Prenatal gene-environment interactions mediate the impact of advanced maternal age on mouse offspring behavior by Marta Marlena Ziętek, Aneta Jaszczyk, Adrian Mateusz Stankiewicz, Silvestre Sampino

“…These findings disentangle the relationship between genetic determinants and maternal age-related factors in shaping the emergence of autism-like behaviors in mice, highlighting the interplay between maternal age, genetic variability, and prenatal programming, in the occurrence of neurodevelopmental disorders.…”
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Using cortical organoids to understand the pathogenesis of malformations of cortical development by Kellen D. Winden, Isabel Gisser, Mustafa Sahin

“…Specific, localized malformations are termed focal cortical dysplasias (FCD). Neurodevelopmental disorders are common in all types of malformations of cortical development with the most prominent being refractory epilepsy, behavioral disorders such as autism spectrum disorder (ASD), and learning disorders. …”
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Immune Dysfunction in Tourette Syndrome by Ishraga Elamin, Mark J. Edwards, Davide Martino

“…The association between immunity and neurodevelopmental disorders has been extensively investigated in autism, suggesting a potential involvement of both cellular and humoral immunity in the establishment of synaptic connectivity modulation during development. …”
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Narrative microstructure and macrostructure in adolescents with Down syndrome and Williams syndrome by Aitana Viejo, Maite Fernández-Urquiza, Eliseo Diez-Itza

“…Down syndrome (DS) and Williams syndrome (WS) are genetic neurodevelopmental disorders associated with intellectual disability, showing contrasting linguistic profiles with asymmetries in grammatical (DS weakness/WS strength) vs. pragmatic abilities (DS strength/WS weakness). …”
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Prevalence and comorbidity rates of disruptive mood dysregulation disorder in epidemiological and clinical samples: systematic review and meta-analysis by Xavier Benarous, Hélène Lahaye, Angèle Consoli, David Cohen, Réal Labelle, Jean-Marc Guilé

“…The association with other neurodevelopmental disorders remained poorly investigated. …”
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Rapid and quantitative functional interrogation of human enhancer variant activity in live mice by Ethan W. Hollingsworth, Taryn A. Liu, Joshua A. Alcantara, Cindy X. Chen, Sandra H. Jacinto, Evgeny Z. Kvon

“…Finally, we demonstrate the widespread utility of dual-enSERT by testing the effects of fifteen previously uncharacterised rare and common non-coding variants linked to neurodevelopmental disorders. In doing so we identify variants that reproducibly alter the in vivo activity of OTX2 and MIR9-2 brain enhancers, implicating them in autism. …”
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In search of prosociality in rodents: A scoping review. by Valérie Charron, Joey Talbot, Patrick R Labelle, Anne T M Konkle, Hélène Plamondon

“…Studying prosociality in rodents can provide insight into brain mechanisms potentially related to neurodevelopmental disorders known to impact social behaviors (e.g., autism spectrum disorder). …”
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Transcriptional role of androgen receptor in the expression of long non-coding RNA Sox2OT in neurogenesis. by Valentina Tosetti, Jenny Sassone, Anna L M Ferri, Michela Taiana, Gloria Bedini, Sara Nava, Greta Brenna, Chiara Di Resta, Davide Pareyson, Anna Maria Di Giulio, Stephana Carelli, Eugenio A Parati, Alfredo Gorio

“…Changes at transcriptional level of genes that regulate migration and differentiation may lead to neurodevelopmental disorders. Androgen receptor (AR) is a transcription factor that is already expressed during early embryonic days. …”
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PWS/AS MS-MLPA Confirms Maternal Origin of 15q11.2 Microduplication by Angelika J. Dawson, Janice Cox, Karine Hovanes, Elizabeth Spriggs

“…The proximal region of the long arm of chromosome 15q11.2-q13 is associated with various neurodevelopmental disorders, including Prader-Willi (PWS) and Angelman (AS) syndromes, autism, and other developmental abnormalities resulting from deletions and duplications. …”
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Erythrocyte Shape Abnormalities, Membrane Oxidative Damage, and β-Actin Alterations: An Unrecognized Triad in Classical Autism by Lucia Ciccoli, Claudio De Felice, Eugenio Paccagnini, Silvia Leoncini, Alessandra Pecorelli, Cinzia Signorini, Giuseppe Belmonte, Roberto Guerranti, Alessio Cortelazzo, Mariangela Gentile, Gloria Zollo, Thierry Durand, Giuseppe Valacchi, Marcello Rossi, Joussef Hayek

