Intravascular large B-cell lymphoma of the central nervous system with renal involvement: a case report and literature review by Jun Li, Zhaojiao Li, Yifeng Shi, Jiajie Chen, Heng Zhao, Xueye Mao, Shan Li, Huiying Wang, Qiang Meng, Lingchun Liu

“…We suggest considering IVLBCL in patients who present with recurrent stroke-like symptoms, fluctuating neurological deficits, the aforementioned MRI findings, and involvement of other organs. …”
Get full text

Impact of Deep Brain Stimulation on Daily Routine Driving Practice in Patients with Parkinson’s Disease by Carsten Buhmann, Eik Vettorazzi, Christian Oehlwein, Fred Rikkers, Monika Poetter-Nerger, Alessandro Gulberti, Christian Gerloff, Christian K. Moll, Wolfgang Hamel

Get full text

A Case Report of Aicardi-Goutières Syndrome Type 7 Caused by IFIH1 Gene Mutation and a Literature Review by ZHAO Min, SHU Zhou, HAN Tongxin, FU Yanhua, GAO Tianji, MAO Huawei

“…Through review of the literature, we identified 69 cases of AGS type 7 (including the case reported here)which showed that skin and neurological system involvement are most commonly seen. …”
Get full text

Conformational diversity in class C GPCR positive allosteric modulation by Giuseppe Cannone, Ludovic Berto, Fanny Malhaire, Gavin Ferguson, Aurelien Fouillen, Stéphanie Balor, Joan Font-Ingles, Amadeu Llebaria, Cyril Goudet, Abhay Kotecha, Vinothkumar K.R., Guillaume Lebon

“…The mGlu receptors signal transduction can be allosterically potentiated by positive allosteric modulators (PAMs) binding to the 7TMs, which are of therapeutic interest in various neurological disorders. Here, we report the cryoEM structures of metabotropic glutamate receptor 5 (mGlu5) purified with three chemically and pharmacologically distinct PAMs. …”
Get full text

Clinical Characteristics of Three Cases with SAMD9/SAMD9L Gene Mutations by ZHU Ke, SUN Bijun, WANG Wenjie, ZHOU Qinhua, LIU Luyao, HOU Jia, WANG Xiaochuan, SUN Jinqiao

“…All patients presented with recurrent infections, growth retardation, and myelodys-plasia, with varying degrees of involvement of multiple systems, including respiratory, gastrointestinal, immune, endocrine, neurological, and reproductive systems. In terms of treatment, two patients underwent regular intravenous immunoglobulin and their clinical symptoms improved, while one patient had a favorable recovery following hematopoietic stem cell transplantation at the age of 1 year and 5 months of age. …”
Get full text

A low pre-existing anti-NS1 humoral immunity to DENV is associated with microcephaly development after gestational ZIKV exposure. by Sebastián Castro-Trujillo, William R Mejía, Katherine Segura, Juanita Castro-Meneses, Rocío Vega, Doris Salgado, Carlos E Fonseca, Ángela M Ortiz, Federico Perdomo-Celis, Irene Bosch, Carlos F Narváez

“…We also performed clinical evaluation and pediatric neurological follow-up. The relative levels of circulating NS1-specific IgM and IgG against ZIKV and DENV were evaluated in mothers and children, and the association with the development of microcephaly was analyzed.…”
Get full text

Pimavanserin Treatment for Parkinson’s Disease Psychosis in Clinical Practice by Khashayar Dashtipour, Fiona Gupta, Robert A. Hauser, Cherian A. Karunapuzha, John C. Morgan

“…In addition, effective pharmacotherapy for PDP may also facilitate the use of other medications needed to treat neurological symptoms of PD (e.g., tremor, bradykinesia, and dyskinesia), although they may also have adverse effects that contribute to symptoms of PDP.…”
Get full text

Rhythm and Movement for Self-Regulation (RAMSR) intervention for preschool self-regulation development in disadvantaged communities: a clustered randomised controlled trial study p... by Kate E Williams, Sally Savage, Rebecca Eager

“…Self-regulation skills are critical to ongoing learning behaviours, achievement and well-being. Emerging neurological evidence suggests coordinated music and movement participation could support self-regulation development for all children. …”
Get full text

Longitudinal Assessment of Abnormal Cortical Folding in Fetuses and Neonates With Isolated Non‐Severe Ventriculomegaly by Andrea Urru, Oualid Benkarim, Gerard Martí‐Juan, Nadine Hahner, Gemma Piella, Elisenda Eixarch, Miguel A. González Ballester

Get full text

Alexithymia in multiple sclerosis: past, present and future by Samar S. Ayache, Samar S. Ayache, Samar S. Ayache, Samar S. Ayache, Moussa A. Chalah, Moussa A. Chalah, Moussa A. Chalah

