Evolutionarily Developed Alternatively Spliced Exons Containing Translation Initiation Sites by Jun-ichi Takeda, Takaaki Okamoto, Akio Masuda

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COMPUTER ANALYSIS OF DATA ON GENE EXPRESSION IN BRAIN CELLS OBTAINED BY MICROARRAY TESTS AND HIGH-THROUGHPUT SEQUENCING by I. V. Medvedeva, O. V. Vishnevsky, N. S. Safronova, O. S. Kozhevnikova, M. A. Genaev, A. V. Kochetov, D. A. Afonnikov, Y. L. Orlov

“…Some genes overexpressed in brain tissues are associated with neurological diseases. The numbers of exons and active transcripts in genes differentially expressed in different organs are considered. …”
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Neutrophil to Lymphocyte Ratio in Epilepsy: A Systematic Review by Samaneh Hosseini, Amir Mohammad Eghbalnejad Mofrad, Peyman Mokarian, Shima Nourigheimasi, Amir Azarhomayoun, Shokoufeh Khanzadeh, Saba Habibzadeh, Arshin Ghaedi

“…Epilepsy is one of the most important neurological diseases in the world, and millions of people around the world suffer from it, and a cheap and fast biomarker is needed for it. …”
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Advances in Gene Therapy for Neurologic Disorders: An Overview by Pallavi Chand, K. Trideva Sastri, Ashish Singh Chauhan, Souvik Chakraborty, Vikash Jakhmola

“…Neurologic disorders most often occur due to inherent genetic mutations, which lead to numerous types of functional disruptions in nervous system development. Neurologic disease-related events, such as genetic and epigenetic changes, cause inflammatory processes in the area which may enhance the disease cycle. …”
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Machine learning identified novel players in lipid metabolism, endosomal trafficking, and iron metabolism of the ALS spinal cord by Jack Cheng, Bor-Tsang Wu, Hsin-Ping Liu, Wei-Yong Lin

“…In this study, we adopted machine learning to build binary classifiers based on the New York Genome Center (NYGC) ALS Consortium’s RNA-seq data of the postmortem spinal cord of ALS and non-neurological disease control. The accuracy of the classifiers was greater than 83% and 77% for the training set and the unseen test set, respectively. …”
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Combining Convolutional Neural Network (CNN) and Grad-CAM for Parkinson’s Disease Prediction and Visual Explanation by Reyhaneh Dehghan, Marjan Naderan, Seyed Enayatallah Alavi

“…Parkinson's disease is one of the types of neurological diseases that is caused by the destruction of brain cells that produce dopamine. …”
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Characteristics of TSPO expression in marmoset EAE by Irene Falk, Dragan Maric, Emily Leibovitch, Pascal Sati, Jennifer Lefeuvre, Nicholas J. Luciano, Joseph Guy, Seung-Kwon Ha, David R. Owen, Franklin Aigbirhio, Paul M. Matthews, Daniel S. Reich, Steven Jacobson

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Effect of age and sex differences on the abundances of neuronal, glial, and endothelial cells in non-diseased brain tissue. by Arttu Autio-Kimura, Tapio Nevalainen, Mikko Hurme

“…These findings contribute to our understanding of the effects of age and sex differences on the cellular composition of the brain and shed light on the potential roles of age and sex in neurological diseases.…”
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COVID-19 Mortality in Children: A Referral Center Experience from Iran (Mofid Children’s Hospital, Tehran, Iran) by Shahnaz Armin, Seyed Alireza Fahimzad, Sedigheh Rafiei Tabatabaei, Roxana Mansour Ghanaiee, Noushin Marhamati, Seyyedeh Narjes Ahmadizadeh, Azita Behzad, Seyedeh Masumeh Hashemi, Saeed Sadr, Maryam Rajabnejad, Mahnaz Jamee, Abdollah Karimi

“…The median length of stay in the hospital was 10 days (range 1–215). 91.52% had underlying comorbidities of which neurological diseases accounted for the largest share. 54 patients were admitted to the ICU and 83.05% of them had intubation during their hospitalization. …”
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Transition from paediatric to adult neurological care: What do we know? by A. Valero-Mut, M.M. Rosselló-Vadell, M. Caner-Faig, J. Rubies-Olives, M. Carmona-Belda, E. Córdoba-Borrás, M.A. Grimalt-Calatayud, E. Miravet-Fuster

“…Introduction: Healthcare advances have allowed an increase in the survival of paediatric patients with neurological diseases. As a result, it is increasingly common to find these patients in adult neurology consultations. …”
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Biomaterial-based regenerative therapeutic strategies for spinal cord injury by Keyi Chen, Wei Yu, Genjiang Zheng, Zeng Xu, Chen Yang, Yunhao Wang, Zhihao Yue, Weien Yuan, Bo Hu, Huajiang Chen

