, Zhentong Li, Shuxin Zeng, Sheng Xiao, Suyue Pan, Kaibin Huang

“…In summary, this study deciphers that SUR1-TRPM4 crucially mediates the persistent activation of microglial NLRP3 inflammasome under the action of ROS after whole-brain radiation, offering novel therapeutic strategies for delayed RIBI as well as other NLRP3-related neurological disorders involving excessive ROS production.…”
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Spatial metabolomics in mental disorders and traditional Chinese medicine: a review by Chaofang Lei, Jiaxu Chen, Zhigang Chen, Chongyang Ma, Xudong Chen, Xiongxing Sun, Xukun Tang, Jun Deng, Shiliang Wang, Junlin Jiang, Dahua Wu, Le Xie

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Targeting NF-kappaB-inducing kinase shapes B-cell homeostasis in myasthenia gravis by Xiaoyu Huang, Zhouao Zhang, Zhouyi Wang, Tiancheng Luo, Mingjin Yang, Xinyan Guo, Xue Du, Tianyu Ma, Yong Zhang

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Diagnostic efficiency of exome-based sequencing in pediatric patients with epilepsy by Huafang Zou, Huafang Zou, Qian Zhang, Jianxiang Liao, Jianxiang Liao, Dongfang Zou, Zhanqi Hu, Bing Li, Li Chen, Jialun Wen, Xia Zhao, Victor Wei Zhang, Dezhi Cao, Dezhi Cao

“…ObjectiveEpilepsy, a prevalent neurological disorder, has multifaceted etiologies. Next-generation sequencing (NGS) has emerged as a robust diagnostic tool for this condition. …”
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Biomarker combinations from different modalities predict early disability accumulation in multiple sclerosis by Vinzenz Fleischer, Tobias Brummer, Muthuraman Muthuraman, Muthuraman Muthuraman, Falk Steffen, Milena Heldt, Maria Protopapa, Muriel Schraad, Gabriel Gonzalez-Escamilla, Sergiu Groppa, Stefan Bittner, Frauke Zipp

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Optic nerve sonographic parameters in idiopathic intracranial hypertension, case-control study by Islam El Malky, Wael Elshazly Aita, Alaa Elkordy, Marwa Nasreldeen, Mahmoud Abdelhafiz, Amr M. Tael, Hazem Mo. Abdelkhalek

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Using Electrocardiogram Signal Features and Heart Rate Variability to Predict Epileptic Attacks by Ying Jiang, Yuan Feng, Danni Lu, Lin Yang, Qun Zhang, Haiyan Yang, Ning Li

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The Natural History of Depression in Parkinson’s Disease within 30-Month Follow-Up by Yuan-Yuan Xu, Sheng-Han Kuo, Zheng Liang, Hui Xu, Wu-Ruo Feng, Cui-Yu Yu, Wei-Guo Liu

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Bidirectional relationship between epigenetic age and stroke, dementia, and late-life depression by Cyprien A. Rivier, Natalia Szejko, Daniela Renedo, Santiago Clocchiatti-Tuozzo, Shufan Huo, Adam de Havenon, Hongyu Zhao, Thomas M. Gill, Kevin N. Sheth, Guido J. Falcone

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Metabolic Syndrome, Obesity, and Gastrointestinal Cancer by Shintaro Fujihara, Hirohito Mori, Hideki Kobara, Noriko Nishiyama, Mitsuyoshi Kobayashi, Makoto Oryu, Tsutomu Masaki

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Deciphering Parkinson’s Disease through Eye Movements: A Promising Tool for Early Diagnosis in the Face of Cognitive Impairment by Xianglian Liao, Jian Yao, Hongyin Tang, Yilan Xing, Xin Zhao, Daao Nie, Ping Luan, Guihua Li

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Correlation of Visuospatial Ability and EEG Slowing in Patients with Parkinson’s Disease by Dominique Eichelberger, Pasquale Calabrese, Antonia Meyer, Menorca Chaturvedi, Florian Hatz, Peter Fuhr, Ute Gschwandtner

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Role of Inflammasomes in Neuroimmune and Neurodegenerative Diseases: A Systematic Review by Yue Lang, Fengna Chu, Donghui Shen, Weiguanliu Zhang, Chao Zheng, Jie Zhu, Li Cui

“…Many recent studies suggest a strong correlation between inflammasomes and neurological diseases, such as multiple sclerosis (MS), Alzheimer’s disease (AD), and Parkinson’s disease (PD). …”
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Globular-shaped Aβ oligomers have diverse mechanisms for promoting Aβ aggregations with the facilitation of fibril elongation by Hiroto Nakano, Sadao Hikishima, Makoto Mori, Jota Minamikawa, Daiki Muramatsu, Yasuhiro Sakashita, Tokuhei Ikeda, Moeko Noguchi-Shinohara, David B. Teplow, Kenjiro Ono

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LRRK2 Mutations and Asian Disease-Associated Variants in the First Parkinson’s Disease Cohort from Kazakhstan by Rauan Kaiyrzhanov, Akbota Aitkulova, Chingiz Shashkin, Nazira Zharkinbekova, Mie Rizig, Elena Zholdybayeva, Zharkyn Jarmukhanov, Vadim Akhmetzhanov, Gulnaz Kaishibayeva, Talgat Khaibullin, Altynay Karimova, Serik Akshulakov, Askhat Bralov, Nurlan Kissamedenov, Zhanar Seidinova, Anjela Taskinbayeva, Aliya Muratbaikyzy, Henry Houlden

“…Methods. 246 PD patients were consecutively recruited by movement disorder specialists from four medical centers in Kazakhstan, and clinicodemographic data and genomic DNA from blood were systematically obtained and shipped to the Institute of Neurology University College London together with DNAs from 200 healthy controls. …”
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Updates in Refractory Status Epilepticus by Rohit Marawar, Maysaa Basha, Advait Mahulikar, Aaron Desai, Kushak Suchdev, Aashit Shah

“…Short-term and long-term outcomes tend to be poor with significant morbidity and mortality with only one-third of patients reaching baseline neurological status.…”
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Screening of Dementia by Rajka M. Liscic, Görsev G. Yener, Huali Wang, Jong-Ling Fuh, Jianjun Jia, Yuan-Han Yang

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The REpeated ASSEssment of SurvivorS in intracerebral haemorrhage: protocol for a multicentre, prospective observational study by Daniel Woo, Richard Thompson, Carl D Langefeld, Nichol McBee, Daniel Hanley, Matthew L Flaherty, Lauren Sansing, Karen Lane, Lee A Gilkerson, Achala Vagal, Nathan Walborn, Wendy Ziai, Noeleen Ostapkovich, Kevin Triene, Timothy David Howard

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Less Experienced Telestroke Consultants Are More Likely to Go On-Camera, but Less Likely to Give tPA by Adam de Havenon, Lee S. Chung, Jaleen Smith, Kirby Taylor, Jennifer J. Majersik, Nabeel Chauhan

“…This supports the introduction of telestroke didactics during vascular neurology training.…”
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Nuclear Factor-Kappa B Activity Regulates Brain Expression of P-Glycoprotein in the Kainic Acid-Induced Seizure Rats by Nian Yu, Qing Di, Hao Liu, Yong Hu, Ying Jiang, Yu-kui Yan, Yan-fang Zhang, Ying-dong Zhang

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