The molecular view of mechanical stress of brain cells, local translation, and neurodegenerative diseases by T. M. Khlebodarova

“…The assumption that chronic mechanical stress in brain cells stemming from intracranial hypertension, arterial hypertension, or mechanical injury is a risk factor for neurodegenerative diseases was put forward in the 1990s and has since been supported. …”
Get full text

New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases by Yan-rui Sun, Qian-Kun Lv, Jun-Yi Liu, Fen Wang, Chun-Feng Liu

Subjects: Get full text

Mechanisms of ubiquitin-independent proteasomal degradation and their roles in age-related neurodegenerative disease by Taylor R. Church, Seth S. Margolis, Seth S. Margolis

Subjects: “…neurodegenerative disease…”
Get full text

Bidirectional Mendelian Randomization Analysis of the Association Between Mitochondrial Proteins and Neurodegenerative Diseases by Fangyuan Wang, Zhou Jing, Qingyi Wang, Minghe Li, Bingqi Lu, Ao Huo, Chenglin Zhao, Huanyu Zhou, Wulong Liang, Weihua Hu, Xudong Fu

Subjects: Get full text

Oxidative Stress, DNA Damage, and c-Abl Signaling: At the Crossroad in Neurodegenerative Diseases? by Stefania Gonfloni, Emiliano Maiani, Claudia Di Bartolomeo, Marc Diederich, Gianni Cesareni

Get full text

AI-optimized electrochemical aptasensors for stable, reproducible detection of neurodegenerative diseases, cancer, and coronavirus by Amira Elsir Tayfour Ahmed, Th.S. Dhahi, Tahani A. Attia, Fawzia Awad Elhassan Ali, Mohamed Elshaikh Elobaid, Tijjani Adam, Subash C.B. Gopinath

“…Leveraging data-driven AI techniques, these sensors provide a non-invasive, cost-effective alternative to traditional methods, with applications in detecting molecular biomarkers for neurodegenerative diseases, cancer, and coronavirus. The performance metrics outlined in the comparative table illustrate the significant advancements enabled by AI integration. …”
Get full text

Impact of physical exercise on the regulation of brain-derived neurotrophic factor in people with neurodegenerative diseases by Ana Romero Garavito, Valery Díaz Martínez, Estherz Juárez Cortés, José Vicente Negrete Díaz, José Vicente Negrete Díaz, Liliana Marcela Montilla Rodríguez

Subjects: Get full text

Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review by Maroua Jalouli, Md Ataur Rahman, Partha Biswas, Hasanur Rahman, Abdel Halim Harrath, In-Seon Lee, In-Seon Lee, Sojin Kang, Jinwon Choi, Moon Nyeo Park, Bonglee Kim, Bonglee Kim

Subjects: Get full text

Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO by Vidya Narayanaswami PhD, Kenneth Dahl PhD, Vadim Bernard-Gauthier PhD, Lee Josephson PhD, Paul Cumming PhD, Neil Vasdev PhD

“…On the other hand, chronic neuroglial activation is a major pathological mechanism in neurodegenerative diseases, likely contributing to neuronal dysfunction, injury, and disease progression. …”
Get full text

Retraction: Specific Transfection of Inflamed Brain by Macrophages: A New Therapeutic Strategy for Neurodegenerative Diseases. by PLOS ONE Editors

Get full text

Addressing inter individual variability in CSF levels of brain derived proteins across neurodegenerative diseases by Sára Mravinacová, Sofia Bergström, Jennie Olofsson, Nerea Gómez de San José, Sarah Anderl-Straub, Janine Diehl-Schmid, Klaus Fassbender, Klaus Fliessbach, Holger Jahn, Johannes Kornhuber, G. Bernhard Landwehrmeyer, Martin Lauer, Johannes Levin, Albert C. Ludolph, Johannes Prudlo, Anja Schneider, Matthias L. Schroeter, Jens Wiltfang, Petra Steinacker, FTLD Consortium, Markus Otto, Peter Nilsson, Anna Månberg