“…Abstract As one of the most intractable neurological diseases, spinal cord injury (SCI) often leads to permanent neurological impairment in patients. …”
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Epstein-Barr Virus Encephalitis in an Immunocompetent Child: A Case Report and Management of Epstein-Barr Virus Encephalitis by Gulsen Akkoc, Eda Kepenekli Kadayifci, Ayse Karaaslan, Serkan Atici, Nurhayat Yakut, Sevliya Ocal Demir, Ahmet Soysal, Mustafa Bakir

“…Epstein-Barr virus (EBV) usually causes mild, asymptomatic, and self-limited infections in children and adults; however, it may occasionally lead to severe conditions such as neurological diseases, malignant diseases, hepatic failure, and myocarditis. …”
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Using the Ethereum Blockchain in the Internet of Things Network for IT Diagnostics by U. A. Vishniakou, YiWei Xia, Chuyue Yu

“…This integration is proving effective for storing and managing sensitive data of patients with neurological diseases. An integrated system architecture has been developed that combines the IoT network, the IPFS (InterPlanetary File System) file structure with the Ethereum blockchain to create a reliable data storage model. …”
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The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases by Keshav Raj Sigdel, Ao Cheng, Yin Wang, Lihua Duan, YanLin Zhang

“…The lncRNAs play crucial role in various multigenetics human diseases including cancers and neurological diseases and currently its role in autoimmune diseases is attracting many researchers. …”
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Genomic exploration of pediatric neurological disorders: a case series by Naresh Tayade, Gautham Manoj, Akshay Kewat, Anjali Krishna A, Rajiv Devulapalli, Somesh Kumar, Sunil Kumar Polipalli, Bipin G. Nair, Obul Reddy Bandapalli, Prashanth Suravajhala

“…Case presentation We explore three Indian cases of pediatric neurological diseases (with age presented at the clinic), viz. arthrogryposis (8 years), autism (18 months), and congenital bilateral cataract (3 years), by analyzing clinical exomes. …”
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Motor modules are largely unaffected by pathological walking biomechanics: a simulation study by Mohammad Rahimi Goloujeh, Jessica L. Allen

“…In other words, changes in number and structure of motor modules can be a valuable indicator of alterations in neuromuscular control and may therefore be useful for guiding rehabilitation interventions and controlling exoskeletons and prosthetic devices in individuals with impaired walking function due to neurological disease or injury.…”
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Global glucose metabolism rate as diagnostic marker for disorder of consciousness of patients: quantitative FDG-PET study by Dongsheng Liu, Dongsheng Liu, Dongsheng Liu, Nan Wang, Nan Wang, Nan Wang, Ming Song, Ming Song, Ming Song, Xiaoke Chai, Xiaoke Chai, Qiheng He, Tianqing Cao, Dawei Kong, Zhuhuan Song, Guangming Zhang, Lei Liu, Xiaosong Wang, Guoqiang Chen, Shaoya Yin, Shaoya Yin, Shaoya Yin, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Jizong Zhao, Jizong Zhao

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Stem Cell Tracking Technologies for Neurological Regenerative Medicine Purposes by Yongtao Zheng, Jiongwei Huang, Tongming Zhu, Ronggang Li, Zhifu Wang, Fukai Ma, Jianhong Zhu

“…The growing field of stem cell therapy is moving toward clinical trials in a variety of applications, particularly for neurological diseases. However, this translation of cell therapies into humans has prompted a need to create innovative and breakthrough methods for stem cell tracing, to explore the migration routes and its reciprocity with microenvironment targets in the body, to monitor and track the outcome after stem cell transplantation therapy, and to track the distribution and cell viability of transplanted cells noninvasively and longitudinally. …”
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Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus by Natalia Avaliani, Ulrich Pfisterer, Andreas Heuer, Malin Parmar, Merab Kokaia, My Andersson

“…Direct conversion of human somatic cells to induced neurons (iNs), using lineage-specific transcription factors has opened new opportunities for cell therapy in a number of neurological diseases, including epilepsy. In most severe cases of epilepsy, seizures often originate in the hippocampus, where populations of inhibitory interneurons degenerate. …”
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Phospholipase D, a Novel Therapeutic Target Contributes to the Pathogenesis of Neurodegenerative and Neuroimmune Diseases by Weiwei Zhang, Feiqi Zhu, Jie Zhu, Kangding Liu

“…In this review, family members, characterizations, structure, functions and related signaling pathways, and therapeutic values of PLD was summarized, then five representative diseases including Alzheimer disease (AD), Parkinson’s disease (PD), etc. were selected as examples to tell the involvement of PLD in these neurological diseases. Notably, recent advances in the development of tools for studying PLD therapy envisaged novel therapeutic interventions. …”
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