“…It is frequently observed in neurological diseases. Nevertheless, its mechanisms, assessment, and management remain overlooked. …”
Get full text

Protein palmitoylation is involved in regulating mouse sperm motility via the signals of calcium, protein tyrosine phosphorylation and reactive oxygen species by Yuping Xiong, Chenchen Yi, Haixia Zheng, Ya Ni, Yamei Xue, Kun Li

“…It is also implicated in the pathogenesis of diseases, such as cancer, neurological disorders, inflammation, metabolic disorders, infections, and neurodegenerative diseases. …”
Get full text

Computer-Assisted Design Template Guided Percutaneous Radiofrequency Thermocoagulation through Foramen Rotundum for Treatment of Isolated V2 Trigeminal Neuralgia: A Retrospective C... by Ran Wang, Ying Han, Lijuan Lu

“…The outcome of pain remission was evaluated utilizing the Barrow Neurological Institute’s (BNI) pain score. Complications and recurrence of pain were also recorded. …”
Get full text

Analysis of Contact Position for Subthalamic Nucleus Deep Brain Stimulation-Induced Hyperhidrosis by Chunhui Yang, Yiqing Qiu, Xi Wu, Jiali Wang, Yina Wu, Xiaowu Hu

“…The study standardized electrode position with Lead-DBS software to Montreal Neurological Institute (MNI) standard stereotactic space to compare the differences in three-dimensional coordinates of activated contacts between groups. …”
Get full text

Gender-related Therapeutical Response to Apremilast: New Insights in a Tailored Management of Psoriasis by Emanuele Trovato, Federico Bardazzi, Vito Di Lernia, Monica Corazza, Claudia Lasagni, Francesca Prignano

Get full text

Dispatcher-Assisted Cardiopulmonary Resuscitation: Disparity between Urban and Rural Areas by Yen-Chin Chen, Shao-Hua Yu, Wei-Jen Chen, Li-Chi Huang, Chih-Yu Chen, Hong-Mo Shih

“…Continued laypersons CPR until the EMT’ arrival also improved survival with favorable neurological function, with aOR of 1.16, 95% CI of 0.61–2.20 in urban areas and aOR of 2.90 95% CI of 0.18–46.81 in rural areas. …”
Get full text

Patients with dementia with Lewy bodies display a signature alteration of their cognitive connectome by Roraima Yanez-Perez, Eloy Garcia-Cabello, Annegret Habich, Nira Cedres, Patricia Diaz-Galvan, Carla Abdelnour, Jon B. Toledo, José Barroso, Daniel Ferreira

Get full text

Inhibition of P38 MAPK Downregulates the Expression of IL-1β to Protect Lung from Acute Injury in Intestinal Ischemia Reperfusion Rats by De-Yi Zheng, Min Zhou, Jiao Jin, Mu He, Yi Wang, Jiao Du, Xiang-Yang Xiao, Ping-Yang Li, Ai-Zhu Ye, Jia Liu, Ting-Hua Wang

Get full text

Sacral Stress Fracture following the Bone Union of Lumbar Spondylolysis by Tatsuro Sasaji, Hideki Imaizumi, Hiroyuki Takano, Hideo Saitoh, Taishi Murakami, Ryuichi Kanabuchi, Motohiko Sekiya

“…At his first visit to our hospital, his general and neurological conditions were normal and laboratory data were within the normal range. …”
Get full text

Microglia Play a Major Role in Direct Viral-Induced Demyelination by Dhriti Chatterjee, Kaushiki Biswas, Soma Nag, S. G. Ramachandra, Jayasri Das Sarma

“…Previous studies demonstrated that microglia can be persistently infected by neurotropic mouse hepatitis virus (MHV) which causes meningoencephalitis, myelitis with subsequent axonal loss, and demyelination and serve as a virus-induced model of human neurological disease multiple sclerosis (MS). Current studies revealed that MHV infection is associated with the pronounced activation of microglia during acute inflammation, as evidenced by characteristic changes in cellular morphology and increased expression of microglia-specific proteins, Iba1 (ionized calcium-binding adaptor molecule 1), which is a macrophage/microglia-specific novel calcium-binding protein and involved in membrane ruffling and phagocytosis. …”
Get full text

Chronic Rapamycin Prevents Electrophysiological and Morphological Alterations Produced by Conditional Pten Deletion in Mouse Cortex by Jason S. Hauptman, Joseph Antonios, Gary W. Mathern, Michael S. Levine, Carlos Cepeda

“…These findings have potential implications for the treatment of neurological disorders associated with mTOR pathway dysfunction, such as epilepsy and autism.…”
Get full text