Structural insights into human topoisomerase 3β DNA and RNA catalysis and nucleic acid gate dynamics by Xi Yang, Xuemin Chen, Wei Yang, Yves Pommier

“…Defects in TOP3B lead to severe neurological diseases. We present a series of cryo-EM structures of human TOP3B with its cofactor TDRD3 during cleavage and rejoining of DNA or RNA, thus elucidating the roles of divalent metal ions and key enzyme residues in each step of the catalytic cycle. …”
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Sulforaphane Wrapped in Self-Assembled Nanomicelle Enhances the Effect of Sonodynamic Therapy on Glioma by Yihong Li, Xuejie Yang, Zhen Wei, Heng Niu, Liyang Wu, Caijing Chen, Huina Liu, Ting Cai, Huadong Fan

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Impact of remnant cholesterol on acute ischemic stroke prognosis: a nationwide cohort analysis stratified by non-alcoholic fatty liver disease status by Sili Jiang, Aoming Jin, Aoming Jin, Wenli Xing, Jing Jing, Jing Jing

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Krait2: a versatile software for microsatellite investigation, visualization and marker development by Lianming Du, Jiahao Chen, Dalin Sun, Kelei Zhao, Qianglin Zeng, Nan Yang

“…Microsatellite expansions play pivotal roles in gene expression regulation and are implicated in various neurological diseases and cancers. Although much effort has been devoted to developing efficient tools for microsatellite identification, there is still a lack of a powerful tool for large-scale microsatellite analysis. …”
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Brain targeting based nanocarriers loaded with resveratrol in Alzheimer's disease: A review by Cyrus Jalili, Amir Kiani, Mohammadreza Gholami, Fariborz Bahrehmand, Sajad Fakhri, Somayeh Kakehbaraei, Seyran Kakebaraei

“…Encapsulation of this compound in the form of nanocarriers to treat neurological diseases to improve BBB crossing is also discussed.…”
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Systemic Lupus Erythematosus with Concurrent Thrombotic Thrombocytopenic Purpura: A Case Report of Diagnostic Challenges and Management Approaches by Sonu Rahul Tej Gaddam, Manideep Katta, Sumana Simarla, Pruthvi Raj Kukunoor, Manichandana Katta

“…This condition can manifest as a pentad of symptoms that includes fever, thrombocytopenia, Microangiopathic Haemolytic Anemia (MAHA), renal disease and neurological disease. Authors hereby, detail the case of a 29-year-old female with a rare combination of TTP and Systemic Lupus Erythematosus (SLE), which presents challenges in diagnosis, clinical progression and therapeutic response. …”
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Factors Affecting Vagus Nerve Stimulation Outcomes in Epilepsy by Mehdi Abbasi, Atie Moghtadaie, Seyed Amir Miratashi Yazdi

“…Epilepsy as a common neurological disease is mostly managed effectively with antiepileptic medications. …”
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MiRNAs as major players in brain health and disease: current knowledge and future perspectives by Sarika V. Kapplingattu, Sujata Bhattacharya, Yogita K. Adlakha

“…We summarize the biological significance, roles, and signaling pathways of miRNAs in general, with a focus on miR-135 in different neurological diseases including brain tumors, and neurodegenerative and neurodevelopmental disorders. …”
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The Importance of Detailed Audio-Vestibular Monitoring in Familial Non-Syndromic Hearing Losses: A Longitudinal Study by Burak Kabiş, Nuriye Yıldırım Gökay

“…A videonystagmography was performed to rule out neurological diseases. A computerized dynamic posturography (CDP) was performed to evaluate postural control. …”
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The evaluation of the malnutrition in hospitalized infants by Sinem Akbay Ak, Oya Baltalı, Özkan İlhan, Sezin Akman

“…At the time of hospitalization, 101 (33.9%) patients had chronic disease. Neurological diseases were the most common chronic diseases, accounting for 31.7% (n=32) of the chronic diseases. …”
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The Promise of Artificial Intelligence in Neuroanesthesia: An Update by Zhenrui Liao, Niharika Mathur, Vidur Joshi, Shailendra Joshi

“…It will advance the diagnosis and treatment of neurological diseases due to improved risk identification, data integration, early diagnosis, image analysis, and pharmacological and surgical robotic assistance. …”
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Role of Inflammasomes in Neuroimmune and Neurodegenerative Diseases: A Systematic Review by Yue Lang, Fengna Chu, Donghui Shen, Weiguanliu Zhang, Chao Zheng, Jie Zhu, Li Cui