“…Here, we investigated RBC morphology by scanning electron microscopy in patients with classical autism, that is, the predominant ASDs phenotype (age range: 6–26 years), nonautistic neurodevelopmental disorders (i.e., “positive controls”), and healthy controls (i.e., “negative controls”). …”
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Profiles of Early Expressive Phonological Skills-Brazilian Portuguese (PEEPS-BP): a diagnostic accuracy study by Simone Nicolini de Simoni, Denis Altieri de Oliveira Moraes, Karina Carlesso Pagliarin, Márcia Keske-Soares

“…The sample consisted of 30 children with no identified neurodevelopmental disorders aged 24 to 36 months. Twenty-three were part of the control group, and seven were part of the clinical group, which consisted of children with reported delays in vocabulary acquisition and phonological development. …”
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Coexisting Congenital Mesoblastic Nephroma and Lissencephaly: Unique Case Report with Pathological Analysis and Its Clinical Significance by Hristina Zakić, Olivera Kontić Vučinić, Jelena Stamenković, Jovan Jevtić, Milena Perišić Mitrović, Maja Životić

“…Lissencephaly belongs to a rare category of neurodevelopmental disorders marked by the absence of a substantial reduction in the typical folds and grooves in the cerebral cortex. …”
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An unstable variant of GAP43 leads to neurodevelopmental deficiency by Mariko Noda, Ayumi Matsumoto, Hidenori Ito, Masayo Kagami, Toshihiro Tajima, Takayoshi Matsumura, Takanori Yamagata, Koh-ichi Nagata

“…We performed whole exome sequencing on a patient with intellectual disability (ID), neurodevelopmental disorders, short stature, and skeletal abnormalities such as left–right difference in legs and digital deformities, and identified a heterozygous missense variation in the GAP43 gene [NM_001130064.2: c.436G > A/p.…”
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Neuroligin-3 R451C induces gain-of-function gene expression in astroglia in an astroglia-enriched brain organoid model by Rui Dang, Mridul Dalmia, Ziyuan Ma, Mengmeng Jin, Kushal Aluru, Vincent R. Mirabella, Ava V. Papetti, Li Cai, Peng Jiang

“…Abstract Astroglia are integral to brain development and the emergence of neurodevelopmental disorders. However, studying the pathophysiology of human astroglia using brain organoid models has been hindered by inefficient astrogliogenesis. …”
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Cerebral organoids: a promising model in cellular technologies by T. A. Shnaider

“…In addition, we discuss successful implementation of this technology in fundamental and applied research like modeling of different neurodevelopmental disorders and drug screening. Finally, we regard existing problems and prospects for development of human pluripotent stem cell-derived threedimensional cerebral organoid technology.…”
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MicroRNA-219 in the central nervous system: a potential theranostic approach by Nahal Shamaeizadeh, Mina Mirian

“…MicroRNA-219 is a specific brain-enriched miRNA associated with neurodevelopmental disorders that play crucial roles in the differentiation of oligodendrocyte progenitorcells, promotion of oligodendrocyte maturation, remyelination, and cognitive functions to the extent that it can be considered a potential therapeutic option for demyelination in multiple sclerosis and spinal cord injury and reverse chronic inflammation pains. …”
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Contribution of a virtual magic camp to enhancing self-esteem in children with ADHD: A pilot study by Hon K. Yuen, Kevin Spencer, Kimberly Kirklin, Lauren Edwards, Gavin R. Jenkins

“…Magic, a performing art, when used therapeutically, has been shown to enhance self-esteem in children with neurodevelopmental disorders. However, there is a paucity of evaluation studies using this intervention applied to children with ADHD…”
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A systematic review of exposure to toxic elements and neurocognitive development in children by Tingyi Guo, Moslem Lari Najafi, Junmei Zhang

“…Exposure to potentially toxic elements (PTEs) has been implicated in neurodevelopmental disorders and cognitive deficits in children. …”
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Neurodevelopment in very low birth weight newborns in Matanzas during 2016-2018 by Gerardo Rogelio Robaina Castellanos, Solangel de la Caridad Riesgo Rodríguez, Dariana Hernández Morales

“…<br /><strong>Conclusion</strong>: The incidence of neurodevelopmental disorders at two years old of corrected age in very low birth weight newborns in Matanzas was lower in the period studied, in relation to previous years, although this finding was not statistically significant.…”
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Can attention-deficit/hyperactivity disorder be considered a form of cerebellar dysfunction? by Valeria Isaac, Vladimir Lopez, Maria Josefina Escobar

“…The rapidly growing field of the clinical cognitive neuroscience of the cerebellum has begun to relate cerebro-cerebellar circuits to neurodevelopmental disorders. While the cerebellum’s role in motor function, such as balance, motor coordination, and execution, is well recognized, ongoing research has evidenced its additional and fundamental role in neurocognitive development and executive function, including attention and social cognition, which are all areas of impairment commonly found in ADHD. …”
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