“…Abstract Accurate diagnosis and monitoring of neurodegenerative diseases require reliable biomarkers. Cerebrospinal fluid (CSF) proteins are promising candidates for reflecting brain pathology; however, their diagnostic utility may be compromised by natural variability between individuals, weakening their association with disease. …”
Get full text

Having a Coffee Break: The Impact of Caffeine Consumption on Microglia-Mediated Inflammation in Neurodegenerative Diseases by Maria H. Madeira, Raquel Boia, António F. Ambrósio, Ana R. Santiago

“…Epidemiological evidence suggests that caffeine consumption reduces the risk of several neurological and neurodegenerative diseases. However, despite the beneficial effects of caffeine consumption in human health and behaviour, the mechanisms by which it impacts the pathophysiology of neurodegenerative diseases still remain to be clarified. …”
Get full text

Phenolic Compounds and Pharmacological Potential of <em>Lavandula angustifolia</em> Extracts for the Treatment of Neurodegenerative Diseases by Olha Mykhailenko, Viktoriia Hurina, Nataliia Herbina, Yuliia Maslii, Liudas Ivanauskas, Inna Vladymyrova, Dmytro Lytkin, Zigmantas Gudžinskas, Hanna Severina, Olena Ruban, Victoriya Georgiyants

“…These results demonstrate the potential neuroprotective activity of lavender herb and open new possibilities for its use in the treatment of various neurodegenerative diseases.…”
Get full text

Deciphering the spectrum of astrocyte diversity: Insights into molecular, morphological, and functional dimensions in health and neurodegenerative diseases by Fumito Endo

“…This review discusses recent advances in understanding the molecular and morphological diversity of astrocytes in healthy individuals and those with neurodegenerative diseases, such as Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis.…”
Get full text

Targeting uric acid: a promising intervention against oxidative stress and neuroinflammation in neurodegenerative diseases by Lin Xu, Chengwei Li, Tiantian Wan, Xinyi Sun, Xiaojie Lin, Dong Yan, Jianjun Li, Penghui Wei

Subjects: Get full text

Application of psychobiotics in clinical treatment of mental disorders: Neurodevelopmental disorders, neurodegenerative diseases, depression and anxiety by Jingwei Cui, Wenxin Wang, Yue Tang, Siyuan Feng, Hong Liu, Zikai Hao

“…This article briefly reviews the clinical applications of psychobiotics in improving and treating conditions such as neurodevelopmental disorders, neurodegenerative diseases, depression and anxiety. It is proposed that the novel therapeutic approach of using Bacillus licheniformis as an adjuvant treatment for patients with depression shows a certain degree of feasibility. …”
Get full text

Scrutinizing neurodegenerative diseases: decoding the complex genetic architectures through a multi-omics lens by Relu Cocoș, Bogdan Ovidiu Popescu

“…Abstract Neurodegenerative diseases present complex genetic architectures, reflecting a continuum from monogenic to oligogenic and polygenic models. …”
Get full text

The role of CXCL12/CXCR4/CXCR7 axis in cognitive impairment associated with neurodegenerative diseases by Rojin Sarallah, Shima Jahani, Alireza Soltani Khaboushan, Amir Kian Moaveni, Maryam Amiri, Masoumeh Majidi Zolbin

Subjects: Get full text

Role of exercise on ncRNAs and exosomal ncRNAs in preventing neurodegenerative diseases: a narrative review by Shangwu Liu, Runhong Zhang, Jamal Hallajzadeh

Subjects: Get full text

Editorial: To Know or Not to Know: causes and evolution of lack of awareness of cognitive decline in neurodegenerative diseases, volume II by Federica Cacciamani, Federica Cacciamani, Kristy A. Nielson, Kristy A. Nielson, Bernard J. Hanseeuw, Bernard J. Hanseeuw, Geoffroy P. Gagliardi, Geoffroy P. Gagliardi, Patrizia Vannini, Patrizia Vannini

Get full text