“…Many recent studies suggest a strong correlation between inflammasomes and neurological diseases, such as multiple sclerosis (MS), Alzheimer’s disease (AD), and Parkinson’s disease (PD). …”
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α-Synuclein fibrils enhance HIV-1 infection of human T cells, macrophages and microglia by Lia-Raluca Olari, Sichen Liu, Franziska Arnold, Julia Kühlwein, Marta Gil Miró, Ajeet Rijal Updahaya, Christina Stürzel, Dietmar Rudolf Thal, Paul Walther, Konstantin M. J. Sparrer, Karin M. Danzer, Jan Münch, Frank Kirchhoff

“…Here, we show that α-synuclein and (to a lesser extent) Aβ fibrils associated with neurological diseases enhance HIV-1 entry and replication in human T cells, macrophages, and microglia. …”
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Dysfunctional BCAA degradation triggers neuronal damage through disrupted AMPK-mitochondrial axis due to enhanced PP2Ac interaction by Shih-Cheng Wu, Yan-Jhen Chen, Shih-Han Su, Pai-Hsiang Fang, Rei-Wen Liu, Hui-Ying Tsai, Yen-Jui Chang, Hsing-Han Li, Jian-Chiuan Li, Chun-Hong Chen

“…Our study identifies BCAA imbalance as a critical driver of neuronal damage through AMPK suppression and autophagy dysfunction, offering insights into metabolic-neuronal interactions in neurological diseases and potential therapeutic targets for BCAA-related neurological conditions.…”
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Clinical Decision Support Using Speech Signal Analysis: Systematic Scoping Review of Neurological Disorders by Upeka De Silva, Samaneh Madanian, Sharon Olsen, John Michael Templeton, Christian Poellabauer, Sandra L Schneider, Ajit Narayanan, Rahmina Rubaiat

“…A narrower scope of studies investigating neurological diseases were analyzed using qualitative content analysis. …”
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Transformers for Neuroimage Segmentation: Scoping Review by Maya Iratni, Amira Abdullah, Mariam Aldhaheri, Omar Elharrouss, Alaa Abd-alrazaq, Zahiriddin Rustamov, Nazar Zaki, Rafat Damseh

“… BackgroundNeuroimaging segmentation is increasingly important for diagnosing and planning treatments for neurological diseases. Manual segmentation is time-consuming, apart from being prone to human error and variability. …”
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Functional Role of Milk Fat Globule-Epidermal Growth Factor VIII in Macrophage-Mediated Inflammatory Responses and Inflammatory/Autoimmune Diseases by Young-Su Yi

“…Chronic inflammation is considered to be one of the major causes of serious diseases, including a number of autoimmune/inflammatory diseases, cancers, cardiovascular diseases, and neurological diseases. Milk fat globule-epidermal growth factor 8 (MFG-E8) is a secreted protein found in vertebrates and was initially discovered as a critical component of the milk fat globule. …”
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Widespread Striatal Delivery of GDNF from Encapsulated Cells Prevents the Anatomical and Functional Consequences of Excitotoxicity by Dwaine F. Emerich, Jeffrey H. Kordower, Yaping Chu, Chris Thanos, Briannan Bintz, Giovanna Paolone, Lars U. Wahlberg

“…Because GDNF has been effective in animal models of Parkinson’s disease, stroke, epilepsy, and Huntington’s disease, among other debilitating neurodegenerative diseases, encapsulated cell-based delivery of GDNF might represent one innovative means of slowing the neural degeneration seen in a myriad of currently untreatable neurological diseases.…”
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Targeting Histone Deacetylases: A Novel Approach in Parkinson’s Disease by Sorabh Sharma, Rajeev Taliyan

“…Indeed, it is becoming increasingly evident that chromatin acetylation status can be impaired during the neurological disease conditions. The acetylation and deacetylation of histone proteins are carried out by opposing actions of histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively. …”
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Functional significance of some common oxytocin receptor SNPs involved in complex human traits by Suk Ling Ma, Michael Thomas Bowen, Mark R. Dadds

“…Method The impact of four common OXTR SNPs (rs1042778, rs4686302, rs2254298 and rs237887) on OXTR gene expression were tested in human neuroblastoma cell line, SH-SY5Y, a commonly used cell line for neurological disease. SNPs were chosen as having robust evidence for associations with complex human traits after consideration of linkage patterns across OXTR. …”
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