Toxic Assessment of Heavily Traffic-related Fine Particulate Matter Using an in-vivo Wild-type Caenorhabditis elegans Model by Meng-Ching Chung, Kuo-Lin Huang, Japheth L. Avelino, Lemmuel L. Tayo, Chih-Chung Lin, Ming-Hsien Tsai, Sheng-Lun Lin, Wan Nurdiyana Wan Mansor, Ching-Kai Su, Sen-Ting Huang

“…In conclusion, heavy concentrations of TRAP PM2.5 significantly and severely disrupted toxicological endpoints of neurology and reproduction to C. elegans. TRAP PM2.5 significantly shortened the lifespan of the nematodes compared with the control. …”
Get full text

Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages by Hiroki Yamazaki, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Takeshi Yamamotoya, Yusuke Nakatsu, Takako Kikuchi, Sunao Kaneko, Hirotoshi Tanaka, Tomoichiro Asano

Get full text

The challenge of a late diagnosis of Autism Spectrum Disorder: co-occurring trajectories and camouflage tendencies. a case report of a young Autistic female with Avoidant Restricti... by Sara Passarini, Sara Passarini, Silvia Guerrera, Maria Picilli, Maria Picilli, Elisa Fucà, Laura Casula, Deny Menghini, Sabine Pirchio, Valeria Zanna, Giovanni Valeri, Stefano Vicari, Stefano Vicari

Get full text

Single-cell transcriptome atlas of lamprey exploring Natterin- induced white adipose tissue browning by Yue Pang, Yating Qin, Zeyu Du, Qun Liu, Jin Zhang, Kai Han, Jiali Lu, Zengbao Yuan, Jun Li, Shanshan Pan, Xinrui Dong, Mengyang Xu, Dantong Wang, Shuo Li, Zhen Li, Yadong Chen, Zhisheng Zhao, Zhe Zhang, Shunqin Chuan, Yue Song, Mingjie Sun, Xiaodong Jia, Zhangyong Xia, Liping Zhan, Zhen Yue, Wei Cui, Jun Wang, Ying Gu, Ming Ni, Huanming Yang, Xun Xu, Xin Liu, Qingwei Li, Guangyi Fan

Get full text

Thrombin Cleavage of Osteopontin Modulates Its Activities in Human Cells In Vitro and Mouse Experimental Autoimmune Encephalomyelitis In Vivo by Elena Boggio, Chiara Dianzani, Casimiro Luca Gigliotti, Maria Felicia Soluri, Nausicaa Clemente, Giuseppe Cappellano, Erika Toth, Davide Raineri, Benedetta Ferrara, Cristoforo Comi, Umberto Dianzani, Annalisa Chiocchetti

Get full text

Non‐invasive telemedical care in heart failure patients and stroke: post hoc analysis of TIM‐HF and TIM‐HF2 trials by Serdar Tütüncü, Marcus Honold, Kerstin Koehler, Oliver Deckwart, Friedrich Koehler, Karl Georg Haeusler

Get full text

Application of machine learning algorithms in predicting new onset hypertension: a study based on the China Health and Nutrition Survey by Manhui Zhang, Xian Xia, Qiqi Wang, Yue Pan, Guanyi Zhang, Zhigang Wang

Get full text

Impact of cognition and psychoemotional status on falls in multiple sclerosis by R. Godelienė, E. Sukockienė, V. Danielius, V. Stankunavičiūtė, D. Mickevičienė

“…A self-reported questionnaire about falls in past 6 months was provided for the participants. Neurological examination, EDSS assessment, and symbol digit modality test (SDMT) were performed; anxiety and depression were rated using HAD scale, fatigue was rated using visual analog scale. …”
Get full text

Feasibility Aspects of Exploring Exercise-Induced Neuroplasticity in Parkinson’s Disease: A Pilot Randomized Controlled Trial by Hanna Johansson, Malin Freidle, Urban Ekman, Ellika Schalling, Breiffni Leavy, Per Svenningsson, Maria Hagströmer, Erika Franzén

Get full text

Functional Evaluation of the Visual Pathway in Patients with Multiple Sclerosis Using a Multifunction Stimulator Monitor by M. Satue, L. Jarauta, J. Obis, M. Cipres, M. J. Rodrigo, C. Almarcegui, I. Dolz, J. R. Ara, J. Martin, L. E. Pablo, E. Garcia-Martin

Get full text

A mobile-based multidomain lifestyle intervention using Cognitive Evergreenland for older adults with subjective cognitive decline: a feasibility study by Rong Lin, Yuanjiao Yan, Zhili Chen, Chenshan Huang, Junyu Zhao, Mingfeng Chen, Hong Li

Get full text

Harnessing macrophage-drug conjugates for allogeneic cell-based therapy of solid tumors via the TRAIN mechanism by Bartlomiej Taciak, Maciej Bialasek, Malgorzata Kubiak, Ilona Marszalek, Malgorzata Gorczak, Olha Osadchuk, Daria Kurpiel, Damian Strzemecki, Karolina Barwik, Marcin Skorzynski, Julia Nowakowska, Waldemar Lipiński, Łukasz Kiraga, Jan Brancewicz, Robert Klopfleisch, Łukasz Krzemiński, Emilia Gorka, Anna Smolarska, Irena Padzinska-Pruszynska, Małgorzata Siemińska, Jakub Guzek, Jan Kutner, Marlena Kisiala, Krzysztof Wozniak, Giacomo Parisi, Roberta Piacentini, Luca Cassetta, Lesley M. Forrester, Lubomir Bodnar, Tobias Weiss, Alberto Boffi, Paulina Kucharzewska, Tomasz P. Rygiel, Magdalena Krol

Get full text

Nanosensor-based imaging of realtime dopamine release in neurons derived from iPSCs of patients with Parkinson's disease by Nayeon Lee, Dakyeon Lee, Jae Hyeok Lee, Bo Seok Lee, Sungjee Kim, Jae Ho Kim, Sanghwa Jeong

Get full text

Newly identified single-nucleotide polymorphism associated with the transition from nonalcoholic fatty liver disease to liver fibrosis: results from a nested case-control study in... by Yitong Ling, Yu Xuan Yang, Yan Chun Chen, Jing Hao Wang, Dong Ge Feng, Shi Jian Xiang, Xiaoyu Zhang, Jun Lyu, Sha Sha Li

Get full text

Rapid Screening for Cognitive Impairment in Parkinson’s Disease: A Pilot Study by YanHong Dong, Way Inn Koay, Leonard Leong Litt Yeo, Christopher Li-Hsian Chen, Jing Xu, Raymond Chee Seong Seet, Erle Chuen Hian Lim

“…This study sought to establish the discriminant validity of a rapid cognitive screen, that is, the National Institute of Neurological Disease and Stroke-Canadian Stroke Network (NINDS-CSN) 5-minute protocol, and compare its discriminant validity to the Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE) in detecting cognitive impairment (CI) in PD patients. …”
Get full text

Neural activity responsiveness by maturation of inhibition underlying critical period plasticity by Ibuki Matsumoto, Sou Nobukawa, Sou Nobukawa, Sou Nobukawa, Sou Nobukawa, Takashi Kanamaru, Takashi Kanamaru, Yusuke Sakemi, Yusuke Sakemi, Nina Sviridova, Nina Sviridova, Tomoki Kurikawa, Nobuhiko Wagatsuma, Kazuyuki Aihara, Kazuyuki Aihara

Get full text

Identifying key signs of motor neurone disease in primary care: a nested case–control study using the QResearch database by Aleksandar Radunović, Carol Coupland, Julia Hippisley-Cox, Christopher J McDermott, Tom A Ranger, Judith Burchardt, Xue W Mei

“…Objective To confirm the symptoms and signs for motor neuron disease (MND) in the Red Flag tool; to quantify the extent to which the key symptoms and signs are associated with MND; and to identify additional factors which may be helpful within the primary care setting in recognition of possible MND and triggering timely referral to neurology specialists.Design A nested case–control study.Setting 1292 UK general practices contributing to the QResearch primary care database, linked to hospital and mortality data.Participants Baseline cohort included 16.8 million individuals aged 18 years and over without a diagnosis of MND at study entry and with more than 3 years of digitalised information available. …”
Get full text

The association between TyG index and cardiovascular mortality is modified by antidiabetic or lipid-lowering agent: a prospective cohort study by Changchang Fang, Nanqin Peng, Jiang Cheng, Xiyu Zhang, Wenli Gu, Zicheng Zhu, Xiaoping Yin, Zhiwei Yan, Jing Zhang, Peng Yu, Xiao Liu

Get full text

Association between domain-specific physical activity and triglyceride‑glucose (TyG) index among US adults: Evidence from NHANES 2007–2018 by Kai Yao

Get full text

Efficacy of soft palatal augmentation prosthesis for oral functional rehabilitation in patients with dysarthria and dysphagia: a protocol for a randomised controlled trial by Naoki Kodama, Tomonori Yokoyama, Takao Mukai, Kana Takao, Takashi Hiraoka, Nobuyuki Arai, Jitsuro Yano, Hiroaki Nagatsuka, Yousuke Manda, Kozo Hanayama, Shogo Minagi

Get full text